Integumentary System Quiz
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Questions and Answers

Which layer of the skin is primarily responsible for sensation due to its nerve endings?

  • Papillary dermis (correct)
  • Hypodermis
  • Reticular dermis
  • Epidermis
  • What is the primary function of melanin in the skin?

  • Providing strength to the skin
  • Protecting against UV light (correct)
  • Storing energy
  • Regulating body temperature
  • Which of the following tissues is NOT a component of the integumentary system?

  • Epithelial tissue
  • Nervous tissue
  • Connective tissue
  • Muscle tissue (correct)
  • What do dermal papillae do in relation to the epidermis?

    <p>They elevate the overlying epidermis. (B)</p> Signup and view all the answers

    Which layer of the skin's dermis contains a network of collagen and reticular fibers?

    <p>Reticular layer (D)</p> Signup and view all the answers

    What is the main role of the hypodermis in relation to the integumentary system?

    <p>Anchoring the skin (C)</p> Signup and view all the answers

    Which of the following is true about stretch marks?

    <p>They result from the tearing of elastic fibers. (B)</p> Signup and view all the answers

    What is the primary structural component of nails?

    <p>Hard keratin (A)</p> Signup and view all the answers

    Which part of the hair is responsible for its growth?

    <p>Hair bulb (C)</p> Signup and view all the answers

    Which type of hair is characterized by fine, short strands?

    <p>Vellus hair (B)</p> Signup and view all the answers

    What is the primary function of sebaceous glands?

    <p>Lubricating the skin (D)</p> Signup and view all the answers

    What is the average rate of hair growth per week?

    <p>2 mm (C)</p> Signup and view all the answers

    Which of the following best describes the cuticle of hair?

    <p>A single layer of overlapping cells (B)</p> Signup and view all the answers

    What physiological process do sweat glands primarily facilitate?

    <p>Temperature regulation (B)</p> Signup and view all the answers

    What is the typical cause of male pattern baldness?

    <p>Genetic predisposition (B)</p> Signup and view all the answers

    What distinguishes terminal hair from other types of hair?

    <p>It is longer and coarser. (B)</p> Signup and view all the answers

    What is the primary function of interferons in the immune response?

    <p>To signal to neighboring cells about the presence of a virus. (D)</p> Signup and view all the answers

    Which of the following statements about interleukins is true?

    <p>They modulate the behavior of various immune cells in response to infection. (B)</p> Signup and view all the answers

    How do interferons inhibit viral replication within host cells?

    <p>By inhibiting the synthesis of host proteins necessary for virus replication. (C)</p> Signup and view all the answers

    Which immune cells are known to produce tumor necrosis factor (TNF)?

    <p>Neutrophils, macrophages, and lymphocytes. (D)</p> Signup and view all the answers

    What role do Toll-like receptors (TLRs) play in the immune response?

    <p>They bind to microbial components and initiate immune signaling. (A)</p> Signup and view all the answers

    Which type of skin cancer is associated with the cells of the stratum basale?

    <p>Basal cell carcinoma (D)</p> Signup and view all the answers

    What is the primary characteristic that differentiates adaptive immunity from innate immunity?

    <p>Adaptive immunity develops memory. (A)</p> Signup and view all the answers

    Which of the following is NOT a component of the innate immune system?

    <p>B-lymphocytes (D)</p> Signup and view all the answers

    What is a major function of normal flora in the human body?

    <p>Competing with pathogens for nutrients and space (D)</p> Signup and view all the answers

    Which skin cancer type is recognized as the most dangerous?

    <p>Melanoma (B)</p> Signup and view all the answers

    What does the term 'phagocytosis' literally mean?

    <p>Cell eating (C)</p> Signup and view all the answers

    Which immunological structure is involved in making complement proteins?

    <p>Liver (B)</p> Signup and view all the answers

    Which of the following is a characteristic of the innate immune response?

    <p>Immediate response to a broad range of pathogens (A)</p> Signup and view all the answers

    What is the main role of cytokines in the immune system?

    <p>Facilitate communication between immune cells (D)</p> Signup and view all the answers

    What feature distinguishes T-lymphocytes in the immune response?

    <p>They are involved in cell-mediated immunity. (A)</p> Signup and view all the answers

    Which type of sweat gland is responsible for producing true sweat composed of 99% water?

    <p>Eccrine (merocrine) glands (D)</p> Signup and view all the answers

    What is a characteristic of apocrine glands?

    <p>Their ducts open into hair follicles. (D)</p> Signup and view all the answers

    What distinguishes third-degree burns from first and second-degree burns?

    <p>They destroy the epidermis and dermis. (A)</p> Signup and view all the answers

    Which of the following conditions could be considered critical when assessing burn severity?

    <p>More than 25% of the body has second-degree burns. (A)</p> Signup and view all the answers

    What is a potential risk associated with severe burns?

    <p>Catastrophic loss of body fluids. (D)</p> Signup and view all the answers

    Which glands are responsible for producing earwax?

    <p>Ceruminous glands (D)</p> Signup and view all the answers

    What type of skin cancer is commonly characterized by tumors that are benign?

    <p>Basal cell carcinoma (B)</p> Signup and view all the answers

    Which assessment method is commonly used to estimate the extent of burns on a person's body?

    <p>Rule of Nines (A)</p> Signup and view all the answers

    What is the composition of true sweat produced by eccrine glands?

    <p>99% water with some salts and waste traces (A)</p> Signup and view all the answers

    In the case of second-degree burns, what symptom is primarily associated with them?

    <p>Redness and blistering (C)</p> Signup and view all the answers

    Flashcards

    Epidermis

    The outermost layer of skin, composed of stratified squamous epithelium, responsible for protection and forming a barrier.

    Dermis

    The deeper, thicker layer of skin, composed of connective tissue, responsible for strength, flexibility, and housing blood vessels, nerves, and glands.

    Dermoepidermal Junction

    The junction between the epidermis and dermis, characterized by projections called dermal papillae.

    Collagen

    A type of connective tissue found in the dermis, providing strength and resilience to the skin. It is a major protein in the body.

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    Elastic Fibers

    A type of protein fiber in the dermis, providing elasticity and allowing the skin to stretch and recoil.

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    Hypodermis

    The layer of fat and loose connective tissue beneath the dermis, providing insulation, cushioning, and attaching the skin to underlying muscle.

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    Melanin

    The primary pigment responsible for skin color, produced by melanocytes.

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    What are skin appendages?

    Skin appendages are structures that grow from the epidermis but extend into the dermis. They include hair follicles, sebaceous glands, sweat glands, and nails.

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    What is a nail and how does it grow?

    The nail is a hard keratin structure that corresponds to hooves and claws in other animals. It grows from the nail matrix, a specialized area at the base of the nail.

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    What are hair follicles and where are they located?

    Hair follicles are complex structures derived from both epidermis and dermis. They are found everywhere except the palms of the hands, soles of the feet, nipples, and certain parts of the genitalia.

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    What are the arrector pili and hair bulb?

    The arrector pili is a smooth muscle attached to each hair follicle. Hair bulbs are clusters of epithelial cells that surround the hair papilla. This papilla is connective tissue that provides nutrients to the growing hair.

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    What are the functions and components of hair?

    Hair serves various functions, including warmth, providing a sense of light touch, and protection on the scalp. Hair is made of hard keratin, a protein that gives hair its strength.

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    What are the different types of hair and what happens during hair growth?

    Vellus hairs are fine and short, intermediate hairs are in-between, and terminal hairs are longer and thicker. Hair can be active (growing) or in a resting phase before shedding.

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    Where are sebaceous glands located and what do they produce?

    Sebaceous glands are located throughout the body, except for the palms and soles. They produce sebum, an oily substance that lubricates the skin and hair through holocrine secretion.

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    Where are sweat glands located and what is their function?

    Sweat glands are found on nearly the entire body surface, except for the nipples and some parts of the external genitalia. They play a vital role in thermoregulation by producing sweat, which evaporates and cools the body.

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    What determines hair color?

    Hair color is determined by the amount and type of melanin present. Black and brown hair contain melanin, while red hair contains a distinct form. White hair occurs due to decreased melanin production and the presence of air bubbles within the medulla.

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    Eccrine sweat glands

    A type of sweat gland found in most areas of the body. Produces true sweat, which is mostly water and helps regulate body temperature. Opens through pores.

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    Apocrine sweat glands

    Sweat glands found only in specific areas like the armpits, groin, and around the anus. Produces a thicker sweat containing organic molecules that decompose and cause odor. Opens into hair follicles.

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    Ceruminous glands

    A modified type of apocrine gland found in the ear canal. Secretes earwax (cerumen), which traps debris and protects the ear.

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    Mammary glands

    Modified apocrine glands responsible for producing milk in females. They play a crucial role in lactation.

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    Burns

    A serious injury to the skin involving damage to multiple layers. Can be life-threatening due to fluid loss, infection risk, and shock.

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    First-degree burn

    The least severe type of burn, affecting only the outer layer of skin (epidermis). Causes redness, pain, and mild swelling.

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    Second-degree burn

    A burn that damages both the epidermis and the dermis, causing blisters and pain. Can be more severe than a first-degree burn.

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    Third-degree burn

    The most severe burn, destroying all skin layers (epidermis, dermis, and sometimes hypodermis). Requires immediate medical attention due to tissue damage.

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    Rule of Nines

    A medical method used to assess the severity of burns based on the percentage of the body's surface area affected. Each body region is assigned a specific percentage value.

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    Benign skin tumors

    Non-cancerous growths on the skin. Typically harmless, but can be aesthetically bothersome.

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    Immune System

    The body's defense system against disease and injury, involving both non-specific (innate) and specific (acquired) responses.

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    Innate Immunity

    The body's first line of defense, reacting quickly to a broad range of threats without specific targeting.

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    Adaptive Immunity

    The body's second line of defense, responding slower but specifically targeting particular threats.

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    Anatomical Barriers

    Physical barriers like skin and mucous membranes, and chemical barriers like secretions, forming the first line of defense.

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    Phagocytes

    Specialized white blood cells that engulf and destroy foreign invaders.

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    Complement System

    A protein cascade that amplifies the immune response by tagging invaders for destruction.

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    Natural Killer (NK) Cells

    A type of white blood cell that directly attacks and kills infected cells.

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    Lymphocytes

    Specialized white blood cells responsible for recognizing specific threats and launching targeted responses.

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    B-lymphocytes

    Specialized white blood cells that produce antibodies, proteins that bind to specific antigens.

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    T-lymphocytes

    Specialized white blood cells that directly attack infected cells, participating in cell-mediated immunity.

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    What are interferons?

    These signaling proteins are produced by virus-infected monocytes and lymphocytes, they are key antiviral proteins which "interfere" with virus replication.

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    How do interferons warn neighboring cells?

    Once infected cells release interferons, these neighboring cells then enter an antiviral state, allowing them to quickly inhibit the virus from replicating.

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    How do interferons inhibit viruses?

    Interferons inhibit viruses by activating a host protein, which then triggers a cascade of events that ultimately inhibit the host protein synthesis, preventing the virus from replicating.

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    What are interleukins?

    They are a group of proteins (1-37) that are not stored inside cells, but are quickly synthesized and secreted in response to infection. They are key modulators of immune cell behavior.

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    What do interleukins do?

    Interleukins mainly act by influencing the behavior of immune cells, affecting how they move, differentiate, and even proliferate. They are primarily secreted by T-lymphocytes and macrophages.

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    Study Notes

    Integumentary System

    • The integumentary system includes skin, hair, fingernails, and glands (sweat and oil).
    • The skin acts as a first barrier, protecting the body from harmful substances (e.g., bacteria).
    • Skin also helps to regulate body temperature and excrete waste.
    • It has multiple layers to provide protection.

    Functions of Skin

    • Protection
    • Synthesis of vitamin D with UV light.
    • Homeostasis: regulates body temperature.
    • Sensory reception (nerve endings).

    Epidermis and Dermis

    • The epidermis and dermis are two distinct regions of the skin.
    • Skin is made up of different layers forming the epidermis and dermis.
    • The dermis is a strong, flexible connective tissue with collagen, elastic, and reticular fibers.
    • It contains fibroblasts, macrophages, mast cells, and white blood cells (WBCs).
    • The dermis is important in temperature regulation.
    • The dermis has two layers, the papillary and reticular layers.
    • The papillary layer is areolar connective tissue containing dermal papillae.
    • The reticular layer is a network of collagen and reticular fibers.

    Appendages of the Skin

    • Hair and hair follicles (derived from epidermis and dermis, found everywhere but palms, soles, nipples, parts of genitalia, the arrector pili is smooth muscle)
    • Sebaceous (oil) glands (produce sebum by holocrine secretion - oils and lubricates, found everywhere except palms and soles).
    • Sweat glands (sudoiferous glands) (found on entire skin surface except nipples and part of external genitalia. Prevent overheating, humans are most efficient, produce in response to stress or heat)
    • Nails (hard keratin, corresponds to hooves and claws, grows from nail matrix)

    The Immune System

    • A functional system, not an organ system.
    • Includes skin (physical barrier), lining of mucus membranes (physical barrier), secretions (antimicrobial), blood cells and vasculature (WBCs), bone marrow, liver (complement proteins), lymphatic system, lymphoid organs, and most tissues (resident immune cells)

    The Immune System: Responses to Disease and Injury

    • The body responds to disease and injury with both nonspecific and specific responses.
    • Nonspecific response (innate immunity): a rapid, broad response to a range of microbes.
    • Specific response (adaptive immunity): a slower, more targeted response to a specific microbe.

    Innate Immunity vs Adaptive Immunity

    • Innate immunity (first line of defense) has no time lag and is not antigen-specific, but has no memory.
    • Adaptive immunity (second line of defense) has a lag period with a specific antigen-specific response and memory.

    Anatomical Barriers

    • Mechanical factors: Skin, mucociliary escalator, flushing action of saliva, tears, urine
    • Chemical factors: Lysozyme in tears/saliva, HCI in stomach, peptides in sweat.
    • Biological factors: Normal flora (competes with pathogens for nutrients and space).

    Innate Immune System: Internal Defenses

    • Cellular: Neutrophils, monocytes/macrophages, NK cells, TLRs.
    • Extracellular: Cytokines, complement, coagulation.

    Cytokines

    • Small proteins secreted by cells of the immune system.
    • Affect behavior of other cells, acting as signaling molecules.
    • Key players in both innate and acquired immunity.
    • Examples include interferons, interleukins, and tumor necrosis factor (TNF).

    Complement (C')

    • A complex system of proteins that react with each other (C1 to C9).
    • Binds to microbes, coats them, facilitating phagocytosis.
    • Important for innate immunity and enhances adaptive immunity.
    • Leads to direct lysis of pathogens.

    Coagulation Proteins

    • Coagulation is a mechanism for stopping bleeding after injury.
    • Mechanisms include platelets, coagulation factors, and vitamin K.
    • The pathway is a complex process involving stages.

    Disorders of the Integumentary System

    • Burns (threat to life due to catastrophic loss of body fluids, resulting in dehydration and circulatory shock. Includes 1st, 2nd, 3rd degrees.
    • Infections: Direct Contact, Vector Borne, Wounds.
    • Skin cancer (benign and malignant, e.g., warts, skin cancer associated with UV exposure, basal cell carcinoma, squamous cell carcinoma, melanoma)

    Antibodies

    • Antibodies are proteins produced by plasma cells (B-lymphocytes).
    • They are essential for adaptive immunity.
    • Antibodies bind to specific antigens.
    • Possesses both Fab (fragment, antigen binding) and Fc (fragment, constant) regions.
    • Exist in soluble and membrane-bound forms.

    Specific Response (Adaptive Immunity)

    • Involves B and T lymphocytes and plasma cells.
    • A reaction to antigens in the body.
    • The body responds with the use of the antibodies.

    Important Points

    • Integumentary system forms a protective layer.
    • Critical for defense and homeostasis.
    • Immune system is a functional system with innate and adaptive immunity.

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