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Questions and Answers
True or false:Ligand binding to RTKs causes them to separate and prevents dimerization.
True or false:Ligand binding to RTKs causes them to separate and prevents dimerization.
False (B)
True or false: Proteins with PTB domains bind to phosphorylated tyrosines on RTKs.
True or false: Proteins with PTB domains bind to phosphorylated tyrosines on RTKs.
True (A)
True or false: Adaptor proteins with SH2 and SH3 domains help couple inactive RTK with signaling protein Ras.
True or false: Adaptor proteins with SH2 and SH3 domains help couple inactive RTK with signaling protein Ras.
False (A)
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Study Notes
- There are 60 genes encoding RTKs.
- Ligand binding causes dimerization of RTKs.
- This brings the cytoplasmic kinase domain together, resulting in kinase activity.
- Phosphorylated tyrosines on RTKs serve as docking sites for intracellular signaling molecules.
- This increases the kinase activity of the enzyme and provides a docking site for specific intracellular signaling proteins.
- Proteins with SH2 domains bind to phosphorylated tyrosines.
- Different kinds of proteins can bind to phosphorylated RTKs.
- They share similar interacting domains - SH2 or PTB domains.
- These interactions relay the signal to downstream components, increasing or decreasing the signal.
- Adaptor proteins composed of SH2 and SH3 domains help to couple activated RTK with signaling protein Ras.
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