Large Intestinal Tumors: Colonic Polyps
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Questions and Answers

What is the gross definition of a polyp?

  • A benign colonic epithelial neoplasm
  • A growth projecting from mucus membrane (correct)
  • Dense inflammatory cells in the connective tissue core
  • An increase in the number of colonic glands

Which type of polyp shows smooth muscle fibers in the connective tissue core?

  • Hamartomatous polyp (correct)
  • Inflammatory polyp
  • Adenomatous polyp
  • Hyperplastic polyp

What is the main characteristic of hyperplastic polyps?

  • Dense inflammatory cells in the connective tissue core
  • An increase in the number of colonic glands (correct)
  • Smooth muscle fibers in the connective tissue core
  • Benign colonic epithelial neoplasm

What is the distinguishing feature of adenomatous polyps?

<p>Benign colonic epithelial neoplasm with potential for malignant transformation (C)</p> Signup and view all the answers

At what age does large intestinal adenocarcinoma commonly occur?

<p>6th to 7th decade of life (A)</p> Signup and view all the answers

What is the gender distribution for large intestinal adenocarcinoma?

<p>More in males (Males: Females ratio 2:1) (D)</p> Signup and view all the answers

What is the minimum number of polyps necessary for the diagnosis of familial polyposis coli syndrome?

<p>100 polyps (B)</p> Signup and view all the answers

Which gene is associated with the genetic defect in familial polyposis coli syndrome?

<p>APC (B)</p> Signup and view all the answers

What is the commonest site of large intestinal adenocarcinoma?

<p>Sigmoid colon (A)</p> Signup and view all the answers

In which model does 80% of large intestinal adenocarcinoma arise on top of adenomas?

<p>Adenoma carcinoma model (B)</p> Signup and view all the answers

What is the depth of invasion of the tumor through the colonic wall in T3 staging of large intestinal adenocarcinoma?

<p>Serosa (A)</p> Signup and view all the answers

Which of the following is NOT a potential site of distant metastasis for large intestinal adenocarcinoma?

<p>Brain (C)</p> Signup and view all the answers

What is the pathogenesis of large intestinal adenocarcinoma arising denovo?

<p>Mutation in mismatch repair gene (C)</p> Signup and view all the answers

Which type of colonic polyp is characterized by the presence of dense inflammatory cells in the connective tissue core?

<p>Inflammatory polyps (B)</p> Signup and view all the answers

What is the defining feature of hamartomatous polyps in the connective tissue core?

<p>Smooth muscle fibers (B)</p> Signup and view all the answers

Which term describes the increase in number of glands and cells lining each gland in hyperplastic polyps?

<p>Hyperplasia (A)</p> Signup and view all the answers

What is the defining characteristic of adenomatous polyps?

<p>Potential for malignant transformation (A)</p> Signup and view all the answers

What differentiates hyperplasia from neoplasia in terms of cell division?

<p>Hyperplasia involves monoclonal cells, while neoplasia involves polyclonal cells (C)</p> Signup and view all the answers

In large intestinal adenocarcinoma, which age group is most commonly affected?

<p>6th to 7th decade of life (B)</p> Signup and view all the answers

What is the characteristic feature of familial polyposis coli syndrome?

<p>Minimum of 1000 polyps in affected patients (C)</p> Signup and view all the answers

In the adenoma carcinoma model, what is the initial genetic defect associated with the progression to large intestinal adenocarcinoma?

<p>Mutation in the APC gene (tumor suppressor gene) (C)</p> Signup and view all the answers

What is the most common site for distant metastasis in large intestinal adenocarcinoma?

<p>Liver (B)</p> Signup and view all the answers

What is the characteristic microscopic feature of large intestinal adenocarcinoma?

<p>Cytologic criteria of malignancy such as pleomorphism and increased N/c ratio (B)</p> Signup and view all the answers

What is the TNM stage for a tumor that invades mucosa and submucosa in large intestinal adenocarcinoma?

<p>T1 (A)</p> Signup and view all the answers

What type of polyp is associated with familial polyposis coli syndrome?

<p>Adenomatous polyp (D)</p> Signup and view all the answers

Which gene is implicated in the genetic defect of familial polyposis coli syndrome?

<p>APC (Adenomatous Polyposis Coli) tumor suppressor gene (A)</p> Signup and view all the answers

What is the main characteristic used for diagnosing familial polyposis coli syndrome?

<p>$1000 polyps in affected patients (C)</p> Signup and view all the answers

What is the depth of invasion of the tumor through colonic wall in T3 staging of large intestinal adenocarcinoma?

<p>$serosa (A)</p> Signup and view all the answers

What is the most common site for large intestinal adenocarcinoma?

<p>Sigmoid colon (A)</p> Signup and view all the answers

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