Inherited Antigen Receptor Genes Overview
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Questions and Answers

Which gene segments are found in all antigen receptors?

  • J, D, and C gene segments
  • Only V and C gene segments
  • V, D, and C gene segments
  • V, J, and C gene segments (correct)

    • Which gene segment is found in the Ig heavy chain and TCR β chain, but not in the Ig light chain or TCR α chain?

  • C gene segment
  • D gene segment (correct)
  • J gene segment
  • V gene segment

    • What is the role of the VDJ recombinase enzyme during lymphocyte maturation?

  • It randomly selects one D gene and one J segment to form the DJ complex.
  • It rearranges a V segment to the fused DJ complex.
  • It brings two Ig or TCR gene segments close together and cleaves the DNA at specific sites.
  • All of the above (correct)

    • What is the significance of the CDR3 sequence in antigen receptors?

    <p>It is important for detecting the proliferative expansion of B or T cells.</p> Signup and view all the answers

    Which of the following is the correct order of events during the production of an antigen receptor?

    <p>Random selection of 1 D gene and 1 J segment, rearrangement of a V segment to the fused DJ complex, VDJ recombinase, and ligase.</p> Signup and view all the answers

    What is the first step in the production of an Ig heavy chain during lymphocyte maturation?

    <p>Translation to produce the μ heavy chain.</p> Signup and view all the answers

    What is the main function of B-lymphocytes?

    <p>Identify antigens from macromolecules</p> Signup and view all the answers

    Which region of the antigen receptor is responsible for antigen recognition?

    <p>Variable region</p> Signup and view all the answers

    What is the composition of an antibody molecule?

    <p>Two identical heavy chains and two identical light chains</p> Signup and view all the answers

    Which type of antigens do T-lymphocytes primarily recognize?

    <p>Peptides and smaller molecules</p> Signup and view all the answers

    What is the role of the complementarity-determining regions (CDRs) in antigen receptors?

    <p>Maximize the variability of the antigen-binding part</p> Signup and view all the answers

    What are the forms of antibodies/immunoglobulins produced by B-lymphocytes?

    <p>Both membrane-bound and secreted</p> Signup and view all the answers

    What is responsible for the diversity in antigen recognition by Ig and TCR?

    <p>Combinatorial Diversity</p> Signup and view all the answers

    Which enzyme is involved in the addition or removal of nucleotides during antigen receptor diversity?

    <p>Terminal deoxyribonucletidyl transferase</p> Signup and view all the answers

    What occurs in the large Pre-B cells during the maturation of B lymphocytes?

    <p>Final rearrangement of the VDJ gene for the heavy chain</p> Signup and view all the answers

    What is the function of the pre-BCR complex in the maturation of B cells?

    <p>Promote survival and proliferation of B lineage cells</p> Signup and view all the answers

    Which process accounts for unlimited diversity in antigen recognition by Ig and TCR?

    <p>Junctional Diversity</p> Signup and view all the answers

    At what stage does a Pro-B cell develop into a Pre-B cell?

    <p>When it forms an Ig μ heavy chain</p> Signup and view all the answers

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