Introduction to Immunology

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Questions and Answers

What is the primary focus of immunology?

  • The study of genetic disorders
  • The study of how the body defends itself against invaders (correct)
  • The study of environmental impacts on health
  • The study of human anatomy

Which type of medical intervention is NOT typically associated with immunology?

  • Biologics
  • Vaccines
  • Surgical procedures (correct)
  • Immunotherapy

Which of the following is NOT a type of cancer immunotherapy?

  • Cell-based therapies
  • Chemotherapy (correct)
  • Antibody-based targeted therapies
  • Oncolytic viruses

Who is known for developing the vaccination against smallpox?

<p>Edward Jenner (A)</p> Signup and view all the answers

What key concept did John Marrack contribute to immunology?

<p>Antigen-antibody binding hypothesis (B)</p> Signup and view all the answers

Which of the following hypotheses involves the immune system's ability to tolerate self-antigens?

<p>Immunological tolerance hypothesis (B)</p> Signup and view all the answers

What historical discovery was made by Alick Isaacs and Jean Lindemann in 1957?

<p>Cytokine discovery (A)</p> Signup and view all the answers

In which branch of immunology do specialists focus on patients with autoimmune diseases?

<p>Clinical Immunology (C)</p> Signup and view all the answers

What is the primary function of the innate immune system in the context of immune defenses?

<p>It provides the first line of defense against infection. (B)</p> Signup and view all the answers

Which of the following is NOT considered an external defense mechanism?

<p>Inflammatory response (D)</p> Signup and view all the answers

What distinguishes the adaptive immune system from the innate immune system?

<p>It has the ability to remember previous antigen encounters. (B)</p> Signup and view all the answers

How does the innate immune system interact with the adaptive immune system?

<p>Cues from the innate system inform the adaptive system to respond to infections. (D)</p> Signup and view all the answers

What is meant by immunologic tolerance in the immune system?

<p>The immune system's ability to differentiate between self and foreign antigens. (D)</p> Signup and view all the answers

Which of the following mechanisms is primarily responsible for recognizing and eliminating foreign microbes?

<p>The adaptive immune system's specific recognition of antigens. (B)</p> Signup and view all the answers

Which of the following is a characteristic feature of the immune system?

<p>It can remember past infections for improved future responses. (D)</p> Signup and view all the answers

What role do cytokines and chemokines play in the immune system?

<p>They mediate communication between cells of the innate and adaptive immune systems. (D)</p> Signup and view all the answers

Flashcards

What is Immunology?

The study of how the body defends itself against invading organisms, like bacteria and viruses, as well as internal threats like tumors.

Variolation

Smallpox is a serious infectious disease caused by the variola virus. Variolation was an early method of vaccination using material from smallpox pustules. This risky procedure was practiced in China and India centuries ago.

Immunotherapy

A type of therapy that strengthens the immune system to fight cancer.

Biologics

These are therapies that target specific parts of the immune system to treat autoimmune diseases. They can be monoclonal antibodies or fusion proteins.

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Cell-based Immunotherapy

This involves using cells from the immune system to directly fight cancer.

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Immunomodulators

This refers to different types of drugs that modify the immune system's response.

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Cancer Vaccines

These therapies aim to stimulate the immune system to attack specific cancer cells.

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Oncolytic Viruses

These are a type of therapy that uses viruses engineered to specifically target and kill cancer cells.

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Innate Immune System

A critical component of the immune system, providing the initial rapid response to infections. Its key features include speed, lack of memory, and general recognition of foreign substances.

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Adaptive Immune System

A sophisticated arm of the immune system, characterized by highly specific recognition of foreign antigens and the ability to remember past encounters. This creates a more precise and lasting immune response.

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Immunological Tolerance

The immune system's ability to tolerate self-molecules while recognizing and attacking foreign invaders. This prevents the immune system from harming the body's own tissues.

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Immune Response

The immune system's process of generating a specific and targeted response against a particular antigen, usually a foreign molecule. This involves activation of specific cells and production of antibodies.

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Antigens

Molecules that stimulate an immune response, often associated with foreign invaders like bacteria or viruses. They can be recognized by the immune system's cells and receptors, triggering a reaction.

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Phagocytosis

The process of engulfing and destroying foreign particles, including bacteria and viruses, by certain immune cells. This is a key mechanism of innate immunity.

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B Cells

Specialized immune cells that produce antibodies, which are proteins that bind to specific antigens, helping to neutralize them and control infections.

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Immune Memory

The immune system's long-term memory of past encounters with specific antigens. This allows for faster and stronger responses upon subsequent exposures to the same antigen.

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Study Notes

What is Immunology?

  • Latin immunitas : freedom from disease
  • Study of how the body defends itself
  • Covers internal invaders (tumors)
  • Crucial medical science for developing treatments and preventing diseases

Healthcare Advances

  • Vaccines: Prevent diseases
  • Immunotherapy: Boosts the immune system to fight cancer
  • Biologics (Monoclonal Antibodies): Target specific aspects of the immune system to combat autoimmune issues

Types of Cancer Immunotherapies

  • Cell-based therapies
  • Immunomodulators
  • Vaccines
  • Antibody-based therapies
  • Oncolytic viruses

Historical Events

  • 5th Century BC: Thucydides observed immunity to plague
  • 10th-18th Centuries: Variolation (a method of inducing immunity) against smallpox was practiced by Chinese
  • 1798: Edward Jenner developed smallpox vaccination
  • 18th Century: Germ theory of disease was introduced by Pasteur and Koch
  • 1881: Emile Roux and Yersin isolated diphtheria toxin
  • 1884: Elie Metchnikoff studied phagocytosis
  • 1890s: Paul Ehrlich identified immune defense systems
  • 1890: Emil von Behring and Shibasaburo Kitasato discovered diphtheria antitoxin.
  • 1938: John Marrack formulated antigen-antibody binding hypothesis
  • 1949: Macfarlane Burnet and Frank Fenner formulated immunological tolerance hypothesis
  • 1959: Niels Jerne, David Talmage, and Macfarlane Burnet developed the clonal selection theory
  • 1957: Alick Isaacs and Jean Lindemann discovered interferon
  • 1962: Noel Warner and team distinguished between cellular and humoral immune responses
  • 1968: Anthony Davis and team discovered T cell and B cell cooperation in immune responses
  • 1974: Rolf Zinkernagel and Peter Doherty explored major histocompatibility complex restriction
  • 1985: Susumu Tonegawa and Leroy Hood identified immunoglobulin genes

Branches of Immunology

  • Clinical Immunology: Specializes in immune system deficiencies

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