20 Questions
Which molecule allows cells to adhere reversibly to the vessel wall?
E-selectin
Which molecules are involved in the firm attachment of rolling cells to the endothelium?
Integrins LFA-1 and CR3
Which molecule is expressed at junctions of endothelial cells and allows cells to squeeze through these junctions?
CD31
What triggers the conformational change in rolling cells, increasing their adhesive properties?
Chemokines bound to the surface of endothelial cells
Which molecule is involved in the penetration of the basement membrane by producing enzymes that break down the extracellular matrix protein?
LFA-1
What is the function of C reactive protein during the acute phase response?
Binds to the phosphocholine portion of certain bacterial and fungal cell-wall lipopolysaccharide
Which molecules contribute to the long-range effects of macrophage-produced cytokines during the acute phase response?
IL-1, IL-6, TNF
What is the role of chemokines in the migration of cells through tissue to the infection site?
They are produced at the site of infection and bind to either endothelial cells or proteoglycans in the extracellular matrix
What is the function of mannose binding lectin during the acute phase response?
Opsinizes pathogens and triggers complement cascade
What is the role of pattern recognition receptors in the immune response?
They recognize bacteria and initiate phagocytosis
What is the first step in the recruitment of cells to the site of infection?
Reversible adherence mediated by selectins
What is the function of P-selectin at inflammatory sites?
Appears on endothelial cell surface to allow interaction with cells
Which molecules are induced on the surface of the local blood vessel endothelium and on infiltrating cells during the recruitment of cells to the site of infection?
Selectins, integrins, ICAM/ImmG
What enables the engulfing of bacteria and the recruitment of cells to the site of infection?
Phagocytosis and production of cytokines and chemokines
What is the final step in the recruitment of cells to the site of infection?
Migration under the influence of chemokines
What is the role of cell adhesion molecules during the recruitment of cells to the site of infection?
Mediate the adherence of cells to the endothelium
What is the function of chemokines during the recruitment of cells to the site of infection?
Mediate the migration of cells to the site of infection
Which molecules are involved in the activation of complement during the recruitment of cells to the site of infection?
Cytokines and chemokines
What is the consequence of the vessels being dilated at inflammatory sites?
Slower blood flow allowing cells to interact with the endothelium
What is the initial step in the recruitment of cells to the site of infection?
Reversible adherence mediated by selectins
Test your knowledge of innate immunity in immunology with this quiz. Explore topics such as phagocytosis, cytokine and chemokine production, complement activation, adhesion molecules, and cell recruitment to infection sites.
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