Koch's Postulates and Microbiology
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Questions and Answers

Who was the founder of the electron microscope?

  • Goodpasture
  • Ernst Ruska (correct)
  • Alexander Fleming
  • Charles Chamberland
  • Who introduced variolation for immunizing against smallpox?

  • Elie Metchnikoff
  • Charles Chamberland
  • Ernst Ruska
  • Lady Mary Wortley Montagu (correct)
  • Who discovered the most commonly used antibiotic substance of the last century, i.e. penicillin?

  • Barbara McClintock
  • Alexander Fleming (correct)
  • Karry B Mullis
  • Emmy Klieneberger
  • What is the significance of the additional fifth criterion introduced subsequently to Koch's postulates?

    <p>It demonstrates the presence of antibodies to the causative organism in the patient's serum</p> Signup and view all the answers

    Why is it challenging to apply Koch's postulates to study all human diseases?

    <p>There are exceptions like Neisseria gonorrhoeae and Mycobacterium leprae that do not satisfy all the criteria</p> Signup and view all the answers

    What is the basis of molecular Koch's postulates introduced by Stanley Falkow?

    <p>The identification of the gene linked to suspected virulence trait and its inactivation</p> Signup and view all the answers

    Who is known as the father of chemotherapy?

    <p>Paul Ehrlich</p> Signup and view all the answers

    What did Paul Ehrlich propose for antibody production?

    <p>Side-chain theory</p> Signup and view all the answers

    For what was the 'Gram stain' developed?

    <p>Making bacteria more visible under a microscope</p> Signup and view all the answers

    What did Paul Ehrlich discover as the first effective medicinal treatment for syphilis?

    <p>Salvarsan</p> Signup and view all the answers

    Study Notes

    Milestones in Microbiology

    • Ernst Ruska is the founder of the electron microscope.
    • Lady Mary Wortley Montagu introduced variolation for immunizing against smallpox.
    • Alexander Fleming discovered the most commonly used antibiotic substance of the last century, penicillin.
    • The additional fifth criterion introduced subsequently to Koch's postulates is the requirement for the microbial isolate to recreate the disease in an animal model.
    • It is challenging to apply Koch's postulates to study all human diseases because many diseases cannot be replicated in an animal model.
    • The basis of molecular Koch's postulates introduced by Stanley Falkow is the identification of a specific gene or protein that is responsible for the pathogenesis of the disease.
    • Paul Ehrlich is known as the father of chemotherapy.
    • Paul Ehrlich proposed the side chain theory for antibody production, suggesting that antibodies are produced by the immune system as a response to the presence of foreign substances.
    • The 'Gram stain' was developed to differentiate between different types of bacteria based on the composition of their cell walls.
    • Paul Ehrlich discovered Salvarsan as the first effective medicinal treatment for syphilis.

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    Test your knowledge about Koch's postulates and their application in microbiology. Understand the exceptions to these postulates and their significance in studying human diseases.

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