Iron Deficiency Anaemia Overview

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Where does the process of haemopoiesis start in human development?

Yolk sac

Which cell type is responsible for transporting oxygen, nutrients, carbon dioxide, and waste products in the blood?

Red cells (erythrocytes, RBC)

What is the main function of plasma in blood composition?

Carrying nutrients

At what stage does bone marrow take over the responsibility of haemopoiesis in a developing human embryo?

<p>6 months to birth</p> Signup and view all the answers

What are the average size dimensions of a normal red blood cell (RBC)?

<p>7-8 µm</p> Signup and view all the answers

What is the primary function of reticulocytes in blood?

<p>Indicating new red blood cell formation</p> Signup and view all the answers

What is the average hemoglobin concentration in a red blood cell?

<p>32-36 g/dl</p> Signup and view all the answers

Which stage of erythropoiesis comes after the proerythroblast?

<p>Erythroblast (late)</p> Signup and view all the answers

What are the three essential dietary constituents for erythropoiesis?

<p>Iron, Vitamin B12, Folic Acid</p> Signup and view all the answers

In terms of red cell indices, how is anemia classified?

<p>Based on mean corpuscular volume (MCV)</p> Signup and view all the answers

What are the pathological consequences of anemia?

<p>Tissue hypoxia</p> Signup and view all the answers

Which laboratory finding indicates anisocytosis in a blood film?

<p>Variation in size</p> Signup and view all the answers

What is the commonest cause of anaemia due to haematinic deficiency?

<p>Haemorrhage</p> Signup and view all the answers

Which of the following is NOT a mechanism of iron deficiency leading to anaemia?

<p>Excessive iron absorption</p> Signup and view all the answers

In iron metabolism, iron is stored as:

<p>Haemosiderin</p> Signup and view all the answers

Which of the following is a reason for failure to respond to iron therapy in cases of iron deficiency anaemia?

<p>Non-compliance with treatment</p> Signup and view all the answers

What type of anaemia is characterized by microcytic and hypochromic red blood cells?

<p>Microcytic anaemia</p> Signup and view all the answers

What characterizes megaloblastic anaemia in the bone marrow?

<p>Erythroblasts with delayed nucleus maturation</p> Signup and view all the answers

Which factor is essential for DNA synthesis in the biochemical basis of megaloblastic anaemia?

<p>Deoxyuridine monophosphate</p> Signup and view all the answers

What is the primary source of Vitamin B12?

<p>Meat, fish, dairy produce</p> Signup and view all the answers

What condition can lead to Vitamin B12 deficiency?

<p>Congenital lack of Intrinsic Factor (IF)</p> Signup and view all the answers

Which of the following is a common cause of folate deficiency?

<p>Tropical sprue</p> Signup and view all the answers

What is the function of Intrinsic Factor (IF) in Vitamin B12 absorption?

<p>Aids in the transport of Vitamin B12</p> Signup and view all the answers

Fe+++ is absorbed as Fe++ with the help of gastric HCl.

<p>True</p> Signup and view all the answers

Iron is stored in the body as ferrous sulfate and hemosiderin.

<p>False</p> Signup and view all the answers

Fe deficiency anaemia can be caused by increased iron demands.

<p>True</p> Signup and view all the answers

Oral iron therapy is usually ineffective in treating iron deficiency anemia.

<p>False</p> Signup and view all the answers

Chronic inflammation, including infectious diseases like TB and malaria, can lead to iron deficiency anemia.

<p>True</p> Signup and view all the answers

In adult life, extramedullary haemopoiesis is the main site of blood cell production.

<p>False</p> Signup and view all the answers

Myeloid stem cells differentiate into red cells, white cells, and platelets.

<p>False</p> Signup and view all the answers

The normal range for red blood cell count in adult females is 4.5 - 6.5 x10^12/l.

<p>False</p> Signup and view all the answers

The average size of a red blood cell is 17.5 µm.

<p>False</p> Signup and view all the answers

Mature cells are the earliest recognisable precursors in blood cell differentiation.

<p>False</p> Signup and view all the answers

Reticulocytes account for 1% of total white blood cell count.

<p>False</p> Signup and view all the answers

The average hemoglobin concentration in a red blood cell is 80-95 g/dl.

<p>True</p> Signup and view all the answers

Reticulocytes are the final stage of maturation in the process of erythropoiesis.

<p>False</p> Signup and view all the answers

Erythropoietin is not required for the process of erythropoiesis.

<p>False</p> Signup and view all the answers

Anisocytosis refers to a variation in shape of red blood cells seen in a blood film.

<p>False</p> Signup and view all the answers

Poikilocytosis is a characteristic feature of megaloblastic anemia.

<p>True</p> Signup and view all the answers

Iron deficiency is classified as a normochromic normocytic type of anemia based on red cell indices.

<p>False</p> Signup and view all the answers

Megaloblastic anemia can be characterized by the presence of megaloblasts in the bone marrow.

<p>True</p> Signup and view all the answers

Folate deficiency can lead to hypersegmented neutrophils in peripheral blood.

<p>True</p> Signup and view all the answers

Abnormal metabolism of B12 and folate is not a cause of megaloblastic anemia.

<p>False</p> Signup and view all the answers

Folate is primarily sourced from dairy produce.

<p>False</p> Signup and view all the answers

B12 deficiency can be caused by a congenital lack of Intrinsic Factor (IF).

<p>True</p> Signup and view all the answers

Crohn's disease can lead to folate deficiency due to malabsorption.

<p>True</p> Signup and view all the answers

Study Notes

  • Blood is composed of plasma (55%) and cells (40-45%), including red cells (erythrocytes), white cells (leucocytes), and platelets (thrombocytes).
  • Haemopoiesis, the process of blood cell production, starts in the yolk sac during gestation, then moves to the liver and spleen (extramedullary) before settling in the bone marrow.
  • Blood cell differentiation involves pluripotential stem cells, myeloid or lymphoid stem cells, committed stem cells, and mature cells.
  • Erythropoiesis is the process of red blood cell production and involves stages like proerythroblast, erythroblast, reticulocyte, and finally erythrocyte.
  • Anemia is characterized by low hemoglobin levels, reduced red cell mass, and can be classified based on red cell indices like MCV.
  • Causes of anemia include decreased production (e.g., aplastic bone marrow) and increased destruction/loss (e.g., hemorrhage).
  • Iron deficiency is a common cause of microcytic, hypochromic anemia and can result from factors like increased demands, chronic blood loss, poor diet, or malabsorption.
  • Megaloblastic anemia is characterized by megaloblasts in the bone marrow, large oval RBCs in the blood, and can be caused by vitamin B12 or folate deficiency, leading to defective DNA synthesis.

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