Podcast
Questions and Answers
Which of the following is NOT a primary function of the nervous system?
Which of the following is NOT a primary function of the nervous system?
- Detecting changes in the external environment.
- Regulating and coordinating bodily activities.
- Synthesizing and releasing hormones. (correct)
- Controlling voluntary movements.
The peripheral nervous system (PNS) is composed of which structures?
The peripheral nervous system (PNS) is composed of which structures?
- Brain and spinal cord.
- Brainstem and cerebellum.
- Cerebrum and diencephalon.
- Cranial and spinal nerves. (correct)
Which division of the autonomic nervous system is responsible for the 'fight or flight' response?
Which division of the autonomic nervous system is responsible for the 'fight or flight' response?
- Somatic.
- Sympathetic. (correct)
- Enteric.
- Parasympathetic.
What is the main function of oligodendrocytes?
What is the main function of oligodendrocytes?
Which type of glial cell is responsible for regulating the chemical environment of the synapse by buffering extracellular potassium and taking up neurotransmitters?
Which type of glial cell is responsible for regulating the chemical environment of the synapse by buffering extracellular potassium and taking up neurotransmitters?
Which part of a neuron is primarily responsible for receiving synaptic inputs from other neurons?
Which part of a neuron is primarily responsible for receiving synaptic inputs from other neurons?
What is the role of the myelin sheath in neuronal signaling?
What is the role of the myelin sheath in neuronal signaling?
What is the primary function of the enteric nervous system?
What is the primary function of the enteric nervous system?
What is the function of the subarachnoid space?
What is the function of the subarachnoid space?
Within the spinal cord, where are the cell bodies of motor neurons typically located?
Within the spinal cord, where are the cell bodies of motor neurons typically located?
Which of the following best describes the role of the sodium-potassium pump in establishing the resting membrane potential?
Which of the following best describes the role of the sodium-potassium pump in establishing the resting membrane potential?
What is the primary event that triggers the rising phase (depolarization) of an action potential?
What is the primary event that triggers the rising phase (depolarization) of an action potential?
What is the functional consequence of the inactivation of voltage-gated sodium channels during an action potential?
What is the functional consequence of the inactivation of voltage-gated sodium channels during an action potential?
Which of the following is a key characteristic of action potentials?
Which of the following is a key characteristic of action potentials?
Which of the following neurodegenerative diseases is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc)?
Which of the following neurodegenerative diseases is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc)?
Which plane divides the body into anterior and posterior sections?
Which plane divides the body into anterior and posterior sections?
Regarding neurons, what is the primary function of the axon terminals?
Regarding neurons, what is the primary function of the axon terminals?
What is the endoneurium?
What is the endoneurium?
Which term describes sensory receptors located in muscles, joints, and tendons that contribute to postural awareness and movement?
Which term describes sensory receptors located in muscles, joints, and tendons that contribute to postural awareness and movement?
What distinguishes a 'mixed' nerve in the peripheral nervous system?
What distinguishes a 'mixed' nerve in the peripheral nervous system?
Which of the following is a key function of ependymal cells?
Which of the following is a key function of ependymal cells?
What is the primary function of the hippocampus?
What is the primary function of the hippocampus?
Which feature characterizes the neuropathology of Alzheimer's disease?
Which feature characterizes the neuropathology of Alzheimer's disease?
Damage to the cerebellum would most likely result in impairment of what?
Damage to the cerebellum would most likely result in impairment of what?
What is the functional role of voltage-gated potassium channels in the repolarization phase of the action potential?
What is the functional role of voltage-gated potassium channels in the repolarization phase of the action potential?
How does myelination affect the electrical properties of an axon?
How does myelination affect the electrical properties of an axon?
If a drug were designed to selectively block the function of microglia, which of the following processes within the CNS would be most directly affected?
If a drug were designed to selectively block the function of microglia, which of the following processes within the CNS would be most directly affected?
A researcher is studying a neuron and observes that it has a very short axon, highly complex dendritic branching close to the soma, and primarily uses GABA as its neurotransmitter. Based on these characteristics, which type of neuron is the researcher most likely studying?
A researcher is studying a neuron and observes that it has a very short axon, highly complex dendritic branching close to the soma, and primarily uses GABA as its neurotransmitter. Based on these characteristics, which type of neuron is the researcher most likely studying?
In a patient with amyotrophic lateral sclerosis (ALS), which of the following neuropathological changes would be expected in the spinal cord?
In a patient with amyotrophic lateral sclerosis (ALS), which of the following neuropathological changes would be expected in the spinal cord?
During the relative refractory period, a stronger-than-normal stimulus is required to elicit an action potential. What is the primary reason for this increased threshold?
During the relative refractory period, a stronger-than-normal stimulus is required to elicit an action potential. What is the primary reason for this increased threshold?
A toxin selectively blocks voltage-gated potassium channels in a neuron. Which of the following effects would this toxin have on the action potential?
A toxin selectively blocks voltage-gated potassium channels in a neuron. Which of the following effects would this toxin have on the action potential?
Which of the following would be the MOST immediate consequence of selectively impairing the function of the sodium-potassium pump in a neuron?
Which of the following would be the MOST immediate consequence of selectively impairing the function of the sodium-potassium pump in a neuron?
A researcher discovers a novel neurotoxin that selectively disrupts the function of astrocytes. Which of the following would be the MOST likely and immediate consequence of applying this toxin to a neuronal culture?
A researcher discovers a novel neurotoxin that selectively disrupts the function of astrocytes. Which of the following would be the MOST likely and immediate consequence of applying this toxin to a neuronal culture?
Imagine a hypothetical scenario where a genetic mutation causes Schwann cells to myelinate axons within the central nervous system, a function normally performed by oligodendrocytes. What would be the MOST likely consequence of this mutation on neural function?
Imagine a hypothetical scenario where a genetic mutation causes Schwann cells to myelinate axons within the central nervous system, a function normally performed by oligodendrocytes. What would be the MOST likely consequence of this mutation on neural function?
A researcher is investigating a new drug that selectively enhances the reuptake of glutamate by astrocytes. What effect would this drug likely have on neuronal activity in the vicinity of the astrocytes?
A researcher is investigating a new drug that selectively enhances the reuptake of glutamate by astrocytes. What effect would this drug likely have on neuronal activity in the vicinity of the astrocytes?
In a research study, a scientist selectively prevents the formation of new dendritic spines on neurons within the hippocampus of a mouse. What behavioral change would MOST likely be observed?
In a research study, a scientist selectively prevents the formation of new dendritic spines on neurons within the hippocampus of a mouse. What behavioral change would MOST likely be observed?
A patient presents with a rare neurological disorder characterized by a selective loss of interoceptors. Which of the following symptoms would be MOST likely to manifest in this patient?
A patient presents with a rare neurological disorder characterized by a selective loss of interoceptors. Which of the following symptoms would be MOST likely to manifest in this patient?
Which of the following best describes the primary role of the nervous system?
Which of the following best describes the primary role of the nervous system?
What is the fundamental structural and functional unit of the nervous system?
What is the fundamental structural and functional unit of the nervous system?
Which of the following is a characteristic of the sympathetic nervous system?
Which of the following is a characteristic of the sympathetic nervous system?
What is the main function of the enteric nervous system?
What is the main function of the enteric nervous system?
Which glial cell type is responsible for myelinating axons in the peripheral nervous system (PNS)?
Which glial cell type is responsible for myelinating axons in the peripheral nervous system (PNS)?
Which of the following is a primary function of astrocytes?
Which of the following is a primary function of astrocytes?
What is the major role of microglia in the central nervous system (CNS)?
What is the major role of microglia in the central nervous system (CNS)?
Which of the following describes white matter?
Which of the following describes white matter?
What feature primarily defines the function of the pre-synaptic axon terminal?
What feature primarily defines the function of the pre-synaptic axon terminal?
Which of the following accurately describes the function of dendrites?
Which of the following accurately describes the function of dendrites?
Which of the following best defines the term 'sulcus' in the context of neuroanatomy?
Which of the following best defines the term 'sulcus' in the context of neuroanatomy?
Which of the following neurodegenerative diseases is most closely associated with beta-amyloid plaques and neurofibrillary tangles?
Which of the following neurodegenerative diseases is most closely associated with beta-amyloid plaques and neurofibrillary tangles?
Which of the following represents the correct order of connective tissue layers surrounding a nerve, from the innermost to the outermost layer?
Which of the following represents the correct order of connective tissue layers surrounding a nerve, from the innermost to the outermost layer?
If a researcher were to selectively lesion the hippocampus in an animal model, which function would be most directly impaired?
If a researcher were to selectively lesion the hippocampus in an animal model, which function would be most directly impaired?
Which of the following statements accurately describes the absolute refractory period?
Which of the following statements accurately describes the absolute refractory period?
What is the primary consequence of the inactivation of voltage-gated sodium channels during the falling phase of an action potential?
What is the primary consequence of the inactivation of voltage-gated sodium channels during the falling phase of an action potential?
Concerning sensory transduction, which type of receptor is specialized to respond to painful stimuli?
Concerning sensory transduction, which type of receptor is specialized to respond to painful stimuli?
Which of the following is the most accurate description of how action potentials relay information about stimulus intensity?
Which of the following is the most accurate description of how action potentials relay information about stimulus intensity?
A researcher is studying a neuron and observes that, following an action potential, the cell membrane potential becomes transiently more negative than its normal resting potential. Which of the following ionic events is MOST directly responsible for this phenomenon?
A researcher is studying a neuron and observes that, following an action potential, the cell membrane potential becomes transiently more negative than its normal resting potential. Which of the following ionic events is MOST directly responsible for this phenomenon?
Imagine a hypothetical scenario where a neurotoxin specifically targets and disables ependymal cells within the brain. Which of the following would be the MOST immediate and direct consequence of this neurotoxin's action?
Imagine a hypothetical scenario where a neurotoxin specifically targets and disables ependymal cells within the brain. Which of the following would be the MOST immediate and direct consequence of this neurotoxin's action?
Which of the following is NOT a characteristic of glial cells?
Which of the following is NOT a characteristic of glial cells?
Which of the following best describes the function of the sympathetic nervous system?
Which of the following best describes the function of the sympathetic nervous system?
Which of the following best describes the primary function of dendrites?
Which of the following best describes the primary function of dendrites?
What is the main function of the subarachnoid space?
What is the main function of the subarachnoid space?
Which of the following cell types is responsible for myelinating axons in the central nervous system (CNS)?
Which of the following cell types is responsible for myelinating axons in the central nervous system (CNS)?
Which division of the nervous system is responsible for controlling the digestive processes?
Which division of the nervous system is responsible for controlling the digestive processes?
Which plane divides the body into superior and inferior parts?
Which plane divides the body into superior and inferior parts?
What is the primary function of astrocytes?
What is the primary function of astrocytes?
What is the role of the sodium-potassium pump in establishing the resting membrane potential?
What is the role of the sodium-potassium pump in establishing the resting membrane potential?
What best describes the composition of a mixed nerve?
What best describes the composition of a mixed nerve?
What is the primary function of ependymal cells?
What is the primary function of ependymal cells?
Which of the following accurately pairs a cerebral lobe with its primary associated function?
Which of the following accurately pairs a cerebral lobe with its primary associated function?
Which of the following best describes the role of microglia in the central nervous system (CNS)?
Which of the following best describes the role of microglia in the central nervous system (CNS)?
Which of the following describes the anatomical arrangement of the spinal nerves?
Which of the following describes the anatomical arrangement of the spinal nerves?
How do neurons relay information about stimulus intensity?
How do neurons relay information about stimulus intensity?
Which of the following best describes the function of the enteric nervous system?
Which of the following best describes the function of the enteric nervous system?
Which structure is responsible for the integration of sensory information in the brain?
Which structure is responsible for the integration of sensory information in the brain?
During the falling phase of an action potential, which channels are primarily responsible for the membrane repolarization?
During the falling phase of an action potential, which channels are primarily responsible for the membrane repolarization?
What is the difference in function between preganglionic and postganglionic neurons in the autonomic nervous system?
What is the difference in function between preganglionic and postganglionic neurons in the autonomic nervous system?
Which of the following neural structures is NOT part of the limbic system?
Which of the following neural structures is NOT part of the limbic system?
Which alteration in ion channel function would most likely shorten the relative refractory period?
Which alteration in ion channel function would most likely shorten the relative refractory period?
Why does saltatory conduction occur?
Why does saltatory conduction occur?
Which of the following accurately describes the respective functions of the dorsal and ventral horns of the spinal cord?
Which of the following accurately describes the respective functions of the dorsal and ventral horns of the spinal cord?
What is the underlying mechanism for why action potentials are 'all-or-none' events?
What is the underlying mechanism for why action potentials are 'all-or-none' events?
What is the primary difference between exteroceptors, interoceptors, and proprioceptors?
What is the primary difference between exteroceptors, interoceptors, and proprioceptors?
What is the spatial relationship between the epineurium, perineurium, and endoneurium?
What is the spatial relationship between the epineurium, perineurium, and endoneurium?
In a neuron, which of the following is most crucial for maintaining the ionic concentration gradients necessary for the resting membrane potential?
In a neuron, which of the following is most crucial for maintaining the ionic concentration gradients necessary for the resting membrane potential?
In clinical settings, why do therapeutic interventions for Alzheimer's Disease primarily target cholinergic and glutamatergic neurotransmitter pathways?
In clinical settings, why do therapeutic interventions for Alzheimer's Disease primarily target cholinergic and glutamatergic neurotransmitter pathways?
A researcher observes a population of neurons with a unique characteristic: their action potentials exhibit an unusually prolonged repolarization phase. Which of the following alterations in ion channel function is MOST likely responsible for this observation?
A researcher observes a population of neurons with a unique characteristic: their action potentials exhibit an unusually prolonged repolarization phase. Which of the following alterations in ion channel function is MOST likely responsible for this observation?
A novel neurotoxin is discovered that selectively disrupts the function of proprioceptors. Which of the following symptoms would be MOST likely to manifest in an individual exposed to this toxin?
A novel neurotoxin is discovered that selectively disrupts the function of proprioceptors. Which of the following symptoms would be MOST likely to manifest in an individual exposed to this toxin?
Consider a scenario where a patient has damage exclusively to the white matter of their spinal cord. Which of the following would be the MOST likely primary consequence?
Consider a scenario where a patient has damage exclusively to the white matter of their spinal cord. Which of the following would be the MOST likely primary consequence?
In a research experiment, scientists induce artificial myelination of dendrites in hippocampal pyramidal neurons. Which of the following outcomes would be MOST likely?
In a research experiment, scientists induce artificial myelination of dendrites in hippocampal pyramidal neurons. Which of the following outcomes would be MOST likely?
In a neuron at rest, which situation would lead to the electrochemical gradient for sodium being closest to zero?
In a neuron at rest, which situation would lead to the electrochemical gradient for sodium being closest to zero?
What is the functional unit of the nervous system?
What is the functional unit of the nervous system?
Which of the following is primarily responsible for voluntary movement?
Which of the following is primarily responsible for voluntary movement?
What is the function of the parasympathetic nervous system?
What is the function of the parasympathetic nervous system?
Which type of glial cell forms the myelin sheath in the central nervous system (CNS)?
Which type of glial cell forms the myelin sheath in the central nervous system (CNS)?
What is the primary function of microglia?
What is the primary function of microglia?
What is the main function of dendrites?
What is the main function of dendrites?
Which of the following is the correct order of signal transmission in a basic spinal reflex arc?
Which of the following is the correct order of signal transmission in a basic spinal reflex arc?
Which anatomical plane divides the brain into right and left halves?
Which anatomical plane divides the brain into right and left halves?
What cellular component is responsible for generating cerebrospinal fluid (CSF)?
What cellular component is responsible for generating cerebrospinal fluid (CSF)?
What is the primary role of the sodium-potassium pump in the context of action potentials?
What is the primary role of the sodium-potassium pump in the context of action potentials?
Which of the following best describes the role of voltage-gated potassium channels during the repolarization phase of an action potential?
Which of the following best describes the role of voltage-gated potassium channels during the repolarization phase of an action potential?
How does myelination increase the velocity of action potential conduction?
How does myelination increase the velocity of action potential conduction?
Which of the following is the MOST direct consequence of a drug that selectively blocks voltage-gated sodium channels in a neuron?
Which of the following is the MOST direct consequence of a drug that selectively blocks voltage-gated sodium channels in a neuron?
Why does the action potential propagate in one direction down the axon?
Why does the action potential propagate in one direction down the axon?
A patient exhibits resting tremor, muscle rigidity, and postural instability. Which neurodegenerative disease is MOST likely associated with these symptoms?
A patient exhibits resting tremor, muscle rigidity, and postural instability. Which neurodegenerative disease is MOST likely associated with these symptoms?
Which of the following represents the structural organization of a nerve, from the outside in?
Which of the following represents the structural organization of a nerve, from the outside in?
In a hypothetical experiment, researchers selectively disrupt the function of preganglionic neurons in the sympathetic nervous system. Which of the following would be the MOST likely consequence?
In a hypothetical experiment, researchers selectively disrupt the function of preganglionic neurons in the sympathetic nervous system. Which of the following would be the MOST likely consequence?
Imagine a scenario where a mutation leads to the complete absence of interoceptors throughout the body. Which of the following physiological consequences would be MOST likely to occur?
Imagine a scenario where a mutation leads to the complete absence of interoceptors throughout the body. Which of the following physiological consequences would be MOST likely to occur?
A researcher discovers a novel compound that selectively enhances the activity of protein phosphatases within neurons. What effect would this compound MOST likely have on neuronal function, particularly in the context of synaptic plasticity?
A researcher discovers a novel compound that selectively enhances the activity of protein phosphatases within neurons. What effect would this compound MOST likely have on neuronal function, particularly in the context of synaptic plasticity?
Which of the following best describes the primary role of the nervous system in an organism?
Which of the following best describes the primary role of the nervous system in an organism?
What distinguishes the autonomic nervous system from the somatic nervous system?
What distinguishes the autonomic nervous system from the somatic nervous system?
What is the primary function of the sympathetic nervous system?
What is the primary function of the sympathetic nervous system?
Which of the following glial cells is responsible for myelinating axons in the central nervous system (CNS)?
Which of the following glial cells is responsible for myelinating axons in the central nervous system (CNS)?
What is the main role of microglia in the central nervous system?
What is the main role of microglia in the central nervous system?
Which of the following best describes 'white matter'?
Which of the following best describes 'white matter'?
What primarily defines the function of the pre-synaptic axon terminal?
What primarily defines the function of the pre-synaptic axon terminal?
What is the functional significance of the enteric nervous system?
What is the functional significance of the enteric nervous system?
Which of the following best describes the role of astrocytes?
Which of the following best describes the role of astrocytes?
Which of the following represents the correct order of connective tissue layers surrounding a nerve, from innermost to outermost?
Which of the following represents the correct order of connective tissue layers surrounding a nerve, from innermost to outermost?
What is the key factor that allows the transmission of information to be conveyed by the frequency and pattern of action potential firing?
What is the key factor that allows the transmission of information to be conveyed by the frequency and pattern of action potential firing?
Regarding the molecular basis of the resting membrane potential, which statement is most accurate?
Regarding the molecular basis of the resting membrane potential, which statement is most accurate?
During the falling phase of the action potential, which event contributes significantly to membrane repolarization?
During the falling phase of the action potential, which event contributes significantly to membrane repolarization?
What is the primary event that leads to the hyperpolarization phase (undershoot) of the action potential?
What is the primary event that leads to the hyperpolarization phase (undershoot) of the action potential?
How do neurons relay information about the intensity of a stimulus?
How do neurons relay information about the intensity of a stimulus?
Which best describes the function of the preganglionic neurons in the autonomic nervous system?
Which best describes the function of the preganglionic neurons in the autonomic nervous system?
Which statement accurately contrasts the functions of the dorsal and ventral horns of the spinal cord?
Which statement accurately contrasts the functions of the dorsal and ventral horns of the spinal cord?
Why does saltatory conduction significantly increase the velocity of action potential propagation?
Why does saltatory conduction significantly increase the velocity of action potential propagation?
What is the fundamental difference between exteroceptors, interoceptors, and proprioceptors?
What is the fundamental difference between exteroceptors, interoceptors, and proprioceptors?
If a researcher selectively lesions the hippocampus in an animal model, which function would be most directly impaired?
If a researcher selectively lesions the hippocampus in an animal model, which function would be most directly impaired?
Why are pre-synaptic terminals enriched with mitochondria?
Why are pre-synaptic terminals enriched with mitochondria?
During the rising phase (depolarization) of an action potential, what is the primary event that occurs?
During the rising phase (depolarization) of an action potential, what is the primary event that occurs?
Why does the action potential propagate in only one direction down the axon?
Why does the action potential propagate in only one direction down the axon?
If a drug were designed that selectively enhanced the reuptake of glutamate by astrocytes, what effect would this drug likely have on neuronal activity in the vicinity of the astrocytes?
If a drug were designed that selectively enhanced the reuptake of glutamate by astrocytes, what effect would this drug likely have on neuronal activity in the vicinity of the astrocytes?
Which of the following scenarios would MOST directly challenge the neuron's ability to maintain its resting membrane potential?
Which of the following scenarios would MOST directly challenge the neuron's ability to maintain its resting membrane potential?
Which of the following best describes a primary function of the nervous system?
Which of the following best describes a primary function of the nervous system?
What is the underlying mechanism that allows neurons to relay information about stimulus intensity?
What is the underlying mechanism that allows neurons to relay information about stimulus intensity?
Which anatomical division of the nervous system includes the brain and spinal cord?
Which anatomical division of the nervous system includes the brain and spinal cord?
Which division of the autonomic nervous system is responsible for the 'rest and digest' response?
Which division of the autonomic nervous system is responsible for the 'rest and digest' response?
Which type of glial cell myelinates axons in the peripheral nervous system (PNS)?
Which type of glial cell myelinates axons in the peripheral nervous system (PNS)?
What is the primary function of astrocytes in the nervous system?
What is the primary function of astrocytes in the nervous system?
Which of the following best describes 'white matter' in the nervous system?
Which of the following best describes 'white matter' in the nervous system?
What is the primary function of the pre-synaptic axon terminal?
What is the primary function of the pre-synaptic axon terminal?
Which term describes a ridge on the neocortex?
Which term describes a ridge on the neocortex?
What is the role of the sodium-potassium pump in establishing the resting membrane potential of a neuron?
What is the role of the sodium-potassium pump in establishing the resting membrane potential of a neuron?
During the repolarization phase of an action potential, which channels are primarily responsible for the membrane potential returning to a negative value?
During the repolarization phase of an action potential, which channels are primarily responsible for the membrane potential returning to a negative value?
Which of the following accurately describes the arrangement of connective tissue layers in a nerve, from innermost to outermost?
Which of the following accurately describes the arrangement of connective tissue layers in a nerve, from innermost to outermost?
What is the primary functional difference between preganglionic and postganglionic neurons in the autonomic nervous system?
What is the primary functional difference between preganglionic and postganglionic neurons in the autonomic nervous system?
Which of the following best describes the function of interoceptors?
Which of the following best describes the function of interoceptors?
The molecular basis of the resting membrane potential relies on which of the following conditions?
The molecular basis of the resting membrane potential relies on which of the following conditions?
Which of the following alterations in ion channel function would most likely shorten the relative refractory period?
Which of the following alterations in ion channel function would most likely shorten the relative refractory period?
In a scenario where an individual has damage exclusively to the white matter of their spinal cord, which of the following would be the MOST likely primary consequence?
In a scenario where an individual has damage exclusively to the white matter of their spinal cord, which of the following would be the MOST likely primary consequence?
Consider a hypothetical scenario where a neurotoxin specifically targets and disables ependymal cells within the brain. Which of the following would be the MOST immediate and direct consequence of this neurotoxin's action?
Consider a hypothetical scenario where a neurotoxin specifically targets and disables ependymal cells within the brain. Which of the following would be the MOST immediate and direct consequence of this neurotoxin's action?
Imagine a scientific breakthrough enables researchers to selectively control the expression of myelinating proteins exclusively in astrocytes. If these modified astrocytes were induced to myelinate neuronal axons, but only at the distal portions of the axon far away from the soma and axon hillock, what would be the MOST likely effect on neuronal function?
Imagine a scientific breakthrough enables researchers to selectively control the expression of myelinating proteins exclusively in astrocytes. If these modified astrocytes were induced to myelinate neuronal axons, but only at the distal portions of the axon far away from the soma and axon hillock, what would be the MOST likely effect on neuronal function?
Consider a population of neurons in the cerebral cortex that exhibit a unique form of activity-dependent plasticity where prolonged periods of high-frequency firing lead to a sustained decrease in the threshold required for action potential initiation. Which alteration in the expression or function of ion channels would be MOST consistent with this observation?
Consider a population of neurons in the cerebral cortex that exhibit a unique form of activity-dependent plasticity where prolonged periods of high-frequency firing lead to a sustained decrease in the threshold required for action potential initiation. Which alteration in the expression or function of ion channels would be MOST consistent with this observation?
A research team is investigating a novel neurotoxin, 'ToxK,' that selectively disrupts the interaction between pleckstrin homology (PH) domains and phosphatidylinositol (PI) lipids within neurons. Given the known roles of PI lipids in neuronal signaling and trafficking, which cellular process would be MOST directly and severely compromised by exposure to ToxK?
A research team is investigating a novel neurotoxin, 'ToxK,' that selectively disrupts the interaction between pleckstrin homology (PH) domains and phosphatidylinositol (PI) lipids within neurons. Given the known roles of PI lipids in neuronal signaling and trafficking, which cellular process would be MOST directly and severely compromised by exposure to ToxK?
A neurophysiologist is studying the effects of a novel peptide that selectively binds to and inhibits the function of the Na+/K+-ATPase pump in neurons. Assuming the neuron initially exhibits a stable resting membrane potential, what sequence of events would MOST accurately describe the long-term consequences of continuous exposure to this peptide?
A neurophysiologist is studying the effects of a novel peptide that selectively binds to and inhibits the function of the Na+/K+-ATPase pump in neurons. Assuming the neuron initially exhibits a stable resting membrane potential, what sequence of events would MOST accurately describe the long-term consequences of continuous exposure to this peptide?
Researchers discover a novel genetic mutation that results in a complete loss of function of the dystroglycan protein complex specifically within astrocytes. Given the known roles of dystroglycan in astrocyte function and interaction with the extracellular matrix, which of the following outcomes would be MOST likely to occur in the central nervous system?
Researchers discover a novel genetic mutation that results in a complete loss of function of the dystroglycan protein complex specifically within astrocytes. Given the known roles of dystroglycan in astrocyte function and interaction with the extracellular matrix, which of the following outcomes would be MOST likely to occur in the central nervous system?
A scientist is investigating the effects of a novel compound, 'SynaptoRestore,' on synaptic plasticity in hippocampal neurons. The compound is found to selectively enhance the phosphorylation of serine residues on the GluN2B subunit of NMDA receptors. What effect and molecular mechanism would MOST likely underlie the action of SynaptoRestore?
A scientist is investigating the effects of a novel compound, 'SynaptoRestore,' on synaptic plasticity in hippocampal neurons. The compound is found to selectively enhance the phosphorylation of serine residues on the GluN2B subunit of NMDA receptors. What effect and molecular mechanism would MOST likely underlie the action of SynaptoRestore?
Consider a scenario where a patient exhibits selective damage to the fornix, but with no other apparent brain lesions. What cognitive or behavioral deficit would MOST likely be observed in this patient?
Consider a scenario where a patient exhibits selective damage to the fornix, but with no other apparent brain lesions. What cognitive or behavioral deficit would MOST likely be observed in this patient?
A researcher discovers a novel toxin that selectively disrupts the function of ependymal cells. What would be the MOST immediate and direct consequence of this toxin's action?
A researcher discovers a novel toxin that selectively disrupts the function of ependymal cells. What would be the MOST immediate and direct consequence of this toxin's action?
Imagine a scenario where a genetic mutation causes Schwann cells to myelinate axons within the central nervous system (CNS). What consequence would this have on neural function?
Imagine a scenario where a genetic mutation causes Schwann cells to myelinate axons within the central nervous system (CNS). What consequence would this have on neural function?
A researcher is studying a neuron with a very short axon, highly complex dendritic branching, and primarily uses GABA as its neurotransmitter. What is the researcher most likely studying?
A researcher is studying a neuron with a very short axon, highly complex dendritic branching, and primarily uses GABA as its neurotransmitter. What is the researcher most likely studying?
A patient presents with a rare neurological disorder characterized by a selective loss of interoceptors. What symptom is most likely to manifest in this patient?
A patient presents with a rare neurological disorder characterized by a selective loss of interoceptors. What symptom is most likely to manifest in this patient?
In a research study, a scientist selectively prevents the formation of new dendritic spines on neurons within the hippocampus. What behavioral change would most likely be observed?
In a research study, a scientist selectively prevents the formation of new dendritic spines on neurons within the hippocampus. What behavioral change would most likely be observed?
How would a drug that selectively enhances the reuptake of glutamate by astrocytes affect neuronal activity in the vicinity of the astrocytes?
How would a drug that selectively enhances the reuptake of glutamate by astrocytes affect neuronal activity in the vicinity of the astrocytes?
During amyotrophic lateral sclerosis (ALS), what neuropathological changes would be expected in the spinal cord?
During amyotrophic lateral sclerosis (ALS), what neuropathological changes would be expected in the spinal cord?
If a toxin selectively blocks voltage-gated potassium channels in a neuron, what effects would this toxin have on the action potential?
If a toxin selectively blocks voltage-gated potassium channels in a neuron, what effects would this toxin have on the action potential?
What would be the immediate consequence of selectively impairing the function of the sodium-potassium pump in a neuron?
What would be the immediate consequence of selectively impairing the function of the sodium-potassium pump in a neuron?
A researcher discovers a novel neurotoxin that selectively disrupts astrocytes. What is most likely to happen if applied to neurons?
A researcher discovers a novel neurotoxin that selectively disrupts astrocytes. What is most likely to happen if applied to neurons?
What feature characterizes neurons, enabling them to rapidly transmit information over long distances?
What feature characterizes neurons, enabling them to rapidly transmit information over long distances?
Which of the following structures is part of the central nervous system (CNS)?
Which of the following structures is part of the central nervous system (CNS)?
What is the primary role of the somatic nervous system?
What is the primary role of the somatic nervous system?
The 'fight or flight' response is primarily regulated by which division of the nervous system?
The 'fight or flight' response is primarily regulated by which division of the nervous system?
Which of the following functions is primarily controlled by the enteric nervous system?
Which of the following functions is primarily controlled by the enteric nervous system?
Which of the following glial cells myelinates axons in the peripheral nervous system (PNS)?
Which of the following glial cells myelinates axons in the peripheral nervous system (PNS)?
Which glial cell acts as the primary immune defense in the central nervous system?
Which glial cell acts as the primary immune defense in the central nervous system?
What is the main function of ependymal cells?
What is the main function of ependymal cells?
What is the primary function of axon terminals?
What is the primary function of axon terminals?
Which plane divides the body into right and left halves?
Which plane divides the body into right and left halves?
What is the key function of the thalamus within the diencephalon?
What is the key function of the thalamus within the diencephalon?
Which structure is responsible for regulating emotional behavior and whole-body homeostasis?
Which structure is responsible for regulating emotional behavior and whole-body homeostasis?
Which of the following is a characteristic neuropathological feature of Alzheimer's disease (AD)?
Which of the following is a characteristic neuropathological feature of Alzheimer's disease (AD)?
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) is a primary cause of which neurodegenerative disease?
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) is a primary cause of which neurodegenerative disease?
What type of information is carried by the dorsal roots of the spinal cord?
What type of information is carried by the dorsal roots of the spinal cord?
Which of the following is the correct order of connective tissue layers surrounding a nerve, from innermost to outermost?
Which of the following is the correct order of connective tissue layers surrounding a nerve, from innermost to outermost?
In a hypothetical scenario, a researcher discovers a compound that selectively blocks the interaction between actin filaments and myosin motors within neurons. Which of the following cellular processes would be MOST directly and severely compromised by disruption of this interaction?
In a hypothetical scenario, a researcher discovers a compound that selectively blocks the interaction between actin filaments and myosin motors within neurons. Which of the following cellular processes would be MOST directly and severely compromised by disruption of this interaction?
Which of the following is the MOST encompassing description of the nervous system's primary role?
Which of the following is the MOST encompassing description of the nervous system's primary role?
Which of the following characteristics differentiates the somatic nervous system from the autonomic nervous system?
Which of the following characteristics differentiates the somatic nervous system from the autonomic nervous system?
Which of the following glial cells is responsible for myelinating axons in the peripheral nervous system (PNS)?
Which of the following glial cells is responsible for myelinating axons in the peripheral nervous system (PNS)?
What is the primary function of astrocytes in the central nervous system (CNS)?
What is the primary function of astrocytes in the central nervous system (CNS)?
What best describes the composition of white matter?
What best describes the composition of white matter?
Which characteristic is crucial for enabling neurons to rapidly transmit information over long distances?
Which characteristic is crucial for enabling neurons to rapidly transmit information over long distances?
During the falling phase of the action potential, which event significantly contributes to membrane repolarization?
During the falling phase of the action potential, which event significantly contributes to membrane repolarization?
In the context of a nerve, what is the correct order of layers from the outermost to the innermost?
In the context of a nerve, what is the correct order of layers from the outermost to the innermost?
Imagine a hypothetical mutation that causes a complete loss of function of the protein dystroglycan specifically within astrocytes. What outcome is MOST likely in the central nervous system?
Imagine a hypothetical mutation that causes a complete loss of function of the protein dystroglycan specifically within astrocytes. What outcome is MOST likely in the central nervous system?
Flashcards
Nervous System
Nervous System
Regulatory communication network that responds to environmental stimuli and regulates metabolism and activity.
Central Nervous System (CNS)
Central Nervous System (CNS)
Structures: Brain and spinal cord. Functions: Control centers.
Peripheral Nervous System (PNS)
Peripheral Nervous System (PNS)
Cranial nerves (12 pairs) and spinal nerves (31 pairs). Communicates between CNS and body.
Somatic Nervous System
Somatic Nervous System
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Autonomic Nervous System
Autonomic Nervous System
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Sympathetic Division
Sympathetic Division
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Parasympathetic Division
Parasympathetic Division
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Enteric Nervous System
Enteric Nervous System
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Neurons (Nerve Cells)
Neurons (Nerve Cells)
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Glia (Support Cells)
Glia (Support Cells)
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Oligodendrocytes
Oligodendrocytes
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Schwann Cells
Schwann Cells
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Astrocytes
Astrocytes
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Microglia
Microglia
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Ependymal Cells
Ependymal Cells
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Grey Matter
Grey Matter
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White Matter
White Matter
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Sagittal
Sagittal
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Transverse
Transverse
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Coronal
Coronal
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Neocortex
Neocortex
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Gyrus (gyri)
Gyrus (gyri)
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Sulcus (Sulci)
Sulcus (Sulci)
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Frontal Lobe
Frontal Lobe
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Parietal Lobe
Parietal Lobe
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Temporal Lobe
Temporal Lobe
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Occipital Lobe
Occipital Lobe
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Alzheimer’s Disease (AD)
Alzheimer’s Disease (AD)
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Diencephalon
Diencephalon
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Thalamus
Thalamus
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Hypothalamus
Hypothalamus
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Brainstem
Brainstem
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Parkinson’s Disease (PD)
Parkinson’s Disease (PD)
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Cerebellum
Cerebellum
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Limbic System
Limbic System
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Spinal Cord
Spinal Cord
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Motor Neuron Disease (MND)
Motor Neuron Disease (MND)
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Meninges
Meninges
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Nerve
Nerve
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Afferent Nerves
Afferent Nerves
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Efferent Nerves
Efferent Nerves
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Spinal Nerves
Spinal Nerves
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Exteroceptors
Exteroceptors
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Interoceptors
Interoceptors
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Proprioceptors
Proprioceptors
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Monosynaptic pathway
Monosynaptic pathway
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Disynaptic pathway
Disynaptic pathway
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Electrical Conductance
Electrical Conductance
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Electrical Resistance
Electrical Resistance
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Voltage
Voltage
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Ionic concentration gradients
Ionic concentration gradients
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Action Potential
Action Potential
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Stimuli and Action Potential
Stimuli and Action Potential
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Resting membrane potential
Resting membrane potential
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Depolarization
Depolarization
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Repolarization
Repolarization
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Hyperpolarization
Hyperpolarization
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The sum of all inputs
The sum of all inputs
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Study Notes
- The nervous system is a regulatory communication network
- Allows organism to respond to stimuli and regulate metabolism/activity
- Detects/responds to external and internal environmental changes
- Regulates/coordinates bodily activities
- Conducts stimuli from receptors to brain and spinal cord
- Conducts impulses back to other body parts
- Nerve impulse code is based on the frequency/pattern of action potential firing
- Neurons have morphology and gene expression that enable electrical impulse conduction
Key Features of the Nervous System
- One of two major control systems (with endocrine system)
- Maintains homeostasis of nearly all physiological variables
- Information conveyed via fast electrochemical signaling
- Neuron (nerve cell) is the functional unit
Anatomical Divisions
- Central Nervous System (CNS) structures: Brain and spinal cord which are control centers
- Peripheral Nervous System (PNS) structures: 12 pairs of cranial nerves and 31 pairs of spinal nerves
- PNS functions: Communication between CNS and rest of the body
Functional Divisions: Sensory and Motor
- Spinal reflex arc includes: receptors, afferent signal, integration center, efferent signal, and effectors
Somatic and Visceral (Autonomic)
- Somatic nervous system innervates skeletal muscle for voluntary movement
- Autonomic nervous system innervates cardiac muscle, smooth muscle, and glands
- Regulates involuntary bodily functions
Sympathetic and Parasympathetic
- Sympathetic division regulates Fight or Flight response, primes body for activity
- Parasympathetic division is the Rest and Digest system
- Regulates normal automatic body functions
Enteric Nervous System
- A division of the autonomic nervous system located in the gastrointestinal tract lining
- Referred to as the 'little brain'
- Controls digestion processes
Cells of the Nervous System
- Neurons (nerve cells) are the functional unit specialized for electrochemical signaling
- Glia (support cells) don't directly relay signals but maintain the nervous system
Neurons
- Functional unit of nervous system
- Specialized for electrochemical signaling
- The human brain has ~85 billion neurons
- Dendrites and axons are referred to as neurites
Soma
- Contains same organelles as other cells
- Large nucleus relative to soma
- High demand for protein synthesis
- Proteins are packaged into vesicles and transported to axons
- Some organelles are more abundant in the soma
- Others in distal portions of axons and dendrites
Axons
- Neurons have a single axon which originates from the axon hillock
- Length varies widely
- Can branch off at right angles to form collaterals
- Biochemical composition distinct from soma
- Can be myelinated or unmyelinated
- Conduct action potentials
Axon Terminals & Synapses
- Synapse: region where information is transferred from a neuron to another target cell
- Pre-synaptic axon terminals enriched in synaptic vesicles, contain neurotransmitters
- Pre-synaptic terminals enriched with mitochondria, for high energy demands
- Post-synaptic membranes enriched with neurotransmitter receptors
Dendrites
- Number of dendrites varies per neuron
- Neurons display complex branching networks
- Rarely longer than 2mm, and not subjected to myelination
- Main sites for synaptic input
- Enriched in post-synaptic membrane components
- Can contain spines
Classifying Neurons
- Neurons classified based on: number of neurites dendrites, axon length neurotransmitter, location
Glia
- Glia do not conduct electrical impulses
- Modulate neuronal function
- Essential for maintaining nervous system microenvironment
Oligodendrocytes & Schwann Cells
- Oligodendrocytes myelinate axons in the CNS
- Schwann cells myelinate axons in the PNS
- Myelination increases action potential propagation and conduction velocity
- Restricts nerve impulse generation to less than 0.5% of the axon's surface at the nodes of Ranvier
Astrocytes
- Most abundant glial cell
- Star-like morphology
- Essential for synapse formation/maintenance
- Key regulators of neural chemical environment
- Buffer extracellular K+
- Take up/metabolize neurotransmitters from the synaptic cleft
- Supply metabolites to neurons
- Regulate blood flow and form part of the blood-brain barrier
Microglia
- Innate immune cells of the CNS, similar to macrophages
- Account for ~15% of brain cells
- Possess a ramified morphology
- Key defenders of the CNS, responding to injury/infection
- Phagocytose cellular debris
- Secrete cytokines and growth factors
Ependymal Cells
- Line the ventricles of the CNS, ciliated cells
- Form the Choroid Plexus, which generates cerebrospinal fluid (CSF)
- CSF flows through ventricular system into subarachnoid space
- CSF supplies CNS with metabolites and clears waste products
Grey & White Matter
- Grey matter: collections of neuronal cell bodies
- White matter: collections of axons
Neuroanatomy
- Sagittal: divides body into right and left parts
- Transverse: divides body into superior and inferior parts
- Coronal: divides body into anterior and posterior parts
CNS: The Brain
- Brain consists of 4 main parts: cerebrum, diencephalon, brainstem, cerebellum
- Neocortex: outer layer of the mammalian cerebral cortex
- Gyrus (gyri): Ridge on the neocortex
- Sulcus (Sulci): Groove in the neocortex
- Cerebrum lobes: Frontal (motor), Parietal (somatosensory), Temporal (auditory), Occipital (visual)
Cerebrum: Medial Temporal Lobe & Hippocampus
- Alzheimer’s Disease (AD)
- Most prevalent age-related neurodegenerative disease
- Leading cause of dementia
- Progressive cerebral cortex degeneration, initially in the medial temporal lobe
- Neuropathology: beta-amyloid plaques and neurofibrillary tangles
- Treatments manage symptoms but do not reverse progression
Diencephalon
- Parts: epithalamus, thalamus, subthalamus, and hypothalamus
- Thalamus: sensory integration hub of the brain
- Hypothalamus: regulates emotional behavior and whole-body homeostasis
- Central regulator of the autonomic nervous system
- Regulates endocrine function by innervating the pituitary
Brainstem
- Continuous with the spinal cord
- Midbrain, pons, and medulla oblongata
- Origin of the 12 pairs of cranial nerves
- Regulates motor function and processes essential to life
Parkinson’s Disease (PD)
- Second most prevalent neurodegenerative disease
- Movement disorder with resting tremor, rigidity, and postural gait impairment
- Caused by loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc)
- Neuropathology: Lewy bodies containing misfolded alpha-synuclein
Cerebellum
- Largest structure of the hindbrain
- Cortical layer of grey matter surrounds inner white matter
- Regulates unconscious movement, equilibrium, coordination, posture
Limbic System
- Brain system regulating mood and emotion
- Includes cerebrum and diencephalon structures
- Structures are anatomically interconnected
CNS: Spinal Cord
- Segmented structure within vertebral canal
- Origin of the 31 pairs of spinal nerves
- Receives sensory information from skin and viscera
- Relays sensory information to the brain (ascending pathway)
- Sends somatic and autonomic motor efferents to the periphery
Motor Neuron Disease (MND)
- Also known as amyotrophic lateral sclerosis (ALS)
- Impaired somatic innervation causes loss of ability to speak, move, swallow, and breath
- Primarily caused by loss ventral horn motor neurons
- Inclusions in ventral horn motor neurons and loss of axons in motor tract
- Neuropathology: protein aggregates/inclusions
CNS: Protective Elements
- CNS tissue encased in bone
- CNS tissue protected by three meninges: Dura Mater, Arachnoid membrane, Pia Mater
- Subarachnoid space contains cerebrospinal fluid (CSF) produced by the ventricular system CSF bathes CNS tissues
PNS: Nerve Structure
- Nerve is a collection of many myelinated axons in connective tissue layers
- Individual axons surrounded by endoneurium
- Perineurium binds groups of axons into fascicles
- Epineurium encloses the fascicles to form a nerve
- Nerves can be: Afferent (sensory), Efferent (motor), or Mixed (sensory and motor)
PNS: Cranial Nerves
- Cranial nerves (12 pairs) originate from the brainstem
- Receive stimuli and innervate tissues in head and face
PNS: Spinal Nerves
- 31 pairs of spinal nerves emerge from spinal cord
- Spinal nerves are mixed nerves (sensory and motor fibers)
- Sensory fibers project to CNS via dorsal roots
- Motor fibers project from CNS via ventral roots
PNS: Sensory Receptors
- Sensory receptors transduce mechanical, thermal, chemo, and painful stimuli into nerve impulses
- Exteroceptors: in skin, respond to pain, temperature, touch, and pressure
- Interoceptors: in viscera, respond to mechanical and chemical stimuli
- Proprioceptors: in muscles, joints, respond to postural awareness and movement
PNS: Efferent (motor) division
- Somatic nervous system: Monosynaptic pathway
- Neuron in CNS projects directly to skeletal muscle cell
- Autonomic nervous system: Disynaptic pathway
- Neuron in CNS projects to peripheral ganglionic neuron, which projects to visceral cell
PNS: Autonomic Nervous System
- Cell bodies of autonomic motor neurons are outside the CNS in autonomic ganglia
- These postganglionic neurons are innervated by preganglionic neurons in the CNS
- Preganglionic axons of the sympathetic nervous system emerge from the thoracic and lumbar spinal cord
- Preganglionic axons of the parasympathetic nervous system emerge from the brainstem and sacral spinal cord
Electricity: Key Terms & Principles
- Electrical Current: Net movement of electrical charge
- Electrical potential difference (voltage): Force exerted on a charged particle
- Arises due to the difference in electrical potential between two charged points
- Electrical Conductance: Ability of electrical charge to migrate (generate current)
- Electrical Resistance: Inability of electrical charge to migrate (inverse of conductance)
- Electrical current generation requires both conductance and voltage
The Axon
- Axon conductivity constrained by chemistry of cellular microenvironment
- Polar environments are separated by a non-polar hydrophobic barrier
- Ions carry electrical charge
- Ion movement (diffusion) influenced by concentration and electrostatic forces
Membranes and Ion Movement
- If ions cannot move across the membrane, electrical currents are not conducted
- Increased ionic permeability allows the membrane to conduct electrical current
- Pumps use ATP hydrolysis to transport ions against concentration gradients
Conducting Electricity: What Neurons Need
- Ionic concentration gradients across the cell membrane
- Differences between extracellular and intracellular concentrations of ions
- Voltage across the membrane creates electrostatic forces on ions
- Membrane permeability: selective ion channels allow certain ions to move across, ion pumps actively transport certain ions across the membrane
The Action Potential
- Transient reversal in voltage across the axonal membrane
- Instigated by a rapid change in membrane permeability to Na+
Properties of the Action Potential
- Action potentials are only fired once a critical threshold is met
- Propagate along the axon in a self-regenerating manner
- Size and duration do not change as conducted along the axon
- Nerve impulse code relayed by the frequency/pattern of action potential firing
- Stronger stimuli increase frequency of firing, not size of action potentials
Stages of the Action Potential
- Resting membrane potential: negative voltage (~ -65 mv) when action potentials aren’t fired
- Depolarization: membrane potential becomes more positive, characterizes rising phase
- Repolarization: membrane potential returns to negative value, characterizes falling phase
- Hyperpolarization: membrane potential becomes more negative, characterizes undershoot/refractory period
Molecular Basis of Resting Membrane Potential
- Na+ and K+ ions unevenly distributed
- K+ more concentrated in cytosol, Na+ more concentrated in extracellular fluid
- Resting membrane more permeable to K+ than Na+
- More positive charge lost from cell from K+ efflux than gained from Na+ influx
- Active transport maintains concentration gradients by pumping 3Na+ out and 2K+ in per ATP
- Resting membrane potential is negative because more positive charge flows out than in
Rising Phase (Depolarization)
- When membrane potential reaches critical threshold, voltage-gated sodium channels open
- Rapid influx of Na+ ions (inward positive current) and depolarization of the membrane
Falling Phase (Repolarization)
- Voltage-gated sodium channels become inactivated at peak
- Delayed opening of voltage-gated potassium channels causes efflux of K+ ions
- Outward flow of positive current, repolarizing the membrane
Undershoot/Refractory Period
- K+ efflux continues beyond the resting membrane potential (hyperpolarization)
- Prevents stimuli from depolarizing the membrane to the critical threshold
- Prevents a new action potential from being fired immediately
- Resting membrane potential is re-established by the sodium-potassium pump
Synaptic Transmission
- Sum of all inputs determines if a neuron generates an Action Potential
- Post-synaptic neuron receives thousands of pre-synaptic inputs from other neurons
- Sum of all excitatory and inhibitory inputs determines if post-synaptic neuron will be depolarized to the critical threshold for firing
Alzheimer’s Disease
- Therapeutic targeting of dysfunctional cholinergic and glutamatergic neurotransmitter pathways is used for symptomatic management
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