Sem 3 Large Intestinal Tumors: Types of Colonic Polyps
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Questions and Answers

What is the definition of a polyp?

  • A growth projecting from mucus membrane (correct)
  • A benign tumor in the large intestine
  • A connective tissue core surrounded by smooth muscle fibers
  • A neoplasm formed from monoclonal cells

    • What type of polyp has the potential for malignant transformation?

  • Inflammatory polyps
  • Adenomatous polyps (correct)
  • Hamartomatous polyps
  • Hyperplastic polyps

    • What is the main characteristic of hyperplastic polyps?

  • They have smooth muscle fibers in the connective tissue core
  • They show dense inflammatory cells in the connective tissue core
  • They are formed of connective tissue core surrounded by epithelium from 3 surfaces
  • They show hyperplastic colonic glands (correct)

    • What is the gender distribution of large intestinal adenocarcinoma?

    <p>More in males (Males: Females ratio 2:1)</p> Signup and view all the answers

    What age group is most commonly affected by large intestinal adenocarcinoma?

    <p>6th to 7th decade of life</p> Signup and view all the answers

    Which genetic syndrome is associated with a high risk for large intestinal adenocarcinoma?

    <p>Familial adenomatous polyposis coli syndrome</p> Signup and view all the answers

    Which gene is implicated in familial polyposis coli syndrome?

    <p>APC</p> Signup and view all the answers

    What is the minimum number of polyps necessary for the diagnosis of familial polyposis coli syndrome?

    <p>100 polyps</p> Signup and view all the answers

    In the adenoma carcinoma model, what is the first mutation that initiates the defect?

    <p>Mutation in APC gene</p> Signup and view all the answers

    Which site is the commonest for large intestinal adenocarcinoma?

    <p>Sigmoid colon</p> Signup and view all the answers

    What is the depth of invasion for a T3 stage large intestinal adenocarcinoma?

    <p>Serosa</p> Signup and view all the answers

    What is the primary mode of spread for large intestinal adenocarcinoma to the liver and lungs?

    <p>Blood spread</p> Signup and view all the answers

    Which term describes the microscopic appearance of malignant glands surrounded by desmoplasia in large intestinal adenocarcinoma?

    <p>Tubular adenoma</p> Signup and view all the answers

    In which type of large intestinal adenocarcinoma does the defect start with a mutation in the mismatch repair gene?

    <p>Carcinoma arising denovo</p> Signup and view all the answers

    What is the characteristic feature of cells in large intestinal adenocarcinoma indicative of malignancy?

    <p>Nuclear enlargement and chromatin condensation</p> Signup and view all the answers

    What grading factor depends on the percentage of glandular formations in large intestinal adenocarcinoma?

    <p>Tumor differentiation</p> Signup and view all the answers

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