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Questions and Answers

What is primarily overproduced in Polycythemia Vera?

  • White blood cells
  • Platelets
  • Neutrophils
  • Red blood cells (correct)
  • Which unique symptom is often associated with patients suffering from Polycythemia Vera?

  • Excessive sweating
  • Itching after a hot shower (correct)
  • Bloating of the abdomen
  • Chronic fatigue
  • What does the presence of the Philadelphia chromosome indicate?

  • Chronic myeloid leukemia (correct)
  • Essential thrombocythemia
  • Acute lymphoblastic leukemia
  • Primary myelofibrosis
  • What is a major complication of Essential Thrombocythemia?

    <p>Thrombosis</p> Signup and view all the answers

    Which characteristic blood smear finding is associated with Primary Myelofibrosis?

    <p>Tear drop cells</p> Signup and view all the answers

    What is a common consequence of hyperviscosity in patients with Polycythemia Vera?

    <p>Visual disturbances</p> Signup and view all the answers

    What is the male to female ratio typically seen in Chronic Myeloid Leukemia?

    <p>1.4:1</p> Signup and view all the answers

    Which condition can Chronic Myeloid Leukemia transform into during advanced stages?

    <p>Acute myeloid leukemia</p> Signup and view all the answers

    What is a characteristic feature of Myelodysplastic Neoplasms (MDS)?

    <p>Presence of simultaneous proliferation and apoptosis of hematopoietic cells</p> Signup and view all the answers

    Which cytogenetic abnormality is commonly associated with Myelodysplastic Neoplasms?

    <p>Partial or total loss of chromosomes 5 or 7</p> Signup and view all the answers

    What percentage of cells must be dysplastic in a lineage to consider the diagnosis of MDS?

    <p>10%</p> Signup and view all the answers

    Chronic myeloid leukemia (CML) primarily arises from which type of cells?

    <p>Bone marrow stem cells</p> Signup and view all the answers

    Which clinical feature is most associated with CML in its chronic phase?

    <p>Leukocytosis with a predominance of mature granulocytes</p> Signup and view all the answers

    Which of the following best describes the incidence of Myelodysplastic Neoplasms?

    <p>More common in elderly individuals</p> Signup and view all the answers

    What is the behavior of the bone marrow in Myelodysplastic Neoplasms?

    <p>Hypercellular bone marrow</p> Signup and view all the answers

    What differentiates Myeloproliferative Neoplasms (MPN) from Myelodysplastic Neoplasms (MDS)?

    <p>MPN is characterized by clonal proliferation of hematopoietic components</p> Signup and view all the answers

    What abnormal finding is specifically associated with chronic myeloid leukemia in blast phase?

    <p>Leukocytosis with myeloid left shift</p> Signup and view all the answers

    Which chromosome translocation is implicated in chronic myeloid leukemia?

    <p>Translocation of chromosome 9 and 22</p> Signup and view all the answers

    What is a common hematological feature seen in patients with chronic myeloid leukemia?

    <p>Basophilia</p> Signup and view all the answers

    What represents the cellular composition of blood in the blast phase of CML?

    <p>20% or more blasts</p> Signup and view all the answers

    In chronic myeloid leukemia, what condition may occur secondary to leukocytosis?

    <p>Splenomegaly</p> Signup and view all the answers

    What is the significance of NAP score in chronic myeloid leukemia?

    <p>Reflects myeloid maturation</p> Signup and view all the answers

    What type of blood cell morphology is characterized in the peripheral blood film of a patient with CML?

    <p>Large blasts</p> Signup and view all the answers

    What laboratory finding is NOT typically associated with chronic myeloid leukemia?

    <p>Hypereosinophilia</p> Signup and view all the answers

    What is the molecular consequence of the translocation associated with CML?

    <p>Formation of a BCR::ABL1 fusion oncogene</p> Signup and view all the answers

    Which of the following clinical features is commonly associated with CML?

    <p>Massive splenomegaly</p> Signup and view all the answers

    What characterizes the chronic phase of Chronic Myeloid Leukemia (CML-CP)?

    <p>Blast cell percentage less than 5%</p> Signup and view all the answers

    What laboratory finding is indicative of CML?

    <p>Hypercellular bone marrow with granulopoietic predominance</p> Signup and view all the answers

    Which test result is expected to be low in CML patients?

    <p>Leukocyte alkaline phosphatase (LAP) score</p> Signup and view all the answers

    Which statement about the blast phase of CML is correct?

    <p>More than 20% of the cells are blast cells</p> Signup and view all the answers

    What is the primary mechanism of action for tyrosine kinase inhibitors (TKIs) used in treating CML?

    <p>They block BCR-ABL fusion tyrosine kinase activity</p> Signup and view all the answers

    What is a common finding in the complete blood count (CBC) of a CML patient?

    <p>Leukocytosis with left shift and absolute basophilia</p> Signup and view all the answers

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