Sem 3 Large Intestinal Tumors: Types of Colonic Polyps

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What is the definition of a polyp?

A growth projecting from mucus membrane (correct)

A benign tumor in the large intestine

A connective tissue core surrounded by smooth muscle fibers

A neoplasm formed from monoclonal cells

What type of polyp has the potential for malignant transformation?

Inflammatory polyps

Adenomatous polyps (correct)

Hamartomatous polyps

Hyperplastic polyps

What is the main characteristic of hyperplastic polyps?

They have smooth muscle fibers in the connective tissue core

They show dense inflammatory cells in the connective tissue core

They are formed of connective tissue core surrounded by epithelium from 3 surfaces

They show hyperplastic colonic glands (correct)

What is the gender distribution of large intestinal adenocarcinoma?

More in males (Males: Females ratio 2:1) Signup and view all the answers

What age group is most commonly affected by large intestinal adenocarcinoma?

6th to 7th decade of life Signup and view all the answers

Which genetic syndrome is associated with a high risk for large intestinal adenocarcinoma?

Familial adenomatous polyposis coli syndrome Signup and view all the answers

Which gene is implicated in familial polyposis coli syndrome?

APC Signup and view all the answers

What is the minimum number of polyps necessary for the diagnosis of familial polyposis coli syndrome?

100 polyps Signup and view all the answers

In the adenoma carcinoma model, what is the first mutation that initiates the defect?

Mutation in APC gene Signup and view all the answers

Which site is the commonest for large intestinal adenocarcinoma?

Sigmoid colon Signup and view all the answers

What is the depth of invasion for a T3 stage large intestinal adenocarcinoma?

Serosa Signup and view all the answers

What is the primary mode of spread for large intestinal adenocarcinoma to the liver and lungs?

Blood spread Signup and view all the answers

Which term describes the microscopic appearance of malignant glands surrounded by desmoplasia in large intestinal adenocarcinoma?

Tubular adenoma Signup and view all the answers

In which type of large intestinal adenocarcinoma does the defect start with a mutation in the mismatch repair gene?

Carcinoma arising denovo Signup and view all the answers

What is the characteristic feature of cells in large intestinal adenocarcinoma indicative of malignancy?

Nuclear enlargement and chromatin condensation Signup and view all the answers

What grading factor depends on the percentage of glandular formations in large intestinal adenocarcinoma?

Tumor differentiation Signup and view all the answers

Sem 3 Large Intestinal Tumors: Types of Colonic Polyps

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