16 Questions
What is the definition of a polyp?
A growth projecting from mucus membrane
What type of polyp has the potential for malignant transformation?
Adenomatous polyps
What is the main characteristic of hyperplastic polyps?
They show hyperplastic colonic glands
What is the gender distribution of large intestinal adenocarcinoma?
More in males (Males: Females ratio 2:1)
What age group is most commonly affected by large intestinal adenocarcinoma?
6th to 7th decade of life
Which genetic syndrome is associated with a high risk for large intestinal adenocarcinoma?
Familial adenomatous polyposis coli syndrome
Which gene is implicated in familial polyposis coli syndrome?
APC
What is the minimum number of polyps necessary for the diagnosis of familial polyposis coli syndrome?
100 polyps
In the adenoma carcinoma model, what is the first mutation that initiates the defect?
Mutation in APC gene
Which site is the commonest for large intestinal adenocarcinoma?
Sigmoid colon
What is the depth of invasion for a T3 stage large intestinal adenocarcinoma?
Serosa
What is the primary mode of spread for large intestinal adenocarcinoma to the liver and lungs?
Blood spread
Which term describes the microscopic appearance of malignant glands surrounded by desmoplasia in large intestinal adenocarcinoma?
Tubular adenoma
In which type of large intestinal adenocarcinoma does the defect start with a mutation in the mismatch repair gene?
Carcinoma arising denovo
What is the characteristic feature of cells in large intestinal adenocarcinoma indicative of malignancy?
Nuclear enlargement and chromatin condensation
What grading factor depends on the percentage of glandular formations in large intestinal adenocarcinoma?
Tumor differentiation
This quiz covers the definition of polyps and the types of colonic polyps, including inflammatory, hamartomatous, and hyperplastic polyps. It provides information on the characteristics of each type under both gross and microscopic examination.
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