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Questions and Answers
What is the primary mode of action of antimicrobial drugs that inhibit nucleic acid synthesis?
What is the primary mode of action of antimicrobial drugs that inhibit nucleic acid synthesis?
- Inhibition of purine and pyrimidine nucleotide synthesis (correct)
- Interference with polymerization level
- Binding to the active site of enzymes
- Competing with physiological nucleosides
Which type of enzymes involved in nucleic acid synthesis are different in prokaryotic and eukaryotic cells?
Which type of enzymes involved in nucleic acid synthesis are different in prokaryotic and eukaryotic cells?
- Gyrase enzymes
- Polymerases (correct)
- Topoisomerases
- Helicases
How do fluoroquinolones interfere with DNA replication in bacteria?
How do fluoroquinolones interfere with DNA replication in bacteria?
- Compete with physiological nucleosides
- Prevent stabilization of enzyme-DNA complex (correct)
- Inhibit the catalytic activity of DNA gyrase
- Bind to the active site of gyrase enzymes
Which drugs inhibit bacterial DNA gyrase?
Which drugs inhibit bacterial DNA gyrase?
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What class of chemotherapeutic agents are cytotoxic nucleoside analogues and nucleobases considered?
What class of chemotherapeutic agents are cytotoxic nucleoside analogues and nucleobases considered?
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Why are cytotoxic nucleoside analogues and nucleobases associated with side effects?
Why are cytotoxic nucleoside analogues and nucleobases associated with side effects?
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