Iron Metabolism and Cellular Uptake
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Questions and Answers

Which molecule is the primary carrier of iron in the blood?

  • Ferrous sulfate
  • Hemoglobin
  • Ferritin
  • Transferrin (correct)

    • What is the role of transferrin receptor 1 (TfR1) in iron uptake?

  • It facilitates receptor-mediated endocytosis (correct)
  • It binds to iron(III)
  • It reduces iron(III) to iron(II)
  • It releases iron from transferrin

    • What happens to iron affinity for transferrin in the acidic environment of the endosome?

  • It increases
  • It remains the same
  • It becomes toxic
  • It decreases (correct)

    • How is iron transported into the cytosol from the endosome?

    <p>By divalent metal transporter-1 (DMT1)</p> Signup and view all the answers

    What enzyme reduces iron(III) to iron(II) within the endosomal membrane?

    <p>STEAP3</p> Signup and view all the answers

    Which molecule is responsible for binding the majority of iron in the blood?

    <p>Transferrin</p> Signup and view all the answers

    What is the function of transferrin receptor 1 (TfR1) on the cell surface?

    <p>To facilitate endocytosis of iron-bound transferrin</p> Signup and view all the answers

    What happens to the affinity of transferrin for iron in the acidic environment of the endosome?

    <p>The affinity decreases</p> Signup and view all the answers

    Which enzyme reduces iron(III) to iron(II) within the endosomal membrane?

    <p>Ferrireductase</p> Signup and view all the answers

    How is iron transported into the cytosol from the endosome?

    <p>By divalent metal transporter-1 (DMT1)</p> Signup and view all the answers

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