Malignant Lymphoproliferative Disorders Quiz

Malignant Lymphoproliferative Disorders in Hematology

• The module covers malignant lymphoproliferative disorders, including acute lymphoproliferative disorders, chronic lymphoproliferative leukemic disorders, lymphomas, and plasma cell neoplasms.
• It aims to educate students on understanding the morphological characteristics, pathophysiology, etiology, and diagnostic laboratory examination of leukocyte disorders.
• The reference material for the module is "Rodak’s Hematology 5th Edition," specifically Chapter 35 and Chapter 36.
• The module details specific disorders such as acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL), prolymphocytic leukemia (PLL), multiple myeloma, Waldenstrom macroglobulinemia, Hodgkin lymphoma (classical), and non-Hodgkin lymphoma.
• ALL is characterized by the slow, uncontrollable growth of abnormal lymphoid cells in the bone marrow (BM), spleen, and lymph nodes, leading to the replacement of normal hematopoietic cells.
• It is the most common of all leukemias, accounting for 75% of childhood leukemia and being the most common malignant disease in children aged 2-10 years old.
• Laboratory findings in ALL include varying white blood cell (WBC) counts, with over 60% of cases having more than 10 × 10^9/L, while a significant proportion may have over 100 × 10^9/L, and in some cases, the WBC count may be normal or decreased.
• In cases of ALL, anemia, granulocytopenia, and thrombocytopenia are common.