8 Questions
Which of the following is a constraint for amino acids in peripheral vein delivery?
Insolubility of tyrosine
What is the purpose of giving a precursor that is more soluble than tyrosine?
To address tyrosine insolubility
What is the percentage of nitrogen intake retained by pigglets?
70%
What is the body weight gain of young piglets fed a protein deficient diet?
15%
Explain the challenges associated with delivering amino acids to peripheral veins and bypassing liver metabolism. What are the constraints for amino acids in this context?
The challenges include constraints such as solubility and stability of amino acids, with some amino acids being insoluble (e.g., tyrosine) and unstable (e.g., glutamine). Additionally, bypassing liver metabolism and splanchnic control poses significant constraints for amino acids in this context.
How can the challenges of tyrosine insolubility and transient hyperphenylalaninemia be addressed when designing the optimal amino acid profile for intravenous regimens?
The challenges of tyrosine insolubility and transient hyperphenylalaninemia can be addressed by providing precursors that are more soluble than tyrosine, such as N-acetyltyrosine, and by ensuring the appropriate balance of phenylalanine and tyrosine to support protein synthesis and nitrogen retention.
What is the relationship between nitrogen intake and weight gain in piglets, and what implications does this have for their diet?
The text suggests that 100% retention of nitrogen intake leads to more weight gain, while 0% retention leads to no weight gain. This implies that nitrogen intake is crucial for weight gain in piglets, and optimizing their diet to retain nitrogen is important for their growth.
What are the potential implications of adding phenylalanine to see tyrosine specifically in piglets, and why is this approach not ideal for infants?
Adding phenylalanine to see tyrosine specifically could lead to effective utilization, but this method is expensive. Additionally, it may not be the ideal solution for infants as they may not be able to metabolize the extra phenylalanine faster.
Test your knowledge on designing parenteral/intravenous regimens for delivering amino acids to peripheral veins while bypassing liver metabolism. Explore the constraints, solubility, stability, and composition of free amino acids, and their interaction with lipids in intravenous solutions.
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