Large Intestinal Tumors: Colonic Polyps
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Questions and Answers

What is the gross definition of a polyp?

  • A benign colonic epithelial neoplasm
  • A growth projecting from mucus membrane (correct)
  • Dense inflammatory cells in the connective tissue core
  • An increase in the number of colonic glands
  • Which type of polyp shows smooth muscle fibers in the connective tissue core?

  • Hamartomatous polyp (correct)
  • Inflammatory polyp
  • Adenomatous polyp
  • Hyperplastic polyp
  • What is the main characteristic of hyperplastic polyps?

  • Dense inflammatory cells in the connective tissue core
  • An increase in the number of colonic glands (correct)
  • Smooth muscle fibers in the connective tissue core
  • Benign colonic epithelial neoplasm
  • What is the distinguishing feature of adenomatous polyps?

    <p>Benign colonic epithelial neoplasm with potential for malignant transformation</p> Signup and view all the answers

    At what age does large intestinal adenocarcinoma commonly occur?

    <p>6th to 7th decade of life</p> Signup and view all the answers

    What is the gender distribution for large intestinal adenocarcinoma?

    <p>More in males (Males: Females ratio 2:1)</p> Signup and view all the answers

    What is the minimum number of polyps necessary for the diagnosis of familial polyposis coli syndrome?

    <p>100 polyps</p> Signup and view all the answers

    Which gene is associated with the genetic defect in familial polyposis coli syndrome?

    <p>APC</p> Signup and view all the answers

    What is the commonest site of large intestinal adenocarcinoma?

    <p>Sigmoid colon</p> Signup and view all the answers

    In which model does 80% of large intestinal adenocarcinoma arise on top of adenomas?

    <p>Adenoma carcinoma model</p> Signup and view all the answers

    What is the depth of invasion of the tumor through the colonic wall in T3 staging of large intestinal adenocarcinoma?

    <p>Serosa</p> Signup and view all the answers

    Which of the following is NOT a potential site of distant metastasis for large intestinal adenocarcinoma?

    <p>Brain</p> Signup and view all the answers

    What is the pathogenesis of large intestinal adenocarcinoma arising denovo?

    <p>Mutation in mismatch repair gene</p> Signup and view all the answers

    Which type of colonic polyp is characterized by the presence of dense inflammatory cells in the connective tissue core?

    <p>Inflammatory polyps</p> Signup and view all the answers

    What is the defining feature of hamartomatous polyps in the connective tissue core?

    <p>Smooth muscle fibers</p> Signup and view all the answers

    Which term describes the increase in number of glands and cells lining each gland in hyperplastic polyps?

    <p>Hyperplasia</p> Signup and view all the answers

    What is the defining characteristic of adenomatous polyps?

    <p>Potential for malignant transformation</p> Signup and view all the answers

    What differentiates hyperplasia from neoplasia in terms of cell division?

    <p>Hyperplasia involves monoclonal cells, while neoplasia involves polyclonal cells</p> Signup and view all the answers

    In large intestinal adenocarcinoma, which age group is most commonly affected?

    <p>6th to 7th decade of life</p> Signup and view all the answers

    What is the characteristic feature of familial polyposis coli syndrome?

    <p>Minimum of 1000 polyps in affected patients</p> Signup and view all the answers

    In the adenoma carcinoma model, what is the initial genetic defect associated with the progression to large intestinal adenocarcinoma?

    <p>Mutation in the APC gene (tumor suppressor gene)</p> Signup and view all the answers

    What is the most common site for distant metastasis in large intestinal adenocarcinoma?

    <p>Liver</p> Signup and view all the answers

    What is the characteristic microscopic feature of large intestinal adenocarcinoma?

    <p>Cytologic criteria of malignancy such as pleomorphism and increased N/c ratio</p> Signup and view all the answers

    What is the TNM stage for a tumor that invades mucosa and submucosa in large intestinal adenocarcinoma?

    <p>T1</p> Signup and view all the answers

    What type of polyp is associated with familial polyposis coli syndrome?

    <p>Adenomatous polyp</p> Signup and view all the answers

    Which gene is implicated in the genetic defect of familial polyposis coli syndrome?

    <p>APC (Adenomatous Polyposis Coli) tumor suppressor gene</p> Signup and view all the answers

    What is the main characteristic used for diagnosing familial polyposis coli syndrome?

    <p>$1000 polyps in affected patients</p> Signup and view all the answers

    What is the depth of invasion of the tumor through colonic wall in T3 staging of large intestinal adenocarcinoma?

    <p>$serosa</p> Signup and view all the answers

    What is the most common site for large intestinal adenocarcinoma?

    <p>Sigmoid colon</p> Signup and view all the answers

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