Iron Studies in Hematology

Studio de Ferro

• Thalassemia:

  • Ferro sérico es augmenat.
  • Transferrina o TIBC es deminuate.
  • Ferritina sérica es augmenat.
  • Saturation de transferrina % es deminuate.

• Anemia de Maladia Chronic:

  • Ferro sérico es deminuate.
  • Transferrina o TIBC es deminuate.
  • Ferritina sérica es augmenat.
  • Saturation de transferrina % es deminuate.

• Deficità de Ferro:

  • Ferro sérico es deminuate.
  • Transferrina o TIBC es augmentate.
  • Ferritina sérica es deminuate.
  • Saturation de transferrina % es deminuate.

• Intoxicazione per Pb (Plumbum):

  • Ferro sérico es deminuate.
  • Transferrina o TIBC es augmentate.
  • Ferritina sérica es deminuate.
  • Saturation de transferrina % es deminuate.

• Anemia Sideroblastic:

  • Ferro sérico es augmentate.
  • Transferrina o TIBC es deminuate.
  • Ferritina sérica es augmentate.
  • Saturation de transferrina % es augmentate.

• Hemocromatosis:

  • Ferro sérico es augmentate.
  • Transferrina o TIBC es deminuate.
  • Ferritina sérica es augmentate.
  • Saturation de transferrina % es augmentate.

• Gravidanza / Uso de OCP (Pilule de Controle de Nascita):

  • Ferro sérico non es disponibile.
  • Transferrina o TIBC es augmentate.
  • Ferritina sérica non es disponibile.
  • Saturation de transferrina % es deminuate.

Iron Studies by Cause of Anemia

• Serum Iron Levels:

  • Thalassemia: Increased levels indicating iron overload.
  • Anemia of Chronic Disease: Decreased levels due to inflammation interfering with iron metabolism.
  • Iron Deficiency: Decreased levels reflecting insufficient iron.
  • Lead Poisoning: Decreased levels associated with lead's interference in hemoglobin synthesis.
  • Sideroblastic Anemia: Increased levels due to ineffective erythropoiesis.
  • Hemochromatosis: Increased levels indicating excess iron accumulation.
  • Pregnancy/OCP Use: Not applicable, no change recorded.

• Transferrin or Total Iron Binding Capacity (TIBC):

  • Thalassemia: Decreased, reflecting altered iron processing.
  • Anemia of Chronic Disease: Decreased due to sequestering of iron.
  • Iron Deficiency: Increased, as the body increases transferrin production to capture iron.
  • Lead Poisoning: Increased, similar reasons as iron deficiency.
  • Sideroblastic Anemia: Decreased, as iron is inadequately utilized.
  • Hemochromatosis: Decreased due to saturation of iron stores.
  • Pregnancy/OCP Use: Increased, as demands for iron storage rise.

• Serum Ferritin:

  • Thalassemia: Increased levels because of excess iron in the body.
  • Anemia of Chronic Disease: Increased levels due to the body's response to inflammation.
  • Iron Deficiency: Decreased levels indicating low iron stores.
  • Lead Poisoning: Decreased levels aligning with iron utilization problems.
  • Sideroblastic Anemia: Increased levels reflecting iron accumulation with ineffective use.
  • Hemochromatosis: Increased levels indicating excessive iron storage.
  • Pregnancy/OCP Use: Not applicable, no change recorded.

• Percent Transferrin Saturation (calculated as Serum Iron/TIBC):

  • Thalassemia: Decreased saturation levels, reflecting altered iron handling.
  • Anemia of Chronic Disease: Decreased saturation due to disrupted iron availability.
  • Iron Deficiency: Decreased saturation aligning with insufficient iron.
  • Lead Poisoning: Decreased saturation indicative of disrupted hemoglobin synthesis.
  • Sideroblastic Anemia: Increased saturation due to ineffective erythropoiesis.
  • Hemochromatosis: Increased saturation, consistent with overload of iron.
  • Pregnancy/OCP Use: Decreased saturation reflecting increased iron requirements.