Hematology Lab Quiz

Hematology

• A sample is run multiple times to assess:
  • Precision
• Wright's stain requires a pH of 6.8; a pH of 6.0 would make red cells stain too pink.
• Howell-Jolly bodies are associated with Megaloblastic Anemia.
• Lymphocyte count of 60% is considered normal in children from 6 months to 2 years old.
• Drabkin's reagent is used to measure Cyanmethemoglobin.
• Corrected WBC count = [100/(100+nRBC)] x WBC count.
• Dohle bodies are seen in cases of burn.
• Chediak-Higashi anomaly is characterized by lavender granules and multiple granules present in lymphocytes and neutrophils.
• Erythropoietin production can be increased due to decreased renal oxygen tension.
• FAB classification of Acute Myeloblastic Leukemia includes:
  • M1 and M2
• Hemolysis can be caused by transfusing blood too fast into a tube.
• Reactive lymphocytes are indicative of infectious mononucleosis.
• Hypersplenism is characterized by Leukopenia and Thrombocytopenia.
• An elevated ESR can be caused by Inflammation.
• Spherocytes are detected in Autoimmune Hemolytic Anemia (AIHA).
• Transcobalamin II is responsible for transporting cobalamin from the bloodstream to cells throughout the body.
• Pelger-Huet anomaly is characterized by a dumbbell-shaped nucleus in neutrophils.
• All of the following are reliable criteria for differentiating mature from immature cells:
  • Nucleus
  • Cytoplasm
  • Nuclear Chromatin
• Extramedullary hemostasis does not occur in the bone marrow.

Coagulation

• The preferred blood collection for patients with 5 nRBCs present per 100 WBCs.
• Muramidase (lysosome) activity is highest in M4.
• Extramedullary hematopoiesis in emergencies occurs in the liver.
• Pernicious anemia is caused by a lack of intrinsic factor from the stomach.
• PT and APTT are corrected by adsorbed plasma.
• Factor V deficiency is corrected by adsorbed plasma.
• Vitamin K is the antidote for an overdose of Coumadin.
• Fibrinogen group is activated by activated factor 2.
• APTT and PT are corrected by adsorbed plasma, which suggests a factor deficiency.
• Vitamin K-dependent factors include:
  • Fibrinogen
  • Prothrombin
• The first factor affected by warfarin is Factor VII.
• Precision in bleeding time is controlled by a standardized wound.
• DIC is associated with:
  • Decreased plt count
  • Increase in factors I, V, VIII
  • Positive D-dimer
  • Prolonged APTT
• ADAM-TS 13 is associated with Thrombotic Thrombocytopenic Purpura (TTP).
• Microfilaments are responsible for platelet shape change during activation.
• Vitamin K-dependent factors include:
  • Fibrinogen
  • Prothrombin
• The anticoagulant to blood ratio in 3.2% sodium citrate in coagulant studies is 1:9.
• The Cascade theory involves the intrinsic pathway:
  • Factor 12 -> 11 -> 9 -> 8 -> 10
• PT is used to monitor oral anticoagulant therapy.
• Deficiency of the fibrinolytic system causes Thrombosis.

Platelet and Blood Cells

• Gum bleeding, deep bruising, and nose bleeding are symptoms of Platelet defect.
• Multiple factor deficiency is associated with Severe liver disease.
• Dysfibrinogenemia is a qualitative fibrinogen deficiency.
• An average megakaryocyte generates approximately 2000 platelets.
• The first stage capable of endomitosis is the LD-CFU-Meg.
• Bleeding time assesses platelet adhesion in vivo.
• Fibrinogen deficiency would show abnormal results in:
  • Thrombin Time
  • Prothrombin Time
  • Platelet aggregation tests
• The late stage of megakaryoblast marks the beginning of alpha granules formation.
• The entire central large square is used for counting platelets in a hemocytometer.
• A biphasic curve is shown by:
  • a&c (adrenaline and collagen)
• PFA-100 is used to assess qualitative platelet defects.
• Spurious decreased platelet count can be caused by:
  • Giant platelet
  • Platelet clumping
  • Platelet satellitism
  • Red cell inclusion
• Hemophilia B is the most severe bleeding disorder.
• The preferable site for bone marrow biopsy in children is the posterior iliac crest.

RBC and Hemoglobin

• Hemolysis in the Donath-Landsteiner test is positive for Donath-Landsteiner antibody.
• RBC size is reflected in the MCV parameter.
• Increased reticulocyte count is reflected in Polychromasia.
• Basophilic normoblast is the stage where Hb maturation starts.
• Calcium is not considered a coagulation factor but is known as Factor IV.

Hematology

• A sample is run multiple times to assess:
  • Precision
• Wright's stain requires a pH of 6.8; a pH of 6.0 would make red cells stain too pink.
• Howell-Jolly bodies are associated with Megaloblastic Anemia.
• Lymphocyte count of 60% is considered normal in children from 6 months to 2 years old.
• Drabkin's reagent is used to measure Cyanmethemoglobin.
• Corrected WBC count = [100/(100+nRBC)] x WBC count.
• Dohle bodies are seen in cases of burn.
• Chediak-Higashi anomaly is characterized by lavender granules and multiple granules present in lymphocytes and neutrophils.
• Erythropoietin production can be increased due to decreased renal oxygen tension.
• FAB classification of Acute Myeloblastic Leukemia includes:
  • M1 and M2
• Hemolysis can be caused by transfusing blood too fast into a tube.
• Reactive lymphocytes are indicative of infectious mononucleosis.
• Hypersplenism is characterized by Leukopenia and Thrombocytopenia.
• An elevated ESR can be caused by Inflammation.
• Spherocytes are detected in Autoimmune Hemolytic Anemia (AIHA).
• Transcobalamin II is responsible for transporting cobalamin from the bloodstream to cells throughout the body.
• Pelger-Huet anomaly is characterized by a dumbbell-shaped nucleus in neutrophils.
• All of the following are reliable criteria for differentiating mature from immature cells:
  • Nucleus
  • Cytoplasm
  • Nuclear Chromatin
• Extramedullary hemostasis does not occur in the bone marrow.

Coagulation

• The preferred blood collection for patients with 5 nRBCs present per 100 WBCs.
• Muramidase (lysosome) activity is highest in M4.
• Extramedullary hematopoiesis in emergencies occurs in the liver.
• Pernicious anemia is caused by a lack of intrinsic factor from the stomach.
• PT and APTT are corrected by adsorbed plasma.
• Factor V deficiency is corrected by adsorbed plasma.
• Vitamin K is the antidote for an overdose of Coumadin.
• Fibrinogen group is activated by activated factor 2.
• APTT and PT are corrected by adsorbed plasma, which suggests a factor deficiency.
• Vitamin K-dependent factors include:
  • Fibrinogen
  • Prothrombin
• The first factor affected by warfarin is Factor VII.
• Precision in bleeding time is controlled by a standardized wound.
• DIC is associated with:
  • Decreased plt count
  • Increase in factors I, V, VIII
  • Positive D-dimer
  • Prolonged APTT
• ADAM-TS 13 is associated with Thrombotic Thrombocytopenic Purpura (TTP).
• Microfilaments are responsible for platelet shape change during activation.
• Vitamin K-dependent factors include:
  • Fibrinogen
  • Prothrombin
• The anticoagulant to blood ratio in 3.2% sodium citrate in coagulant studies is 1:9.
• The Cascade theory involves the intrinsic pathway:
  • Factor 12 -> 11 -> 9 -> 8 -> 10
• PT is used to monitor oral anticoagulant therapy.
• Deficiency of the fibrinolytic system causes Thrombosis.

Platelet and Blood Cells

• Gum bleeding, deep bruising, and nose bleeding are symptoms of Platelet defect.
• Multiple factor deficiency is associated with Severe liver disease.
• Dysfibrinogenemia is a qualitative fibrinogen deficiency.
• An average megakaryocyte generates approximately 2000 platelets.
• The first stage capable of endomitosis is the LD-CFU-Meg.
• Bleeding time assesses platelet adhesion in vivo.
• Fibrinogen deficiency would show abnormal results in:
  • Thrombin Time
  • Prothrombin Time
  • Platelet aggregation tests
• The late stage of megakaryoblast marks the beginning of alpha granules formation.
• The entire central large square is used for counting platelets in a hemocytometer.
• A biphasic curve is shown by:
  • a&c (adrenaline and collagen)
• PFA-100 is used to assess qualitative platelet defects.
• Spurious decreased platelet count can be caused by:
  • Giant platelet
  • Platelet clumping
  • Platelet satellitism
  • Red cell inclusion
• Hemophilia B is the most severe bleeding disorder.
• The preferable site for bone marrow biopsy in children is the posterior iliac crest.

RBC and Hemoglobin

• Hemolysis in the Donath-Landsteiner test is positive for Donath-Landsteiner antibody.
• RBC size is reflected in the MCV parameter.
• Increased reticulocyte count is reflected in Polychromasia.
• Basophilic normoblast is the stage where Hb maturation starts.
• Calcium is not considered a coagulation factor but is known as Factor IV.

Hematology

• A sample is run multiple times to assess:
  • Precision
• Wright's stain requires a pH of 6.8; a pH of 6.0 would make red cells stain too pink.
• Howell-Jolly bodies are associated with Megaloblastic Anemia.
• Lymphocyte count of 60% is considered normal in children from 6 months to 2 years old.
• Drabkin's reagent is used to measure Cyanmethemoglobin.
• Corrected WBC count = [100/(100+nRBC)] x WBC count.
• Dohle bodies are seen in cases of burn.
• Chediak-Higashi anomaly is characterized by lavender granules and multiple granules present in lymphocytes and neutrophils.
• Erythropoietin production can be increased due to decreased renal oxygen tension.
• FAB classification of Acute Myeloblastic Leukemia includes:
  • M1 and M2
• Hemolysis can be caused by transfusing blood too fast into a tube.
• Reactive lymphocytes are indicative of infectious mononucleosis.
• Hypersplenism is characterized by Leukopenia and Thrombocytopenia.
• An elevated ESR can be caused by Inflammation.
• Spherocytes are detected in Autoimmune Hemolytic Anemia (AIHA).
• Transcobalamin II is responsible for transporting cobalamin from the bloodstream to cells throughout the body.
• Pelger-Huet anomaly is characterized by a dumbbell-shaped nucleus in neutrophils.
• All of the following are reliable criteria for differentiating mature from immature cells:
  • Nucleus
  • Cytoplasm
  • Nuclear Chromatin
• Extramedullary hemostasis does not occur in the bone marrow.

Coagulation

• The preferred blood collection for patients with 5 nRBCs present per 100 WBCs.
• Muramidase (lysosome) activity is highest in M4.
• Extramedullary hematopoiesis in emergencies occurs in the liver.
• Pernicious anemia is caused by a lack of intrinsic factor from the stomach.
• PT and APTT are corrected by adsorbed plasma.
• Factor V deficiency is corrected by adsorbed plasma.
• Vitamin K is the antidote for an overdose of Coumadin.
• Fibrinogen group is activated by activated factor 2.
• APTT and PT are corrected by adsorbed plasma, which suggests a factor deficiency.
• Vitamin K-dependent factors include:
  • Fibrinogen
  • Prothrombin
• The first factor affected by warfarin is Factor VII.
• Precision in bleeding time is controlled by a standardized wound.
• DIC is associated with:
  • Decreased plt count
  • Increase in factors I, V, VIII
  • Positive D-dimer
  • Prolonged APTT
• ADAM-TS 13 is associated with Thrombotic Thrombocytopenic Purpura (TTP).
• Microfilaments are responsible for platelet shape change during activation.
• Vitamin K-dependent factors include:
  • Fibrinogen
  • Prothrombin
• The anticoagulant to blood ratio in 3.2% sodium citrate in coagulant studies is 1:9.
• The Cascade theory involves the intrinsic pathway:
  • Factor 12 -> 11 -> 9 -> 8 -> 10
• PT is used to monitor oral anticoagulant therapy.
• Deficiency of the fibrinolytic system causes Thrombosis.

Platelet and Blood Cells

• Gum bleeding, deep bruising, and nose bleeding are symptoms of Platelet defect.
• Multiple factor deficiency is associated with Severe liver disease.
• Dysfibrinogenemia is a qualitative fibrinogen deficiency.
• An average megakaryocyte generates approximately 2000 platelets.
• The first stage capable of endomitosis is the LD-CFU-Meg.
• Bleeding time assesses platelet adhesion in vivo.
• Fibrinogen deficiency would show abnormal results in:
  • Thrombin Time
  • Prothrombin Time
  • Platelet aggregation tests
• The late stage of megakaryoblast marks the beginning of alpha granules formation.
• The entire central large square is used for counting platelets in a hemocytometer.
• A biphasic curve is shown by:
  • a&c (adrenaline and collagen)
• PFA-100 is used to assess qualitative platelet defects.
• Spurious decreased platelet count can be caused by:
  • Giant platelet
  • Platelet clumping
  • Platelet satellitism
  • Red cell inclusion
• Hemophilia B is the most severe bleeding disorder.
• The preferable site for bone marrow biopsy in children is the posterior iliac crest.

RBC and Hemoglobin

• Hemolysis in the Donath-Landsteiner test is positive for Donath-Landsteiner antibody.
• RBC size is reflected in the MCV parameter.
• Increased reticulocyte count is reflected in Polychromasia.
• Basophilic normoblast is the stage where Hb maturation starts.
• Calcium is not considered a coagulation factor but is known as Factor IV.