Isoniazid and Rifampin Adverse Effects Quiz

Isoniazid (INH) can cause hepatoxicty (overt hepatitis & asymptomatic increase in LFTs) and peripheral neuropathy. Peripheral neruopathy can be prevented with the administration of pyridoxine.

The most common adverse effect of rifampin is gastrointestinal

Ethambutol is associated with optic neuritis,It is reversible if discontinued. Arthralgias: majority develop mild hypeuricemia & acute gout arthritis is rare

<p>Pyrazinamide (PZA) is commonly associated with arthralgia (40% experience non-gouty, polyarthralgia), flushing reaction, and hepatotoxicity</p> Signup and view all the answers

<p>The adverse effects of streptomycin (STM) include nephrotoxicity (acute tubular necrosis) and ototoxicity (vestibular more common).</p> Signup and view all the answers

<p>The basic principle of antitubercular therapy is to use multiple drugs in order to prevent the emergence of resistance. Multiple drugs are utilized because adherence to therapy is crucial for a successful outcome.</p> Signup and view all the answers

<p>The first-line most potent drugs used in antitubercular therapy are isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin.</p> Signup and view all the answers

<p>NEVER add a single agent to a failing regimen, as adherence to therapy is crucial for a successful outcome.</p> Signup and view all the answers

<p>Adherence to therapy is crucial for a successful outcome in antitubercular therapy to prevent the emergence of resistance and ensure the effectiveness of the treatment.</p> Signup and view all the answers