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Iron Metabolism and Cellular Uptake

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Questions and Answers

Which molecule is the primary carrier of iron in the blood?

Ferrous sulfate

Hemoglobin

Ferritin

Transferrin (correct)

What is the role of transferrin receptor 1 (TfR1) in iron uptake?

It facilitates receptor-mediated endocytosis (correct)

It binds to iron(III)

It reduces iron(III) to iron(II)

It releases iron from transferrin

What happens to iron affinity for transferrin in the acidic environment of the endosome?

It increases

It remains the same

It becomes toxic

It decreases (correct)

How is iron transported into the cytosol from the endosome?

By divalent metal transporter-1 (DMT1) (D) Signup and view all the answers

What enzyme reduces iron(III) to iron(II) within the endosomal membrane?

STEAP3 (D) Signup and view all the answers

Which molecule is responsible for binding the majority of iron in the blood?

Transferrin (A) Signup and view all the answers

What is the function of transferrin receptor 1 (TfR1) on the cell surface?

To facilitate endocytosis of iron-bound transferrin (C) Signup and view all the answers

What happens to the affinity of transferrin for iron in the acidic environment of the endosome?

The affinity decreases (B) Signup and view all the answers

Which enzyme reduces iron(III) to iron(II) within the endosomal membrane?

Ferrireductase (A) Signup and view all the answers

How is iron transported into the cytosol from the endosome?

By divalent metal transporter-1 (DMT1) (C) Signup and view all the answers

Iron Metabolism and Cellular Uptake

Choose a study mode

Podcast

Questions and Answers

Which molecule is the primary carrier of iron in the blood?

What is the role of transferrin receptor 1 (TfR1) in iron uptake?

What happens to iron affinity for transferrin in the acidic environment of the endosome?

How is iron transported into the cytosol from the endosome?

What enzyme reduces iron(III) to iron(II) within the endosomal membrane?

Which molecule is responsible for binding the majority of iron in the blood?

What is the function of transferrin receptor 1 (TfR1) on the cell surface?

What happens to the affinity of transferrin for iron in the acidic environment of the endosome?

Which enzyme reduces iron(III) to iron(II) within the endosomal membrane?

How is iron transported into the cytosol from the endosome?

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