Kidney Function and Acute Injury Electrolytes
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Questions and Answers

What is one of the endocrine functions of the kidneys?

  • Secretion of glucagon
  • Production of insulin
  • Regulation of blood pressure
  • Activation of vitamin D (correct)
  • What is the role of erythropoietin produced by the kidneys?

  • Stimulates kidney filtration
  • Controls blood glucose levels
  • Regulates calcium absorption
  • Regulates the quantity of red blood cells (correct)
  • Which electrolyte is responsible for maintaining osmotic pressure in extracellular fluid?

  • Phosphorus
  • Sodium (correct)
  • Potassium
  • Calcium
  • What is the typical range for potassium levels in the body?

    <p>3.5-5.0 mEq/L (C)</p> Signup and view all the answers

    What potential condition may occur if the kidneys are unable to excrete hydrogen ions?

    <p>Metabolic Acidosis (A)</p> Signup and view all the answers

    What is a consequence of reduced calcium levels in renal failure?

    <p>Stimulation of parathyroid hormone (C)</p> Signup and view all the answers

    Which condition is likely to develop due to excessive stimulation of parathyroid hormone in chronic kidney disease?

    <p>Osteodystrophy (C)</p> Signup and view all the answers

    What happens to phosphorus levels in kidney damage?

    <p>Phosphorus levels increase due to decreased excretion (D)</p> Signup and view all the answers

    What is the main consequence of reduced erythropoietin levels in kidney failure?

    <p>Decreased red blood cell production (C)</p> Signup and view all the answers

    What is the adequate level of Glomerular Filtration Rate (GFR) for kidney function?

    <p>90-120 mL per minute (C)</p> Signup and view all the answers

    What is likely indicated by high levels of protein in urine?

    <p>Impairment in glomerulus function (D)</p> Signup and view all the answers

    In chronic renal failure, what is impaired leading to hypocalcemia?

    <p>Vitamin D production (A)</p> Signup and view all the answers

    What is the normal range for BUN levels if kidney function is adequate?

    <p>Normal BUN levels indicate proper waste filtration (A)</p> Signup and view all the answers

    What does the term 'uremia' refer to?

    <p>Abnormally high waste products in the blood (D)</p> Signup and view all the answers

    What condition is characterized by an abnormal increase of nitrogen waste products in the blood?

    <p>Azotemia (C)</p> Signup and view all the answers

    What is a potential outcome if GFR falls below 15 mL per minute?

    <p>End stage renal disease (D)</p> Signup and view all the answers

    What characterizes prerenal azotemia?

    <p>Reduced blood flow to the kidneys without structural damage. (B)</p> Signup and view all the answers

    Which condition is a possible cause of prerenal azotemia?

    <p>Dehydration. (B)</p> Signup and view all the answers

    What happens in intrinsic (renal) azotemia?

    <p>There is direct damage to kidney structures. (A)</p> Signup and view all the answers

    What is a normal BUN level?

    <p>6-20 mg/dL (C)</p> Signup and view all the answers

    NSAIDs can precipitate prerenal failure by causing what effect?

    <p>Vasoconstriction of afferent arterioles. (D)</p> Signup and view all the answers

    Which of the following describes postrenal azotemia?

    <p>Obstruction of urine outflow. (C)</p> Signup and view all the answers

    What is typically retained in prerenal azotemia?

    <p>Kidneys can still concentrate urine and reabsorb BUN. (A)</p> Signup and view all the answers

    How does hypotension relate to azotemia?

    <p>It tends to precipitate azotemia due to reduced blood flow. (C)</p> Signup and view all the answers

    What is the most common cause of intrarenal acute kidney injury?

    <p>Acute tubular necrosis (A)</p> Signup and view all the answers

    Which of the following conditions can lead to rhabdomyolysis?

    <p>Crushing injury (B)</p> Signup and view all the answers

    Which type of antibiotic is known to be nephrotoxic and ototoxic?

    <p>Aminoglycosides (C)</p> Signup and view all the answers

    What happens during the initial phase of acute tubular necrosis?

    <p>Kidney tubules suffer damage (A)</p> Signup and view all the answers

    What is a symptom of the maintenance phase of acute tubular necrosis?

    <p>Decreased urine output (oliguria) (D)</p> Signup and view all the answers

    Which condition can lead to postrenal acute kidney injury?

    <p>Benign prostatic hyperplasia (D)</p> Signup and view all the answers

    What laboratory values are monitored for nephrotoxic antibiotic use?

    <p>BUN and creatinine (B)</p> Signup and view all the answers

    Which of the following is a clinical manifestation of acute kidney injury?

    <p>Elevated blood pressure (B)</p> Signup and view all the answers

    What is a common indicator of acute kidney injury (AKI) as assessed through urinalysis?

    <p>Elevated RBCs and WBCs (A), Increased proteinuria (B)</p> Signup and view all the answers

    Which of the following medications can help remove excess potassium in hyperkalemia?

    <p>Bumex/bumetanide (A), Calcium gluconate (B), Sodium bicarbonate (C), Lasix/furosemide (D)</p> Signup and view all the answers

    How is chronic kidney disease typically differentiated from end-stage renal disease (ESRD) through renal ultrasonography?

    <p>By identifying the shape of the kidneys (A)</p> Signup and view all the answers

    What role do osmotic diuretics play in the management of acute kidney injury?

    <p>They maintain urinary output (A)</p> Signup and view all the answers

    Which type of dialysis is considered the gold standard for patients requiring renal replacement therapy?

    <p>Arteriovenous fistula (D)</p> Signup and view all the answers

    What is the primary purpose of using calcium chloride in cases of hyperkalemia?

    <p>To restore calcium balance (A)</p> Signup and view all the answers

    In the context of renal failure, which test result would most likely indicate metabolic acidosis?

    <p>Altered arterial blood gases (D)</p> Signup and view all the answers

    Which diuretics specifically target potassium excretion?

    <p>Loop diuretics (C)</p> Signup and view all the answers

    How many times per week is peritoneal dialysis typically performed?

    <p>3-4 times (B)</p> Signup and view all the answers

    What is a key requirement when performing peritoneal dialysis at home?

    <p>Employing aseptic technique (C)</p> Signup and view all the answers

    Which type of peritoneal dialysis requires the patient to be connected to a machine at night?

    <p>Automated Peritoneal Dialysis (C)</p> Signup and view all the answers

    What is a common effect of having a fistula for dialysis?

    <p>Audible sounds upon auscultation (C)</p> Signup and view all the answers

    What complication can occur from elevated potassium levels in renal patients?

    <p>Hyperkalemia (A)</p> Signup and view all the answers

    What is an essential practice when monitoring a patient undergoing dialysis?

    <p>Hourly monitoring of intake and output (B)</p> Signup and view all the answers

    In what year was the law signed that recognized dialysis as a medical intervention?

    <p>1972 (D)</p> Signup and view all the answers

    What is the purpose of using a high concentration of glucose in peritoneal dialysis fluid?

    <p>To increase osmotic pressure for waste removal (B)</p> Signup and view all the answers

    Flashcards

    Kidney Function

    The kidneys maintain fluid balance, remove waste, regulate urine, and perform endocrine functions.

    Erythropoietin

    A hormone produced by kidneys that controls red blood cell production.

    Vitamin D Activation

    Kidneys activate vitamin D, which helps absorb calcium from the intestines.

    Potassium Levels

    Potassium (3.5-5.0 mEq/L) is primarily intracellular and crucial for heart function.

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    Sodium Levels

    Sodium (135-145 mEq/L) maintains osmotic pressure and is essential for proper brain function; low levels cause confusion.

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    Calcium Levels Renal Failure

    Low calcium levels in kidney failure stimulate parathyroid hormone, leading to bone weakening.

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    Phosphorus and Kidneys

    Kidneys are the primary organs for excreting phosphorus; in kidney damage, phosphorus is high.

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    Acid-Base Balance in Kidneys

    Kidneys excrete excess hydrogen ions to maintain acid-base balance; failure to do so can cause metabolic acidosis.

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    Erythropoietin (EPO)

    A hormone produced by the kidneys that stimulates red blood cell production.

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    Kidney Failure and EPO

    In kidney failure, EPO production is reduced, leading to fewer red blood cells and decreased oxygen delivery to the kidneys.

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    GFR (Glomerular Filtration Rate)

    A measure of how well the kidneys are filtering blood. A healthy GFR is 90-120 ml/min.

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    GFR <15 ml/min

    Indicates end-stage renal disease (ESRD), where the kidneys fail to adequately filter the blood.

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    Azotemia

    A condition characterized by abnormal levels of nitrogenous waste products in the blood.

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    BUN (Blood Urea Nitrogen)

    A waste product of protein metabolism, produced by the liver, and filtered by the kidney.

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    Creatinine

    A waste product from muscle metabolism, filtered by the kidneys.

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    Uremia

    A dangerous condition caused by abnormally high levels of waste products in the blood.

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    Prerenal Azotemia

    Reduced blood flow to kidneys without structural damage, causing elevated BUN and creatinine. It's often reversible and can be caused by heart failure or dehydration.

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    Intrinsic (Renal) Azotemia

    Direct damage to the kidneys themselves (glomeruli, tubules, interstitial tissue), impairing blood filtering and urine concentration. It can be caused by acute tubular necrosis or glomerulonephritis.

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    Postrenal Azotemia

    Obstruction of urine outflow, such as kidney stones or an enlarged prostate. Kidneys try to concentrate urine, but eventually, tubular function is lost.

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    BUN

    Blood urea nitrogen (BUN): a waste product in the blood, measured to assess kidney function.

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    Acute Tubular Necrosis

    Kidney damage caused by a lack of blood flow or toxins. Damaged kidney tubules prevent the kidneys from filtering substances from the blood properly.

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    Glomerulonephritis

    Inflammation of the glomeruli (tiny filters in the kidney).

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    Intrarenal AKI: Common Cause

    Acute tubular necrosis (ATN) is the most frequent cause of intrarenal acute kidney injury, damage to the kidney tubules.

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    Nephrotoxic Agents: Radiocontrast

    Radiographic contrast media can damage kidney tubules, leading to ATN. BUN and creatinine should be checked before using it.

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    Rhabdomyolysis: Muscle Breakdown

    Damage to muscle tissue releases proteins into the blood, harming the kidneys. Caused by trauma or crushing injuries.

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    Aminoglycosides: Nephrotoxic Antibiotics

    Aminoglycosides like gentamicin, tobramycin, and streptomycin, are powerful antibiotics but can damage the kidneys and inner ear.

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    Acute Tubular Necrosis (Initial Phase)

    The initial phase of ATN sees kidney tubules starting to suffer injury due to lack of oxygen or toxic substances.

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    Acute Tubular Necrosis (Maintenance Phase)

    The maintenance phase of ATN lasts for 1-2 weeks, with severe kidney dysfunction, low urine output, and electrolyte imbalances.

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    Postrenal AKI: Common Causes

    Postrenal AKI is caused by problems with the urinary tract, like enlarged prostate, blocked catheters, or kidney stones.

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    Postrenal AKI: Drugs

    Certain medications, like acyclovir and indinavir, can cause kidney damage by forming precipitates and clogging the ureters.

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    Peritoneal Dialysis

    A treatment for kidney failure where a special fluid (dialysate) is put into the peritoneal cavity (lining of the abdomen) to remove waste products and excess fluid.

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    Peritoneal Catheter

    A tube inserted into the abdomen to deliver and drain dialysate during peritoneal dialysis.

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    Continuous Ambulatory Dialysis (CAPD)

    A type of peritoneal dialysis where the patient manually exchanges the dialysate multiple times a day.

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    Automated Peritoneal Dialysis (APD)

    A type of peritoneal dialysis using a machine to cycle dialysate exchanges overnight while the patient sleeps.

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    Dialysate Exchange

    The process of filling the peritoneal cavity with fresh dialysate and draining out the used fluid.

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    Continuous Renal Replacement Therapy (CRRT)

    A 24-hour dialysis treatment for patients with acute kidney injury requiring continuous blood purification.

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    Fistula

    A surgically created connection between an artery and vein used for hemodialysis, allowing for easier blood access.

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    Fluid Restriction

    Limiting fluid intake for patients with kidney failure to reduce fluid build-up.

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    Anemia in Kidney Failure

    Anemia caused by the kidneys' inability to produce enough erythropoietin, a hormone that stimulates red blood cell production.

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    Proteinuria

    The presence of protein in the urine, indicating damage to the filtering units of the kidneys.

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    Elevated Creatinine

    An indication of impaired kidney function, as creatinine is a waste product that the kidneys normally filter.

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    Elevated BUN

    A sign of impaired kidney function, as blood urea nitrogen (BUN) is a waste product of protein metabolism filtered out by the kidneys.

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    Hyperkalemia

    Elevated potassium levels in the blood, a potential complication of kidney failure.

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    Loop Diuretics

    Medications that increase urine production by inhibiting reabsorption in the loop of Henle, leading to potassium loss.

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    Osmotic Diuretics

    Medications that pull water from the tissues into the blood vessels, increasing urine production. Used in acute kidney injury to maintain urine output and flush out harmful substances.

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    Dialysis

    A treatment that filters and cleanses the blood when kidneys fail. It can be done through hemodialysis, peritoneal dialysis, or continuous renal replacement therapy.

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    Study Notes

    Kidney Function

    • Responsible for maintaining fluid and electrolyte balance.
    • Removes water-soluble waste products.
    • Regulates the amount and composition of urine.
    • Produces erythropoietin (regulates red blood cell production).
    • Red blood cell reduction leads to less oxygen delivery to the kidneys.
    • Activates vitamin D, important for intestinal calcium absorption.
    • Filters over 7 liters of fluid per hour.
    • Excretes excess hydrogen ions (preventing metabolic acidosis).

    Week 9 Acute Kidney Injury Electrolytes

    • Potassium: 3.5-5.0 mEq/L (intracellular); low or high levels can affect heart function.
    • Sodium: 135-145 mEq/L (low levels cause confusion, high levels cause water retention).

    Week 9 Acute Kidney Injury Electrolytes (cont'd)

    • Low sodium causes muscle cramps and weakness.
    • Maintaining osmotic pressure in extracellular fluid is important.
    • Calcium: 8.5-10.5 mg/dL
    • Low calcium can cause parathyroid hormone release, increasing the risk of fractures.

    Week 9 Acute Kidney Injury Phosphorus and Kidney Function

    • Phosphorus (3.9-4.5 mg/dL): Kidneys are the primary organ for excreting phosphorus, excretion is impaired in kidney failure.
    • High phosphorus and low calcium levels can affect acid-base balance.

    Week 9 Acute Kidney Injury: Addressing Clinical Problems

    • Anemia due to kidney problems can be treated with erythropoietin (Epogen) replacement.
    • Reduced blood flow to the kidneys can be addressed by the renin-angiotensin-aldosterone system.
    • Damage to glomeruli can increase waste products in the kidney tubules.

    Week 9 Acute Kidney Injury: GFR and End Stage Renal Disease

    • Glomerular filtration rate (GFR) of 90-120 mL/min is adequate.
    • GFR below 15 mL/min indicates end-stage renal disease.
    • large amount of protein in urine is a sign that glomerulus is not working properly.

    Week 9 Acute Kidney Injury: Azotemia

    • Azotemia is a condition characterized by abnormal levels of nitrogenous waste products in the blood (e.g., BUN, creatinine).
    • Three types of azotemia: prerenal, intrinsic, and postrenal.
    • Prerenal azotemia can be reversed when addressing the underlying causes.

    Week 9 Acute Kidney Injury: Intrinsic/Intrinsic Renal Azotemia

    • Intrinsic (renal) azotemia involves direct damage to the kidneys.
    • Examples include acute tubular necrosis and glomerulonephritis.

    Week 9 Acute Kidney Injury: Postrenal Azotemia

    • Postrenal azotemia occurs due to obstruction of urine outflow.
    • Examples include kidney stones and enlarged prostate.

    Week 9 Acute Kidney Injury: Causes and Prevention

    • Various conditions can lead to acute kidney injury, including dehydration and exposure to nephrotoxic substances.
    • Proper management, including maintaining appropriate hydration and avoiding nephrotoxins, can prevent acute kidney injury.

    Week 9 Acute Kidney Injury: Radiographic Contrast and Rhabdomyolysis

    • Radiographic contrast media can cause tubular cell toxicity and ischemia.
    • Rhabdomyolysis is the breakdown of muscle tissue, releasing myoglobin into the blood, which can damage kidney tubules.

    Week 9 Acute Kidney Injury: Treatment

    • Treatment strategies involve addressing the underlying cause of AKI and managing complications. Fluid balance, electrolyte levels, and waste product removal are crucial aspects of treatment.

    Week 9 Acute Kidney Injury: Reversibility

    • If recognized early, acute kidney injury may be reversible.
    • Timely diagnosis and intervention can reduce the severity of damage.

    Week 9 Acute Kidney Injury: Acute Tubular Necrosis (cont'd)

    • This is a severe condition that affects kidney tubules, and is often caused by insufficient blood flow.
    • Symptoms can include reduced urine output.

    Week 9 Acute Kidney Injury: Medication

    • Diuretics, such as loop diuretics, can help manage fluid retention.
    • Osmotic diuretics can pull extracellular water into the bloodstream, helping to flush out waste products.

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