29 Questions
What is the gross definition of a polyp?
A growth projecting from mucus membrane
Which type of polyp shows smooth muscle fibers in the connective tissue core?
Hamartomatous polyp
What is the main characteristic of hyperplastic polyps?
An increase in the number of colonic glands
What is the distinguishing feature of adenomatous polyps?
Benign colonic epithelial neoplasm with potential for malignant transformation
At what age does large intestinal adenocarcinoma commonly occur?
6th to 7th decade of life
What is the gender distribution for large intestinal adenocarcinoma?
More in males (Males: Females ratio 2:1)
What is the minimum number of polyps necessary for the diagnosis of familial polyposis coli syndrome?
100 polyps
Which gene is associated with the genetic defect in familial polyposis coli syndrome?
APC
What is the commonest site of large intestinal adenocarcinoma?
Sigmoid colon
In which model does 80% of large intestinal adenocarcinoma arise on top of adenomas?
Adenoma carcinoma model
What is the depth of invasion of the tumor through the colonic wall in T3 staging of large intestinal adenocarcinoma?
Serosa
Which of the following is NOT a potential site of distant metastasis for large intestinal adenocarcinoma?
Brain
What is the pathogenesis of large intestinal adenocarcinoma arising denovo?
Mutation in mismatch repair gene
Which type of colonic polyp is characterized by the presence of dense inflammatory cells in the connective tissue core?
Inflammatory polyps
What is the defining feature of hamartomatous polyps in the connective tissue core?
Smooth muscle fibers
Which term describes the increase in number of glands and cells lining each gland in hyperplastic polyps?
Hyperplasia
What is the defining characteristic of adenomatous polyps?
Potential for malignant transformation
What differentiates hyperplasia from neoplasia in terms of cell division?
Hyperplasia involves monoclonal cells, while neoplasia involves polyclonal cells
In large intestinal adenocarcinoma, which age group is most commonly affected?
6th to 7th decade of life
What is the characteristic feature of familial polyposis coli syndrome?
Minimum of 1000 polyps in affected patients
In the adenoma carcinoma model, what is the initial genetic defect associated with the progression to large intestinal adenocarcinoma?
Mutation in the APC gene (tumor suppressor gene)
What is the most common site for distant metastasis in large intestinal adenocarcinoma?
Liver
What is the characteristic microscopic feature of large intestinal adenocarcinoma?
Cytologic criteria of malignancy such as pleomorphism and increased N/c ratio
What is the TNM stage for a tumor that invades mucosa and submucosa in large intestinal adenocarcinoma?
T1
What type of polyp is associated with familial polyposis coli syndrome?
Adenomatous polyp
Which gene is implicated in the genetic defect of familial polyposis coli syndrome?
APC (Adenomatous Polyposis Coli) tumor suppressor gene
What is the main characteristic used for diagnosing familial polyposis coli syndrome?
$1000 polyps in affected patients
What is the depth of invasion of the tumor through colonic wall in T3 staging of large intestinal adenocarcinoma?
$serosa
What is the most common site for large intestinal adenocarcinoma?
Sigmoid colon
Learn about the types and definitions of colonic polyps, including inflammatory, hamartomatous, and hyperplastic polyps, as well as their microscopic characteristics. This quiz covers the growth projecting from the mucus membrane and the composition of colonic polyps.
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