9 Questions
What is the purpose of measuring immune responses?
To study the magnitude and quality of the immune response induced by natural infection or vaccination, to study correlates of protection against disease, to identify and characterise functional subsets of immune cells, and to evaluate the effect of adjuvantation on immune responses.
What is the significance of correlates of protection (CoP) in measuring immune responses?
CoP is an immune response that is statistically correlated with protection and can facilitate demonstrating vaccine efficacy and support healthcare workers in managing vaccination of (immunocompromised) individuals.
How to measure immunity in vivo
assesment of protective immunity, transfer protective immunity
What is the role of immune response measurement in evaluating the effect of adjuvantation?
The measurement of immune responses helps in evaluating the effect of adjuvantation on immune responses.
How is the area of hemolysis measured in the Single radial haemolysis (SRH) assay?
The area of hemolysis in the SRH assay is measured in mm^2 and is directly proportional to the amount of antibody present in the test serum.
What is the purpose of the Virus neutralization (VN) assay?
The purpose of the Virus neutralization (VN) assay is to determine the neutralization titerand see if a person have been infected with influenca
What is the difference between (Micro)neutralization and pseudovirus neutralisation assay (PNA)?
The difference lies in the use of 'live' virus; (Micro)neutralization assay requires 'live' virus, while the pseudovirus neutralisation assay does not involve 'live' virus.
What is the outcome determined by in the pseudovirus neutralisation assay (PNA)?
The outcome of the pseudovirus neutralisation assay is determined by virus entry and virus replication.
How to measure humoral immunity in vitro?
the main actors in humoral immunity are antibodies and B cells
Test your knowledge of laboratory evaluation of humoral and cellular immune response with this quiz. Explore topics such as measuring immunity in vivo, measuring humoral immunity in vitro, and measuring cell-mediated immunity. Also, learn about assay validation and study endpoints in immunogenicity testing.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
