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Which type of leukemia is most common in children?
Leukemia primarily affects the lungs and kidneys.
False
What is the primary impact of leukemia on the immune system?
Reduced immune defense leading to increased vulnerability to infections.
Leukemia in adults commonly includes chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (_____).
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Match the following potential causes of leukemia with their descriptions:
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What type of cells are affected in Acute Lymphoblastic Leukemia (ALL)?
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Chronic Lymphocytic Leukemia (CLL) manifests primarily with symptoms of fever and anemia.
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What is a common treatment option for Chronic Myeloid Leukemia (CML)?
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In Acute Myeloid Leukemia (AML), there is uncontrolled proliferation of _______.
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Match the following leukemia types with their primary feature:
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Which of the following is a symptom of Acute Lymphoblastic Leukemia (ALL)?
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What is a characteristic feature of Chronic Myeloid Leukemia (CML)?
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Acute Lymphoblastic Leukemia (ALL) is characterized by a gradual onset of symptoms.
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Name one treatment option for Acute Myeloid Leukemia (AML).
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Chronic Lymphocytic Leukemia (CLL) primarily involves abnormal _____ lymphocytes.
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Match the following major leukemia types with their associated clinical features:
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Which of the following are common symptoms of Acute Myeloid Leukemia (AML)?
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Chronic Lymphocytic Leukemia (CLL) is mainly asymptomatic and usually detected during routine tests.
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What genetic abnormality is implicated in Chronic Myeloid Leukemia (CML)?
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In Acute Lymphoblastic Leukemia (ALL), CNS infiltration can lead to symptoms such as _______ and seizures.
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Match the following leukemia types with their symptoms:
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What is the typical 5-year survival rate for children diagnosed with Acute Lymphoblastic Leukemia (ALL)?
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What is a common symptom of Chronic Lymphocytic Leukemia (CLL)?
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Acute Myeloid Leukemia (AML) is more common in children than in older adults.
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What genetic abnormality is associated with Chronic Myeloid Leukemia (CML)?
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Acute Lymphoblastic Leukemia (ALL) is primarily diagnosed in _______ (age group).
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Match the following leukemia types with their characteristic complications:
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Which of the following are common general symptoms of leukemia? (Select all that apply)
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Elevated WBC count is always indicative of leukemia.
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What lab finding typically reveals leukemic cells in leukemia patients?
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Symptoms like petechiae and epistaxis are commonly associated with __________ tendencies in leukemia.
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Match the following lab findings with their implications:
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Which of the following demographics is true regarding leukemia prevalence?
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Exposure to benzene is a known environmental risk factor for leukemia.
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Name one genetic condition that is associated with an increased risk of Acute Lymphoblastic Leukemia (ALL).
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Radiation exposure from nuclear accidents is classified as an __________ risk factor for leukemia.
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Match the following conditions associated with an increased risk of leukemia:
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Study Notes
Leukemia Definition and Characteristics
- A group of malignant diseases originating in blood or bone marrow.
- Characterized by:
- Replacement of bone marrow by malignant, immature white blood cells (WBCs).
- Abnormal WBCs circulating in the bloodstream.
- Infiltration of malignant cells into organs like the liver, spleen, and lymph nodes.
Prevalence
- Common in children, with Acute Lymphoblastic Leukemia (ALL) being the most prevalent type.
- In adults, Chronic Lymphocytic Leukemia (CLL) and Acute Myeloid Leukemia (AML) are more prevalent.
Pathophysiology
- Malignant WBCs clone instead of dividing through mitosis.
- Bone marrow fills with abnormal WBCs, spilling into the bloodstream.
- Leads to a suppressed immune system, increasing susceptibility to infections.
- Disrupts normal blood production, leading to:
- Decreased red blood cell (RBC) count, causing anemia.
- Reduced platelet count, resulting in abnormal bleeding and bruising.
Potential Causes
- Exposure to radiation, chemotherapy, benzene, and viruses.
- Genetic predisposition, including chromosomal defects.
Leukemia Classifications
- Acute leukemia: Characterized by sudden onset, rapid progression, and the presence of immature blast cells.
- Chronic leukemia: Characterized by gradual onset, a prolonged course, and mature-appearing cells.
Cell Type Involved
- Lymphocytic/lymphoblastic leukemia: Impacts immature lymphocytes, leading to infiltration of lymph nodes, spleen, central nervous system, and other tissues.
- Myeloid leukemia: Affects myeloid stem cells, impacting red blood cells, white blood cells, and platelets.
Major Leukemia Types and Clinical Features
- Acute Lymphoblastic Leukemia (ALL): Rapid proliferation of lymphoblasts, causing fatigue, infections, bleeding, bone pain, and central nervous system symptoms. Treatment options include chemotherapy, bone marrow transplant (BMT), and stem cell transplant (SCT).
- Chronic Lymphocytic Leukemia (CLL): Abnormal B lymphocytes, resulting in fatigue, splenomegaly, and recurrent infections. Treatment options include watchful waiting, chemotherapy, and BMT.
- Acute Myeloid Leukemia (AML): Uncontrolled myeloblast proliferation, causing fever, anemia, infections, and bleeding. Treatment options include chemotherapy and SCT.
- Chronic Myeloid Leukemia (CML): Linked to the Philadelphia chromosome, causing weight loss, fever, and splenomegaly. Treatment options include interferon, imatinib (Gleevec), and SCT.
Leukemia Classifications
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Acuity describes the speed of leukemia development.
- Acute leukemia has a sudden onset and rapid progression, with immature blast cells.
- Chronic leukemia has a gradual onset and prolonged course, with mature-appearing cells.
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Cell type involved determines the specific type of leukemia.
- Lymphocytic/lymphoblastic leukemia affects immature lymphocytes, invading lymph nodes, spleen, central nervous system, and other tissues.
- Myeloid leukemia involves myeloid stem cells, impacting red blood cells, white blood cells, and platelets.
Major Leukemia Types and Clinical Features
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Acute Lymphoblastic Leukemia (ALL) is characterized by rapid proliferation of lymphoblasts.
- Symptoms include fatigue, infections, bleeding, bone pain, and central nervous system (CNS) symptoms.
- Treatment includes chemotherapy, bone marrow transplant (BMT), and stem cell transplantation (SCT).
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Chronic Lymphocytic Leukemia (CLL) involves an overabundance of abnormal B lymphocytes.
- Symptoms include fatigue, splenomegaly, and recurrent infections.
- Treatment varies from watchful waiting to chemotherapy and BMT.
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Acute Myeloid Leukemia (AML) is marked by uncontrolled myeloblast proliferation.
- Symptoms include fever, anemia, infections, and bleeding.
- Treatment includes chemotherapy and SCT.
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Chronic Myeloid Leukemia (CML) is linked to the Philadelphia chromosome.
- Symptoms include weight loss, fever, and splenomegaly.
- Treatment includes interferon, imatinib (Gleevec), and SCT.
Acute Myeloid Leukemia (AML)
- Most common in older adults, but rare in children.
- Symptoms include: fatigue, frequent infections, bruising, tiny red spots on the skin (petechiae), and gastrointestinal bleeding.
- Complications can be life-threatening, including anemia, severe infections, and hemorrhage.
- Diagnosis is made by examining bone marrow and finding immature white blood cells along with low platelet count (thrombocytopenia).
Chronic Myeloid Leukemia (CML)
- Characterized by the Philadelphia chromosome (a specific genetic abnormality with a fusion gene called BCR-ABL).
- The disease progresses in three phases:
- Chronic phase: Often mild or no symptoms.
- Accelerated phase: Weight loss, decreased appetite, and fever develop.
- Blast phase: Enlarged spleen, bone damage, and abnormal platelets appear.
Acute Lymphoblastic Leukemia (ALL)
- Most common leukemia in children, less common in adults under 40.
- Symptoms include: fever, bleeding, swollen lymph nodes, bone pain, and central nervous system infiltration leading to headaches and seizures.
- Five-year survival rate is high (~90%) in children, but lower (~40%) in adults.
Chronic Lymphocytic Leukemia (CLL)
- Predominantly found in adults older than 70 years old.
- Symptoms can include: weakness, recurrent infections, swollen lymph nodes, and an enlarged spleen.
- Often, the disease is asymptomatic and discovered during routine medical testing.
Acute Myeloid Leukemia (AML)
- More common in older adults
- Rare in children
- Symptoms include: fatigue, infections, easy bruising, tiny red spots on the skin, and gastrointestinal bleeding
- Complications include: Anemia, severe infections, and hemorrhage which can lead to death
- Diagnosed by examining bone marrow and the presence of immature white blood cells and low platelet count
Chronic Myeloid Leukemia (CML)
- Associated with the Philadelphia chromosome, which is a result of a fusion gene called BCR-ABL
- Has 3 phases
- Chronic phase: Mild or no symptoms
- Accelerated phase: Weight loss, decreased appetite, fever
- Blast phase: Enlarged spleen, bone damage, abnormal platelets
Acute Lymphoblastic Leukemia (ALL)
- Most common in children
- Rare in adults under 40
- Symptoms include: Fever, bleeding, swollen lymph nodes, bone pain, and central nervous system involvement presenting with headaches and seizures
- 5-year survival rates: ~90% in children and ~40% in adults
Chronic Lymphocytic Leukemia (CLL)
- Most common leukemia in adults over 70 years old
- Symptoms include: Weakness, recurrent infections, swollen lymph nodes, and enlarged spleen
- Often asymptomatic and detected during routine blood tests
### Manifestations of (Insert Disease Name Here)
- Fatigue, weakness, and paleness are common due to anemia
- Infections, such as pneumonia, septicemia, and mucous membrane ulcerations, are often seen
- Bleeding tendencies include petechiae, epistaxis, and gastrointestinal bleeding
Diagnostic Findings
- Complete blood count (CBC) may show elevated or decreased white blood cell counts, reduced red blood cells, and low platelet counts
- Bone marrow aspiration reveals hyperplasia, meaning increased cell production, and leukemic cells
Risk Factors for Leukemia
- Gender: Men are more likely to develop leukemia than women.
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Genetic Factors:
- Acute Lymphoblastic Leukemia (ALL): Individuals with Down syndrome and Klinefelter syndrome have an increased risk.
- Acute Myeloid Leukemia (AML): Chromosomal abnormalities, which are not inherited, increase the risk of AML.
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Environmental Risks:
- Radiation Exposure: Exposure to radiation, such as from nuclear accidents, is linked to an increased risk of leukemia.
- **Chemical Exposure:**Exposure to benzene, a chemical found in cigarettes and pesticides, is a known risk factor for leukemia.
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Associated Conditions:
- Immune Deficiency Syndromes: People with immune deficiency syndromes, such as Wiskott-Aldrich syndrome and ataxia-telangiectasia, have an increased risk of leukemia.
- Previous Cancer Treatment: Past cancer treatment, particularly with certain chemotherapy drugs, increases the risk of developing leukemia.
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Description
This quiz covers the definition and characteristics of leukemia, a group of malignant diseases that affect blood and bone marrow. Learn about its prevalence in different age groups, pathophysiology, and the impact on normal blood production. Test your knowledge on Acute Lymphoblastic Leukemia (ALL) and other types.
