Podcast
Questions and Answers
True or false:Ligand binding to RTKs causes them to separate and prevents dimerization.
True or false:Ligand binding to RTKs causes them to separate and prevents dimerization.
False
True or false: Proteins with PTB domains bind to phosphorylated tyrosines on RTKs.
True or false: Proteins with PTB domains bind to phosphorylated tyrosines on RTKs.
True
True or false: Adaptor proteins with SH2 and SH3 domains help couple inactive RTK with signaling protein Ras.
True or false: Adaptor proteins with SH2 and SH3 domains help couple inactive RTK with signaling protein Ras.
False
Study Notes
- There are 60 genes encoding RTKs.
- Ligand binding causes dimerization of RTKs.
- This brings the cytoplasmic kinase domain together, resulting in kinase activity.
- Phosphorylated tyrosines on RTKs serve as docking sites for intracellular signaling molecules.
- This increases the kinase activity of the enzyme and provides a docking site for specific intracellular signaling proteins.
- Proteins with SH2 domains bind to phosphorylated tyrosines.
- Different kinds of proteins can bind to phosphorylated RTKs.
- They share similar interacting domains - SH2 or PTB domains.
- These interactions relay the signal to downstream components, increasing or decreasing the signal.
- Adaptor proteins composed of SH2 and SH3 domains help to couple activated RTK with signaling protein Ras.
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Description
"Test your knowledge on the intricate signaling pathways of Receptor Tyrosine Kinases (RTKs) with our quiz! From genes to protein interactions, explore the essential mechanisms behind ligand binding, kinase activity, and downstream signaling. Identify key domains and proteins crucial for relaying signals and understand how adaptor proteins play a vital role in coupling RTKs with signaling protein Ras. Sharpen your expertise on RTKs and ace this quiz!"
