Ischemic Heart Disease Overview
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Questions and Answers

What is the main cause of Ischemic heart disease?

  • Thromboembolism of coronary arteries
  • Genetic factors related to atherosclerosis (correct)
  • Functional myocardial overstrain
  • Prolonged spasm of coronary arteries

Why was Ischemic heart disease identified as an 'independent disease' by the World Health Organization in 1965?

  • Its association with psycho-emotional stress
  • Sudden death as a danger factor (correct)
  • Because of its prevalence in economically developed countries
  • Due to its relationship with hypertension

What accounts for approximately 2/3 of deaths from cardiovascular diseases?

  • Functional myocardial overstrain
  • Genetic factors
  • Coronary heart disease (correct)
  • Thromboembolism

What is a local cause of ischemia and necrosis of the heart muscle in coronary heart disease?

<p>Spasm of coronary arteries (C)</p> Signup and view all the answers

Apart from local causes, what are the etiological factors of coronary heart disease?

<p>Psycho-emotional stress leading to angio-neurotic disorders (C)</p> Signup and view all the answers

Who are more likely to be affected by coronary heart disease according to the text?

<p>Men aged 40-65 (B)</p> Signup and view all the answers

What is the term used to describe the necrobiotic changes in muscle fibers caused by ischemic myocardial dystrophy?

<p>Dystrophic calcification (A)</p> Signup and view all the answers

Which staining method results in muscle fibers giving off a green glow when viewed under a fluorescent microscope after being ischemic?

<p>Acridine orange (B)</p> Signup and view all the answers

What is the main reason for an extensive myocardial infarction when both branches of the left coronary artery are occluded by atherosclerosis?

<p>Increased anaerobic glycolysis (C)</p> Signup and view all the answers

Which of the following is NOT associated with decreased activity during early electron microscopic and histochemical changes in ischemic myocardial tissue?

<p>Increased activity of dehydrogenases (B)</p> Signup and view all the answers

Which characteristic is typical of an ischemic (white) infarction in myocardial pathology?

<p>Fermentemia (B)</p> Signup and view all the answers

What is the significance of accumulations of leukocytes along the periphery of the ischemic zone?

<p>Indicates necrobiotic changes (A)</p> Signup and view all the answers

Which of the following is associated with the late stages of myocardial ischemia, causing hydropic-destructive changes in ultrastructures?

<p>Accumulation of sodium (B)</p> Signup and view all the answers

What differentiates a recurrent myocardial infarction from a repeated one?

<p>Time of occurrence (C)</p> Signup and view all the answers

What is the primary cause of acute heart failure in the context of ischemic myocardial dystrophy?

<p>Uncoupling of respiration and oxidative phosphorylation (D)</p> Signup and view all the answers

Where is a heart attack most likely to develop, rarely in the context of myocardial infarction?

<p>Circumflex branch of the left coronary artery (A)</p> Signup and view all the answers

What determines the size of the infarct in myocardial infarction?

<p>All of the above (D)</p> Signup and view all the answers

Why are infarctions more common in hypertension?

<p>Due to the hypertrophy of the heart muscle (A)</p> Signup and view all the answers

What type of infarction involves the entire thickness of the heart muscle?

<p>Transmural infarction (C)</p> Signup and view all the answers

What is the characteristic of the necrotic stage of myocardial infarction?

<p>The presence of leukocyte infiltration and plethora (B)</p> Signup and view all the answers

What occurs in the brain during the necrotic stage of myocardial infarction?

<p>Uneven plethora and stasis in capillaries (D)</p> Signup and view all the answers

What is the duration of the scarring stage of myocardial infarction?

<p>7-8 weeks (B)</p> Signup and view all the answers

What is responsible for the resorption of necrotic masses during the scarring stage?

<p>Macrophages (C)</p> Signup and view all the answers

What is the result of atherosclerotic changes in the coronary arteries?

<p>Stenosing of the coronary arteries (C)</p> Signup and view all the answers

What is the type of inflammation observed with subepicardial and transmural infarcts?

<p>Fibrinous pericarditis (A)</p> Signup and view all the answers

What is the characteristic of large-focal myocardial infarction?

<p>Large area of necrosis (D)</p> Signup and view all the answers

What is the primary morphological basis of coronary heart disease?

<p>Coronary atherosclerosis (B)</p> Signup and view all the answers

Which pathogenetic factor of coronary heart disease has a 'predictive' value of 21%?

<p>Hyperlipidemia (C)</p> Signup and view all the answers

Which pathogenetic factor of coronary heart disease is not mentioned as a risk factor for myocardial infarction?

<p>Uric acid diathesis (C)</p> Signup and view all the answers

What is the role of smoking in the development of coronary heart disease?

<p>It causes vasomotor dysfunction (A)</p> Signup and view all the answers

Which form of coronary heart disease is morphologically manifested by ischemic myocardial dystrophy and myocardial infarction?

<p>Acute coronary heart disease (D)</p> Signup and view all the answers

What is the role of arterial hypertension in the development of myocardial ischemia?

<p>It leads to functional aggravation of the myocardium (C)</p> Signup and view all the answers

What is the significance of diabetes mellitus in the context of coronary heart disease?

<p>It contributes to the development of coronary atherosclerosis (B)</p> Signup and view all the answers

Which pathogenetic factor of coronary heart disease is not a risk factor for the development of myocardial infarction?

<p>Genetic predisposition (C)</p> Signup and view all the answers

Which form of coronary heart disease is complicated in some cases by chronic heart aneurysm?

<p>Cardiosclerosis (A)</p> Signup and view all the answers

What is the significance of hyperlipidemia in the development of coronary heart disease?

<p>It contributes to the development of coronary atherosclerosis (A)</p> Signup and view all the answers

What type of scar is formed when organizing the infarction?

<p>Coarse fibrous scar (C)</p> Signup and view all the answers

What is the term used to describe the melting of necrotic myocardium?

<p>Myomalacia (C)</p> Signup and view all the answers

What is the immediate cause of death in the early period of infarction?

<p>Asystole (C)</p> Signup and view all the answers

Which complication is associated with extensive infarctions?

<p>Acute aneurysm of the heart (C)</p> Signup and view all the answers

Which condition is usually formed as a result of a massive transmural infarction?

<p>Chronic aneurysm of the heart (B)</p> Signup and view all the answers

What is the term used to describe the regenerative hypertrophy of the preserved myocardium?

<p>Cardiomegaly (C)</p> Signup and view all the answers

What type of pericarditis is often found in subepicardial and transmural infarcts?

<p>Fibrinous pericarditis (B)</p> Signup and view all the answers

What is the term used to describe the improvement of blood supply to the myocardium?

<p>Revascularization (D)</p> Signup and view all the answers

Which complication is associated with the risk of thromboembolic complications?

<p>Parietal thrombi (D)</p> Signup and view all the answers

What is the term used to describe the predominance of the processes of autolysis of dead tissue in the myocardium?

<p>Myomalacia (B)</p> Signup and view all the answers

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