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Questions and Answers

In the context of Aplysia californica's gill withdrawal reflex, which of the following statements accurately describes the molecular and physiological mechanisms underlying long-term habituation?

  • Long-term habituation arises due to a progressive decrease in the number of available postsynaptic receptors on the gill motor neurons, diminishing the response to subsequent stimulations.
  • Long-term habituation results from a sustained increase in neurotransmitter release at the motor neuron synapse, leading to a prolonged potentiation of the gill withdrawal response.
  • Long-term habituation is characterized by a persistent reduction in neurotransmitter release from sensory neurons, coupled with structural changes at the synapse that decrease the efficiency of synaptic transmission. (correct)
  • Long-term habituation involves epigenetic modifications, such as histone deacetylation, that suppress the expression of genes encoding proteins crucial for neurotransmitter release at the sensory-motor neuron synapse.

Considering the role of the amygdala and hippocampus in fear conditioning, which of the following scenarios would most likely result in a context-independent fear response that is resistant to extinction?

  • Pharmacological blockade of NMDA receptors in the hippocampus during fear acquisition, followed by extinction training in multiple, varied contexts.
  • Repeated pairings of a conditioned stimulus (CS) with an unconditioned stimulus (US) in a novel environment, followed by extinction training in the original conditioning context.
  • Simultaneous lesions to both the amygdala and hippocampus prior to fear conditioning, preventing the encoding of both the emotional and contextual components of the fear memory.
  • A lesion to the hippocampus combined with pharmacological enhancement of GABAergic neurotransmission in the amygdala during fear acquisition. (correct)

Given the principles of Hebbian learning and synaptic plasticity, which of the following scenarios would result in the most robust and enduring long-term potentiation (LTP) at a glutamatergic synapse in the CA1 region of the hippocampus?

  • Repeatedly stimulating the presynaptic neuron at a high frequency (tetanus) after pre-treating the synapse with a protein synthesis inhibitor.
  • Stimulating the presynaptic neuron at a theta frequency (4-12 Hz) while maintaining the postsynaptic membrane potential at its resting level.
  • Applying a low-frequency stimulation (LFS) protocol while simultaneously blocking postsynaptic NMDA receptors with APV.
  • Pairing a weak presynaptic stimulation with a strong postsynaptic depolarization induced by direct current injection into the postsynaptic neuron. (correct)

In the context of second-order conditioning, if a dog initially learns to salivate to a bell (CS1) that is paired with food (US), and subsequently learns to salivate to a light (CS2) that is paired with the bell (CS1) but never directly with the food (US), which statement accurately describes the underlying neural mechanisms?

<p>The light (CS2) activates a neural representation of the bell (CS1), which in turn activates the neural representation of the food (US), leading to salivation. (A)</p> Signup and view all the answers

Considering the principles of operant conditioning, which of the following scenarios would result in the most rapid acquisition of a new behavior, followed by the greatest resistance to extinction?

<p>Continuous reinforcement during acquisition, followed by a variable-interval schedule during maintenance. (C)</p> Signup and view all the answers

When comparing sensitization and habituation in non-associative learning, which statement accurately describes the differential impact on synaptic transmission at the sensory-motor neuron synapse?

<p>Sensitization involves presynaptic facilitation due to the release of neuromodulators, whereas habituation involves presynaptic depression due to decreased calcium influx. (B)</p> Signup and view all the answers

In the context of observational learning, which of the following best explains the cognitive and neural mechanisms underlying vicarious reinforcement, where an observer learns by watching another individual receive rewards or punishments?

<p>Vicarious reinforcement involves the observer's prefrontal cortex evaluating the consequences of the model's actions, updating their own action-outcome expectancies, and modulating dopaminergic activity in the striatum. (D)</p> Signup and view all the answers

Considering the reconsolidation theory of memory, which of the following conditions would be most effective in permanently disrupting a previously consolidated fear memory in humans?

<p>Administering a beta-blocker, such as propranolol, immediately after retrieving the fear memory by presenting the conditioned stimulus (CS) in the absence of the unconditioned stimulus (US). (D)</p> Signup and view all the answers

In the context of Alzheimer's disease, which of the following statements best describes the relationship between acetylcholine deficiency, amyloid plaques, neurofibrillary tangles, and the resulting cognitive impairments?

<p>Amyloid plaques initiate a cascade of events that lead to hyperphosphorylation of tau protein, forming neurofibrillary tangles, which disrupt axonal transport and synaptic function, ultimately resulting in acetylcholine deficiency and cognitive impairments. (A)</p> Signup and view all the answers

Considering the distinct roles of sensory memory, short-term memory (STM), working memory, and long-term memory (LTM), which of the following scenarios best illustrates the interaction between these memory systems during a complex cognitive task?

<p>While navigating a familiar route, sensory memory captures visual information, STM briefly holds the sequence of turns, working memory integrates this information with spatial knowledge retrieved from LTM to guide decision-making. (C)</p> Signup and view all the answers

Given the phenomena of stimulus generalization and stimulus discrimination in classical conditioning, which of the following scenarios best demonstrates the neural mechanisms underlying successful stimulus discrimination following initial generalization?

<p>After an animal generalizes its conditioned response to stimuli similar to the original CS, subsequent discrimination training leads to a sharpening of the neural representation of the original CS in the sensory cortex, accompanied by decreased activity for similar stimuli. (A)</p> Signup and view all the answers

Considering the role of the medial temporal lobe (MTL) in memory, select the option that accurately describes the specific and differential contributions of the hippocampus and surrounding cortical regions (e.g., entorhinal, perirhinal, parahippocampal cortices) to declarative memory formation:

<p>The hippocampus binds together disparate elements of an event to form a cohesive, context-rich episodic memory, while the surrounding cortical regions process and represent individual items and their features. (B)</p> Signup and view all the answers

In light of what is understood about cell assemblies and Hebb’s postulate, if Neuron A consistently and repeatedly activates Neuron B, what is the MOST LIKELY long-term synaptic change predicted by Hebbian theory?

<p>The efficiency of Neuron A in activating Neuron B will increase, potentially via changes in synaptic morphology or receptor expression. (C)</p> Signup and view all the answers

Considering the processes of long-term potentiation (LTP) and long-term depression (LTD) in synaptic plasticity, which statement MOST ACCURATELY contrasts the roles of NMDA receptors in these two opposing phenomena?

<p>LTP induction depends on NMDA receptor-mediated calcium influx activating protein kinases, whereas LTD induction relies on NMDA receptor-mediated calcium influx activating protein phosphatases. (B)</p> Signup and view all the answers

How does operant conditioning BEST account for the development and maintenance of complex behavioral sequences such as those observed in expert musicians or athletes?

<p>Each component action is acquired through shaping, where successive approximations of the target behavior are reinforced, gradually building the entire sequence, with intermittent reinforcement schedules ensuring maintenance. (D)</p> Signup and view all the answers

When considering the role of the amygdala in fear conditioning, WHAT MECHANISM BEST describes the differential impact of lesions to the basolateral amygdala (BLA) versus the central nucleus of the amygdala (CeA) on the expression of conditioned fear responses?

<p>Lesions to the BLA disrupt the acquisition and storage of fear associations, whereas lesions to the CeA impair the expression of conditioned fear responses. (D)</p> Signup and view all the answers

Compared to long-term memory (LTM), what crucial limitation is MOST CHARACTERISTIC of working memory (WM) that makes it unsuitable as a permanent storage system for information?

<p>Working memory has a very limited capacity and is highly susceptible to distraction, unlike long-term memory which can store vast amounts of information for extended periods. (C)</p> Signup and view all the answers

When evaluating encoding, storage, and retrieval, which of the following scenarios BEST exemplifies the concept of encoding specificity and accurately predicts how retrieval performance will be affected?

<p>Studying course material in a quiet library and attempting to recall the information in a loud concert will greatly minimize recall ability, as the contexts are different. (B)</p> Signup and view all the answers

Given the current understanding of amnesia, WHAT DISTINCT COGNITIVE FEATURE differentiates anterograde from retrograde amnesia, that provides insights into memory consolidation and retrieval processes?

<p>Anterograde amnesia impairs the ability to form new memories after the onset of the condition, whereas retrograde amnesia impairs the ability to recall memories formed before the onset of the condition. (C)</p> Signup and view all the answers

In what way do classical and operant conditioning DIFFER in terms of the CAUSAL relationship between behavior and environmental events, informing our understanding of voluntary vs. involuntary actions?

<p>In classical conditioning, behavior is elicited by a preceding stimulus, with the organism passively responding, whereas in operant conditioning, behavior is emitted by the organism and its consequences determine future occurrence. (D)</p> Signup and view all the answers

Considering the phenomenon of spontaneous recovery in classical conditioning, which statement BEST CAPTURES the current understanding of its underlying neural mechanisms and cognitive implications?

<p>After extinction, the original conditioned association remains intact but is temporarily suppressed by contextual cues, with spontaneous recovery representing a release from this contextual inhibition. (B)</p> Signup and view all the answers

How do positive reinforcement and negative reinforcement DIFFER in their impact on behavior, and WHAT potential unintended consequences should be considered when applying these techniques?

<p>Positive reinforcement strengthens behavior by adding a pleasant stimulus, whereas negative reinforcement strengthens behavior by removing an aversive stimulus, but both can lead to unintended consequences such as dependence or avoidance. (D)</p> Signup and view all the answers

How does the Premack principle inform us about the effectiveness of using one behavior to reinforce another, and WHAT underlying factors determine whether this strategy will be successful?

<p>The Premack principle states that a more preferred behavior can be used to reinforce a less preferred behavior, but the effectiveness of this strategy depends on the relative values of the behaviors to the individual and the contingency between them. (D)</p> Signup and view all the answers

When considering the effectiveness of different reinforcement schedules, WHAT are the KEY distinctions between fixed-ratio, variable-ratio, fixed-interval, and variable-interval schedules, and how do these differences impact response rates and resistance to extinction?

<p>Ratio schedules produce higher response rates than interval schedules, and variable schedules produce greater resistance to extinction than fixed schedules, reflecting the predictability and contingency of the reinforcement. (C)</p> Signup and view all the answers

Considering the processes of social learning and modeling behaviors, WHAT CRUCIAL factors influence the likelihood that an individual will imitate a model, and how do these factors interact with the individual's own cognitive and emotional states?

<p>Individuals are more likely to imitate models who are attractive, high-status, and similar to themselves, and this effect is modulated by the individual's attention, memory, and motivation. (D)</p> Signup and view all the answers

In context of social learning theory, WHAT distinct roles do attention, retention, reproduction, and motivation play in the acquisition and performance of modeled behaviors, and how can these processes be optimized to enhance learning outcomes?

<p>Attention, retention, reproduction, and motivation are sequentially dependent, influenced by model characteristics, task complexity, and individual reinforcement. (C)</p> Signup and view all the answers

What key factor is responsible for the increased resistance to extinction seen with partial reinforcement compared to continuous reinforcement?

<p>With partial reinforcement, organisms learn that reinforcement is less predictable, so they persist longer in the absence of reinforcement because they have learned reinforcement comes sporadically. (A)</p> Signup and view all the answers

How does the psychodynamic approach to learning DIFFER from the behaviorist approach, and WHAT are the potential limitations and strengths of each perspective in explaining complex human behaviors?

<p>The psychodynamic approach emphasizes the role of unconscious processes and early experiences and focuses on observable behaviors and environmental influences, considering internal states. (A)</p> Signup and view all the answers

Select the statement that BEST reflects the relationship between classical conditioning, operant conditioning, and observational learning, in relation to fear acquisition and the development of phobias:

<p>Classical conditioning can explain how a neutral stimulus becomes associated with a fearful experience, while operant conditioning maintains avoidance behaviors, and observational learning facilitates the acquisition of fears through vicarious experiences. (D)</p> Signup and view all the answers

What statement BEST captures the current understanding of how long-term potentiation (LTP) and long-term depression (LTD) interact to refine synaptic connections and optimize neural circuits for information processing?

<p>LTP and LTD are opposing forces that work together to selectively strengthen and weaken synaptic connections, thereby sculpting neural circuits and enabling adaptive responses to experience. (D)</p> Signup and view all the answers

Flashcards

Learning

Enduring change in behavior from experience. Helps predict events and adapt to the environment.

Psychodynamic approach

Emphasizes unconscious mental processes as drivers of behavior, using introspection.

Behaviorist approach

Focuses on the environment's effects on observable behavior as a measure of psychological activity.

Non-associative learning

Change in behavior after repeated exposure to a stimulus.

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Habituation

Decrease in behavioral response after repeated exposure to a stimulus.

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Dishabituation

Increased response due to change in a familiar stimulus.

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Sensitization

Increased response after exposure to a threatening stimulus; heightened response.

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Associative learning

Learning the connection between two pieces of information. Includes classical and operant conditioning.

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Unconditioned stimulus (US)

Stimulus that naturally triggers a response.

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Unconditioned response (UR)

Automatic reaction to an unconditioned stimulus.

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Conditioned stimulus (CS)

Previously neutral stimulus that, after association with a US, elicits a response.

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Conditioned response (CR)

Learned response to a conditioned stimulus.

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Acquisition (Classical Conditioning)

Phase where the CS and US are repeatedly paired, leading to the CR.

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Extinction (Classical Conditioning)

When the CS is repeatedly presented without the US, the CR weakens and eventually disappears.

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Spontaneous Recovery

After extinction, the CR reappears if the CS is presented again after a rest period.

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Second Order Conditioning

A neutral stimulus paired with the CS can elicit the CR, even without direct exposure to the US.

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Stimulus Generalization

Stimuli similar to the CS produce the CR.

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Stimulus Discrimination

Animal learns to differentiate between similar stimuli, responding only when one stimulus is paired with the US.

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Phobia

Acquired fear out of proportion to the real threat. Develops through generalization.

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Thorndike's Law of Effect

Behaviors followed by satisfying outcomes are more likely to be repeated; unpleasant outcomes less likely.

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Shaping (operant conditioning)

Process of reinforcing behaviors that are increasingly similar to the desired behavior.

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Primary Reinforcers

Basically biological needs (food, water) essential for survival.

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Secondary Reinforcers

Learned through classical conditioning by being associated with primary reinforcers.

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Premack Principle

More valued activity can reinforce a less valued activity.

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Continuous Reinforcement

Every time the desired behavior occurs, it is reinforced; leads to fast learning but quick extinction.

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Partial Reinforcement

Reinforcement is given only some of the time, leading to slower learning but greater resistance to extinction.

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Fixed Interval

Reinforcement given after a set amount of time

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Variable Interval

Reinforcement given after varying amounts of time

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Fixed Ratio

Reinforcement given after a set number of behaviors.

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Variable Ratio

Reinforcement is given after a variable number of behaviors

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Positive Reinforcement

Adding a pleasant stimulus to increase behavior.

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Negative Reinforcement

Removing an unpleasant stimulus to increase behavior.

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Observational Learning

Learning by watching and imitating others.

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Modeling (Observational Learning)

Likely to imitate models who are attractive, high status, and similar to us.

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Vicarious learning and reinforcement

Learning by observing others being rewarded or punished.

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Learning

Acquiring new information.

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Memory

Persistence of learning in a state that can be revealed later.

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Encoding (Memory)

Converting sensory input into short-term memory.

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Storage (Memory)

Consolidating short-term memory into long-term storage.

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Retrieval (Memory)

Accessing stored information to guide behavior.

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Study Notes

  • A relatively enduring change in behaviour results from experience, improving event prediction and environmental preparedness.

Learning Theory

  • The psychodynamic approach emphasizes unconscious mental processes, using introspection to examine thoughts and emotions.
  • The behaviourist approach emphasizes environmental influences and focuses on observable behaviour as a valid measure.

Types of Learning

  • Non-associative learning involves a change in behaviour after repeated or continuous stimulus exposure.
    • Habituation refers to a decrease in behavioral response after repeated stimulus exposure.
    • Dishabituation refers to an increased response due to a change in a familiar stimulus.
    • Sensitization refers to an increased response after exposure to a threatening stimulus, resulting in a heightened response.

Aplysia Californica

  • Gill withdrawal in aplysia demonstrates non-associative learning.
    • Habituation occurs with repeated, harmless siphon stimulation, weakening the gill withdrawal response due to reduced neurotransmitter release in motor neurons.
    • Sensitization occurs when a strong stimulus, such as a tail shock, increases neurotransmitter release, making the gill withdrawal more pronounced.
      • Short-term habituation involves response recovery after a short break.
      • Long-term habituation involves a response remaining reduced with minimal recovery after repeated exposure over several days.
  • Observational learning involves learning by watching or imitating.
  • Associative learning involves learning the connection between two pieces of information through classical and operant conditioning.
    • The unconditioned stimulus (US) naturally triggers a response, such as food.
    • The unconditioned response (UR) is an automatic reaction to the US, such as salivation to food.
    • A conditioned stimulus (CS) is a previously neutral stimulus that elicits a response after association with the US, such as a bell.
    • The conditioned response (CR) is the learned response to the CS, such as salivation to the bell.

Classical Conditioning Processes

  • Acquisition involves repeatedly pairing the CS and US, leading to the CR.
  • Extinction involves the CR weakening and eventually disappearing if the CS is repeatedly presented without the US.
  • Spontaneous recovery involves the CR reappearing if the CS is presented again after a rest period, though usually weaker.

Second Order Conditioning

  • A neutral stimulus paired with the CS can elicit the CR without direct exposure to the US.
    • For example, a light paired with a bell causes a dog to salivate at the sight of the light alone.
  • Associating money with happiness: Money can be associated with happiness because it is linked to experiences that are pleasurable.
  • Stimulus generalization involves similar stimuli producing the CR and is adaptive.
  • Stimulus discrimination enables animals to differentiate between similar stimuli, responding only when the stimulus is paired with the US.
    • A dog learns to discriminate between similar bells, salivating only to the original tone if similar bells are played without food.
  • Phobia is an acquired fear disproportionate to the real threat, developed through fear experience generalization via fear conditioning.
    • The amygdala processes fear responses triggered by specific stimuli.
    • The hippocampus encodes context-dependent fear tied to environment or situation.

Operant Conditioning

  • Behaviour is influenced by consequences, such as rewards or punishments.
  • Thorndike’s law of effect states behaviours followed by satisfying outcomes are more likely to be repeated (reinforcement) while unwanted behaviours are less likely to be repeated.
    • In a Skinner box, rabbits could press a lever to reveal food or avoid a mild shock.
  • Shaping is the process of reinforcing behaviours that are increasingly similar to the desired behaviours..
  • Primary reinforcers are biological needs and inherently reinforcing because they are essential for survival e.g food, water, and sleep.
  • Secondary reinforcers are learned through classical conditioning by associating with primary reinforcers.
    • According to the Premack principle, a more valued activity can reinforce a less valued activity.
  • Continuous reinforcement involves reinforcing every desired behaviour, leading to fast learning but quick extinction.
  • Partial reinforcement involves reinforcing behaviour only some of the time, leading to slower learning but greater resistance to extinction.
    • Fixed interval reinforcement occurs after a set amount of time.
    • Variable interval reinforcement occurs irregularly.
    • Fixed ratio reinforcement occurs after a set number of behaviours.
    • Variable ratio reinforcement occurs after a variable number of behaviours.

Positive and Negative Reinforcement

  • Reinforcement - Increase behaviour
    • Positive Reinforcement - Add something pleasant
    • Negative Reinforcement - Remove somethine unpleasant.
  • Punishment - Decrease behavior
    • Positive Punishment - Add something unpleasant
    • Negative Punishment - Remove something pleasant.

Observational Learning

  • Observational learning is a social learning and adaptive tool to learn what is safe versus dangerous and to learn language and cultural beliefs.
  • Modelling (Demonstration and Imitation)
    • Modelling is more likely to occur when imitating model that are attractive, high status, and similar to us.
    • Often implicit (unconscious). Only effective if observer physically capable of imitating the behaviour.
  • Vicarious learning and reinforcement occurs by learning behaviours by observing others being rewarded or punished.
    • Lab-raised monkeys, with no fear of snakes, learned fear by observing wild monkeys' fearful reactions.

Learning and Memory

  • Learning is the process of acquiring new information, while memory is the persistence of learning in a state that can be revealed later.
  • Memory can fail due to amnesia, head injury, psychological trauma, disease, dementia, or Korsakoff’s syndrome.

Alzheimers disease

  • Most common form of dementia, primarily affecting older adults.
  • Linked causes
    • Acetylcholine deficiency affecting memory and cognition
    • Amyloid plaques disrupting cell function
    • Neurofibrillary tangles damaging neuron structure

Memory Processes

  • Encoding converts sensory input into short-term memory.
  • Storage consolidates short-term memory into long-term storage.
  • Retrieval accesses stored information to guide behaviour.

Memory Types

  • Sensory memory involves brief storage of sensory input.
    • Iconic for visual, echoic for auditory
  • Short-term memory (STM) temporarily holds limited information.
  • Working memory is part of STM for active information processing.
  • Long-term memory (LTM) is for large, enduring information storage.
  • Reconsolidation is reactivation of memories from LTM to working memory which requires reconsolidation to be stored again, it can be altered and evolved over time.

Long Term Memory

  • Explicit memory includes episodic memory (experienced events) and semantic memory (knowledge and concepts).
  • Implicit memory includes procedural memory (skills and actions) and emotional conditioning.
  • Emotional memories are stored separately from factual details.

H.M Anterograde Amnesia

  • Removal of parts of medial temporal lobes resulted in H.M losing the ability to form new explicit memories, but retained past memories and procedural learning.

H.M.'s case revealed four key principles about memory:

  • Different types of memory exist: H.M could learn motor skills (implicit memory) despite losing the ability to form new explicit memories.
  • The medial temporal lobe is crucial for new explicit memories: H.M’s damage affected memory formation but not intelligence or perception.
  • Working memory is separate from long-term memory: H.M could maintain attention and rehearse information but couldn't transfer it to long-term storage.
  • Long-term memories are stored elsewhere: H.M’s past memories remained intact, suggesting the medial temporal lobe is not the final storage site.
  • Lashley and the engram: memory is distributed rather than localized, and include amygdala, hippocampus, cerebellum, prefrontal cortex.

Neuronal Remodelling

  • "Neurons that fire together, wire together.”
  • When presynaptic and postsynaptic neurons are repeatedly activated together, their synaptic connection strengthens.
  • Cell assemblies: network of neurons that store information and support learning/memory.
  • Hebb’s postulate: “When an axon of cell A excites cell B and repeatedly takes part in firing it, some growth process takes place so that A’s efficiency as one of the cells firing B is increased.”

Synaptic Basis of Memory

  • Memories are stored in networks of interconnected neurons and modify due to plasticity, synaptic changes, and hippocampus.
  • Long-term potentiation (LTP) refers to a lasting increase in synaptic strength.
    • LTP occurs in the hippocampal formation, including the hippocampus, dentate gyrus, and subiculum.
      • Perforant pathway connects the entorhinal cortex through the subiculum to the dentate gyrus.
      • Mossy fibres connect the dentate gyrus to CA3 pyramidal cells.
      • Schaffer collateral pathway connects CA3 pyramidal cells to CA1 pyramidal cells.
  • LTP strengthens synapses.
  • Weak stimulating of electrodes resulted in stable EPSP's.
  • Tetanus stimulation resulted in larger EPSP's improving learning and memory.
  • Increased neurotransmitter release in the stimulated presynaptic terminal increases dendritic spine and thickness.

Chemical Basis of LTP

  • LTP relies on glutamate.
  • glutamate is released and binds to ionotropic receptors, activating ligand-gated ion channels to strengthen synaptic connections.

Pharmacological Inhibition of LTP

  • LTP can be pharmacologically inhibited using NMDA receptor antagonists, such as Amino-Phosphono-Valeric Acid (APV) blocking NMDA receptors and preventing synaptic strengthening.
  • Glutamate binding to NMDA receptors is essential for inducing LTP.

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