12 Questions
Which proteins can lyse bacterial cell walls?
Defensins
What is the primary role of the complement system?
To bind C3 and C4 covalently to microbial surfaces
Which pathway of complement activation is triggered by bacterial surfaces that bind C3?
Alternative pathway
What triggers the classic pathway of complement activation?
Antibodies binding to microbial surfaces
What is the primary function of the antimicrobial peptides in tissues?
Preventing bacterial growth by multiple mechanisms
Which proteins prevent bacterial growth by depriving them of essential iron?
Hepcidin
What is the role of the complement system in killing invading microbes?
Binding C3 and C4 covalently to microbial surfaces
Which pathway of complement activation is triggered by bacterial surfaces binding to mannose-binding protein in serum?
Classic pathway
Which type of proteins can prevent bacterial growth by depriving them of essential iron?
Hepcidin
What is the primary function of the complement system in animals?
To bind C3 and C4 covalently to microbial surfaces
What triggers the alternative pathway of complement activation?
Bacterial surfaces binding to C3
Which group of proteins act collectively to kill invading microbes in the complement system?
The ~30 proteins of the complement system
Test your knowledge on the innate chemical defenses present in animal tissues, including antimicrobial peptides like defensins, cathelicidins, lysozyme, hepcidin, and haptoglobin. Explore the role of the complement system in preventing bacterial growth.
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