10 Questions
Which molecule is the primary carrier of iron in the blood?
Transferrin
What is the role of transferrin receptor 1 (TfR1) in iron uptake?
It facilitates receptor-mediated endocytosis
What happens to iron affinity for transferrin in the acidic environment of the endosome?
It decreases
How is iron transported into the cytosol from the endosome?
By divalent metal transporter-1 (DMT1)
What enzyme reduces iron(III) to iron(II) within the endosomal membrane?
STEAP3
Which molecule is responsible for binding the majority of iron in the blood?
Transferrin
What is the function of transferrin receptor 1 (TfR1) on the cell surface?
To facilitate endocytosis of iron-bound transferrin
What happens to the affinity of transferrin for iron in the acidic environment of the endosome?
The affinity decreases
Which enzyme reduces iron(III) to iron(II) within the endosomal membrane?
Ferrireductase
How is iron transported into the cytosol from the endosome?
By divalent metal transporter-1 (DMT1)
Test your knowledge of iron metabolism and cellular uptake with this quiz! Learn about how iron is transported in the blood, the role of transferrin and transferrin receptor 1, and the process of receptor-mediated endocytosis. Explore the internalization of iron and the impact of acidic environments.
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