Iron Binding Capacity in Serum

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Questions and Answers

What percentage of all NHL does mantle cell lymphoma account for?

5% (correct)

At what age range is mantle cell lymphoma most common?

30-40

50-60

40-50 (correct)

60-70

Which of the following is a characteristic of mantle cell lymphoma?

Male predominance (correct)

No sex predominance

Equally affects both sexes

Female predominance

What is the approximate percentage of transferrin saturated with iron?

33% Signup and view all the answers

What type of NHL is mantle cell lymphoma classified as?

Intermediate grade B-cell NHL Signup and view all the answers

What is the normal range of total iron binding capacity of serum?

300 to 350 μg/dL Signup and view all the answers

What is a notable characteristic of the cells in mantle cell lymphoma?

They are small and resemble marginal cells Signup and view all the answers

What is the primary function of transferrin in the blood?

To transport iron in the blood Signup and view all the answers

What would be the consequence if the total iron binding capacity of serum is lower than 300 μg/dL?

Increased risk of iron overload Signup and view all the answers

What percentage of transferrin is unsaturated with iron?

67% Signup and view all the answers

What is a characteristic of neoplastic cells in mantle cell lymphoma?

They express surface IgM Signup and view all the answers

What is typically associated with advanced stages of mantle cell lymphoma?

Fever Signup and view all the answers

What is a feature of bulky tumors in mantle cell lymphoma?

They are typically large and aggressive Signup and view all the answers

What is a surface marker expressed by neoplastic cells in mantle cell lymphoma?

CD10 Signup and view all the answers

What is a common systemic symptom of mantle cell lymphoma?

Weight loss Signup and view all the answers

In which patients are retroperitoneal nodes commonly affected?

Immune-compromised patients Signup and view all the answers

What is the frequency of abdominal involvement in mantle cell lymphoma patients?

Half of the patients Signup and view all the answers

At what stages is mantle cell lymphoma usually diagnosed?

Stages III and IV Signup and view all the answers

Which of the following is a characteristic of retroperitoneal node involvement in mantle cell lymphoma?

Usually diagnosed at stage I or II Signup and view all the answers

What is the significance of abdominal involvement in mantle cell lymphoma?

It is seen in half of the patients Signup and view all the answers

What is the median age of patients with a certain type of lymphoma?

60 years Signup and view all the answers

What percentage of childhood lymphomas is accounted for by this type of lymphoma?

25% Signup and view all the answers

What is the result of prominent cell death in this type of lymphoma?

Macrophages engulfing debris Signup and view all the answers

What is the characteristic appearance of this type of lymphoma?

Starry sky appearance Signup and view all the answers

What is the sequence of events that leads to the characteristic appearance of this type of lymphoma?

Prominent cell death → macrophages engulfing debris → starry sky appearance Signup and view all the answers

Study Notes

Iron and Transferrin

Transferrin is 33% saturated with iron
The normal total iron binding capacity of serum is 300 to 350 μg/dL

Intermediate Grade B-Cell NHL: Mantle Cell Lymphoma

Accounts for 5% of all NHL
Age range: 40-50 years, with a median age of 60 years
Male predominance
Accounts for 25% of childhood lymphomas
Characteristics:
- Prominent cell death
- Macrophages engulfing debris, resulting in a "starry sky" appearance
- Fever and weight loss
Neoplastic cells:
- Peripheral B-lymphocytes
- Express surface IgM and CD10
Common features:
- Bulky tumors
- Advanced stages, particularly in immune-compromised patients
- Sites involved: retroperitoneal nodes
Staging:
- Abdominal involvement in half of the patients
- Stages III and IV are most common
- Stage I or II disease is less common

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Description

This quiz covers the normal iron binding capacity of serum and the saturation of transferrin with iron. Learn about the iron binding capacity of serum and its significance in the body.