Lec. 7: Blood Groups, Hemostasis, and Blood Coagulation

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What is the primary function of hemostasis?

To prevent and stop bleeding, keeping blood within a damaged blood vessel

What is the first response of the blood vessel to hemostasis?

Vascular spasm

What prevents blood clotting in intact blood vessels?

Heparin-like molecule and thrombomodulin

What is the function of nitric oxide and prostacyclin in hemostasis?

To inhibit platelet aggregation

What is the purpose of the platelet plug in hemostasis?

To form a temporary seal to cover the break in the vessel wall

What is the final step in the hemostasis process?

Blood coagulation, or formation of a fibrin clot

What is the primary function of vasoconstriction in hemostasis?

To reduce blood flow through the injured area and limit blood loss

What is the role of collagen in hemostasis?

To promote platelet adhesion to the injury site

What is the primary function of platelets in hemostasis?

To form a platelet plug and then degranulate

What is the result of the coagulation cascade in hemostasis?

Formation of a Fibrin mesh around the platelet plug

What is the term for the process of platelet plug formation and degranulation?

Primary hemostasis

What is the term for the step that involves the formation of a Fibrin mesh around the platelet plug?

Secondary hemostasis

What is the immediate consequence of the formation of prothrombin activator in the blood coagulation process?

Conversion of prothrombin to thrombin

Which of the following is NOT a mechanism that initiates clotting?

Release of histamine from mast cells

What is the role of ionic Ca++ in the conversion of prothrombin to thrombin?

It causes the conversion of prothrombin to thrombin in the presence of prothrombin activator

What is the final product of the clotting process?

A mesh of platelets, blood cells, and plasma

What is the primary function of thrombin in the blood coagulation process?

To act as an enzyme to convert fibrinogen into fibrin fibers

What is the initial step in the clotting process?

Formation of prothrombin activator

This quiz covers the process of hemostasis, which prevents and stops bleeding, and its relation to blood coagulation, a crucial stage of wound healing. Topics include endothelial cells, platelet aggregation, and blood clotting.

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