Lansoprazole (Prevacid) Flashcards
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Questions and Answers

What is the generic name of the medication?

  • Lansoprazole (correct)
  • Omeprazole
  • Rabeprazole
  • Prevacid
  • What is the trade name of Lansoprazole?

  • Prevacid (correct)
  • Pantoprazole
  • Ranitidine
  • Esomeprazole
  • What is the classification of Lansoprazole?

  • Antibiotic
  • Analgesic
  • Antidepressant
  • Proton pump inhibitor (correct)
  • What is the usual dose of Lansoprazole?

    <p>15mg/day</p> Signup and view all the answers

    How is Lansoprazole administered?

    <p>po</p> Signup and view all the answers

    What is the time/frequency of Lansoprazole administration?

    <p>daily for 8-14 weeks</p> Signup and view all the answers

    What is the peak absorption percentage of Lansoprazole after the granules leave the stomach?

    <p>80%</p> Signup and view all the answers

    What is the plasma half-life of Lansoprazole?

    <p>1 1/2 - 2 hours</p> Signup and view all the answers

    What is the normal dosage range for Lansoprazole?

    <p>15-30 mg/daily</p> Signup and view all the answers

    What are the primary uses of Lansoprazole?

    <p>All of the above</p> Signup and view all the answers

    What action does Lansoprazole perform in the stomach?

    <p>Suppresses gastric secretion</p> Signup and view all the answers

    What is a potential nursing implication when administering Lansoprazole?

    <p>Acute stomach pain</p> Signup and view all the answers

    What should be assessed before administering Lansoprazole?

    <p>Pseudomembranous colitis</p> Signup and view all the answers

    What condition may require discontinuation of Lansoprazole?

    <p>Pseudomembranous colitis</p> Signup and view all the answers

    What is a side effect of Lansoprazole?

    <p>Headache</p> Signup and view all the answers

    What is a contraindication for taking Lansoprazole?

    <p>Hypersensitivity</p> Signup and view all the answers

    What should patients report when taking Lansoprazole?

    <p>Severe diarrhea, cramping, blood in stools</p> Signup and view all the answers

    What interactions should be noted with Lansoprazole?

    <p>Increased interaction with warfarin</p> Signup and view all the answers

    Study Notes

    Lansoprazole Overview

    • Generic Name: Lansoprazole
    • Trade Names: Prevacid, Prevacid SoluTab
    • Classification: Anti-ulcer, proton pump inhibitor

    Dosage Information

    • Standard dosage: 15mg/day
    • Normal dosage range: 15-30 mg/day
    • Administered orally (po)
    • Treatment duration: Daily for 8-14 weeks

    Pharmacokinetics

    • Onset of action: Absorption occurs after granules leave the stomach, approximately 80% absorbed
    • Peak effect: Information not specified
    • Duration: Plasma half-life between 1.5-2 hours

    Indications and Uses

    • FDA-approved for:
      • Gastroesophageal reflux disease (GERD)
      • Severe erosive esophagitis
      • Pathologic hypersecretory conditions (e.g., Zollinger-Ellison syndrome, systemic mastocytosis, multiple endocrine adenomas)
      • Potential treatment for duodenal and gastric ulcers
      • Maintenance of healed duodenal ulcers
    • Unlabeled use: Effective for GERD in infants

    Mechanism of Action

    • Suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells
    • Characterized as a gastric acid pump inhibitor, blocking the final step in acid production

    Nursing Implications

    • Monitor for acute stomach pain
    • Be aware of pseudomembranous colitis as a potential condition to assess

    Pre-Administration Assessment

    • Risk of pseudomembranous colitis; assess bowel sounds, abdominal pain, swelling, anorexia, and blood in stool even after therapy completion
    • Conduct hepatic function studies (AST, ALT, alkaline phosphatase)
    • Check INR and prothrombin time in patients on warfarin
    • Monitor magnesium levels, as low magnesium may occur

    Contraindications and Precautions

    • Contraindications: Hypersensitivity to the drug
    • Precautions: Use cautiously in pregnancy (category B), breastfeeding, children, patients with hypomagnesemia, and osteoporosis

    Post-Administration Monitoring

    • Check for absence of epigastric pain, swelling, and fullness

    Side Effects and Adverse Reactions

    • Possible CNS side effects: Headaches
    • GI effects: Diarrhea, abdominal pain, vomiting, nausea, constipation, flatulence, acid regurgitation, anorexia, irritable colon, microscopic colitis, and pseudomembranous colitis
    • GU issues: Hematuria, glycosuria, impotence, kidney stones, and breast enlargement

    Administration Guidelines

    • Oral administration: Swallow capsules whole 30 minutes before meals; do not crush or chew
    • NG tube administration: Open capsule to use granules; ensure proper mixing with water for NG delivery
    • Oral disintegrating tablet can be mixed with water before NG tube administration

    Patient Education

    • Advise patients to report severe diarrhea, cramps, blood in stools, or fever; possible discontinuation of therapy may be needed
    • Caution about hypoglycemia in diabetics
    • Warn against hazardous activities due to possible dizziness
    • Advise against alcohol, salicylates, and ibuprofen due to potential GI irritation
    • Full therapeutic effect for heartburn may take 1-4 days
    • Pregnant patients should notify healthcare provider if pregnancy is suspected

    Drug Interactions

    • Decreases efficacy of antiplatelet drugs like clopidogrel
    • Increased toxicity risk with fluvoxamine and voriconazole
    • Increased bleeding risk with warfarin
    • Decreased absorption of several drugs (e.g., sucralfate, ketoconazole, iron, ampicillin)
    • Potentiate hypomagnesemia with loop/thiazide diuretics
    • Consider interactions with St. John's Wort and red yeast rice
    • Administer 30 minutes before food to enhance absorption rate

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    Description

    Test your knowledge on Lansoprazole, also known as Prevacid, with these flashcards. Learn key details such as its generic name, dosing information, and classification as a proton pump inhibitor. Perfect for students in pharmacology or anyone interested in medication details.

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