Pharmacology: Ionophores

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Questions and Answers

Which antimicrobials are included in the family Ionophores?

Lasalocid, monensin, narasin, salinomycin

According to Ionophores rank in the WHO list of medically important antimicrobials, they are authorized for human use

False (B)

What is a key pharmacokinetic characteristic of ionophores?

  • They accumulate in tissues over time
  • They are poorly absorbed in monogastric animals
  • They have good and rapid oral bioavailability in monogastric animals (correct)
  • They are excreted unchanged in urine

What is the primary function of ionophores in bacterial cells?

<p>Facilitating ion transport across biological membranes (B)</p> Signup and view all the answers

What is the primary route of elimination for ionophores after extensive hepatic metabolism?

<p>Excretion primarily through bile and renal pathways (B)</p> Signup and view all the answers

Why are horses more susceptible to ionophore toxicity?

<p>They have a slower hepatic metabolism of ionophores (A)</p> Signup and view all the answers

What is an important drug interaction concern with ionophores?

<p>They can cause neurological signs if administered with pleuromutilins (B)</p> Signup and view all the answers

How do ionophores disrupt bacterial cell membranes?

<p>By altering permeability of Gram-positive bacteria, leading to potassium leakage and replacement by hydrogen (D)</p> Signup and view all the answers

What clinical signs may occur if ionophores and pleuromutilins are used too closely together?

<p>Growth depression, ataxia, paralysis, and death (C)</p> Signup and view all the answers

What are the adverse effects of ionophores? (Hint two)

<p>Rhabdomyolysis and cardiac myolysis</p> Signup and view all the answers

Which of the following statements is FALSE about the adverse effects about Ionophores?

<p>Both effects in cats (D)</p> Signup and view all the answers

What is the spectrum of activity of ionophores?

<p>Narrow spectrum</p> Signup and view all the answers

There are oral formulations of ionophores in veterinary medicine for food animals

<p>True (A)</p> Signup and view all the answers

In food animals, ionophores are commonly used for which purposes?

<p>Growth promotion and anticoccidial control (A)</p> Signup and view all the answers

What is the primary clinical use of ionophores in poultry?

<p>Treatment of respiratory infections (B)</p> Signup and view all the answers

Flashcards

Ionophore Antimicrobials

Lasalocid, monensin, narasin, and salinomycin.

Ionophores and Human Use

Ionophores are not authorized for human use.

Ionophore Bioavailability

Ionophores have good and rapid oral bioavailability in monogastric animals.

Ionophore Function

Ionophores facilitate ion transport across biological membranes, disrupting cellular function.

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Ionophore Elimination

Ionophores are primarily eliminated through bile and renal pathways after hepatic metabolism.

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Ionophore Toxicity in Horses

Horses have slower hepatic metabolism of ionophores, making them more prone to toxicity.

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Ionophore Drug Interaction

Ionophores can cause neurological signs if administered with pleuromutilins.

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