Podcast
Questions and Answers
Which of the following is an example of a soluble effector in innate immunity?
Which of the following is an example of a soluble effector in innate immunity?
- Defensins
- Interferon
- Collectins
- Lysozyme (correct)
What is the main function of antimicrobial peptides in innate immunity?
What is the main function of antimicrobial peptides in innate immunity?
- Target pathogens for phagocytosis
- Induce inflammation
- Disrupt microbial membranes (correct)
- Opsonize pathogens
Which of the following is NOT a characteristic of innate immunity?
Which of the following is NOT a characteristic of innate immunity?
- Metabolic reprogramming
- Epigenetic reprogramming
- Specific response to pathogens (correct)
- Trained immunity
What is the main function of collectins, ficolins, and pentraxins in innate immunity?
What is the main function of collectins, ficolins, and pentraxins in innate immunity?
Which of the following is true about complement components in innate immunity?
Which of the following is true about complement components in innate immunity?
Which of the following is an example of an anatomical barrier in innate immunity?
Which of the following is an example of an anatomical barrier in innate immunity?
What is the main function of lysozyme in innate immunity?
What is the main function of lysozyme in innate immunity?
Which of the following is an example of a pattern recognition receptor (PRR) in innate immunity?
Which of the following is an example of a pattern recognition receptor (PRR) in innate immunity?
Which of the following is NOT an innate barrier to infection?
Which of the following is NOT an innate barrier to infection?
What is the main function of defensins in innate immunity?
What is the main function of defensins in innate immunity?
Which molecule forms a pore that inserts into the membrane, allowing diffusion of ions and small molecules?
Which molecule forms a pore that inserts into the membrane, allowing diffusion of ions and small molecules?
What is the function of complement inhibitors in human cells?
What is the function of complement inhibitors in human cells?
Which deficiency in the complement pathway leads to serious pyogenic infections in neonates and children?
Which deficiency in the complement pathway leads to serious pyogenic infections in neonates and children?
Which complement deficiency is the most severe and leads to successive severe infections?
Which complement deficiency is the most severe and leads to successive severe infections?
Which autoimmune disease is associated with a deficiency in C4?
Which autoimmune disease is associated with a deficiency in C4?
Which component of the complement pathway deficiency makes patients prone to Neisseria meningitis infection?
Which component of the complement pathway deficiency makes patients prone to Neisseria meningitis infection?
What is the role of CR1 on erythrocytes in the complement pathway?
What is the role of CR1 on erythrocytes in the complement pathway?
How do phagocytes recognize immune complexes in the complement pathway?
How do phagocytes recognize immune complexes in the complement pathway?
What are the consequences of complement system deficiencies?
What are the consequences of complement system deficiencies?
Which book is recommended for further reading on immunology?
Which book is recommended for further reading on immunology?
Which type of antimicrobial peptide kills bacteria by disrupting their membrane?
Which type of antimicrobial peptide kills bacteria by disrupting their membrane?
Which type of antimicrobial peptide is constitutively secreted by neutrophils, epithelial cells, and paneth cells in the crypts of the small intestine?
Which type of antimicrobial peptide is constitutively secreted by neutrophils, epithelial cells, and paneth cells in the crypts of the small intestine?
Which type of antimicrobial peptide can also attack fungi and viruses?
Which type of antimicrobial peptide can also attack fungi and viruses?
Which type of antimicrobial peptide has globular lectin-like heads that bind bacterial cell surface sugars?
Which type of antimicrobial peptide has globular lectin-like heads that bind bacterial cell surface sugars?
Which type of antimicrobial peptide can activate complement through the classical pathway/lectin pathway?
Which type of antimicrobial peptide can activate complement through the classical pathway/lectin pathway?
Which complement pathway is antibody-independent and activated by ficolins and mannose binding lectin (MBL)?
Which complement pathway is antibody-independent and activated by ficolins and mannose binding lectin (MBL)?
Which complement pathway is initiated by C1 activation and requires at least 2 FC domains of an antibody-antigen complex?
Which complement pathway is initiated by C1 activation and requires at least 2 FC domains of an antibody-antigen complex?
Which complement pathway involves the spontaneous hydrolysis of C3 into C3a and C3b?
Which complement pathway involves the spontaneous hydrolysis of C3 into C3a and C3b?
Which complement component can form a complex with MASP-1 and MASP2 to cleave C2 and C4 in the lectin pathway?
Which complement component can form a complex with MASP-1 and MASP2 to cleave C2 and C4 in the lectin pathway?
Which complement component is an important component of the membrane attack complex?
Which complement component is an important component of the membrane attack complex?
Which immune response is more rapid, the innate immune response or the adaptive immune response?
Which immune response is more rapid, the innate immune response or the adaptive immune response?
Which immune response is more specific, the innate immune response or the adaptive immune response?
Which immune response is more specific, the innate immune response or the adaptive immune response?
Which immune response has memory, the innate immune response or the adaptive immune response?
Which immune response has memory, the innate immune response or the adaptive immune response?
Which immune response recognizes broad classes of pathogens, the innate immune response or the adaptive immune response?
Which immune response recognizes broad classes of pathogens, the innate immune response or the adaptive immune response?
Which type of antimicrobial peptide kills bacteria by disrupting their membrane?
Which type of antimicrobial peptide kills bacteria by disrupting their membrane?
What is the main function of collectins, ficolins, and pentraxins in innate immunity?
What is the main function of collectins, ficolins, and pentraxins in innate immunity?
Which component of the complement pathway deficiency makes patients prone to Neisseria meningitis infection?
Which component of the complement pathway deficiency makes patients prone to Neisseria meningitis infection?
Which of the following is NOT a characteristic of innate immunity?
Which of the following is NOT a characteristic of innate immunity?
Which of the following is NOT a topic that will be covered in this lecture?
Which of the following is NOT a topic that will be covered in this lecture?
What is the function of lysozyme in innate immunity?
What is the function of lysozyme in innate immunity?
Which of the following is NOT an example of a soluble molecule that defends against infection?
Which of the following is NOT an example of a soluble molecule that defends against infection?
Which complement pathway requires at least 2 FC domains of an antibody-antigen complex for activation?
Which complement pathway requires at least 2 FC domains of an antibody-antigen complex for activation?
Which term is used to describe the concept of innate immune cells changing their response after exposure to a pathogen or vaccine?
Which term is used to describe the concept of innate immune cells changing their response after exposure to a pathogen or vaccine?
What is the name of the vaccine that was the first real discovery of trained immunity?
What is the name of the vaccine that was the first real discovery of trained immunity?
Which type of immune cells undergo long-term trained immunity, despite their short lifespan in the bloodstream?
Which type of immune cells undergo long-term trained immunity, despite their short lifespan in the bloodstream?
What are the three main barriers to pathogen entry in the body?
What are the three main barriers to pathogen entry in the body?
Which of the following is true about the complement system?
Which of the following is true about the complement system?
Which pathway of the complement system requires at least 2 FC domains of an antibody-antigen complex for activation?
Which pathway of the complement system requires at least 2 FC domains of an antibody-antigen complex for activation?
Which complement component deficiency makes patients prone to Neisseria meningitis infection?
Which complement component deficiency makes patients prone to Neisseria meningitis infection?
What is the main function of the complement system in innate immunity?
What is the main function of the complement system in innate immunity?
Which of the following is true about lysozyme in innate immunity?
Which of the following is true about lysozyme in innate immunity?
Which type of antimicrobial peptide is found in the oral cavity and has broad spectrum activity against both gram positive and gram negative bacteria?
Which type of antimicrobial peptide is found in the oral cavity and has broad spectrum activity against both gram positive and gram negative bacteria?
What is the main function of anti-microbial peptides in innate immunity?
What is the main function of anti-microbial peptides in innate immunity?
Which complement pathway is initiated by C1 activation and requires at least 2 FC domains of an antibody-antigen complex?
Which complement pathway is initiated by C1 activation and requires at least 2 FC domains of an antibody-antigen complex?
Which complement component is cleaved into a small and large fragment, resulting in amplification of the cascade and activation of complement effector functions?
Which complement component is cleaved into a small and large fragment, resulting in amplification of the cascade and activation of complement effector functions?
Which complement component is the first cleaver molecule discovered to be cleaved, resulting in the generation of an active fragment labeled 'a'?
Which complement component is the first cleaver molecule discovered to be cleaved, resulting in the generation of an active fragment labeled 'a'?
Which complement pathway involves the spontaneous hydrolysis of C3 into C3a and C3b?
Which complement pathway involves the spontaneous hydrolysis of C3 into C3a and C3b?
Which complement pathway is antibody-independent and activated by ficolins and mannose binding lectin (MBL)?
Which complement pathway is antibody-independent and activated by ficolins and mannose binding lectin (MBL)?
Which complement component deficiency makes patients prone to Neisseria meningitis infection?
Which complement component deficiency makes patients prone to Neisseria meningitis infection?
Which complement component is an important component of the membrane attack complex?
Which complement component is an important component of the membrane attack complex?