35 Questions
What is the main characteristic that distinguishes rapid-acting insulins?
Rapid onset and short duration of action
What is the primary difference between insulin lispro and regular (short-acting) human insulin?
Absorption rate and half-life after subcutaneous injection
What distinguishes insulin lispro from human insulin at the molecular level?
Reversal of two amino acids
Which rapid-acting insulin has the shortest onset of action?
Insulin glulisine
What is the duration of action for rapid-acting insulins?
4–8 hours
What is the primary benefit of insulin lispro over regular (short-acting) human insulin?
More effective at decreasing postprandial hyperglycemia
What is the primary advantage of injecting insulin lispro just before a meal?
Produces hypoglycemic effects similar to conventional regular insulin given 30 minutes before a meal
Which insulin analog was the first to be marketed?
Insulin lispro
What is the primary advantage of insulin aspart over insulin lispro?
Even more rapid onset and shorter duration of action
What is the primary benefit of insulin glulisine's rapid onset of action?
Quickly reduces postprandial hyperglycemia
What is the approximate onset of action for rapid-acting insulins?
5–15 minutes
What is the primary reason for insulin lispro's similarity to physiologic insulin secretion after a meal?
Rapid absorption and shorter half-life
What is the main reason for the U.S. Food and Drug Administration issuing a BLACK BOX WARNING for Afrezza?
Increased risk of acute bronchospasm in patients with diabetes and chronic lung disease
Which insulin is contraindicated in patients with asthma and chronic obstructive pulmonary disease?
Afrezza
What is the primary purpose of evaluating the patient’s spirometry before prescribing Afrezza?
To assess lung function
Where is insulin absorbed most rapidly after subcutaneous injection?
Abdomen
Which insulin is of choice during acute situations such as diabetic ketoacidosis (DKA) or severe infection?
Regular insulin
Which insulin is often used for long-term insulin therapy?
Isophane insulin (NPH)
What is the main characteristic of insulin lispro, aspart, or glulisine?
Rapid onset of action
For what purpose are all rapid-acting insulins approved?
Use in external insulin pumps
Which insulin may be used to provide a basal amount of insulin over 24 hours?
Insulin glargine
What distinguishes regular insulin from isophane insulin (NPH)?
Ability to be given intravenously
What is the insulin of choice for a mixture administered before the morning and evening meals?
Regular and NPH insulins
Which insulin may be used instead of regular subcutaneous insulin in most situations?
Insulin lispro, aspart, or glulisine
Which insulin has a rapid onset of action and can be given intravenously?
Regular insulin (insulin injection)
What is the main insulin concentration in the United States?
U-100
Which insulin is administered at the beginning of every meal?
Regular insulin (insulin injection)
Which insulin is used to provide a basal amount of insulin through 24 hours, similar to normal, endogenous insulin secretion?
Insulin glargine
Which insulin is contraindicated in patients with asthma and chronic obstructive pulmonary disease who need insulin?
Afrezza
Which insulin has been modified by protamine in a neural buffer to slow the absorption and prolong the duration of action?
Isophane insulin (NPH)
Which insulin is absorbed most rapidly from the abdomen after subcutaneous injection?
Regular insulin (insulin injection)
Which insulin is often used for long-term insulin therapy and can be combined with short-acting insulin for more consistent control of blood glucose levels?
Isophane insulin (NPH)
Which insulin has a mixture available that is more convenient and probably more accurate than a mixture prepared by a patient or caregiver?
Isophane insulin (NPH)
Which insulin is approved for use in external insulin pumps that administer a continuous subcutaneous infusion?
Insulin lispro
Which insulin is used to provide a basal amount of insulin over 24 hours, with a short-acting or rapid-acting insulin at meal times?
Insulin glargine
Test your knowledge of different types of insulin with this quiz. Explore the characteristics, onset, and duration of action of short, intermediate, and long-acting insulins. Learn about the synthesis of insulin analogs and rapid-acting insulins such as insulin lispro.
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