25 Questions
What percentage of all NHL does mantle cell lymphoma account for?
5%
At what age range is mantle cell lymphoma most common?
40-50
Which of the following is a characteristic of mantle cell lymphoma?
Male predominance
What is the approximate percentage of transferrin saturated with iron?
33%
What type of NHL is mantle cell lymphoma classified as?
Intermediate grade B-cell NHL
What is the normal range of total iron binding capacity of serum?
300 to 350 μg/dL
What is a notable characteristic of the cells in mantle cell lymphoma?
They are small and resemble marginal cells
What is the primary function of transferrin in the blood?
To transport iron in the blood
What would be the consequence if the total iron binding capacity of serum is lower than 300 μg/dL?
Increased risk of iron overload
What percentage of transferrin is unsaturated with iron?
67%
What is a characteristic of neoplastic cells in mantle cell lymphoma?
They express surface IgM
What is typically associated with advanced stages of mantle cell lymphoma?
Fever
What is a feature of bulky tumors in mantle cell lymphoma?
They are typically large and aggressive
What is a surface marker expressed by neoplastic cells in mantle cell lymphoma?
CD10
What is a common systemic symptom of mantle cell lymphoma?
Weight loss
In which patients are retroperitoneal nodes commonly affected?
Immune-compromised patients
What is the frequency of abdominal involvement in mantle cell lymphoma patients?
Half of the patients
At what stages is mantle cell lymphoma usually diagnosed?
Stages III and IV
Which of the following is a characteristic of retroperitoneal node involvement in mantle cell lymphoma?
Usually diagnosed at stage I or II
What is the significance of abdominal involvement in mantle cell lymphoma?
It is seen in half of the patients
What is the median age of patients with a certain type of lymphoma?
60 years
What percentage of childhood lymphomas is accounted for by this type of lymphoma?
25%
What is the result of prominent cell death in this type of lymphoma?
Macrophages engulfing debris
What is the characteristic appearance of this type of lymphoma?
Starry sky appearance
What is the sequence of events that leads to the characteristic appearance of this type of lymphoma?
Prominent cell death → macrophages engulfing debris → starry sky appearance
Study Notes
Iron and Transferrin
- Transferrin is 33% saturated with iron
- The normal total iron binding capacity of serum is 300 to 350 μg/dL
Intermediate Grade B-Cell NHL: Mantle Cell Lymphoma
- Accounts for 5% of all NHL
- Age range: 40-50 years, with a median age of 60 years
- Male predominance
- Accounts for 25% of childhood lymphomas
- Characteristics:
- Prominent cell death
- Macrophages engulfing debris, resulting in a "starry sky" appearance
- Fever and weight loss
- Neoplastic cells:
- Peripheral B-lymphocytes
- Express surface IgM and CD10
- Common features:
- Bulky tumors
- Advanced stages, particularly in immune-compromised patients
- Sites involved: retroperitoneal nodes
- Staging:
- Abdominal involvement in half of the patients
- Stages III and IV are most common
- Stage I or II disease is less common
This quiz covers the normal iron binding capacity of serum and the saturation of transferrin with iron. Learn about the iron binding capacity of serum and its significance in the body.
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