Ischemic Heart Disease Overview
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Questions and Answers

What is the main cause of Ischemic heart disease?

  • Thromboembolism of coronary arteries
  • Genetic factors related to atherosclerosis (correct)
  • Functional myocardial overstrain
  • Prolonged spasm of coronary arteries
  • Why was Ischemic heart disease identified as an 'independent disease' by the World Health Organization in 1965?

  • Its association with psycho-emotional stress
  • Sudden death as a danger factor (correct)
  • Because of its prevalence in economically developed countries
  • Due to its relationship with hypertension
  • What accounts for approximately 2/3 of deaths from cardiovascular diseases?

  • Functional myocardial overstrain
  • Genetic factors
  • Coronary heart disease (correct)
  • Thromboembolism
  • What is a local cause of ischemia and necrosis of the heart muscle in coronary heart disease?

    <p>Spasm of coronary arteries</p> Signup and view all the answers

    Apart from local causes, what are the etiological factors of coronary heart disease?

    <p>Psycho-emotional stress leading to angio-neurotic disorders</p> Signup and view all the answers

    Who are more likely to be affected by coronary heart disease according to the text?

    <p>Men aged 40-65</p> Signup and view all the answers

    What is the term used to describe the necrobiotic changes in muscle fibers caused by ischemic myocardial dystrophy?

    <p>Dystrophic calcification</p> Signup and view all the answers

    Which staining method results in muscle fibers giving off a green glow when viewed under a fluorescent microscope after being ischemic?

    <p>Acridine orange</p> Signup and view all the answers

    What is the main reason for an extensive myocardial infarction when both branches of the left coronary artery are occluded by atherosclerosis?

    <p>Increased anaerobic glycolysis</p> Signup and view all the answers

    Which of the following is NOT associated with decreased activity during early electron microscopic and histochemical changes in ischemic myocardial tissue?

    <p>Increased activity of dehydrogenases</p> Signup and view all the answers

    Which characteristic is typical of an ischemic (white) infarction in myocardial pathology?

    <p>Fermentemia</p> Signup and view all the answers

    What is the significance of accumulations of leukocytes along the periphery of the ischemic zone?

    <p>Indicates necrobiotic changes</p> Signup and view all the answers

    Which of the following is associated with the late stages of myocardial ischemia, causing hydropic-destructive changes in ultrastructures?

    <p>Accumulation of sodium</p> Signup and view all the answers

    What differentiates a recurrent myocardial infarction from a repeated one?

    <p>Time of occurrence</p> Signup and view all the answers

    What is the primary cause of acute heart failure in the context of ischemic myocardial dystrophy?

    <p>Uncoupling of respiration and oxidative phosphorylation</p> Signup and view all the answers

    Where is a heart attack most likely to develop, rarely in the context of myocardial infarction?

    <p>Circumflex branch of the left coronary artery</p> Signup and view all the answers

    What determines the size of the infarct in myocardial infarction?

    <p>All of the above</p> Signup and view all the answers

    Why are infarctions more common in hypertension?

    <p>Due to the hypertrophy of the heart muscle</p> Signup and view all the answers

    What type of infarction involves the entire thickness of the heart muscle?

    <p>Transmural infarction</p> Signup and view all the answers

    What is the characteristic of the necrotic stage of myocardial infarction?

    <p>The presence of leukocyte infiltration and plethora</p> Signup and view all the answers

    What occurs in the brain during the necrotic stage of myocardial infarction?

    <p>Uneven plethora and stasis in capillaries</p> Signup and view all the answers

    What is the duration of the scarring stage of myocardial infarction?

    <p>7-8 weeks</p> Signup and view all the answers

    What is responsible for the resorption of necrotic masses during the scarring stage?

    <p>Macrophages</p> Signup and view all the answers

    What is the result of atherosclerotic changes in the coronary arteries?

    <p>Stenosing of the coronary arteries</p> Signup and view all the answers

    What is the type of inflammation observed with subepicardial and transmural infarcts?

    <p>Fibrinous pericarditis</p> Signup and view all the answers

    What is the characteristic of large-focal myocardial infarction?

    <p>Large area of necrosis</p> Signup and view all the answers

    What is the primary morphological basis of coronary heart disease?

    <p>Coronary atherosclerosis</p> Signup and view all the answers

    Which pathogenetic factor of coronary heart disease has a 'predictive' value of 21%?

    <p>Hyperlipidemia</p> Signup and view all the answers

    Which pathogenetic factor of coronary heart disease is not mentioned as a risk factor for myocardial infarction?

    <p>Uric acid diathesis</p> Signup and view all the answers

    What is the role of smoking in the development of coronary heart disease?

    <p>It causes vasomotor dysfunction</p> Signup and view all the answers

    Which form of coronary heart disease is morphologically manifested by ischemic myocardial dystrophy and myocardial infarction?

    <p>Acute coronary heart disease</p> Signup and view all the answers

    What is the role of arterial hypertension in the development of myocardial ischemia?

    <p>It leads to functional aggravation of the myocardium</p> Signup and view all the answers

    What is the significance of diabetes mellitus in the context of coronary heart disease?

    <p>It contributes to the development of coronary atherosclerosis</p> Signup and view all the answers

    Which pathogenetic factor of coronary heart disease is not a risk factor for the development of myocardial infarction?

    <p>Genetic predisposition</p> Signup and view all the answers

    Which form of coronary heart disease is complicated in some cases by chronic heart aneurysm?

    <p>Cardiosclerosis</p> Signup and view all the answers

    What is the significance of hyperlipidemia in the development of coronary heart disease?

    <p>It contributes to the development of coronary atherosclerosis</p> Signup and view all the answers

    What type of scar is formed when organizing the infarction?

    <p>Coarse fibrous scar</p> Signup and view all the answers

    What is the term used to describe the melting of necrotic myocardium?

    <p>Myomalacia</p> Signup and view all the answers

    What is the immediate cause of death in the early period of infarction?

    <p>Asystole</p> Signup and view all the answers

    Which complication is associated with extensive infarctions?

    <p>Acute aneurysm of the heart</p> Signup and view all the answers

    Which condition is usually formed as a result of a massive transmural infarction?

    <p>Chronic aneurysm of the heart</p> Signup and view all the answers

    What is the term used to describe the regenerative hypertrophy of the preserved myocardium?

    <p>Cardiomegaly</p> Signup and view all the answers

    What type of pericarditis is often found in subepicardial and transmural infarcts?

    <p>Fibrinous pericarditis</p> Signup and view all the answers

    What is the term used to describe the improvement of blood supply to the myocardium?

    <p>Revascularization</p> Signup and view all the answers

    Which complication is associated with the risk of thromboembolic complications?

    <p>Parietal thrombi</p> Signup and view all the answers

    What is the term used to describe the predominance of the processes of autolysis of dead tissue in the myocardium?

    <p>Myomalacia</p> Signup and view all the answers

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