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Inhibitors of DNA Replication in Antimicrobial Drugs
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Inhibitors of DNA Replication in Antimicrobial Drugs

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Questions and Answers

What is the primary mode of action of antimicrobial drugs that inhibit nucleic acid synthesis?

  • Inhibition of purine and pyrimidine nucleotide synthesis (correct)
  • Interference with polymerization level
  • Binding to the active site of enzymes
  • Competing with physiological nucleosides

    • Which type of enzymes involved in nucleic acid synthesis are different in prokaryotic and eukaryotic cells?

  • Gyrase enzymes
  • Polymerases (correct)
  • Topoisomerases
  • Helicases

    • How do fluoroquinolones interfere with DNA replication in bacteria?

  • Compete with physiological nucleosides
  • Prevent stabilization of enzyme-DNA complex (correct)
  • Inhibit the catalytic activity of DNA gyrase
  • Bind to the active site of gyrase enzymes

    • Which drugs inhibit bacterial DNA gyrase?

    <p>Novobiocin and Nalidixic acid</p> Signup and view all the answers

    What class of chemotherapeutic agents are cytotoxic nucleoside analogues and nucleobases considered?

    <p>Antimetabolites</p> Signup and view all the answers

    Why are cytotoxic nucleoside analogues and nucleobases associated with side effects?

    <p>Interacting with a large number of intracellular targets</p> Signup and view all the answers

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