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How are adaptive immune cells able to generate receptors that specifically recognize virtually every pathogen, while sparing self-antigens?
How are adaptive immune cells able to generate receptors that specifically recognize virtually every pathogen, while sparing self-antigens?
According to Paul Ehrlich, what was the first proposed regulatory mechanism to prevent autoimmunity called?
According to Paul Ehrlich, what was the first proposed regulatory mechanism to prevent autoimmunity called?
What did Paul Ehrlich propose in 1906 to prevent the immune system from acting against the organism's own elements?
What did Paul Ehrlich propose in 1906 to prevent the immune system from acting against the organism's own elements?
What are the two plausible hypotheses for how tolerance to self could be formed, as mentioned in the text?
What are the two plausible hypotheses for how tolerance to self could be formed, as mentioned in the text?
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Why does the adaptive immune response take time to form, as mentioned in the text?
Why does the adaptive immune response take time to form, as mentioned in the text?
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How does the innate immune response differ from the adaptive immune response, as mentioned in the text?
How does the innate immune response differ from the adaptive immune response, as mentioned in the text?
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What is the capacity for different clonotypes formed by the rearrangement of distinct genetic loci and random addition of nucleotides in the variable regions of B/T cell receptors?
What is the capacity for different clonotypes formed by the rearrangement of distinct genetic loci and random addition of nucleotides in the variable regions of B/T cell receptors?
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In thymic T cell development, which signaling pathway is associated with checkpoint 1 for thymocyte development?
In thymic T cell development, which signaling pathway is associated with checkpoint 1 for thymocyte development?
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According to Burnett's clonal selection theory, what happens to immature lymphocytes carrying receptors with specificity for self-antigens?
According to Burnett's clonal selection theory, what happens to immature lymphocytes carrying receptors with specificity for self-antigens?
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Which type of T cells branch off at an early DN stage during thymic T cell development?
Which type of T cells branch off at an early DN stage during thymic T cell development?
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What is the name of the protein loops of the T cell receptor that touch the peptide in the context of MHC?
What is the name of the protein loops of the T cell receptor that touch the peptide in the context of MHC?
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Which molecule is NOT involved in positive/negative selection during thymic T cell development?
Which molecule is NOT involved in positive/negative selection during thymic T cell development?
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What is the name of the process by which mature lymphocytes that interact with foreign molecules are activated and proliferate with the same receptor specificity according to Burnett's clonal selection theory?
What is the name of the process by which mature lymphocytes that interact with foreign molecules are activated and proliferate with the same receptor specificity according to Burnett's clonal selection theory?
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Which cellular compartments do developing thymocytes move through and interact with specific stromal cell types during thymic T cell development?
Which cellular compartments do developing thymocytes move through and interact with specific stromal cell types during thymic T cell development?
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In transplantation tolerance experiments by Peter Medawar, if bone marrow is transferred when the mouse is young, what happens to the graft later?
In transplantation tolerance experiments by Peter Medawar, if bone marrow is transferred when the mouse is young, what happens to the graft later?
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What does alloantigen-specific B cell tolerance after neonatal injection of donor lymphoid cells indicate about the immune system response?
What does alloantigen-specific B cell tolerance after neonatal injection of donor lymphoid cells indicate about the immune system response?
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