9 Questions
Which drug can cause hepatoxicity and peripheral neuropathy? How can you prevent peripheral neuropathy?
Isoniazid (INH) can cause hepatoxicty (overt hepatitis & asymptomatic increase in LFTs) and peripheral neuropathy. Peripheral neruopathy can be prevented with the administration of pyridoxine.
What is the most common adverse effect of rifampin
The most common adverse effect of rifampin is gastrointestinal
What adverse effect is associated with ethambutol?
Ethambutol is associated with optic neuritis,It is reversible if discontinued. Arthralgias: majority develop mild hypeuricemia & acute gout arthritis is rare
What adverse effects are commonly associated with pyrazinamide (PZA)?
Pyrazinamide (PZA) is commonly associated with arthralgia (40% experience non-gouty, polyarthralgia), flushing reaction, and hepatotoxicity
What are the adverse effects of streptomycin (STM) and the risk factors associated with them?
The adverse effects of streptomycin (STM) include nephrotoxicity (acute tubular necrosis) and ototoxicity (vestibular more common).
What is the basic principle of antitubercular therapy, and why are multiple drugs utilized?
The basic principle of antitubercular therapy is to use multiple drugs in order to prevent the emergence of resistance. Multiple drugs are utilized because adherence to therapy is crucial for a successful outcome.
What are the first-line most potent drugs used in antitubercular therapy?
The first-line most potent drugs used in antitubercular therapy are isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin.
Is it okay to add a single agent to a failing antitubercular regimen?
NEVER add a single agent to a failing regimen, as adherence to therapy is crucial for a successful outcome.
Why is adherence to therapy crucial for a successful outcome in antitubercular therapy?
Adherence to therapy is crucial for a successful outcome in antitubercular therapy to prevent the emergence of resistance and ensure the effectiveness of the treatment.
Test your knowledge of adverse effects associated with isoniazid (INH) and rifampin (RIF) by taking this quiz. Learn about neurotoxicity, peripheral neuropathy, and hepatotoxicity, along with prevention and risk factors for these adverse effects.
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