23 Questions
Which type of antagonism occurs when an antagonist binds to the same site as the endogenous ligand?
Competitive antagonism
Which type of antagonism occurs when an antagonist binds at a site other than the receptor binding site?
Allosteric antagonism
Which type of antagonism inactivates an agonist by forming a complex with it?
Chemical antagonism
Which type of agonist produces a lower response than full agonists?
Partial agonists
Which theory explains the molecular basis of partial agonism by suggesting that partial agonists form complexes with both active and inactive receptor states?
Theory 2
Which term describes the dose of a drug that produces a given effect in a population?
ED50
What type of distribution is used to describe the frequency of drug responses in a population?
Frequency distribution
Which term refers to the measure of how much of a drug is needed to produce a given effect?
Potency
Which term refers to the measure of the maximum effect a drug can produce?
Efficacy
Which two drugs are being compared in terms of potency in the given text?
Ibuprofen and aspirin
Which one of the following is the correct definition of an agonist?
A drug that binds to a receptor and causes an effect
Which one of the following is the correct definition of an antagonist?
A drug that prevents the agonist-induced activation of the receptor
Which of the following types of interactions do not fit neatly into the simple definition of agonist and antagonist?
Partial agonists and inverse agonists
What is the correct equation for calculating potency in dose-response relationships?
$EC50 + Emax$
What is the correct equation for calculating efficacy in dose-response relationships?
$EC50 - Emax$
Which type of ligand binds to receptors and reduces the fraction of them in an active conformation?
Inverse agonist
Which of the following is an example of an inverse agonist?
Cimetidine
According to the text, what is the classical idea of an agonist?
It activates the whole repertoire of signals following activation
Which of the following is an example of a biased agonist?
TRV027
What parameters can be derived from dose-response curves?
Concentration and response
Which of the following accurately describes the relationship between drug concentration and the biological response in the given data?
The biological response increases as the drug concentration increases.
Which of the following statements accurately describes the relationship between ED50 and drug potency?
The lower the ED50, the greater the drug potency.
Which type of dose-response curve relates dose to the intensity of effect?
Graded dose-response curve
Test your knowledge on inverse agonists and their effects on receptor activity with this quiz. Learn about how these ligands bind to receptors and reduce their active conformation, producing biological effects opposite to those of agonists.
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