Podcast
Questions and Answers
Which class of enzyme-coupled receptors is the most common?
Which class of enzyme-coupled receptors is the most common?
- Receptor tyrosine kinases (correct)
- Phospholipase C
- Ras
- Gq
What activity does the receptor tyrosine kinase have?
What activity does the receptor tyrosine kinase have?
- GTP binding
- Activation of Ras
- Intrinsic enzyme activity (correct)
- Phosphorylation
What happens when the receptor tyrosine kinase binds to a ligand?
What happens when the receptor tyrosine kinase binds to a ligand?
- It phosphorylates itself on specific residues
- It dimerizes and activates a tyrosine kinase (correct)
- It activates phospholipase C
- It binds to GTP and activates Ras
What is the function of Ras in the signaling cascade?
What is the function of Ras in the signaling cascade?
Which of the following is NOT a ligand example for receptor tyrosine kinases?
Which of the following is NOT a ligand example for receptor tyrosine kinases?
What is the role of the ligand in the signaling process of receptor tyrosine kinases?
What is the role of the ligand in the signaling process of receptor tyrosine kinases?
What is the function of phospholipase C in the signaling pathway of receptor tyrosine kinases?
What is the function of phospholipase C in the signaling pathway of receptor tyrosine kinases?
What does the activation of Ras lead to in the signaling pathway of receptor tyrosine kinases?
What does the activation of Ras lead to in the signaling pathway of receptor tyrosine kinases?
What is the function of Raf in the signaling cascade of receptor tyrosine kinases?
What is the function of Raf in the signaling cascade of receptor tyrosine kinases?
What is the role of the ligand in the dimerization of receptor tyrosine kinases?
What is the role of the ligand in the dimerization of receptor tyrosine kinases?
Which pathway is most commonly associated with RTK activation?
Which pathway is most commonly associated with RTK activation?
What is the key signaling mechanism that is key to insulin signaling?
What is the key signaling mechanism that is key to insulin signaling?
Which molecule is the second messenger in the PI-3-Kinase (PI3K) → Akt system?
Which molecule is the second messenger in the PI-3-Kinase (PI3K) → Akt system?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What is the key mediator that relaxes smooth muscle in a wide variety of blood vessels and visceral organs?
What is the key mediator that relaxes smooth muscle in a wide variety of blood vessels and visceral organs?
What is the molecule produced enzymatically by the action of nitric oxide synthase (NOs) on L-arginine?
What is the molecule produced enzymatically by the action of nitric oxide synthase (NOs) on L-arginine?
What molecule is produced from GTP by guanylyl cyclase (GC) in the nitric oxide-mediated signaling pathway?
What molecule is produced from GTP by guanylyl cyclase (GC) in the nitric oxide-mediated signaling pathway?
What molecule is activated by elevations in cytosolic cGMP in the nitric oxide-mediated signaling pathway?
What molecule is activated by elevations in cytosolic cGMP in the nitric oxide-mediated signaling pathway?
What is the result of PKG activity in many cases in the nitric oxide-mediated signaling pathway?
What is the result of PKG activity in many cases in the nitric oxide-mediated signaling pathway?
What is the most common pathway associated with RTK activation?
What is the most common pathway associated with RTK activation?
Which of the following is a general model of intracellular signaling?
Which of the following is a general model of intracellular signaling?
What is the function of phospholipase C in the signaling pathway of receptor tyrosine kinases?
What is the function of phospholipase C in the signaling pathway of receptor tyrosine kinases?
What is the role of Ras in the signaling cascade of receptor tyrosine kinases?
What is the role of Ras in the signaling cascade of receptor tyrosine kinases?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What is the function of Raf in the signaling cascade of receptor tyrosine kinases?
What is the function of Raf in the signaling cascade of receptor tyrosine kinases?
What is the key mediator that relaxes smooth muscle in a wide variety of blood vessels and visceral organs?
What is the key mediator that relaxes smooth muscle in a wide variety of blood vessels and visceral organs?
Which of the following is a key function of membrane receptors in intracellular signaling?
Which of the following is a key function of membrane receptors in intracellular signaling?
What is the role of effectors in intracellular signaling?
What is the role of effectors in intracellular signaling?
What happens when the concentration of the first messenger (ligand) increases in intracellular signaling?
What happens when the concentration of the first messenger (ligand) increases in intracellular signaling?
What is the typical process of signal termination in intracellular signaling?
What is the typical process of signal termination in intracellular signaling?
What does the model of intracellular signaling offer?
What does the model of intracellular signaling offer?
Which type of cell membrane receptor is described in the text?
Which type of cell membrane receptor is described in the text?
Which of the following is true about G-protein-coupled receptors (GPCRs)?
Which of the following is true about G-protein-coupled receptors (GPCRs)?
What is the structure of a G-protein-coupled receptor (GPCR)?
What is the structure of a G-protein-coupled receptor (GPCR)?
Which G-protein mechanism uses calcium and IP3 as second messenger systems?
Which G-protein mechanism uses calcium and IP3 as second messenger systems?
What is the impact of Gs GPCR on adenylyl cyclase activity?
What is the impact of Gs GPCR on adenylyl cyclase activity?
What is the result of cAMP binding to protein kinase A (PK A)?
What is the result of cAMP binding to protein kinase A (PK A)?
What is the function of adenylyl cyclase in G-protein-coupled receptor signaling?
What is the function of adenylyl cyclase in G-protein-coupled receptor signaling?
According to the text, what is the concentration gradient for calcium between the cytosol and the endoplasmic reticulum and extracellular space?
According to the text, what is the concentration gradient for calcium between the cytosol and the endoplasmic reticulum and extracellular space?
What happens to the cytosolic calcium concentration if a channel that allows calcium to cross the cell membrane is opened?
What happens to the cytosolic calcium concentration if a channel that allows calcium to cross the cell membrane is opened?
What is the impact on the membrane potential if sodium enters the cell?
What is the impact on the membrane potential if sodium enters the cell?
What is the impact on the activation of certain membrane-associated proteins if the membrane becomes more inside-positive or more inside-negative?
What is the impact on the activation of certain membrane-associated proteins if the membrane becomes more inside-positive or more inside-negative?
What is the function of Gq-alpha in the Gq GPCR signaling pathway?
What is the function of Gq-alpha in the Gq GPCR signaling pathway?
What is the ligand example for receptor tyrosine kinases?
What is the ligand example for receptor tyrosine kinases?
Which molecule is phosphorylated by the receptor tyrosine kinase in the signaling process?
Which molecule is phosphorylated by the receptor tyrosine kinase in the signaling process?
What is the function of phosphoinositide-3-kinase (PI3K) in the PI-3-Kinase (PI3K) → Akt system?
What is the function of phosphoinositide-3-kinase (PI3K) in the PI-3-Kinase (PI3K) → Akt system?
What is the key role of Ras in the signaling cascade of receptor tyrosine kinases?
What is the key role of Ras in the signaling cascade of receptor tyrosine kinases?
What is the function of guanylyl cyclase (GC) in the nitric oxide-mediated signaling pathway?
What is the function of guanylyl cyclase (GC) in the nitric oxide-mediated signaling pathway?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What is the most common pathway associated with receptor tyrosine kinase (RTK) activation?
What is the most common pathway associated with receptor tyrosine kinase (RTK) activation?
Which molecule is the second messenger in the PI-3-Kinase (PI3K) → Akt system?
Which molecule is the second messenger in the PI-3-Kinase (PI3K) → Akt system?
What is the result of PKG activity in many cases in the nitric oxide-mediated signaling pathway?
What is the result of PKG activity in many cases in the nitric oxide-mediated signaling pathway?
What is the function of phospholipase C in the signaling pathway of receptor tyrosine kinases?
What is the function of phospholipase C in the signaling pathway of receptor tyrosine kinases?
What is the key mediator that relaxes smooth muscle in a wide variety of blood vessels and visceral organs?
What is the key mediator that relaxes smooth muscle in a wide variety of blood vessels and visceral organs?
What is the function of Ras in the signaling cascade of receptor tyrosine kinases?
What is the function of Ras in the signaling cascade of receptor tyrosine kinases?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What is the effector molecule in the PI-3-Kinase (PI3K) → Akt system?
What happens when the concentration of the first messenger (ligand) increases in intracellular signaling?
What happens when the concentration of the first messenger (ligand) increases in intracellular signaling?
Which pathway is most commonly associated with RTK activation?
Which pathway is most commonly associated with RTK activation?
What is the function of guanylyl cyclase (GC) in the nitric oxide-mediated signaling pathway?
What is the function of guanylyl cyclase (GC) in the nitric oxide-mediated signaling pathway?
What molecule is phosphorylated by the receptor tyrosine kinase in the signaling process?
What molecule is phosphorylated by the receptor tyrosine kinase in the signaling process?
Flashcards are hidden until you start studying
