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Questions and Answers
What is the primary function of the protein complex regulated by PKD genes?
What is the primary function of the protein complex regulated by PKD genes?
- Regulation of extracellular Mg2+ in response to fluid flow
- Regulation of intracellular Na+ in response to fluid flow
- Regulation of extracellular K+ in response to fluid flow
- Regulation of intracellular Ca2+ in response to fluid flow (correct)
What is the consequence of mutation in either PKD genes?
What is the consequence of mutation in either PKD genes?
- Increased intracellular Na+
- Loss of polycystin complex or formation of an aberrant complex (correct)
- Formation of a normal polycystin complex
- Decreased intracellular Ca2+
What is the ultimate outcome of increased intracellular Ca2+ in epithelial cells?
What is the ultimate outcome of increased intracellular Ca2+ in epithelial cells?
- Induction of apoptosis
- Inhibition of proliferation and secretion
- Differentiation of epithelial cells
- Stimulation of proliferation and secretion (correct)
What is the characteristic of the protein encoded by the PKD1 gene?
What is the characteristic of the protein encoded by the PKD1 gene?
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In which region of the epithelial cells is polycystin-1 primarily located?
In which region of the epithelial cells is polycystin-1 primarily located?
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What is the primary function of polycystin-2?
What is the primary function of polycystin-2?
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At what age is the likelihood of renal failure approximately 35%?
At what age is the likelihood of renal failure approximately 35%?
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What is the characteristic of cyst fluid in PKD?
What is the characteristic of cyst fluid in PKD?
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What is the location of the PKD2 gene?
What is the location of the PKD2 gene?
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