Iron Metabolism and Cellular Uptake
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Questions and Answers

Which molecule is the primary carrier of iron in the blood?

  • Ferrous sulfate
  • Hemoglobin
  • Ferritin
  • Transferrin (correct)

What is the role of transferrin receptor 1 (TfR1) in iron uptake?

  • It facilitates receptor-mediated endocytosis (correct)
  • It binds to iron(III)
  • It reduces iron(III) to iron(II)
  • It releases iron from transferrin

What happens to iron affinity for transferrin in the acidic environment of the endosome?

  • It increases
  • It remains the same
  • It becomes toxic
  • It decreases (correct)

How is iron transported into the cytosol from the endosome?

<p>By divalent metal transporter-1 (DMT1) (D)</p> Signup and view all the answers

What enzyme reduces iron(III) to iron(II) within the endosomal membrane?

<p>STEAP3 (D)</p> Signup and view all the answers

Which molecule is responsible for binding the majority of iron in the blood?

<p>Transferrin (A)</p> Signup and view all the answers

What is the function of transferrin receptor 1 (TfR1) on the cell surface?

<p>To facilitate endocytosis of iron-bound transferrin (C)</p> Signup and view all the answers

What happens to the affinity of transferrin for iron in the acidic environment of the endosome?

<p>The affinity decreases (B)</p> Signup and view all the answers

Which enzyme reduces iron(III) to iron(II) within the endosomal membrane?

<p>Ferrireductase (A)</p> Signup and view all the answers

How is iron transported into the cytosol from the endosome?

<p>By divalent metal transporter-1 (DMT1) (C)</p> Signup and view all the answers

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