10 Questions
Which antibodies are associated with Type 1 diabetes mellitus?
Anti-GAD, Anti-islet cell, Anti-Zn transporter-8
What is the primary defect in Type 2 diabetes mellitus?
Defect in receptor of target tissue leading to reduced utilization of glucose by peripheral tissue
Which risk factor is NOT associated with Type 2 diabetes mellitus?
Low C-peptide level
How does the onset of symptoms differ between Type 1 and Type 2 diabetes mellitus?
Symptoms are abrupt in Type 1 and gradual in Type 2
Which chronic complication is NOT associated with diabetes mellitus?
Chronic obstructive pulmonary disease
What is the main function of the delta cell in the pancreas?
Secretion of somatostatin
How many amino acids does the A chain of insulin contain?
21
What is the metabolic effect of insulin?
Promotion of glucose uptake by cells
Which type of diabetes mellitus is characterized by an autoimmune destruction of beta cells in the pancreas?
Type 1 DM
What is the first step in the pathogenesis of Type 1 DM?
Genetic susceptibility with HLA-DR3 or HLA-DR4
Test your knowledge on the physiology of insulin, including its production in the pancreas, metabolic effects, and the mechanism of its release. Also, assess your understanding of Diabetes Mellitus as a complex clinical syndrome characterized by hyperglycemia due to insulin deficiency.
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