Nervous System

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Questions and Answers

Which of the following is NOT a primary function of the nervous system?

  • Detecting changes in the external environment.
  • Regulating and coordinating bodily activities.
  • Synthesizing and releasing hormones. (correct)
  • Controlling voluntary movements.

The peripheral nervous system (PNS) is composed of which structures?

  • Brain and spinal cord.
  • Brainstem and cerebellum.
  • Cerebrum and diencephalon.
  • Cranial and spinal nerves. (correct)

Which division of the autonomic nervous system is responsible for the 'fight or flight' response?

  • Somatic.
  • Sympathetic. (correct)
  • Enteric.
  • Parasympathetic.

What is the main function of oligodendrocytes?

<p>Myelinating axons in the central nervous system. (C)</p> Signup and view all the answers

Which type of glial cell is responsible for regulating the chemical environment of the synapse by buffering extracellular potassium and taking up neurotransmitters?

<p>Astrocytes. (D)</p> Signup and view all the answers

Which part of a neuron is primarily responsible for receiving synaptic inputs from other neurons?

<p>Dendrites. (D)</p> Signup and view all the answers

What is the role of the myelin sheath in neuronal signaling?

<p>To increase the speed of action potential propagation. (C)</p> Signup and view all the answers

What is the primary function of the enteric nervous system?

<p>Controlling processes involved in the transport and digestion of food. (A)</p> Signup and view all the answers

What is the function of the subarachnoid space?

<p>It contains cerebrospinal fluid (CSF) that cushions the CNS. (A)</p> Signup and view all the answers

Within the spinal cord, where are the cell bodies of motor neurons typically located?

<p>Ventral horn of the gray matter. (A)</p> Signup and view all the answers

Which of the following best describes the role of the sodium-potassium pump in establishing the resting membrane potential?

<p>It pumps three sodium ions out of the cell and two potassium ions into the cell. (B)</p> Signup and view all the answers

What is the primary event that triggers the rising phase (depolarization) of an action potential?

<p>Influx of sodium ions (Na+) through voltage-gated channels. (B)</p> Signup and view all the answers

What is the functional consequence of the inactivation of voltage-gated sodium channels during an action potential?

<p>Prevention of further sodium influx. (B)</p> Signup and view all the answers

Which of the following is a key characteristic of action potentials?

<p>They are 'all-or-nothing' events. (D)</p> Signup and view all the answers

Which of the following neurodegenerative diseases is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc)?

<p>Parkinson's Disease (PD). (C)</p> Signup and view all the answers

Which plane divides the body into anterior and posterior sections?

<p>Coronal. (A)</p> Signup and view all the answers

Regarding neurons, what is the primary function of the axon terminals?

<p>To transmit signals to other cells via synapses. (B)</p> Signup and view all the answers

What is the endoneurium?

<p>Connective tissue that surrounds individual axons. (C)</p> Signup and view all the answers

Which term describes sensory receptors located in muscles, joints, and tendons that contribute to postural awareness and movement?

<p>Proprioceptors. (D)</p> Signup and view all the answers

What distinguishes a 'mixed' nerve in the peripheral nervous system?

<p>It contains axons from both sensory and motor neurons. (B)</p> Signup and view all the answers

Which of the following is a key function of ependymal cells?

<p>Forming the choroid plexus and generating cerebrospinal fluid (CSF). (D)</p> Signup and view all the answers

What is the primary function of the hippocampus?

<p>Forming new memories. (A)</p> Signup and view all the answers

Which feature characterizes the neuropathology of Alzheimer's disease?

<p>Beta-amyloid plaques and neurofibrillary tangles. (C)</p> Signup and view all the answers

Damage to the cerebellum would most likely result in impairment of what?

<p>Motor coordination. (B)</p> Signup and view all the answers

What is the functional role of voltage-gated potassium channels in the repolarization phase of the action potential?

<p>Promoting potassium efflux. (D)</p> Signup and view all the answers

How does myelination affect the electrical properties of an axon?

<p>It decreases membrane capacitance and increases resistance. (C)</p> Signup and view all the answers

If a drug were designed to selectively block the function of microglia, which of the following processes within the CNS would be most directly affected?

<p>Immune response and phagocytosis of cellular debris. (D)</p> Signup and view all the answers

A researcher is studying a neuron and observes that it has a very short axon, highly complex dendritic branching close to the soma, and primarily uses GABA as its neurotransmitter. Based on these characteristics, which type of neuron is the researcher most likely studying?

<p>An interneuron in the cerebral cortex. (C)</p> Signup and view all the answers

In a patient with amyotrophic lateral sclerosis (ALS), which of the following neuropathological changes would be expected in the spinal cord?

<p>Loss of axons in the motor tracts (white matter) and inclusions in ventral horn (grey matter) motor neurons. (D)</p> Signup and view all the answers

During the relative refractory period, a stronger-than-normal stimulus is required to elicit an action potential. What is the primary reason for this increased threshold?

<p>The membrane is hyperpolarized due to continued potassium efflux, and some sodium channels are still inactivated. (C)</p> Signup and view all the answers

A toxin selectively blocks voltage-gated potassium channels in a neuron. Which of the following effects would this toxin have on the action potential?

<p>The action potential would have a prolonged repolarization phase. (C)</p> Signup and view all the answers

Which of the following would be the MOST immediate consequence of selectively impairing the function of the sodium-potassium pump in a neuron?

<p>Abolishment of the resting membrane potential over time. (D)</p> Signup and view all the answers

A researcher discovers a novel neurotoxin that selectively disrupts the function of astrocytes. Which of the following would be the MOST likely and immediate consequence of applying this toxin to a neuronal culture?

<p>Disrupted ion homeostasis and neurotransmitter clearance, leading to excitotoxicity. (C)</p> Signup and view all the answers

Imagine a hypothetical scenario where a genetic mutation causes Schwann cells to myelinate axons within the central nervous system, a function normally performed by oligodendrocytes. What would be the MOST likely consequence of this mutation on neural function?

<p>Impaired action potential propagation due to inappropriate myelination patterns or altered node of Ranvier structure. (C)</p> Signup and view all the answers

A researcher is investigating a new drug that selectively enhances the reuptake of glutamate by astrocytes. What effect would this drug likely have on neuronal activity in the vicinity of the astrocytes?

<p>Decreased neuronal excitation due to reduced glutamate availability in the synapse. (C)</p> Signup and view all the answers

In a research study, a scientist selectively prevents the formation of new dendritic spines on neurons within the hippocampus of a mouse. What behavioral change would MOST likely be observed?

<p>Impaired long-term potentiation and spatial memory formation. (B)</p> Signup and view all the answers

A patient presents with a rare neurological disorder characterized by a selective loss of interoceptors. Which of the following symptoms would be MOST likely to manifest in this patient?

<p>Impaired awareness of internal bodily states such as hunger, thirst, and visceral pain. (D)</p> Signup and view all the answers

Which of the following best describes the primary role of the nervous system?

<p>Facilitating communication and regulation within the body by responding to stimuli. (B)</p> Signup and view all the answers

What is the fundamental structural and functional unit of the nervous system?

<p>Neuron (D)</p> Signup and view all the answers

Which of the following is a characteristic of the sympathetic nervous system?

<p>Increasing heart rate and blood pressure during emergencies. (A)</p> Signup and view all the answers

What is the main function of the enteric nervous system?

<p>Controlling the processes involved in transport and digestion of food. (C)</p> Signup and view all the answers

Which glial cell type is responsible for myelinating axons in the peripheral nervous system (PNS)?

<p>Schwann cells (D)</p> Signup and view all the answers

Which of the following is a primary function of astrocytes?

<p>Regulating the chemical environment and providing metabolic support to neurons. (D)</p> Signup and view all the answers

What is the major role of microglia in the central nervous system (CNS)?

<p>Functioning as immune cells to protect against pathogens and clear debris. (C)</p> Signup and view all the answers

Which of the following describes white matter?

<p>Collections of myelinated axons. (B)</p> Signup and view all the answers

What feature primarily defines the function of the pre-synaptic axon terminal?

<p>Enrichment in synaptic vesicles containing neurotransmitters. (D)</p> Signup and view all the answers

Which of the following accurately describes the function of dendrites?

<p>Receiving synaptic inputs from other neurons. (D)</p> Signup and view all the answers

Which of the following best defines the term 'sulcus' in the context of neuroanatomy?

<p>A groove in the neocortex. (A)</p> Signup and view all the answers

Which of the following neurodegenerative diseases is most closely associated with beta-amyloid plaques and neurofibrillary tangles?

<p>Alzheimer's Disease (D)</p> Signup and view all the answers

Which of the following represents the correct order of connective tissue layers surrounding a nerve, from the innermost to the outermost layer?

<p>Endoneurium, perineurium, epineurium (C)</p> Signup and view all the answers

If a researcher were to selectively lesion the hippocampus in an animal model, which function would be most directly impaired?

<p>Memory formation (A)</p> Signup and view all the answers

Which of the following statements accurately describes the absolute refractory period?

<p>The neuron cannot fire another action potential, regardless of the stimulus strength. (C)</p> Signup and view all the answers

What is the primary consequence of the inactivation of voltage-gated sodium channels during the falling phase of an action potential?

<p>Prevention of further sodium influx. (C)</p> Signup and view all the answers

Concerning sensory transduction, which type of receptor is specialized to respond to painful stimuli?

<p>Nociceptors (D)</p> Signup and view all the answers

Which of the following is the most accurate description of how action potentials relay information about stimulus intensity?

<p>By modulating the frequency and pattern of action potential firing. (B)</p> Signup and view all the answers

A researcher is studying a neuron and observes that, following an action potential, the cell membrane potential becomes transiently more negative than its normal resting potential. Which of the following ionic events is MOST directly responsible for this phenomenon?

<p>Continued efflux of potassium ions. (A)</p> Signup and view all the answers

Imagine a hypothetical scenario where a neurotoxin specifically targets and disables ependymal cells within the brain. Which of the following would be the MOST immediate and direct consequence of this neurotoxin's action?

<p>Compromised formation and circulation of cerebrospinal fluid (CSF). (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of glial cells?

<p>They directly participate in relaying electrochemical signals. (D)</p> Signup and view all the answers

Which of the following best describes the function of the sympathetic nervous system?

<p>Priming the body for activity in response to a threat (fight or flight). (D)</p> Signup and view all the answers

Which of the following best describes the primary function of dendrites?

<p>To receive synaptic inputs from other neurons. (B)</p> Signup and view all the answers

What is the main function of the subarachnoid space?

<p>To provide a protective cushion for the brain and spinal cord. (B)</p> Signup and view all the answers

Which of the following cell types is responsible for myelinating axons in the central nervous system (CNS)?

<p>Oligodendrocytes (B)</p> Signup and view all the answers

Which division of the nervous system is responsible for controlling the digestive processes?

<p>Enteric nervous system (B)</p> Signup and view all the answers

Which plane divides the body into superior and inferior parts?

<p>Transverse (B)</p> Signup and view all the answers

What is the primary function of astrocytes?

<p>Regulating the chemical environment of the synapse. (A)</p> Signup and view all the answers

What is the role of the sodium-potassium pump in establishing the resting membrane potential?

<p>Maintaining concentration gradients by pumping sodium ions out of the cell and potassium ions into the cell. (C)</p> Signup and view all the answers

What best describes the composition of a mixed nerve?

<p>Containing axons of both sensory and motor neurons (C)</p> Signup and view all the answers

What is the primary function of ependymal cells?

<p>Lining the ventricles of the CNS and forming the choroid plexus. (C)</p> Signup and view all the answers

Which of the following accurately pairs a cerebral lobe with its primary associated function?

<p>Occipital lobe: Visual processing (A)</p> Signup and view all the answers

Which of the following best describes the role of microglia in the central nervous system (CNS)?

<p>Acting as the primary immune cells (D)</p> Signup and view all the answers

Which of the following describes the anatomical arrangement of the spinal nerves?

<p>Sensory fibers project to the CNS via the dorsal roots. (B)</p> Signup and view all the answers

How do neurons relay information about stimulus intensity?

<p>By modulating the frequency of action potentials (D)</p> Signup and view all the answers

Which of the following best describes the function of the enteric nervous system?

<p>Regulating digestive processes. (D)</p> Signup and view all the answers

Which structure is responsible for the integration of sensory information in the brain?

<p>Thalamus (C)</p> Signup and view all the answers

During the falling phase of an action potential, which channels are primarily responsible for the membrane repolarization?

<p>Voltage-gated sodium channels inactivating and voltage-gated potassium channels opening (B)</p> Signup and view all the answers

What is the difference in function between preganglionic and postganglionic neurons in the autonomic nervous system?

<p>Preganglionic neurons project from the CNS to autonomic ganglia, and postganglionic neurons project from the ganglia to target tissues. (D)</p> Signup and view all the answers

Which of the following neural structures is NOT part of the limbic system?

<p>Thalamus (A)</p> Signup and view all the answers

Which alteration in ion channel function would most likely shorten the relative refractory period?

<p>A speeding up of the closing of voltage-gated K+ channels. (D)</p> Signup and view all the answers

Why does saltatory conduction occur?

<p>Because voltage-gated ion channels are only found at the nodes of Ranvier. (A)</p> Signup and view all the answers

Which of the following accurately describes the respective functions of the dorsal and ventral horns of the spinal cord?

<p>The dorsal horn receives sensory information, and the ventral horn contains motor neuron cell bodies. (A)</p> Signup and view all the answers

What is the underlying mechanism for why action potentials are 'all-or-none' events?

<p>The influx of sodium ions either reaches the threshold to open all voltage-gated sodium channels, or it doesn't reach threshold at all. (B)</p> Signup and view all the answers

What is the primary difference between exteroceptors, interoceptors, and proprioceptors?

<p>Their location and the type of stimuli they detect. (C)</p> Signup and view all the answers

What is the spatial relationship between the epineurium, perineurium, and endoneurium?

<p>The epineurium encloses the fascicles to form a nerve, the perineurium binds groups of axons into fascicles, and the endoneurium surrounds individual axons. (A)</p> Signup and view all the answers

In a neuron, which of the following is most crucial for maintaining the ionic concentration gradients necessary for the resting membrane potential?

<p>The activity of the sodium-potassium pump. (A)</p> Signup and view all the answers

In clinical settings, why do therapeutic interventions for Alzheimer's Disease primarily target cholinergic and glutamatergic neurotransmitter pathways?

<p>For their roles in cognitive functions severely impacted by the disease. (B)</p> Signup and view all the answers

A researcher observes a population of neurons with a unique characteristic: their action potentials exhibit an unusually prolonged repolarization phase. Which of the following alterations in ion channel function is MOST likely responsible for this observation?

<p>A mutation causing prolonged opening of voltage-gated K+ channels. (D)</p> Signup and view all the answers

A novel neurotoxin is discovered that selectively disrupts the function of proprioceptors. Which of the following symptoms would be MOST likely to manifest in an individual exposed to this toxin?

<p>Difficulty maintaining balance and coordinating movements. (C)</p> Signup and view all the answers

Consider a scenario where a patient has damage exclusively to the white matter of their spinal cord. Which of the following would be the MOST likely primary consequence?

<p>Severely impaired long-distance communication within the spinal cord (A)</p> Signup and view all the answers

In a research experiment, scientists induce artificial myelination of dendrites in hippocampal pyramidal neurons. Which of the following outcomes would be MOST likely?

<p>Impaired synaptic integration. (D)</p> Signup and view all the answers

In a neuron at rest, which situation would lead to the electrochemical gradient for sodium being closest to zero?

<p>Introducing an external voltage source to clamp the membrane potential at the sodium equilibrium potential. (D)</p> Signup and view all the answers

What is the functional unit of the nervous system?

<p>Neuron (B)</p> Signup and view all the answers

Which of the following is primarily responsible for voluntary movement?

<p>Somatic nervous system (D)</p> Signup and view all the answers

What is the function of the parasympathetic nervous system?

<p>Regulating normal automatic body functions (C)</p> Signup and view all the answers

Which type of glial cell forms the myelin sheath in the central nervous system (CNS)?

<p>Oligodendrocytes (C)</p> Signup and view all the answers

What is the primary function of microglia?

<p>To act as the innate immune cells of the CNS (D)</p> Signup and view all the answers

What is the main function of dendrites?

<p>To receive synaptic inputs from other neurons (B)</p> Signup and view all the answers

Which of the following is the correct order of signal transmission in a basic spinal reflex arc?

<p>Receptor, afferent signal, integration center, efferent signal, effector (B)</p> Signup and view all the answers

Which anatomical plane divides the brain into right and left halves?

<p>Sagittal (C)</p> Signup and view all the answers

What cellular component is responsible for generating cerebrospinal fluid (CSF)?

<p>Ependymal Cells (D)</p> Signup and view all the answers

What is the primary role of the sodium-potassium pump in the context of action potentials?

<p>To re-establish and maintain the resting membrane potential after an action potential. (B)</p> Signup and view all the answers

Which of the following best describes the role of voltage-gated potassium channels during the repolarization phase of an action potential?

<p>They open, allowing efflux of $K^+$ ions, repolarizing the membrane towards its resting potential. (C)</p> Signup and view all the answers

How does myelination increase the velocity of action potential conduction?

<p>By allowing saltatory conduction (A)</p> Signup and view all the answers

Which of the following is the MOST direct consequence of a drug that selectively blocks voltage-gated sodium channels in a neuron?

<p>The neuron will be unable to depolarize in response to stimulation. (B)</p> Signup and view all the answers

Why does the action potential propagate in one direction down the axon?

<p>Because of the refractory period following depolarization. (D)</p> Signup and view all the answers

A patient exhibits resting tremor, muscle rigidity, and postural instability. Which neurodegenerative disease is MOST likely associated with these symptoms?

<p>Parkinson's Disease (B)</p> Signup and view all the answers

Which of the following represents the structural organization of a nerve, from the outside in?

<p>Epineurium, Perineurium, Endoneurium (B)</p> Signup and view all the answers

In a hypothetical experiment, researchers selectively disrupt the function of preganglionic neurons in the sympathetic nervous system. Which of the following would be the MOST likely consequence?

<p>Impaired 'fight or flight' responses and dysregulation of visceral functions. (D)</p> Signup and view all the answers

Imagine a scenario where a mutation leads to the complete absence of interoceptors throughout the body. Which of the following physiological consequences would be MOST likely to occur?

<p>Profound disruption of autonomic functions and impaired homeostasis (C)</p> Signup and view all the answers

A researcher discovers a novel compound that selectively enhances the activity of protein phosphatases within neurons. What effect would this compound MOST likely have on neuronal function, particularly in the context of synaptic plasticity?

<p>Promotion of long-term depression (LTD) by reversing kinase-mediated phosphorylation events (A)</p> Signup and view all the answers

Which of the following best describes the primary role of the nervous system in an organism?

<p>To regulate and coordinate responses to internal and external stimuli. (D)</p> Signup and view all the answers

What distinguishes the autonomic nervous system from the somatic nervous system?

<p>The autonomic nervous system controls cardiac muscle, smooth muscle, and glands, regulating involuntary functions, while the somatic nervous system controls skeletal muscle, responsible for voluntary movements. (C)</p> Signup and view all the answers

What is the primary function of the sympathetic nervous system?

<p>To prepare the body for 'fight or flight' responses. (C)</p> Signup and view all the answers

Which of the following glial cells is responsible for myelinating axons in the central nervous system (CNS)?

<p>Oligodendrocytes (D)</p> Signup and view all the answers

What is the main role of microglia in the central nervous system?

<p>To act as immune cells, defending against infection and injury. (B)</p> Signup and view all the answers

Which of the following best describes 'white matter'?

<p>Collections of axons (A)</p> Signup and view all the answers

What primarily defines the function of the pre-synaptic axon terminal?

<p>Releasing neurotransmitters (B)</p> Signup and view all the answers

What is the functional significance of the enteric nervous system?

<p>Control of digestive processes (D)</p> Signup and view all the answers

Which of the following best describes the role of astrocytes?

<p>Regulating the chemical environment of the synapse (A)</p> Signup and view all the answers

Which of the following represents the correct order of connective tissue layers surrounding a nerve, from innermost to outermost?

<p>Endoneurium, perineurium, epineurium (C)</p> Signup and view all the answers

What is the key factor that allows the transmission of information to be conveyed by the frequency and pattern of action potential firing?

<p>The all-or-nothing nature of action potentials. (D)</p> Signup and view all the answers

Regarding the molecular basis of the resting membrane potential, which statement is most accurate?

<p>The resting membrane is more permeable to potassium ions than sodium ions. (A)</p> Signup and view all the answers

During the falling phase of the action potential, which event contributes significantly to membrane repolarization?

<p>Efflux of potassium ions through voltage-gated channels. (B)</p> Signup and view all the answers

What is the primary event that leads to the hyperpolarization phase (undershoot) of the action potential?

<p>Continued efflux of potassium ions (A)</p> Signup and view all the answers

How do neurons relay information about the intensity of a stimulus?

<p>By modulating the frequency of action potentials (B)</p> Signup and view all the answers

Which best describes the function of the preganglionic neurons in the autonomic nervous system?

<p>To synapse onto postganglionic neurons located in autonomic ganglia (C)</p> Signup and view all the answers

Which statement accurately contrasts the functions of the dorsal and ventral horns of the spinal cord?

<p>The dorsal horn receives sensory input, while the ventral horn contains motor neurons. (C)</p> Signup and view all the answers

Why does saltatory conduction significantly increase the velocity of action potential propagation?

<p>Because action potentials jump between the nodes of Ranvier, where ion channels are concentrated. (B)</p> Signup and view all the answers

What is the fundamental difference between exteroceptors, interoceptors, and proprioceptors?

<p>Their location and the type of stimuli they respond to (e.g., external, internal, body position) (C)</p> Signup and view all the answers

If a researcher selectively lesions the hippocampus in an animal model, which function would be most directly impaired?

<p>Formation of new memories (A)</p> Signup and view all the answers

Why are pre-synaptic terminals enriched with mitochondria?

<p>To meet the high energy demands of synaptic transmission (B)</p> Signup and view all the answers

During the rising phase (depolarization) of an action potential, what is the primary event that occurs?

<p>Sodium ions (Na+) flow into the cell. (B)</p> Signup and view all the answers

Why does the action potential propagate in only one direction down the axon?

<p>Because the region of the membrane behind the action potential is in the refractory period. (D)</p> Signup and view all the answers

If a drug were designed that selectively enhanced the reuptake of glutamate by astrocytes, what effect would this drug likely have on neuronal activity in the vicinity of the astrocytes?

<p>Reduce excitatory neurotransmission by decreasing the availability of glutamate in the synaptic cleft. (B)</p> Signup and view all the answers

Which of the following scenarios would MOST directly challenge the neuron's ability to maintain its resting membrane potential?

<p>A genetic mutation that impairs the function of the sodium-potassium pump. (C)</p> Signup and view all the answers

Which of the following best describes a primary function of the nervous system?

<p>Maintaining homeostasis by detecting and responding to changes in the internal and external environments. (B)</p> Signup and view all the answers

What is the underlying mechanism that allows neurons to relay information about stimulus intensity?

<p>The frequency and pattern of action potential firing change with stimulus intensity. (C)</p> Signup and view all the answers

Which anatomical division of the nervous system includes the brain and spinal cord?

<p>Central nervous system (CNS) (D)</p> Signup and view all the answers

Which division of the autonomic nervous system is responsible for the 'rest and digest' response?

<p>Parasympathetic division (D)</p> Signup and view all the answers

Which type of glial cell myelinates axons in the peripheral nervous system (PNS)?

<p>Schwann cells (B)</p> Signup and view all the answers

What is the primary function of astrocytes in the nervous system?

<p>Regulating the chemical environment, supplying metabolites to neurons, and forming part of the blood-brain barrier. (D)</p> Signup and view all the answers

Which of the following best describes 'white matter' in the nervous system?

<p>Collections of axons. (A)</p> Signup and view all the answers

What is the primary function of the pre-synaptic axon terminal?

<p>Converting electrical signals into chemical signals for transmission to the next neuron. (D)</p> Signup and view all the answers

Which term describes a ridge on the neocortex?

<p>Gyrus (D)</p> Signup and view all the answers

What is the role of the sodium-potassium pump in establishing the resting membrane potential of a neuron?

<p>It maintains the concentration gradients of Na+ and K+ ions, which are crucial for the resting membrane potential. (B)</p> Signup and view all the answers

During the repolarization phase of an action potential, which channels are primarily responsible for the membrane potential returning to a negative value?

<p>Voltage-gated potassium channels. (D)</p> Signup and view all the answers

Which of the following accurately describes the arrangement of connective tissue layers in a nerve, from innermost to outermost?

<p>Endoneurium, perineurium, epineurium (B)</p> Signup and view all the answers

What is the primary functional difference between preganglionic and postganglionic neurons in the autonomic nervous system?

<p>Preganglionic neurons originate in the CNS and synapse in ganglia, while postganglionic neurons project from ganglia to target organs. (A)</p> Signup and view all the answers

Which of the following best describes the function of interoceptors?

<p>Sensing mechanical and chemical changes within the viscera. (C)</p> Signup and view all the answers

The molecular basis of the resting membrane potential relies on which of the following conditions?

<p>Uneven distribution of Na+ and K+ ions, with the resting membrane being more permeable to K+ than Na+. (B)</p> Signup and view all the answers

Which of the following alterations in ion channel function would most likely shorten the relative refractory period?

<p>Increased density of voltage-gated potassium channels, leading to faster repolarization. (C)</p> Signup and view all the answers

In a scenario where an individual has damage exclusively to the white matter of their spinal cord, which of the following would be the MOST likely primary consequence?

<p>Disrupted transmission of action potentials, leading to motor and sensory deficits. (C)</p> Signup and view all the answers

Consider a hypothetical scenario where a neurotoxin specifically targets and disables ependymal cells within the brain. Which of the following would be the MOST immediate and direct consequence of this neurotoxin's action?

<p>Decreased production of cerebrospinal fluid (CSF). (D)</p> Signup and view all the answers

Imagine a scientific breakthrough enables researchers to selectively control the expression of myelinating proteins exclusively in astrocytes. If these modified astrocytes were induced to myelinate neuronal axons, but only at the distal portions of the axon far away from the soma and axon hillock, what would be the MOST likely effect on neuronal function?

<p>Paradoxical reduction in action potential propagation velocity due to altered distribution of voltage-gated ion channels. (C)</p> Signup and view all the answers

Consider a population of neurons in the cerebral cortex that exhibit a unique form of activity-dependent plasticity where prolonged periods of high-frequency firing lead to a sustained decrease in the threshold required for action potential initiation. Which alteration in the expression or function of ion channels would be MOST consistent with this observation?

<p>Enhanced activity-dependent trafficking of Nav1.6 channels to the axon initial segment, increasing sodium channel density and lowering the threshold for depolarization. (A)</p> Signup and view all the answers

A research team is investigating a novel neurotoxin, 'ToxK,' that selectively disrupts the interaction between pleckstrin homology (PH) domains and phosphatidylinositol (PI) lipids within neurons. Given the known roles of PI lipids in neuronal signaling and trafficking, which cellular process would be MOST directly and severely compromised by exposure to ToxK?

<p>Vesicle trafficking and exocytosis of neurotransmitters at the presynaptic terminal due to disruption of PI(4,5)P2-dependent machinery. (D)</p> Signup and view all the answers

A neurophysiologist is studying the effects of a novel peptide that selectively binds to and inhibits the function of the Na+/K+-ATPase pump in neurons. Assuming the neuron initially exhibits a stable resting membrane potential, what sequence of events would MOST accurately describe the long-term consequences of continuous exposure to this peptide?

<p>Progressive depolarization of the membrane potential due to accumulation of intracellular sodium, eventually leading to a sustained depolarization block. (B)</p> Signup and view all the answers

Researchers discover a novel genetic mutation that results in a complete loss of function of the dystroglycan protein complex specifically within astrocytes. Given the known roles of dystroglycan in astrocyte function and interaction with the extracellular matrix, which of the following outcomes would be MOST likely to occur in the central nervous system?

<p>Disruption of the blood-brain barrier integrity, leading to increased permeability and infiltration of peripheral immune cells into the brain parenchyma. (B)</p> Signup and view all the answers

A scientist is investigating the effects of a novel compound, 'SynaptoRestore,' on synaptic plasticity in hippocampal neurons. The compound is found to selectively enhance the phosphorylation of serine residues on the GluN2B subunit of NMDA receptors. What effect and molecular mechanism would MOST likely underlie the action of SynaptoRestore?

<p>Increased LTP magnitude due to enhanced calcium influx through NMDA receptors and subsequent activation of CaMKII and CREB. (B)</p> Signup and view all the answers

Consider a scenario where a patient exhibits selective damage to the fornix, but with no other apparent brain lesions. What cognitive or behavioral deficit would MOST likely be observed in this patient?

<p>Impaired spatial navigation and episodic memory retrieval due to disruption of hippocampal projections to the mammillary bodies and anterior thalamus. (C)</p> Signup and view all the answers

A researcher discovers a novel toxin that selectively disrupts the function of ependymal cells. What would be the MOST immediate and direct consequence of this toxin's action?

<p>Reduced clearance of metabolic waste products from the CNS due to decreased cerebrospinal fluid (CSF) production. (A)</p> Signup and view all the answers

Imagine a scenario where a genetic mutation causes Schwann cells to myelinate axons within the central nervous system (CNS). What consequence would this have on neural function?

<p>Dysfunctional neural signalling because Schwann cells lack the appropriate molecular signaling cues for CNS axons. (C)</p> Signup and view all the answers

A researcher is studying a neuron with a very short axon, highly complex dendritic branching, and primarily uses GABA as its neurotransmitter. What is the researcher most likely studying?

<p>An inhibitory interneuron in the cerebral cortex. (C)</p> Signup and view all the answers

A patient presents with a rare neurological disorder characterized by a selective loss of interoceptors. What symptom is most likely to manifest in this patient?

<p>Difficulty in sensing internal physiological states such as hunger and thirst. (B)</p> Signup and view all the answers

In a research study, a scientist selectively prevents the formation of new dendritic spines on neurons within the hippocampus. What behavioral change would most likely be observed?

<p>Deficits in spatial learning and memory. (C)</p> Signup and view all the answers

How would a drug that selectively enhances the reuptake of glutamate by astrocytes affect neuronal activity in the vicinity of the astrocytes?

<p>Decrease neuronal excitability by reducing glutamate's concentration in the synaptic cleft. (B)</p> Signup and view all the answers

During amyotrophic lateral sclerosis (ALS), what neuropathological changes would be expected in the spinal cord?

<p>Loss of ventral horn motor neurons and protein aggregates. (C)</p> Signup and view all the answers

If a toxin selectively blocks voltage-gated potassium channels in a neuron, what effects would this toxin have on the action potential?

<p>Prolonged action potential duration and after-hyperpolarization. (A)</p> Signup and view all the answers

What would be the immediate consequence of selectively impairing the function of the sodium-potassium pump in a neuron?

<p>Gradual dissipation of ion gradients and depolarization of the resting membrane potential. (A)</p> Signup and view all the answers

A researcher discovers a novel neurotoxin that selectively disrupts astrocytes. What is most likely to happen if applied to neurons?

<p>Increased neuronal excitability, potentially leading to excitotoxicity. (C)</p> Signup and view all the answers

What feature characterizes neurons, enabling them to rapidly transmit information over long distances?

<p>Their specialized morphology and gene expression profiles for electrochemical signaling. (C)</p> Signup and view all the answers

Which of the following structures is part of the central nervous system (CNS)?

<p>Brain. (D)</p> Signup and view all the answers

What is the primary role of the somatic nervous system?

<p>Innervating skeletal muscle and controlling voluntary movements. (A)</p> Signup and view all the answers

The 'fight or flight' response is primarily regulated by which division of the nervous system?

<p>Sympathetic division. (C)</p> Signup and view all the answers

Which of the following functions is primarily controlled by the enteric nervous system?

<p>Managing transport and digestion of food. (B)</p> Signup and view all the answers

Which of the following glial cells myelinates axons in the peripheral nervous system (PNS)?

<p>Schwann cells. (C)</p> Signup and view all the answers

Which glial cell acts as the primary immune defense in the central nervous system?

<p>Microglia. (C)</p> Signup and view all the answers

What is the main function of ependymal cells?

<p>Production of cerebrospinal fluid (CSF). (C)</p> Signup and view all the answers

What is the primary function of axon terminals?

<p>Releasing neurotransmitters. (B)</p> Signup and view all the answers

Which plane divides the body into right and left halves?

<p>Sagittal. (D)</p> Signup and view all the answers

What is the key function of the thalamus within the diencephalon?

<p>Sensory integration hub. (A)</p> Signup and view all the answers

Which structure is responsible for regulating emotional behavior and whole-body homeostasis?

<p>Hypothalamus. (D)</p> Signup and view all the answers

Which of the following is a characteristic neuropathological feature of Alzheimer's disease (AD)?

<p>Presence of beta-amyloid plaques and neurofibrillary tangles. (B)</p> Signup and view all the answers

Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) is a primary cause of which neurodegenerative disease?

<p>Parkinson's disease. (A)</p> Signup and view all the answers

What type of information is carried by the dorsal roots of the spinal cord?

<p>Sensory. (B)</p> Signup and view all the answers

Which of the following is the correct order of connective tissue layers surrounding a nerve, from innermost to outermost?

<p>Endoneurium, perineurium, epineurium. (C)</p> Signup and view all the answers

In a hypothetical scenario, a researcher discovers a compound that selectively blocks the interaction between actin filaments and myosin motors within neurons. Which of the following cellular processes would be MOST directly and severely compromised by disruption of this interaction?

<p>Axonal transport of synaptic vesicles. (B)</p> Signup and view all the answers

Which of the following is the MOST encompassing description of the nervous system's primary role?

<p>To regulate and coordinate responses to internal and external stimuli. (C)</p> Signup and view all the answers

Which of the following characteristics differentiates the somatic nervous system from the autonomic nervous system?

<p>The somatic nervous system controls skeletal muscle, whereas the autonomic nervous system controls smooth muscle, cardiac muscle, and glands. (D)</p> Signup and view all the answers

Which of the following glial cells is responsible for myelinating axons in the peripheral nervous system (PNS)?

<p>Schwann cells (D)</p> Signup and view all the answers

What is the primary function of astrocytes in the central nervous system (CNS)?

<p>To regulate the chemical environment, supply metabolites to neurons, and form part of the blood-brain barrier. (B)</p> Signup and view all the answers

What best describes the composition of white matter?

<p>Collections of myelinated axons (A)</p> Signup and view all the answers

Which characteristic is crucial for enabling neurons to rapidly transmit information over long distances?

<p>The presence of a myelin sheath around the axon (C)</p> Signup and view all the answers

During the falling phase of the action potential, which event significantly contributes to membrane repolarization?

<p>Efflux of K+ ions through voltage-gated potassium channels. (B)</p> Signup and view all the answers

In the context of a nerve, what is the correct order of layers from the outermost to the innermost?

<p>Epineurium, Perineurium, Endoneurium (C)</p> Signup and view all the answers

Imagine a hypothetical mutation that causes a complete loss of function of the protein dystroglycan specifically within astrocytes. What outcome is MOST likely in the central nervous system?

<p>Compromised astrocyte interaction with the extracellular matrix leading to disruption of the blood-brain barrier. (C)</p> Signup and view all the answers

Flashcards

Nervous System

Regulatory communication network that responds to environmental stimuli and regulates metabolism and activity.

Central Nervous System (CNS)

Structures: Brain and spinal cord. Functions: Control centers.

Peripheral Nervous System (PNS)

Cranial nerves (12 pairs) and spinal nerves (31 pairs). Communicates between CNS and body.

Somatic Nervous System

Innervates skeletal muscle, responsible for voluntary movement.

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Autonomic Nervous System

Innervates cardiac muscle, smooth muscle, and glands; regulating involuntary functions.

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Sympathetic Division

Regulates fight or flight response, priming the body for activity.

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Parasympathetic Division

The rest and digest system, regulating normal automatic body functions.

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Enteric Nervous System

Located in the gastrointestinal tract lining, controls digestion.

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Neurons (Nerve Cells)

Functional unit of the nervous system, specialized for electrochemical signaling.

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Glia (Support Cells)

Support cells essential for maintenance of the nervous system; don't directly relay signals.

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Oligodendrocytes

Responsible for myelinating axon membranes in the CNS.

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Schwann Cells

Responsible for myelinating axon membranes in the PNS.

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Astrocytes

Star-like glial cells essential for synapse formation, regulating the neural chemical environment and forming part of the blood-brain barrier.

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Microglia

Innate immune cells of the CNS, key defenders, and first responders to injury and infection.

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Ependymal Cells

Line the ventricles of the CNS, forming the Choroid Plexus which generates cerebrospinal fluid (CSF).

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Grey Matter

Collections of neuronal cell bodies

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White Matter

Collections of axons.

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Sagittal

A plane that divides the body into right and left parts.

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Transverse

A plane that divides the body into superior and inferior parts.

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Coronal

A plane that divides the body into anterior and posterior parts.

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Neocortex

Outer layer of the mammalian cerebral cortex.

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Gyrus (gyri)

Ridge on the neocortex.

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Sulcus (Sulci)

Groove in the neocortex.

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Frontal Lobe

Motor

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Parietal Lobe

Somatosensory

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Temporal Lobe

Auditory

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Occipital Lobe

Visual

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Alzheimer’s Disease (AD)

Most prevalent age-related neurodegenerative disease causing dementia.

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Diencephalon

Consists of the epithalamus, thalamus, subthalamus, and hypothalamus.

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Thalamus

Functions as a sensory integration hub of the brain.

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Hypothalamus

Involved in regulation of emotional behavior and whole-body homeostasis.

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Brainstem

Continuous with the spinal cord, consisting of the midbrain, pons, and medulla oblongata.

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Parkinson’s Disease (PD)

Movement disorder caused by loss of dopaminergic neurons in the Substantia Nigra.

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Cerebellum

Largest structure of the hindbrain, involved in unconscious regulation of movement.

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Limbic System

Brain system involved in regulating mood and emotion.

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Spinal Cord

Segmented structure within the vertebral canal of the vertebral column, origin of the 31 pairs of spinal nerves.

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Motor Neuron Disease (MND)

Impaired somatic (skeletal muscle) innervation leads to progressive loss of ability to speak, move, swallow and breath

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Meninges

three membranes that protect the tissue of the CNS.

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Nerve

A collection of many myelinated axons enclosed in layers of connective tissue.

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Afferent Nerves

Nerves that containing axons of sensory neurons

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Efferent Nerves

Nerves that containing axons of motor neurons

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Spinal Nerves

31 pairs of spinal nerves emerge from the spinal cord that consist of both sensory and motor fibers.

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Exteroceptors

Located in the skin, respond to painful stimuli, temperature, touch, and pressure.

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Interoceptors

Located in the viscera, respond to mechanical and chemical stimuli.

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Proprioceptors

Located in muscles, joints, and tendons, promote postural awareness and movement.

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Monosynaptic pathway

Pathway where Neuron in CNS projects directly to skeletal muscle cell

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Disynaptic pathway

Pathway where Neuron in CNS projects to peripheral ganglionic neuron, which projects to visceral cell

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Electrical Conductance

Relative ability of an electrical charge to migrate from one point to another.

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Electrical Resistance

Relative inability of an electrical charge to migrate from one point to another.

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Voltage

The generation of an electrical current requires both conductance and voltage

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Ionic concentration gradients

Differences between extracellular and intracellular concentrations of ions such as Na+ and K+.

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Action Potential

A transient reversal in the voltage across the axonal membrane.

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Stimuli and Action Potential

Increase the frequency of action potential firing, not the size of individual action potentials.

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Resting membrane potential

The negative voltage (~ -65 mv) across the neuronal membrane when action potentials aren’t fired.

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Depolarization

When the membrane potential becomes more positive (less negative) than the resting potential.

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Repolarization

When the membrane potential returns to a negative value following depolarization.

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Hyperpolarization

When the membrane potential becomes more negative than the resting potential.

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The sum of all inputs

The sum of all excitatory and inhibitory inputs determines whether the post-synaptic neuron will be depolarized to the critical threshold needed for firing an action potential.

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Study Notes

  • The nervous system is a regulatory communication network
  • Allows organism to respond to stimuli and regulate metabolism/activity
  • Detects/responds to external and internal environmental changes
  • Regulates/coordinates bodily activities
  • Conducts stimuli from receptors to brain and spinal cord
  • Conducts impulses back to other body parts
  • Nerve impulse code is based on the frequency/pattern of action potential firing
  • Neurons have morphology and gene expression that enable electrical impulse conduction

Key Features of the Nervous System

  • One of two major control systems (with endocrine system)
  • Maintains homeostasis of nearly all physiological variables
  • Information conveyed via fast electrochemical signaling
  • Neuron (nerve cell) is the functional unit

Anatomical Divisions

  • Central Nervous System (CNS) structures: Brain and spinal cord which are control centers
  • Peripheral Nervous System (PNS) structures: 12 pairs of cranial nerves and 31 pairs of spinal nerves
  • PNS functions: Communication between CNS and rest of the body

Functional Divisions: Sensory and Motor

  • Spinal reflex arc includes: receptors, afferent signal, integration center, efferent signal, and effectors

Somatic and Visceral (Autonomic)

  • Somatic nervous system innervates skeletal muscle for voluntary movement
  • Autonomic nervous system innervates cardiac muscle, smooth muscle, and glands
  • Regulates involuntary bodily functions

Sympathetic and Parasympathetic

  • Sympathetic division regulates Fight or Flight response, primes body for activity
  • Parasympathetic division is the Rest and Digest system
  • Regulates normal automatic body functions

Enteric Nervous System

  • A division of the autonomic nervous system located in the gastrointestinal tract lining
  • Referred to as the 'little brain'
  • Controls digestion processes

Cells of the Nervous System

  • Neurons (nerve cells) are the functional unit specialized for electrochemical signaling
  • Glia (support cells) don't directly relay signals but maintain the nervous system

Neurons

  • Functional unit of nervous system
  • Specialized for electrochemical signaling
  • The human brain has ~85 billion neurons
  • Dendrites and axons are referred to as neurites

Soma

  • Contains same organelles as other cells
  • Large nucleus relative to soma
  • High demand for protein synthesis
  • Proteins are packaged into vesicles and transported to axons
  • Some organelles are more abundant in the soma
  • Others in distal portions of axons and dendrites

Axons

  • Neurons have a single axon which originates from the axon hillock
  • Length varies widely
  • Can branch off at right angles to form collaterals
  • Biochemical composition distinct from soma
  • Can be myelinated or unmyelinated
  • Conduct action potentials

Axon Terminals & Synapses

  • Synapse: region where information is transferred from a neuron to another target cell
  • Pre-synaptic axon terminals enriched in synaptic vesicles, contain neurotransmitters
  • Pre-synaptic terminals enriched with mitochondria, for high energy demands
  • Post-synaptic membranes enriched with neurotransmitter receptors

Dendrites

  • Number of dendrites varies per neuron
  • Neurons display complex branching networks
  • Rarely longer than 2mm, and not subjected to myelination
  • Main sites for synaptic input
  • Enriched in post-synaptic membrane components
  • Can contain spines

Classifying Neurons

  • Neurons classified based on: number of neurites dendrites, axon length neurotransmitter, location

Glia

  • Glia do not conduct electrical impulses
  • Modulate neuronal function
  • Essential for maintaining nervous system microenvironment

Oligodendrocytes & Schwann Cells

  • Oligodendrocytes myelinate axons in the CNS
  • Schwann cells myelinate axons in the PNS
  • Myelination increases action potential propagation and conduction velocity
  • Restricts nerve impulse generation to less than 0.5% of the axon's surface at the nodes of Ranvier

Astrocytes

  • Most abundant glial cell
  • Star-like morphology
  • Essential for synapse formation/maintenance
  • Key regulators of neural chemical environment
  • Buffer extracellular K+
  • Take up/metabolize neurotransmitters from the synaptic cleft
  • Supply metabolites to neurons
  • Regulate blood flow and form part of the blood-brain barrier

Microglia

  • Innate immune cells of the CNS, similar to macrophages
  • Account for ~15% of brain cells
  • Possess a ramified morphology
  • Key defenders of the CNS, responding to injury/infection
  • Phagocytose cellular debris
  • Secrete cytokines and growth factors

Ependymal Cells

  • Line the ventricles of the CNS, ciliated cells
  • Form the Choroid Plexus, which generates cerebrospinal fluid (CSF)
  • CSF flows through ventricular system into subarachnoid space
  • CSF supplies CNS with metabolites and clears waste products

Grey & White Matter

  • Grey matter: collections of neuronal cell bodies
  • White matter: collections of axons

Neuroanatomy

  • Sagittal: divides body into right and left parts
  • Transverse: divides body into superior and inferior parts
  • Coronal: divides body into anterior and posterior parts

CNS: The Brain

  • Brain consists of 4 main parts: cerebrum, diencephalon, brainstem, cerebellum
  • Neocortex: outer layer of the mammalian cerebral cortex
  • Gyrus (gyri): Ridge on the neocortex
  • Sulcus (Sulci): Groove in the neocortex
  • Cerebrum lobes: Frontal (motor), Parietal (somatosensory), Temporal (auditory), Occipital (visual)

Cerebrum: Medial Temporal Lobe & Hippocampus

  • Alzheimer’s Disease (AD)
    • Most prevalent age-related neurodegenerative disease
    • Leading cause of dementia
    • Progressive cerebral cortex degeneration, initially in the medial temporal lobe
    • Neuropathology: beta-amyloid plaques and neurofibrillary tangles
    • Treatments manage symptoms but do not reverse progression

Diencephalon

  • Parts: epithalamus, thalamus, subthalamus, and hypothalamus
  • Thalamus: sensory integration hub of the brain
  • Hypothalamus: regulates emotional behavior and whole-body homeostasis
    • Central regulator of the autonomic nervous system
    • Regulates endocrine function by innervating the pituitary

Brainstem

  • Continuous with the spinal cord
  • Midbrain, pons, and medulla oblongata
  • Origin of the 12 pairs of cranial nerves
  • Regulates motor function and processes essential to life

Parkinson’s Disease (PD)

  • Second most prevalent neurodegenerative disease
  • Movement disorder with resting tremor, rigidity, and postural gait impairment
  • Caused by loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc)
  • Neuropathology: Lewy bodies containing misfolded alpha-synuclein

Cerebellum

  • Largest structure of the hindbrain
  • Cortical layer of grey matter surrounds inner white matter
  • Regulates unconscious movement, equilibrium, coordination, posture

Limbic System

  • Brain system regulating mood and emotion
  • Includes cerebrum and diencephalon structures
  • Structures are anatomically interconnected

CNS: Spinal Cord

  • Segmented structure within vertebral canal
  • Origin of the 31 pairs of spinal nerves
  • Receives sensory information from skin and viscera
  • Relays sensory information to the brain (ascending pathway)
  • Sends somatic and autonomic motor efferents to the periphery

Motor Neuron Disease (MND)

  • Also known as amyotrophic lateral sclerosis (ALS)
  • Impaired somatic innervation causes loss of ability to speak, move, swallow, and breath
  • Primarily caused by loss ventral horn motor neurons
  • Inclusions in ventral horn motor neurons and loss of axons in motor tract
  • Neuropathology: protein aggregates/inclusions

CNS: Protective Elements

  • CNS tissue encased in bone
  • CNS tissue protected by three meninges: Dura Mater, Arachnoid membrane, Pia Mater
  • Subarachnoid space contains cerebrospinal fluid (CSF) produced by the ventricular system CSF bathes CNS tissues

PNS: Nerve Structure

  • Nerve is a collection of many myelinated axons in connective tissue layers
  • Individual axons surrounded by endoneurium
  • Perineurium binds groups of axons into fascicles
  • Epineurium encloses the fascicles to form a nerve
  • Nerves can be: Afferent (sensory), Efferent (motor), or Mixed (sensory and motor)

PNS: Cranial Nerves

  • Cranial nerves (12 pairs) originate from the brainstem
  • Receive stimuli and innervate tissues in head and face

PNS: Spinal Nerves

  • 31 pairs of spinal nerves emerge from spinal cord
  • Spinal nerves are mixed nerves (sensory and motor fibers)
  • Sensory fibers project to CNS via dorsal roots
  • Motor fibers project from CNS via ventral roots

PNS: Sensory Receptors

  • Sensory receptors transduce mechanical, thermal, chemo, and painful stimuli into nerve impulses
  • Exteroceptors: in skin, respond to pain, temperature, touch, and pressure
  • Interoceptors: in viscera, respond to mechanical and chemical stimuli
  • Proprioceptors: in muscles, joints, respond to postural awareness and movement

PNS: Efferent (motor) division

  • Somatic nervous system: Monosynaptic pathway
    • Neuron in CNS projects directly to skeletal muscle cell
  • Autonomic nervous system: Disynaptic pathway
    • Neuron in CNS projects to peripheral ganglionic neuron, which projects to visceral cell

PNS: Autonomic Nervous System

  • Cell bodies of autonomic motor neurons are outside the CNS in autonomic ganglia
  • These postganglionic neurons are innervated by preganglionic neurons in the CNS
  • Preganglionic axons of the sympathetic nervous system emerge from the thoracic and lumbar spinal cord
  • Preganglionic axons of the parasympathetic nervous system emerge from the brainstem and sacral spinal cord

Electricity: Key Terms & Principles

  • Electrical Current: Net movement of electrical charge
  • Electrical potential difference (voltage): Force exerted on a charged particle
  • Arises due to the difference in electrical potential between two charged points
  • Electrical Conductance: Ability of electrical charge to migrate (generate current)
  • Electrical Resistance: Inability of electrical charge to migrate (inverse of conductance)
  • Electrical current generation requires both conductance and voltage

The Axon

  • Axon conductivity constrained by chemistry of cellular microenvironment
  • Polar environments are separated by a non-polar hydrophobic barrier
  • Ions carry electrical charge
  • Ion movement (diffusion) influenced by concentration and electrostatic forces

Membranes and Ion Movement

  • If ions cannot move across the membrane, electrical currents are not conducted
  • Increased ionic permeability allows the membrane to conduct electrical current
  • Pumps use ATP hydrolysis to transport ions against concentration gradients

Conducting Electricity: What Neurons Need

  • Ionic concentration gradients across the cell membrane
  • Differences between extracellular and intracellular concentrations of ions
  • Voltage across the membrane creates electrostatic forces on ions
  • Membrane permeability: selective ion channels allow certain ions to move across, ion pumps actively transport certain ions across the membrane

The Action Potential

  • Transient reversal in voltage across the axonal membrane
  • Instigated by a rapid change in membrane permeability to Na+

Properties of the Action Potential

  • Action potentials are only fired once a critical threshold is met
  • Propagate along the axon in a self-regenerating manner
  • Size and duration do not change as conducted along the axon
  • Nerve impulse code relayed by the frequency/pattern of action potential firing
  • Stronger stimuli increase frequency of firing, not size of action potentials

Stages of the Action Potential

  • Resting membrane potential: negative voltage (~ -65 mv) when action potentials aren’t fired
  • Depolarization: membrane potential becomes more positive, characterizes rising phase
  • Repolarization: membrane potential returns to negative value, characterizes falling phase
  • Hyperpolarization: membrane potential becomes more negative, characterizes undershoot/refractory period

Molecular Basis of Resting Membrane Potential

  • Na+ and K+ ions unevenly distributed
  • K+ more concentrated in cytosol, Na+ more concentrated in extracellular fluid
  • Resting membrane more permeable to K+ than Na+
  • More positive charge lost from cell from K+ efflux than gained from Na+ influx
  • Active transport maintains concentration gradients by pumping 3Na+ out and 2K+ in per ATP
  • Resting membrane potential is negative because more positive charge flows out than in

Rising Phase (Depolarization)

  • When membrane potential reaches critical threshold, voltage-gated sodium channels open
  • Rapid influx of Na+ ions (inward positive current) and depolarization of the membrane

Falling Phase (Repolarization)

  • Voltage-gated sodium channels become inactivated at peak
  • Delayed opening of voltage-gated potassium channels causes efflux of K+ ions
  • Outward flow of positive current, repolarizing the membrane

Undershoot/Refractory Period

  • K+ efflux continues beyond the resting membrane potential (hyperpolarization)
  • Prevents stimuli from depolarizing the membrane to the critical threshold
  • Prevents a new action potential from being fired immediately
  • Resting membrane potential is re-established by the sodium-potassium pump

Synaptic Transmission

  • Sum of all inputs determines if a neuron generates an Action Potential
  • Post-synaptic neuron receives thousands of pre-synaptic inputs from other neurons
  • Sum of all excitatory and inhibitory inputs determines if post-synaptic neuron will be depolarized to the critical threshold for firing

Alzheimer’s Disease

  • Therapeutic targeting of dysfunctional cholinergic and glutamatergic neurotransmitter pathways is used for symptomatic management

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