Podcast
Questions and Answers
Where are most neurotransmitter receptors commonly thought to be located?
Where are most neurotransmitter receptors commonly thought to be located?
- Plasma membrane (correct)
- Mitochondria and endoplasmic reticulum
- Nuclear membranes and endoplasmic reticulum
- Endosomes and Golgi apparatus
Which subtype is generally the most abundant within the CNS for muscarinic AChRs?
Which subtype is generally the most abundant within the CNS for muscarinic AChRs?
- M3
- M5
- M2
- M1 (correct)
In which region of rodents and humans were intracellular membranes of M1 mAChRs found?
In which region of rodents and humans were intracellular membranes of M1 mAChRs found?
- Hippocampus and other telencephalon regions (correct)
- Cortex and thalamus
- Spinal cord and optic nerve
- Cerebellum and brainstem
According to recent studies, where have M1 mAChRs been found in addition to the cell surface?
According to recent studies, where have M1 mAChRs been found in addition to the cell surface?
What has recent evidence suggested about the location of several G-protein-coupled receptors including AChRs?
What has recent evidence suggested about the location of several G-protein-coupled receptors including AChRs?
Which of the following statements about the expression of muscarinic AChR subtypes is accurate?
Which of the following statements about the expression of muscarinic AChR subtypes is accurate?
Where are the intracellular M1 mAChRs immunohistochemically shown to localize?
Where are the intracellular M1 mAChRs immunohistochemically shown to localize?
What is the main intracellular site where M1 mAChRs are abundantly distributed in pyramidal neurons?
What is the main intracellular site where M1 mAChRs are abundantly distributed in pyramidal neurons?
Which pathway is exclusively mediated by surface M1 mAChRs on a time scale of seconds?
Which pathway is exclusively mediated by surface M1 mAChRs on a time scale of seconds?
What does the C-terminal tryptophan-based motif of M1 subtype require for intracellular localization?
What does the C-terminal tryptophan-based motif of M1 subtype require for intracellular localization?
Where are the intracellular M1 mAChRs immunohistochemically shown to detect in cerebral cortex neurons?
Where are the intracellular M1 mAChRs immunohistochemically shown to detect in cerebral cortex neurons?
What is the main extracellular site where M1 mAChRs are detected in cerebral cortex neurons?
What is the main extracellular site where M1 mAChRs are detected in cerebral cortex neurons?
What type of binding density is used to detect total mAChRs?
What type of binding density is used to detect total mAChRs?
What is the main effect caused by M1 mAChRs through the Gαq/11 protein?
What is the main effect caused by M1 mAChRs through the Gαq/11 protein?
What is the main pathway activated by intracellular M1 mAChRs on a slow time scale of minutes?
What is the main pathway activated by intracellular M1 mAChRs on a slow time scale of minutes?
What is the main function with which M1 mAChRs are involved in the CNS?
What is the main function with which M1 mAChRs are involved in the CNS?
