Innate vs Adaptive Immunity: Receptor Generation

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IdealForeshadowing
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14 Questions

How are adaptive immune cells able to generate receptors that specifically recognize virtually every pathogen, while sparing self-antigens?

False

How do precursors decide to become a particular cell type (lineage), e.g. a CD4+ T cell, or a regulatory T cell?

False

According to Paul Ehrlich, why does the immune system not destroy the body despite its powerful immune reactions against pathogens?

False

What are the two plausible hypotheses about how tolerance to self could be formed?

False

Each lymphocyte expresses a unique antigen receptor, according to Burnett's clonal selection theory.

True

Thymic T cell development involves three distinct checkpoints, including b-selection and pos/neg selection.

True

The thymus lacks progenitors with self-renewing capacity, as mentioned in the text.

True

The crystal structure of the T cell receptor involves protein loops of the TCR touching the peptide in the context of MHC.

True

If BM is transferred to a young mouse, then graft acceptance is possible later, as mentioned in the text.

True

Immature lymphocytes carrying receptors with specificity for self-antigens are eliminated, according to Burnett's clonal selection theory.

True

Thymic seeding progenitors and early thymic progenitors are part of the thymic T cell development process.

True

Developing thymocytes interact with specific stromal cell types such as cortical and medullary thymic epithelial cells.

True

B and T cell receptors have the capacity for 10151020 different clonotypes.

True

Frank Macfarlane Burnett postulated about clonal expansion of mature lymphocytes with the same receptor specificity.

True

Test your understanding of how adaptive immune cells generate receptors to specifically recognize a wide range of pathogens. This quiz is based on information from Abbas' Immunology (10th edition) by Florian Mair.

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