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Questions and Answers
How are adaptive immune cells able to generate receptors that specifically recognize virtually every pathogen, while sparing self-antigens?
False
How do precursors decide to become a particular cell type (lineage), e.g. a CD4+ T cell, or a regulatory T cell?
False
According to Paul Ehrlich, why does the immune system not destroy the body despite its powerful immune reactions against pathogens?
False
What are the two plausible hypotheses about how tolerance to self could be formed?
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Each lymphocyte expresses a unique antigen receptor, according to Burnett's clonal selection theory.
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Thymic T cell development involves three distinct checkpoints, including b-selection and pos/neg selection.
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The thymus lacks progenitors with self-renewing capacity, as mentioned in the text.
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The crystal structure of the T cell receptor involves protein loops of the TCR touching the peptide in the context of MHC.
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If BM is transferred to a young mouse, then graft acceptance is possible later, as mentioned in the text.
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Immature lymphocytes carrying receptors with specificity for self-antigens are eliminated, according to Burnett's clonal selection theory.
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Thymic seeding progenitors and early thymic progenitors are part of the thymic T cell development process.
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Developing thymocytes interact with specific stromal cell types such as cortical and medullary thymic epithelial cells.
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B and T cell receptors have the capacity for 10151020 different clonotypes.
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Frank Macfarlane Burnett postulated about clonal expansion of mature lymphocytes with the same receptor specificity.
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