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Questions and Answers

What is primarily overproduced in Polycythemia Vera?

  • White blood cells
  • Platelets
  • Neutrophils
  • Red blood cells (correct)

Which unique symptom is often associated with patients suffering from Polycythemia Vera?

  • Excessive sweating
  • Itching after a hot shower (correct)
  • Bloating of the abdomen
  • Chronic fatigue

What does the presence of the Philadelphia chromosome indicate?

  • Chronic myeloid leukemia (correct)
  • Essential thrombocythemia
  • Acute lymphoblastic leukemia
  • Primary myelofibrosis

What is a major complication of Essential Thrombocythemia?

<p>Thrombosis (B)</p> Signup and view all the answers

Which characteristic blood smear finding is associated with Primary Myelofibrosis?

<p>Tear drop cells (B)</p> Signup and view all the answers

What is a common consequence of hyperviscosity in patients with Polycythemia Vera?

<p>Visual disturbances (C)</p> Signup and view all the answers

What is the male to female ratio typically seen in Chronic Myeloid Leukemia?

<p>1.4:1 (D)</p> Signup and view all the answers

Which condition can Chronic Myeloid Leukemia transform into during advanced stages?

<p>Acute myeloid leukemia (C)</p> Signup and view all the answers

What is a characteristic feature of Myelodysplastic Neoplasms (MDS)?

<p>Presence of simultaneous proliferation and apoptosis of hematopoietic cells (C)</p> Signup and view all the answers

Which cytogenetic abnormality is commonly associated with Myelodysplastic Neoplasms?

<p>Partial or total loss of chromosomes 5 or 7 (A)</p> Signup and view all the answers

What percentage of cells must be dysplastic in a lineage to consider the diagnosis of MDS?

<p>10% (D)</p> Signup and view all the answers

Chronic myeloid leukemia (CML) primarily arises from which type of cells?

<p>Bone marrow stem cells (B)</p> Signup and view all the answers

Which clinical feature is most associated with CML in its chronic phase?

<p>Leukocytosis with a predominance of mature granulocytes (D)</p> Signup and view all the answers

Which of the following best describes the incidence of Myelodysplastic Neoplasms?

<p>More common in elderly individuals (A)</p> Signup and view all the answers

What is the behavior of the bone marrow in Myelodysplastic Neoplasms?

<p>Hypercellular bone marrow (D)</p> Signup and view all the answers

What differentiates Myeloproliferative Neoplasms (MPN) from Myelodysplastic Neoplasms (MDS)?

<p>MPN is characterized by clonal proliferation of hematopoietic components (A)</p> Signup and view all the answers

What abnormal finding is specifically associated with chronic myeloid leukemia in blast phase?

<p>Leukocytosis with myeloid left shift (C)</p> Signup and view all the answers

Which chromosome translocation is implicated in chronic myeloid leukemia?

<p>Translocation of chromosome 9 and 22 (D)</p> Signup and view all the answers

What is a common hematological feature seen in patients with chronic myeloid leukemia?

<p>Basophilia (A)</p> Signup and view all the answers

What represents the cellular composition of blood in the blast phase of CML?

<p>20% or more blasts (B)</p> Signup and view all the answers

In chronic myeloid leukemia, what condition may occur secondary to leukocytosis?

<p>Splenomegaly (D)</p> Signup and view all the answers

What is the significance of NAP score in chronic myeloid leukemia?

<p>Reflects myeloid maturation (A)</p> Signup and view all the answers

What type of blood cell morphology is characterized in the peripheral blood film of a patient with CML?

<p>Large blasts (C)</p> Signup and view all the answers

What laboratory finding is NOT typically associated with chronic myeloid leukemia?

<p>Hypereosinophilia (A)</p> Signup and view all the answers

What is the molecular consequence of the translocation associated with CML?

<p>Formation of a BCR::ABL1 fusion oncogene (D)</p> Signup and view all the answers

Which of the following clinical features is commonly associated with CML?

<p>Massive splenomegaly (A)</p> Signup and view all the answers

What characterizes the chronic phase of Chronic Myeloid Leukemia (CML-CP)?

<p>Blast cell percentage less than 5% (C)</p> Signup and view all the answers

What laboratory finding is indicative of CML?

<p>Hypercellular bone marrow with granulopoietic predominance (D)</p> Signup and view all the answers

Which test result is expected to be low in CML patients?

<p>Leukocyte alkaline phosphatase (LAP) score (B)</p> Signup and view all the answers

Which statement about the blast phase of CML is correct?

<p>More than 20% of the cells are blast cells (A)</p> Signup and view all the answers

What is the primary mechanism of action for tyrosine kinase inhibitors (TKIs) used in treating CML?

<p>They block BCR-ABL fusion tyrosine kinase activity (D)</p> Signup and view all the answers

What is a common finding in the complete blood count (CBC) of a CML patient?

<p>Leukocytosis with left shift and absolute basophilia (C)</p> Signup and view all the answers

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