Metabolic and Granulomatous Diseases

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Questions and Answers

What is a common deficiency encountered despite eating a varied diet?

  • Iron deficiency anemia (correct)
  • Vitamin C deficiency
  • Vitamin B12 deficiency
  • Calcium deficiency

What could be a cause of iron deficiency anemia?

  • Low demand for RBCs
  • Excessive vitamin intake
  • Decreased iron intake (correct)
  • High absorption due to systemic issues

What could lead to increased demand for RBCs?

  • Menstruation (correct)
  • Decreased physical activity
  • Low oxygen levels
  • High iron intake

What is mentioned as a potential cause of iron deficiency anemia?

<p>Decreased iron intake (D)</p> Signup and view all the answers

What is the most common cause of anemia in the US?

<p>Iron deficiency anemia (A)</p> Signup and view all the answers

What could be a reason for encountering nutritional deficiencies despite eating a varied diet?

<p>Decreased absorption due to systemic issues (C)</p> Signup and view all the answers

Which of the following is a characteristic of granulomatous inflammatory disorders?

<p>Fishery grooves and snail track pustules (B)</p> Signup and view all the answers

What can the presence of multi-nucleated giant cells and granulomas in salivary gland tissue indicate?

<p>Sarcoidosis (B)</p> Signup and view all the answers

Which condition is a granulomatous disease affecting the lungs, salivary glands, eyes, and lymph nodes?

<p>Sarcoidosis (D)</p> Signup and view all the answers

What is the diagnosis of exclusion, affecting only the oral cavity, and possibly linked to an overreaction of the immune system or genetic predisposition?

<p>Oral facial granuloma ptosis (C)</p> Signup and view all the answers

What can granulomatous inflammation in glandular tissue raise suspicion of?

<p>Sarcoidosis (B)</p> Signup and view all the answers

What may be related to an overreaction of the immune system and genetic factors in the context of granulomatous inflammation?

<p>Oral facial granuloma ptosis (D)</p> Signup and view all the answers

Which condition is granulomatous inflammation associated with?

<p>Inflammatory bowel diseases (D)</p> Signup and view all the answers

What can oral manifestations of Crohn's disease include?

<p>Focal erythematous and ulcerated gingiva (B)</p> Signup and view all the answers

Which age group is often diagnosed with Crohn's disease?

<p>Teenagers or early 20s (A)</p> Signup and view all the answers

What can granulomatous inflammation in Crohn's disease cause in the lips and buccal mucosa?

<p>Firm, persistent swelling (A)</p> Signup and view all the answers

What can oral lesions in Crohn's disease present as in the vestibule?

<p>Redundant tissue folds and ulcerated linear folds (D)</p> Signup and view all the answers

What can early detection of oral manifestations of Crohn's disease be beneficial for?

<p>Patients (B)</p> Signup and view all the answers

What oral manifestation can be seen in patients with iron deficiency anemia?

<p>Bald, beefy red tongue due to loss of form papillae (D)</p> Signup and view all the answers

What is a characteristic oral manifestation of pernicious anemia?

<p>Burning sensation in the oral mucosa (B)</p> Signup and view all the answers

What may be observed in the jawbones of patients with B12 deficiency?

<p>Altered trabecular patterns due to increased hematopoiesis (D)</p> Signup and view all the answers

How can nutritional deficiencies be diagnosed and managed in relation to oral findings?

<p>Routine blood work (B)</p> Signup and view all the answers

What is a characteristic oral manifestation of untreated Addison's disease?

<p>Diffuse bronzing of the skin (A)</p> Signup and view all the answers

What is the responsibility of dental professionals in relation to oral manifestations of Addison's disease?

<p>Consider in differential diagnosis and refer to a physician (B)</p> Signup and view all the answers

Which clinical manifestation is indicative of severe iron deficiency anemia?

<p>Atrophic loss situs with mucosal burning and dysphagia (C)</p> Signup and view all the answers

What is a characteristic feature of iron deficiency anemia seen in the blood smear?

<p>Smaller, paler red blood cells (hypo chromic microfluidic) (C)</p> Signup and view all the answers

What is a clinical feature of iron deficiency anemia related to oral mucosal changes?

<p>Diffuse erythema of the oral mucosa due to thinner epithelium (C)</p> Signup and view all the answers

What is a characteristic symptom of Plummer Vincent syndrome associated with severe iron deficiency anemia?

<p>Dysphagia (difficulty swallowing) (D)</p> Signup and view all the answers

What is a potential cause of iron deficiency anemia according to the text?

<p>Dietary choices and absorption issues (C)</p> Signup and view all the answers

What is a characteristic feature of iron deficiency anemia related to oral mucosal changes?

<p>Diffuse erythema of the oral mucosa due to thinner epithelium (C)</p> Signup and view all the answers

What is a common cause of iron deficiency anemia?

<p>Excessive blood loss (C)</p> Signup and view all the answers

What is a potential reason for encountering nutritional deficiencies despite eating a varied diet?

<p>Decreased absorption due to systemic issues (D)</p> Signup and view all the answers

What is a very common deficiency encountered in clinical endeavors?

<p>Iron deficiency anemia (C)</p> Signup and view all the answers

What is a characteristic feature of iron deficiency anemia related to oral mucosal changes?

<p>Oral ulcers (C)</p> Signup and view all the answers

What can lead to increased demand for red blood cells?

<p>Pregnancy (C)</p> Signup and view all the answers

What is a systemic issue that can result in decreased iron absorption?

<p>Genetic factors (B)</p> Signup and view all the answers

Which systemic condition can lead to a bald, beefy red tongue due to loss of form papillae?

<p>Iron deficiency anemia (C)</p> Signup and view all the answers

What is the cause of macrocytic anemia and a burning sensation in the oral mucosa?

<p>Pernicious anemia (D)</p> Signup and view all the answers

What can result in altered trabecular patterns in the jawbones due to increased hematopoiesis in response to the need for more red blood cells?

<p>B12 deficiency (C)</p> Signup and view all the answers

Which systemic condition can cause diffuse bronzing of the skin and flat brown pigmented lesions on the oral mucosa?

<p>Addison's disease (B)</p> Signup and view all the answers

What can nutritional deficiencies manifest with, and how can they be diagnosed and managed?

<p>With oral findings, and routine blood work can help diagnose and manage these deficiencies (B)</p> Signup and view all the answers

What can occur in non-vital teeth, leading to the formation of a radicular cyst or a periapical granuloma at the tooth apex?

<p>Inflammation due to systemic conditions (B)</p> Signup and view all the answers

What is a characteristic feature of sarcoidosis?

<p>Affects the lungs, salivary glands, eyes, and lymph nodes (B)</p> Signup and view all the answers

What can the presence of multi-nucleated giant cells and granulomas in salivary gland tissue indicate?

<p>Sarcoidosis (B)</p> Signup and view all the answers

What can oral facial granuloma ptosis be linked to?

<p>Overreaction of the immune system or genetic predisposition (D)</p> Signup and view all the answers

What is a potential cause of granulomatous inflammation?

<p>Bacterial infections (A)</p> Signup and view all the answers

What can granulomatous inflammation in glandular tissue raise suspicion of?

<p>Sarcoidosis (A)</p> Signup and view all the answers

What can the condition of oral facial granuloma ptosis be related to?

<p>Overreaction of the immune system and genetic factors (C)</p> Signup and view all the answers

Which clinical manifestation is not associated with iron deficiency anemia?

<p>Angular colitis (A)</p> Signup and view all the answers

What is a characteristic oral manifestation of severe iron deficiency anemia?

<p>Baldness of the tongue due to loss of papillae (D)</p> Signup and view all the answers

What is the clinical feature of Plummer Vincent syndrome associated with severe iron deficiency anemia?

<p>Difficulty swallowing (dysphagia) (C)</p> Signup and view all the answers

What is a feature of iron deficiency anemia related to oral mucosal changes?

<p>Diffuse erythema of the oral mucosa (B)</p> Signup and view all the answers

What is a potential cause of iron deficiency anemia according to the text?

<p>Genetic predisposition (B)</p> Signup and view all the answers

What is the diagnosis method mentioned in the text for confirming iron deficiency anemia?

<p>Hematologic studies to assess iron levels (A)</p> Signup and view all the answers

Which oral manifestation can be seen in Crohn's disease but not in ulcerative colitis?

<p>Redundant tissue folds in the vestibule (A)</p> Signup and view all the answers

What is the term for the punctuate ulcerative lesions seen in Crohn's disease?

<p>Snail track pustules (C)</p> Signup and view all the answers

What is a characteristic clinical sign of granulomatous inflammation in Crohn's disease?

<p>Staghorn appearance of Wharton's duct (A)</p> Signup and view all the answers

What is the term for the firm, persistent swelling in the lips and buccal mucosa associated with Crohn's disease?

<p>Labial fullness (B)</p> Signup and view all the answers

In what age group is Crohn's disease often diagnosed?

<p>Teenagers or early 20s (D)</p> Signup and view all the answers

What is the term for the periodical granuloma associated with inflammatory bowel diseases?

<p>Granulomatous inflammation (B)</p> Signup and view all the answers

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Study Notes

Clinical Manifestations of Iron Deficiency Anemia

  • Blood smear of iron deficiency anemia shows smaller, paler red blood cells (hypo chromic microfluidic).
  • Patients with iron deficiency can exhibit clinical manifestations such as vulnerability to angular colitis, characterized by scaling, erythema, and redness at the corners of the mouth.
  • Atrophic loss situs, indicated by baldness of the tongue due to loss of papillae, is a feature of iron deficiency anemia.
  • Generalized mucosal atrophy in iron deficiency anemia presents as diffuse erythema of the oral mucosa due to thinner epithelium, making blood vessels more visible.
  • Severe iron deficiency anemia can lead to Plummer Vincent syndrome, with symptoms including atrophic loss situs, mucosal burning, irritation, and dysphagia (difficulty swallowing).
  • A patient with iron deficiency anemia had a traumatic esophageal injury from a motor vehicle accident, leading to a restrictive diet and mucosal burning in the mouth.
  • The patient's pale conjunctiva and extremely pale oral mucosa indicated severe anemia and reduced oxygen-carrying capacity of blood.
  • The patient's diagnosis was confirmed through hematologic studies to assess iron levels, and she received iron infusions for treatment.
  • Iron deficiency anemia can occur due to dietary choices, absorption issues, or changes in dietary choices post-injury.
  • Angular colitis, characterized by ulcer and redness at the corner of the mouth, is a clinical feature that can be seen in iron deficiency anemia.
  • Clinical manifestations of iron deficiency anemia can vary from typical blood smear findings to specific oral and systemic symptoms.
  • Identifying clinical manifestations of iron deficiency anemia, such as oral mucosal changes and systemic symptoms, is essential for prompt diagnosis and management.

Oral Manifestations of Crohn's Disease

  • Periodical granuloma is another term for granulation tissue
  • Granulomatous inflammation is associated with inflammatory bowel diseases
  • Granulomatous inflammation can be seen in conditions like ulcerative colitis and Crohn's disease
  • Crohn's disease can affect the entire GI tract, including the oral cavity
  • Oral manifestations of Crohn's disease can include focal erythematous and ulcerated gingiva
  • Oral lesions can precede GI lesions in Crohn's disease
  • Oral lesions in Crohn's disease can present as redundant tissue folds and ulcerated linear folds in the vestibule
  • Crohn's disease is often diagnosed in teenagers or early 20s
  • Granulomatous inflammation in Crohn's disease can cause firm, persistent swelling in the lips and buccal mucosa
  • Clinical signs of granulomatous inflammation in Crohn's disease include labial fullness, staghorn appearance of Wharton's duct, and pie stomatitis vegetans
  • Punctuate ulcerative lesions known as snail track pustules can also be seen in Crohn's disease
  • Early detection of oral manifestations of Crohn's disease can be beneficial for patients

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