Intestinal Gas and Cough Quiz
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Questions and Answers

Which antihistamine is recommended for acute motion sickness in adults?

  • Diphenhydramine
  • Meclizine (correct)
  • Levocetirizine
  • Cetirizine

Which of the following is a key characteristic of 2nd generation antihistamines compared to 1st generation?

  • They cause significant sedation.
  • They have minimal to no anticholinergic effects. (correct)
  • They cross the blood-brain barrier.
  • They require multiple daily doses.

What is the maximum daily dosage for Diphenhydramine in adults?

  • 300 mg (correct)
  • 400 mg
  • 500 mg
  • 200 mg

What is a common indication for Doxylamine?

<p>Insomnia (A)</p> Signup and view all the answers

For which condition is Fexofenadine indicated?

<p>Seasonal allergic rhinitis (B)</p> Signup and view all the answers

Why are 1st generation antihistamines generally avoided in elderly patients?

<p>Higher incidence of anticholinergic side effects (B)</p> Signup and view all the answers

How often should Loratadine be dosed for adults?

<p>Once daily (C)</p> Signup and view all the answers

What is a characteristic side effect of 1st generation antihistamines?

<p>Blurry vision (D)</p> Signup and view all the answers

Which of the following is NOT a common dietary contributor to intestinal gas?

<p>Rice (B)</p> Signup and view all the answers

What is the primary action of dextromethorphan as an OTC antitussive?

<p>Suppresses the cough reflex in the medulla (B)</p> Signup and view all the answers

Which medication is specifically known to decrease mucus viscosity in the treatment of cough?

<p>Guaifenesin (C)</p> Signup and view all the answers

Which of the following should not be considered a reason for referral in cases of cough?

<p>Mild occasional hacking (A)</p> Signup and view all the answers

Which factor is considered a risk factor for increased intestinal gas production?

<p>Carbonated beverages (B)</p> Signup and view all the answers

Which of the following is the mechanism of action of intranasal steroids like fluticasone for allergic rhinitis?

<p>Reduce nasal inflammation (B)</p> Signup and view all the answers

In the context of musculoskeletal pain, which of the following summarizes the role of capsaicin?

<p>Depletes substance P (A)</p> Signup and view all the answers

What is a recommended lifestyle adjustment to reduce intestinal gas?

<p>Eat slowly (A)</p> Signup and view all the answers

What is the maximum daily dose of ibuprofen for over-the-counter use in adults?

<p>1200 mg (D)</p> Signup and view all the answers

What mechanism of action does acetaminophen primarily utilize?

<p>Inhibition of prostaglandin synthesis in the CNS (B)</p> Signup and view all the answers

Which of the following types of headaches is considered a primary headache?

<p>Migraine headache (D)</p> Signup and view all the answers

What is the referral criterion for a patient with fever?

<p>Fever lasting longer than 3 days (C)</p> Signup and view all the answers

For which of the following conditions is loperamide typically used?

<p>Diarrhea (B)</p> Signup and view all the answers

Which agent is first-line treatment for mild to moderate tension headaches?

<p>NSAIDs (D)</p> Signup and view all the answers

Which of the following is an indication for referral in cases of fungal infections?

<p>Chronic infections with systemic symptoms (C)</p> Signup and view all the answers

What does the pathophysiology of heartburn encompass?

<p>Reflux of stomach acid into the esophagus (B)</p> Signup and view all the answers

Which of the following treatments may be used for severe acne?

<p>Isotretinoin (A)</p> Signup and view all the answers

What is the appropriate dosing of ibuprofen for a child weighing 20 kg?

<p>100-200 mg per dose (C)</p> Signup and view all the answers

What nonpharmacologic approach is recommended for managing nausea and vomiting?

<p>Regular hydration (D)</p> Signup and view all the answers

What complication can arise from excessive acetaminophen use?

<p>Hepatotoxicity (D)</p> Signup and view all the answers

What is the purpose of using proton pump inhibitors (PPIs) in managing dyspepsia?

<p>Inhibit H+/K+ ATPase (B)</p> Signup and view all the answers

What should be monitored when alternating ibuprofen and acetaminophen in treatment?

<p>Hydration status (A)</p> Signup and view all the answers

What is the duration of diarrhea lasting less than 14 days classified as?

<p>Acute Diarrhea (C)</p> Signup and view all the answers

What is the duration of diarrhea lasting between 14 and 30 days classified as?

<p>Persistent Diarrhea (B)</p> Signup and view all the answers

What is the duration of diarrhea lasting more than 30 days classified as?

<p>Chronic Diarrhea (A)</p> Signup and view all the answers

What is the definition of diarrhea?

<p>3 loose or watery stools per day</p> Signup and view all the answers

What is the preferred method for treating dehydration?

<p>Oral hydration (B)</p> Signup and view all the answers

When is parenteral hydration recommended?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following symptoms warrant a referral to a healthcare professional?

<p>All of the above (H)</p> Signup and view all the answers

What is the first-line therapy for dehydration?

<p>Reduced osmolarity oral rehydration solution (ORS)</p> Signup and view all the answers

ORS is recommended for whom?

<p>All of the above (D)</p> Signup and view all the answers

Low-osmolarity ORS is safe for use in all age groups with any cause of diarrhea.

<p>True (A)</p> Signup and view all the answers

Which of the following products are not ideal for rehydration?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following represents a 3-5% fluid loss?

<p>Mild dehydration (B)</p> Signup and view all the answers

Which of the following represents a fluid loss greater than 10%?

<p>Severe dehydration (B)</p> Signup and view all the answers

What is the recommended rehydration volume for infants and children with mild to moderate dehydration?

<p>50-100 mL/kg over 3-4 hours</p> Signup and view all the answers

What is the recommended rehydration volume for adolescents and adults with mild to moderate dehydration?

<p>2-4 L</p> Signup and view all the answers

What is the treatment for severe dehydration?

<p>IV isotonic crystalloid boluses as per current resuscitation guidelines</p> Signup and view all the answers

What should be done during maintenance hydration therapy?

<p>Replace the fluid losses</p> Signup and view all the answers

Dehydration should be evaluated in all ages, not just infants and children.

<p>True (A)</p> Signup and view all the answers

Which of the following symptoms are indicative of severe dehydration?

<p>All of the above (E)</p> Signup and view all the answers

What type of stool testing is recommended in specific cases?

<p>All of the above (G)</p> Signup and view all the answers

Traveler's diarrhea lasting more than 14 days should be evaluated for what?

<p>Intestinal parasitic infections (A)</p> Signup and view all the answers

What is the recommended hydration strategy until symptoms abate?

<p>Maintain increased hydration</p> Signup and view all the answers

Which of the following situations would warrant a referral to the ER?

<p>Both of the above (C)</p> Signup and view all the answers

If symptoms improve, it is not necessary to assess further treatment options.

<p>False (B)</p> Signup and view all the answers

What is skin turgor assessment used for?

<p>To determine level of dehydration</p> Signup and view all the answers

What is the appearance of the eyes in mild dehydration?

<p>Normal (C)</p> Signup and view all the answers

What is the appearance of the eyes in moderate dehydration?

<p>Sunken (B)</p> Signup and view all the answers

What is the tear production in infants with mild dehydration?

<p>Present (A)</p> Signup and view all the answers

What is the tear production in infants with moderate dehydration?

<p>Decreased (A)</p> Signup and view all the answers

What is the urine output in mild dehydration?

<p>Mildly reduced (C), Normal (D)</p> Signup and view all the answers

What is the urine output in moderate dehydration?

<p>Markedly reduced (B)</p> Signup and view all the answers

What does ORS stand for?

<p>Oral Rehydration Solutions</p> Signup and view all the answers

What is an electrolyte discrepancy?

<p>Difference in electrolyte levels between ORS and beverages.</p> Signup and view all the answers

What is the sodium content in CeraLyte ORS?

<p>40 mEq/L</p> Signup and view all the answers

What is the range of sodium content in apple juice?

<p>100-150 mEq/L</p> Signup and view all the answers

What is the typical osmolarity range of ORS?

<p>200-250 mOSM/kg</p> Signup and view all the answers

What is the osmolarity of apple juice?

<p>700 mOSM/kg</p> Signup and view all the answers

What is loperamide?

<p>OTC medication for acute diarrhea management.</p> Signup and view all the answers

What is bismuth subsalicylate used for?

<p>Diarrhea and gastric distress management.</p> Signup and view all the answers

What is the initial loperamide dose for adults?

<p>4 mg</p> Signup and view all the answers

What is the loperamide dose after each unformed stool for adults?

<p>2 mg</p> Signup and view all the answers

Loperamide dosing for children is standardized based on age and weight.

<p>True (A)</p> Signup and view all the answers

What potential risk is associated with bismuth subsalicylate in children?

<p>Reye's Syndrome</p> Signup and view all the answers

Bismuth subsalicylate can prevent traveler's diarrhea.

<p>True (A)</p> Signup and view all the answers

Who should exercise caution when taking bismuth subsalicylate?

<p>Both of the above (C)</p> Signup and view all the answers

What is the maximum daily dose of bismuth subsalicylate for gastric distress?

<p>4200 mg</p> Signup and view all the answers

What is the bismuth subsalicylate dose for diarrhea treatment?

<p>524 mg PO four times daily</p> Signup and view all the answers

Probiotics may reduce the severity and duration of diarrhea.

<p>True (A)</p> Signup and view all the answers

Zinc supplementation has been shown to reduce diarrhea duration in malnourished children.

<p>True (A)</p> Signup and view all the answers

Bismuth subsalicylate may affect blood glucose levels.

<p>True (A)</p> Signup and view all the answers

Bismuth subsalicylate poses a risk of salicylate toxicity in patients with renal impairment.

<p>True (A)</p> Signup and view all the answers

Salicylates can interfere with medications used for gout.

<p>True (A)</p> Signup and view all the answers

What are the key components of ORS?

<p>Sodium, potassium, and carbohydrates</p> Signup and view all the answers

What is the osmolarity of colas?

<p>550 mOSM/kg</p> Signup and view all the answers

Geriatric patients have an increased risk of salicylate toxicity.

<p>True (A)</p> Signup and view all the answers

Anti-motility medications are generally recommended for children under 18 with infectious diarrhea.

<p>False (B)</p> Signup and view all the answers

Diagnostic testing is routinely recommended for uncomplicated traveler's diarrhea.

<p>False (B)</p> Signup and view all the answers

Which of the following beverages are inappropriate for ORS?

<p>Both of the above (C)</p> Signup and view all the answers

What is the potassium content in chicken broth?

<p>250 mEq/L</p> Signup and view all the answers

Compare the sodium content of Gatorade to ORS.

<p>Gatorade has 61 mEq/L sodium, lower than ORS.</p> Signup and view all the answers

What is a recommended first-line treatment for allergic conjunctivitis?

<p>Combined dual action antihistamine/mast cell stabilizers (B)</p> Signup and view all the answers

What potential issue should be considered when prescribing oral antihistamines for patients with allergic conjunctivitis?

<p>Worsening of dry eye syndrome (D)</p> Signup and view all the answers

What is one of the primary goals of treating allergic conjunctivitis?

<p>Control symptoms and minimize inflammation (D)</p> Signup and view all the answers

What caution should be provided regarding combination ocular antihistamines/vasoconstrictors?

<p>They may lead to rebound symptoms and reduced effectiveness (A)</p> Signup and view all the answers

How can the use of artificial tears benefit patients using oral antihistamines for allergic conjunctivitis?

<p>They can help alleviate tear deficiency and reduce inflammation (B)</p> Signup and view all the answers

Which symptom is NOT characteristic of bacterial acute rhinosinusitis (ARS)?

<p>Persistent cough for less than 7 days (D)</p> Signup and view all the answers

What is the main reason antibiotics may not be necessary for treating bacterial sinusitis?

<p>Most sinusitis cases improve with symptomatic management (A)</p> Signup and view all the answers

What is the definition of 'double-sickening' in the context of bacterial sinusitis?

<p>Worsening symptoms after an initial improvement (A)</p> Signup and view all the answers

Which of the following is a recommended approach to managing bacterial sinusitis symptoms when antibiotics are not indicated?

<p>Increased fluid intake and rest (A)</p> Signup and view all the answers

Which laboratory markers are often elevated in cases of bacterial ARS indicating inflammation?

<p>C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (C)</p> Signup and view all the answers

Which of the following statements is true regarding the use of intranasal corticosteroids (INCS) in young patients?

<p>2nd generation INCS may minimize systemic exposure and are preferred. (A)</p> Signup and view all the answers

What is an important therapeutic effect of azelastine (Astepro) beyond its antihistaminic properties?

<p>It acts as a mast cell stabilizer. (B)</p> Signup and view all the answers

What is a common local side effect reported by 2 to 10 percent of patients using intranasal sprays?

<p>Nasal irritation or burning. (D)</p> Signup and view all the answers

Which group of patients is budesonide (Rhinocort) particularly recommended for?

<p>Pregnant patients. (B)</p> Signup and view all the answers

What is the duration for which INCS are recommended to be used?

<p>Less than 5 days. (D)</p> Signup and view all the answers

What is a caution regarding formulations containing alcohol or propylene glycol in intranasal sprays?

<p>They can cause increased nasal irritation. (C)</p> Signup and view all the answers

In patients with longstanding untreated allergic rhinitis symptoms, what is notable about the maximal effect of intranasal corticosteroids?

<p>It may take days or even weeks to achieve. (A)</p> Signup and view all the answers

What component of the IgE mediated pathways does azelastine effectively mitigate?

<p>Histamine release. (B)</p> Signup and view all the answers

Which of the following tests is primarily recommended for patients with a clinical suspicion of pneumonia?

<p>Chest X-ray (D)</p> Signup and view all the answers

What is a commonly recognized symptom of rhinosinusitis?

<p>Thick nasal discharge (A)</p> Signup and view all the answers

Which condition presents similarly to rhinosinusitis but is differentiated by the absence of inflammation in the sinuses?

<p>Allergic rhinitis (C)</p> Signup and view all the answers

What is a potential treatment for malaise associated with viral upper respiratory symptoms?

<p>Analgesics (D)</p> Signup and view all the answers

What symptom might indicate that a patient's viral upper respiratory symptoms are not resolving?

<p>Symptoms persisting beyond 3 weeks (D)</p> Signup and view all the answers

Which of the following symptoms predominates in the first three days of viral upper respiratory symptoms?

<p>Sore throat and malaise (D)</p> Signup and view all the answers

In which scenarios is chest X-ray testing most appropriate?

<p>Patients with suspected pneumonia and comorbid conditions (A)</p> Signup and view all the answers

What differentiates allergic rhinitis from rhinosinusitis regarding relief methods?

<p>Allergic rhinitis is treated using antihistamines, not antibiotics (B)</p> Signup and view all the answers

What is the maximum duration of use for intranasal decongestants to avoid rebound congestion?

<p>5 consecutive days (A)</p> Signup and view all the answers

Which of the following oral second generation antihistamines has the lowest recommended daily dose?

<p>Levocetirizine (A)</p> Signup and view all the answers

Which decongestant is contraindicated in patients with uncontrolled hypertension?

<p>Phenylephrine (D)</p> Signup and view all the answers

Which of the following symptoms is NOT commonly associated with the use of second-generation antihistamines?

<p>Dry mouth (C)</p> Signup and view all the answers

What is the maximum recommended dosage for Oxymetazoline in a 24-hour period?

<p>2 doses every 12 hours (C)</p> Signup and view all the answers

Which oral antihistamine is dosed only once daily at a maximum of 120 mg?

<p>Fexofenadine (B)</p> Signup and view all the answers

What is the maximum duration for the use of Benzedrex (Propylhexedrine)?

<p>3 days (A)</p> Signup and view all the answers

Which medication is found in combination menstruation products along with acetaminophen and caffeine?

<p>Pyrilamine (B)</p> Signup and view all the answers

What is the primary action of azelastine as an H1-receptor antagonist?

<p>Blocking the binding of histamine to H1-receptors (B)</p> Signup and view all the answers

Which mediator besides histamine does azelastine inhibit that is related to allergic reactions?

<p>Leukotrienes (C)</p> Signup and view all the answers

What potential effect does azelastine have on eosinophils?

<p>Inhibition of eosinophil activation (A)</p> Signup and view all the answers

Which of the following statements about second generation antihistamines is correct?

<p>They prevent histamine from binding to H1 receptors. (C)</p> Signup and view all the answers

What is one advantage of azelastine over oral first generation antihistamines?

<p>Does not cause systemic anticholinergic effects (B)</p> Signup and view all the answers

Which statement best describes the mechanism of action for oral second generation antihistamines?

<p>They compete with free histamine for binding at H1 receptor sites. (D)</p> Signup and view all the answers

What characteristic differentiates azelastine from oral second generation antihistamines?

<p>Azelastine inhibits histamine release from mast cells. (A)</p> Signup and view all the answers

How does azelastine potentially interfere with bronchospasm?

<p>By inhibiting histamine-induced bronchospasm (A)</p> Signup and view all the answers

Flashcards

Intestinal Gas

Gas in the gut caused by swallowed air or bacterial fermentation, leading to bloating, flatulence, and abdominal discomfort.

Dietary Contributors to Gas

Foods like beans, broccoli, onions, and dairy (for lactose-intolerant individuals) are common culprits.

Cough Reflex

Triggered by irritation in the respiratory tract, it signals the medulla oblongata to expel irritants.

OTC Antitussives

Medications like codeine and dextromethorphan suppress the cough center in the medulla.

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Allergic Rhinitis

Triggered by allergens, causing histamine release and inflammation, leading to sneezing, nasal congestion, and runny nose.

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Intranasal Steroids for Allergic Rhinitis

Fluticasone reduces inflammation, lessening allergic symptoms.

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Musculoskeletal Pain

Pain in muscles, bones, joints, or connective tissues, lasting up to 12 weeks.

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Pain Mechanisms in Musculoskeletal Pain

Caused by localized inflammation or systemic conditions like arthritis.

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1st Generation Antihistamines

These medications block histamine receptors, but also cross the blood-brain barrier, leading to sedation and drowsiness. They are used for allergies, motion sickness, and insomnia.

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Diphenhydramine (Benadryl®)

A common 1st generation antihistamine used for allergies, motion sickness, and insomnia. It can cause sedation and drowsiness.

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2nd Generation Antihistamines

These medications selectively block histamine receptors, but have limited CNS penetration, causing less sedation. They are primarily used for allergies and other histamine-mediated conditions.

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Fexofenadine (Allegra®)

A common 2nd generation antihistamine used for seasonal allergies and hives. It has a longer duration of action and is less likely to cause drowsiness.

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Duration of Action

Describes how long a medication remains effective in the body.

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Anticholinergic Side Effects

Side effects associated with blocking acetylcholine receptors, leading to dry mouth, blurred vision, and urinary retention.

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When to Use 1st Generation Antihistamines

They are best for acute, short-term symptom relief (e.g., motion sickness, insomnia) but avoid in elderly patients due to fall risk and anticholinergic side effects.

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When to Use 2nd Generation Antihistamines

They are preferred for long-term management of allergic rhinitis or hives, especially in patients needing minimal sedation.

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Fever

A body temperature above 100.4°F caused by pyrogens elevating the hypothalamic set point.

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Fever Treatment Goals

Reduce discomfort and identify the underlying cause of the fever.

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Acetaminophen Mechanism

Reduces prostaglandin synthesis in the central nervous system (CNS), leading to pain and fever reduction.

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Ibuprofen Mechanism

Blocks COX-1 and COX-2 enzymes, decreasing prostaglandin production, which reduces pain, inflammation, and fever.

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Ibuprofen Dosage for Children (6 months+)

5-10 mg/kg every 6-8 hours as needed. Maximum daily dose: 40 mg/kg/day.

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Headache Types

Primary: Tension (bilateral pressure), Migraine (unilateral throbbing, with/without aura), and Cluster. Secondary: Due to underlying pathology.

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Tension Headache Management

Nonpharmacologic: Stress reduction, sleep hygiene. Pharmacologic: NSAIDs.

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Migraine Treatment

Triptans are commonly used to treat migraines.

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Fungal Infections Common Types

Tinea pedis (feet), Tinea corporis (body), Tinea cruris (groin), and Tinea capitis (scalp).

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Acne Pathogenesis

Follicular hyperkeratinization, increased sebum production, and inflammation.

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Acne Treatment

Topical Agents: Benzoyl peroxide, retinoids. Oral Agents: Isotretinoin for severe acne. Nonpharmacologic: Gentle cleansing.

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Nausea and Vomiting Mechanisms

Mediated by the vomiting center, chemoreceptor trigger zone, and vestibular system.

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Diarrhea Etiology

Infectious (e.g., E. coli) or non-infectious (e.g., IBS, medications).

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Diarrhea Treatment

Hydration: Oral rehydration solutions (ORS). Antidiarrheals: Loperamide, bismuth subsalicylate.

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Constipation Definition

Difficult or infrequent bowel movements, often lasting 7 days or more.

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Acute Diarrhea

Diarrhea lasting less than 14 days.

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Persistent Diarrhea

Diarrhea lasting between 14 and 30 days.

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Chronic Diarrhea

Diarrhea lasting longer than 30 days.

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Diarrhea Definition

Having three or more loose or watery stools per day.

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Oral Hydration

The preferred method for treating dehydration caused by diarrhea.

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Parenteral Hydration

Intravenous fluid therapy used for severe dehydration or when oral hydration isn't possible.

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Symptoms for Referral

Persistent fever exceeding 101°F for over 72 hours, bloody stools, recent travel, severe abdominal pain, signs of sepsis, compromised immune system, recent hospitalization, or recent antibiotic use.

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First-Line Therapy for Dehydration

Reduced osmolarity oral rehydration solution (ORS).

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ORS for Mild to Moderate Dehydration

Recommended for infants, children, and adults with acute diarrhea.

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Low-Osmolarity ORS

A safe and effective ORS for all age groups with any cause of diarrhea.

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Products Not Ideal for Rehydration

Apple juice, Gatorade, and commercial soft drinks.

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Mild Dehydration Symptoms

A fluid loss of 3-5%.

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Moderate Dehydration Symptoms

A fluid loss of 6-9%.

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Severe Dehydration Symptoms

A fluid loss exceeding 10%.

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Infants and Children Rehydration

Give 50-100 mL/kg of ORS over 3-4 hours for mild to moderate dehydration.

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Adolescents and Adults Rehydration

Give 2-4 liters of ORS for mild to moderate dehydration.

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Severe Dehydration Treatment

Intravenous isotonic crystalloid boluses based on current resuscitation guidelines.

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Replacement of Losses

This is done during maintenance hydration therapy.

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Dehydration Assessment

Evaluating for signs of dehydration in all age groups.

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Symptoms Indicative of Severe Dehydration

Listlessness, irritability, increased thirst, and coma.

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Stool Testing

Recommended for Salmonella, Shigella, Campylobacter, Yersinia, C. difficile, and STEC in specific cases.

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Traveler's Diarrhea Evaluation

Consider intestinal parasitic infections if diarrhea persists for more than 14 days.

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Hydration Until Symptoms Abate

Maintain increased hydration levels even after diarrhea symptoms subside.

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Signs of Sepsis

Seek emergency care for severe abdominal pain or persistent fever above 101°F for over 72 hours.

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Symptoms Improving

Assess improvement to determine further treatment options.

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Skin Turgor Assessment

A method to determine the level of dehydration.

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Eyes Assessment

Eye appearance can indicate dehydration levels.

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Tears in Infants

Tear production signifies dehydration level.

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Urine Output in Dehydration

Urine output reflects dehydration levels.

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ORS Composition

Contains sodium, potassium, and carbohydrates for effective rehydration.

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Common Beverages Osmolarity

Colas have a high osmolarity (550 mOSM/kg), making them unsuitable for rehydration.

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Caution in Geriatric Patients

Elderly patients are at increased risk of salicylate toxicity.

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Infectious Diarrhea Guidelines

Avoid anti-motility medications in children under 18 years old.

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Diagnostic Testing

Not typically recommended for uncomplicated traveler's diarrhea.

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Beverages Not for Rehydration

Apple juice and Gatorade have high sugar and electrolyte imbalances.

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Electrolyte Levels in Beverages

Chicken broth contains 250 mEq/L potassium.

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Beverage Sodium Comparison

Gatorade has 61 mEq/L sodium, lower than ORS.

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Allergic Conjunctivitis: What is it?

Allergic conjunctivitis is an eye allergy caused by allergens triggering inflammation in the conjunctiva, the clear membrane covering the white part of the eye and the inside of the eyelids. This can lead to itchiness, redness, watery eyes, and sensitivity to light.

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Allergic Conjunctivitis Management: First-Line Treatment

The recommended first-line treatment for allergic conjunctivitis is a combination of antihistamine and mast cell stabilizer eye drops. These dual-action drops help control itching, redness, and watery eyes by targeting the inflammatory process.

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Oral Antihistamines for Conjunctivitis: Caution Needed

While oral antihistamines might seem helpful, they can actually worsen dry eye syndrome and make allergic conjunctivitis worse by interfering with the protective tear film. Artificial tears may help alleviate this issue.

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Allergic Rhinitis: Why Control It?

Controlling allergic rhinitis (hay fever) is crucial because ongoing inflammation can lead to a vicious cycle, making symptoms worse. Untreated allergies can also worsen asthma and eczema in some individuals.

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Allergic Conjunctivitis: Goals of Treatment

The primary goals of managing allergic conjunctivitis are to control symptoms, minimize inflammation, reduce fatigue, improve sleep quality, and prevent worsening of other allergy-related conditions like asthma or eczema.

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INCS for Allergic Rhinitis

Intranasal corticosteroids (INCS) are the preferred treatment for allergic rhinitis, offering superior efficacy compared to oral antihistamines and equal effectiveness to intranasal antihistamines (INAH). They are particularly beneficial for patients who want to minimize systemic exposure or are younger.

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Second-Generation INCS: Preferred Choice

Second-generation INCS, like budesonide (Rhinocort), are often preferred, especially in pregnant women, due to their lower risk of systemic side effects.

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INCS: Time to See Results

While INCS are effective, achieving maximal benefits may take days or even weeks, especially in individuals with long-standing untreated symptoms.

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INCS: Potential Side Effects

INCS can cause local irritation, such as nasal dryness, burning, and discomfort. Formulations containing alcohol or propylene glycol are more prone to irritation.

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Azelastine: The Only OTC INAH

Azelastine (Astepro) is the first and only over-the-counter intranasal antihistamine (INAH). It effectively manages allergic rhinitis symptoms, including congestion, runny nose, and itchiness, by targeting histamine receptors.

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INAH: Beyond Antihistamine

Azelastine is more than just a histamine blocker; it also stabilizes mast cells, reducing the release of inflammatory chemicals that contribute to allergic reactions.

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INAH: Similar to INCS

Like INCS, INAH effectively targets multiple components of the IgE-mediated allergic response, making them potent treatments for allergic rhinitis.

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Budesonide (Rhinocort): Preferred in Pregnancy

Budesonide is a specific type of second generation INCS that is often considered the preferred choice during pregnancy due to its safety profile and lower risk of systemic side effects.

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What are the tests typically used to diagnose a sore throat?

Tests may include rapid antigen detection testing for streptococcus or throat culture, rapid antigen testing for influenza, and pulse oximetry to assess for hypoxia and lower respiratory tract infection.

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When is a chest X-ray indicated for a sore throat?

Chest X-rays should be reserved for patients with clinical suspicion of pneumonia, acute upper airway infection with comorbid conditions, and patients with symptoms not resolving after 3 weeks.

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What are the symptoms of rhinosinusitis?

Rhinosinusitis presents with nasal congestion, overall nasal discharge (anterior and posterior nasal drip), facial pressure or pain.

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How does allergic rhinitis differ from rhinosinusitis?

Allergic rhinitis is different from rhinosinusitis, although symptom overlap exists, such as rhinorrhea and nasal congestion.

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What are the typical symptoms of a sore throat in the first few days?

Days 1-3 of a sore throat may present with sore throat and malaise.

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What are the typical symptoms of a sore throat in the following days?

Days 4-7 of a sore throat may see nasal symptoms worsen, with thicker excretions.

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What are some treatments for a sore throat?

Topical throat products and/or analgesics may be helpful for sore throat. Analgesics can help with malaise. Post viral ARS and INCS may be helpful for persistent symptoms.

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What are some common symptoms of a sore throat ?

Common symptoms of a sore throat may include sore throat, malaise, nasal congestion, nasal discharge and facial pressure or pain.

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H1-receptor Antagonists

Drugs like azelastine block histamine from binding to H1 receptors, preventing allergic reactions.

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Azelastine's Actions

Azelastine not only blocks histamine but also inhibits its release from mast cells, further reducing allergic responses.

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Second Generation Antihistamines

These newer antihistamines are highly selective for H1 receptors, causing less sedation than older generations.

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Competitive Antagonism

Antihistamines block histamine from binding to H1 receptors by competing for the same binding site.

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Levocetirizine (Xyzal®)

Another second-generation antihistamine with long-lasting effects and minimal drowsiness.

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Lora­tadine (Claritin®)

A widely used second-generation antihistamine known for its long-lasting effects and minimal daytime drowsiness.

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Bacterial ARS Symptoms

Three key symptoms indicating bacterial Acute Respiratory Syndrome (ARS) include:

  1. Fever above 102.2°F (39°C)
  2. Double-sickening (initial recovery followed by worsening)
  3. Elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)
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Double-Sickening in ARS

A characteristic symptom of bacterial ARS where initial improvement is followed by a worsening of symptoms. This indicates a potential bacterial infection requiring further evaluation.

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Bacterial Sinusitis Symptoms

Bacterial sinusitis presents with more severe symptoms than viral sinusitis, including:

  1. Congestion lasting more than 10 days
  2. Facial pain (often resembling maxillary tooth pain)
  3. Fever above 102°F
  4. Worsening symptoms after initial improvement ('double-sickening')
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Treatment for Bacterial Sinusitis

Treatment for bacterial sinusitis may involve:

  1. Analgesics: To manage pain
  2. Antipyretics: To reduce fever
  3. Watchful waiting: If symptoms do not improve within 7 days, antibiotics may be considered.
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Antibiotics for Bacterial Sinusitis

Antibiotics are not always necessary for bacterial sinusitis. Current guidelines emphasize careful assessment before prescribing them. Antibiotics are considered only after watchful waiting for 7 days, if symptoms do not improve.

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First-Generation Antihistamines: Sedation?

These antihistamines, like diphenhydramine (Benadryl), cross the blood-brain barrier leading to sedation and drowsiness.

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Second-Generation Antihistamines: Less Drowsy?

These antihistamines like fexofenadine (Allegra) selectively block histamine receptors, causing less sedation.

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Intranasal Decongestants: Rebound Congestion?

Using these medications for more than 5 days can lead to rebound congestion, making congestion worse.

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Oral Decongestants: Caution in Certain Patients?

Patients with conditions like high blood pressure, heart problems, or bladder issues should be cautious with oral decongestants.

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Intranasal Corticosteroids (INCS): Superior to INAH?

INCS are generally preferred for allergic rhinitis as they are more effective than oral antihistamines and equal to intranasal antihistamines (INAH).

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Second-Generation INCS: Pregnancy Safety?

Second-generation INCS, like budesonide (Rhinocort), are often preferred during pregnancy due to their lower risk of systemic side effects.

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INAH: More Than Just Antihistamine?

Azelastine (Astepro) is the first OTC INAH, but it also stabilizes mast cells to reduce inflammation.

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Budesonide (Rhinocort): Pregnancy Preferred

It's a second-generation INCS often considered the preferred option during pregnancy due to its safety profile.

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Study Notes

Intestinal Gas

  • Intestinal gas arises from swallowed air or bacterial fermentation.
  • Symptoms include bloating, flatulence, and abdominal discomfort.
  • Dietary triggers: beans, broccoli, onions, and dairy (lactose intolerance).
  • Medications that increase gas: antibiotics, α-glucosidase inhibitors.
  • Risk factors: high-fiber diets, carbonated drinks, and rapid eating.
  • Over-the-counter (OTC) treatments:
    • Simethicone: reduces gas bubble surface tension.
    • Alpha-galactosidase: aids in digesting complex carbs.
    • Lactase: aids lactose digestion.
  • Lifestyle adjustments: eat slowly, avoid chewing gum, reduce carbonated drinks.
  • Warning signs: persistent or severe symptoms, unintentional weight loss, or rectal bleeding.
  • Referral criteria: persistent or severe symptoms, unintentional weight loss, or rectal bleeding.

Cough

  • Cough reflex: initiated by respiratory tract irritation, processed in the medulla oblongata.
  • OTC antitussives:
    • Codeine: suppresses the cough center in the medulla.
    • Dextromethorphan: non-opioid acting on the medulla.
  • Expectorants:
    • Guaifenesin: reduces mucus viscosity, facilitates expectoration.
  • Non-pharmacological therapies:
    • Honey: superior efficacy in children over 1 year old.
    • Hydration: maintains mucosal moisture.
  • Referral criteria: cough lasting >7 days, fever >100.4°F, or hemoptysis (coughing up blood).

Allergic Rhinitis and Cold

  • Pathophysiology: allergen triggers histamine release and inflammation.
  • Symptoms: sneezing, nasal congestion, watery rhinorrhea.
  • Treatment:
    • Intranasal steroids (INCS): fluticasone reduces inflammation.
    • Oral antihistamines: loratadine and cetirizine block H1 receptors.
    • Decongestants: pseudoephedrine relieves nasal congestion.
    • First-line treatments may be INCS or oral 2nd generation antihistamines for moderate/severe symptoms.
  • Complementary therapies: zinc and vitamin C, variable efficacy.
  • Referral criteria: symptoms persisting >10 days or significant facial pain/swelling.

Musculoskeletal Pain

  • Classification: acute (<12 weeks).
  • Pain mechanisms: localized inflammation or systemic conditions (e.g., arthritis).
  • Therapies:
    • Topical analgesics: capsaicin depletes substance P.
    • Oral analgesics: NSAIDs (e.g., ibuprofen) inhibit COX enzymes.
    • Non-pharmacological: ice/heat therapy, physical therapy.
  • Referral criteria: severe or persistent pain, numbness, or signs of systemic illness.

Fever

  • Definition: temperature >100.4°F due to pyrogen-induced hypothalamic set-point elevation.
  • Treatment goals: reduce discomfort, identify the cause.
  • Medications:
    • Acetaminophen: reduces prostaglandin synthesis in the CNS.
    • Ibuprofen: blocks COX-1 and COX-2 enzymes for adults and children aged 6+ months.
  • Dosing: ibuprofen 5-10 mg/kg every 6-8 hours for children.
  • Referral criteria: fever >3 days, unresponsive to antipyretics, or >104°F.

Headache

  • Types:
    • Primary: tension (bilateral pressure), migraine (unilateral throbbing, with/without aura), cluster.
    • Secondary: due to underlying pathology.
  • Management:
    • Non-pharmacological: stress reduction, sleep hygiene.
    • Pharmacologic:
      • NSAIDs for tension headaches.
      • Triptans for migraines.
  • Referral criteria: sudden-onset headache, signs of systemic illness.

Fungal Infections

  • Common types: tinea pedis (feet), tinea corporis (body), tinea cruris (groin), tinea capitis (scalp).
  • Treatment: topical antifungals (e.g., terbinafine, clotrimazole).
  • Non-pharmacological: keep affected areas dry.
  • Referral criteria: chronic infections, systemic symptoms.

Acne

  • Pathogenesis: follicular hyperkeratinization, increased sebum production, and inflammation.
  • Treatment:
    • Topical agents: benzoyl peroxide, retinoids.
    • Oral agents: isotretinoin for severe cases.
    • Non-pharmacological: gentle cleansing, avoid comedogenic products.
    • Counseling: adherence and side effect management.

Nausea and Vomiting

  • Mechanisms: mediated by the vomiting center, chemoreceptor trigger zone, and vestibular system.
  • OTC antiemetics: diphenhydramine, meclizine (block H1 and muscarinic receptors).
  • Non-pharmacological: ginger, hydration.
  • Referral criteria: persistent vomiting, dehydration, or abdominal pain.

Diarrhea

  • Etiology: infectious (e.g., E. coli) or non-infectious (e.g., IBS, medications).
  • Treatment: fluid replacement (e.g., oral rehydration solutions), antidiarrheals (e.g., loperamide, bismuth subsalicylate).
  • Referral criteria: bloody stools, fever, or severe dehydration.
  • Acute diarrhea: < 14 days
  • Persistent diarrhea: 14 to 30 days
  • Chronic diarrhea: > 30 days
  • Definition: 3 or more loose or watery stools per day
  • Preferred rehydration method: Oral rehydration solution (ORS)
  • Parenteral rehydration: Recommended only when oral route is not tolerated or for severe dehydration/sepsis
  • Referral indicators (for diarrhea): Persistent fever (above 101°F for >72 hours), bloody stool, recent travel, severe abdominal pain, sepsis signs, immunocompromised status, recent hospitalization, or antibiotic use.
  • First line therapy for dehydration: ORS (reduced osmolarity).
  • ORS use: Safe for infants, children, and adults with acute diarrhea.
  • Avoid: Apple juice, Gatorade, and commercial soft drinks for rehydration.
  • Mild dehydration symptoms: 3–5% fluid loss.
  • Moderate dehydration symptoms: loss of 6–9% of body fluids.
  • Severe dehydration symptoms: loss of over 10% bodily fluids.
  • Infant/child rehydration: 50–100 mL/kg over 3-4 hours (mild-moderate dehydration).
  • Adolescent/adult rehydration: 2-4 L (mild-moderate dehydration).
  • Severe dehydration treatment: intravenous isotonic crystalloids, following resuscitation guidelines.
  • Stool testing: Recommended for Salmonella, Shigella, Campylobacter, Yersinia, C. difficile, and STEC in specific cases.
  • Traveler's diarrhea evaluation: Should be evaluated for parasitic infections if lasting >14 days.
  • Loperamide dosing (adults): Initially 4 mg, then 2 mg after each loose stool (max 16mg/day for acute diarrhea)
  • Loperamide dosing (children): Dosage varies by weight/age, maximum 6 mg/day.
  • Bismuth subsalicylate: Useful for diarrhea and gastric distress.
  • Dosing (for gastric distress): 262-524 mg every 30 minutes, max of 4200mg/day
  • Dosing (for diarrhea): 524 mg PO four times daily until diarrhea subsides.
  • Avoid in children under 18 for infectious diarrhea

Constipation

  • Definition: infrequent bowel movements (e.g., 7 days or less). Details of the condition are lacking from the provided text.

Heartburn and Dyspepsia

  • Pathophysiology: reflux of stomach acid into the esophagus.
  • Treatment:
    • Antacids: neutralize stomach acid (e.g., calcium carbonate).
    • H2 blockers: reduce acid production (e.g., ranitidine).
    • Proton pump inhibitors (PPIs): inhibit H+/K+ ATPase (e.g., omeprazole).
    • Non-pharmacological: avoid trigger foods, smaller meals, and elevate head during sleep.
  • Referral criteria: symptoms persisting >2 weeks despite treatment.

Ibuprofen Dosing

  • Mechanism: inhibits COX-1 and COX-2 enzymes reducing prostaglandin production, thus alleviating pain and inflammation.
  • Adult dosing: 200-400 mg every 4-6 hours. Maximum daily dose is 1200mg.
  • Child dosing: 5-10 mg/kg every 6-8 hours. Maximum daily dose is 40 mg/kg.
  • Precautions: use with food or milk. Contraindicated for children under 6 months unless physician-approved; contraindicated with dehydration, renal impairment, or GI ulcer history.

Acetaminophen Dosing

  • Mechanism: inhibits prostaglandin synthesis in the central nervous system, but lacks peripheral anti-inflammatory effects.
  • Adult dosing: 325-1000 mg every 4-6 hours. Maximum daily dose: 3000mg.
  • Child dosing: 10-15 mg/kg every 4-6 hours. Maximum daily dose: 75 mg/kg
  • Precautions: use with or without food. Avoid exceeding maximum dose and in combination with other acetaminophen products. Potential for hepatotoxicity with overdose.

Antihistamines

  • 1st Generation: Sedating, readily cross blood-brain barrier, used for short-term relief and acute symptoms. Associated with anticholinergic effects.

  • 2nd Generation: Non-sedating, minimal CNS penetration, long duration of action, often preferred for long-term use for conditions like allergic rhinitis.

  • Generic Name | Brand Name | Indications | Dosing

  • ------ | -------- | -------- | -------- Diphenhydramine|Benadryl®|Allergies, motion sickness, nausea| Adults: 25-50 mg every 4-6 hrs (max 300 mg/day) Dimenhydrinate|Dramamine®|Motion sickness| Adults: 50-100 mg every 4-6 hrs (max 400 mg/day) Chlorpheniramine|Chlor-Trimeton®|Allergies|Adults: 4 mg every 4-6 hrs (max 24 mg/day) Meclizine|Dramamine® Less Drowsy|Motion sickness, vertigo| Adults: 25-50 mg 1 hour before travel (max 50 mg/day) Doxylamine|Unisom®|Allergies, insomnia| Adults: 25 mg at bedtime (as a sleep aid) Fexofenadine|Allegra®|Seasonal allergic rhinitis, urticaria| Adults: 60 mg twice daily or 120 mg once daily Loratadine|Claritin®|Allergic rhinitis, chronic urticaria| Adults: 10 mg once daily Cetirizine|Zyrtec®|Seasonal allergic rhinitis, chronic urticaria| Adults: 10 mg once daily Levocetirizine|Xyzal®|Allergic rhinitis, chronic urticaria| Adults: 5 mg once daily

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Test your knowledge on intestinal gas and cough mechanisms, symptoms, and treatments. This quiz covers dietary triggers, medications, and OTC remedies for both conditions. Learn about lifestyle adjustments and when to seek medical advice.

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