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Inhibitors of DNA Replication in Antimicrobial Drugs

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Inhibitors of DNA Replication in Antimicrobial Drugs

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Questions and Answers

What is the primary mode of action of antimicrobial drugs that inhibit nucleic acid synthesis?

Inhibition of purine and pyrimidine nucleotide synthesis (correct)

Interference with polymerization level

Binding to the active site of enzymes

Competing with physiological nucleosides

Which type of enzymes involved in nucleic acid synthesis are different in prokaryotic and eukaryotic cells?

Gyrase enzymes

Polymerases (correct)

Topoisomerases

Helicases

How do fluoroquinolones interfere with DNA replication in bacteria?

Compete with physiological nucleosides

Prevent stabilization of enzyme-DNA complex (correct)

Inhibit the catalytic activity of DNA gyrase

Bind to the active site of gyrase enzymes

Which drugs inhibit bacterial DNA gyrase?

Novobiocin and Nalidixic acid Signup and view all the answers

What class of chemotherapeutic agents are cytotoxic nucleoside analogues and nucleobases considered?

Antimetabolites Signup and view all the answers

Why are cytotoxic nucleoside analogues and nucleobases associated with side effects?

Interacting with a large number of intracellular targets Signup and view all the answers

Inhibitors of DNA Replication in Antimicrobial Drugs

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Podcast

Questions and Answers

What is the primary mode of action of antimicrobial drugs that inhibit nucleic acid synthesis?

Which type of enzymes involved in nucleic acid synthesis are different in prokaryotic and eukaryotic cells?

How do fluoroquinolones interfere with DNA replication in bacteria?

Which drugs inhibit bacterial DNA gyrase?

What class of chemotherapeutic agents are cytotoxic nucleoside analogues and nucleobases considered?

Why are cytotoxic nucleoside analogues and nucleobases associated with side effects?

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