18 Questions
Which gene segments are found in all antigen receptors?
V, J, and C gene segments
Which gene segment is found in the Ig heavy chain and TCR β chain, but not in the Ig light chain or TCR α chain?
D gene segment
What is the role of the VDJ recombinase enzyme during lymphocyte maturation?
All of the above
What is the significance of the CDR3 sequence in antigen receptors?
It is important for detecting the proliferative expansion of B or T cells.
Which of the following is the correct order of events during the production of an antigen receptor?
Random selection of 1 D gene and 1 J segment, rearrangement of a V segment to the fused DJ complex, VDJ recombinase, and ligase.
What is the first step in the production of an Ig heavy chain during lymphocyte maturation?
Translation to produce the μ heavy chain.
What is the main function of B-lymphocytes?
Identify antigens from macromolecules
Which region of the antigen receptor is responsible for antigen recognition?
Variable region
What is the composition of an antibody molecule?
Two identical heavy chains and two identical light chains
Which type of antigens do T-lymphocytes primarily recognize?
Peptides and smaller molecules
What is the role of the complementarity-determining regions (CDRs) in antigen receptors?
Maximize the variability of the antigen-binding part
What are the forms of antibodies/immunoglobulins produced by B-lymphocytes?
Both membrane-bound and secreted
What is responsible for the diversity in antigen recognition by Ig and TCR?
Combinatorial Diversity
Which enzyme is involved in the addition or removal of nucleotides during antigen receptor diversity?
Terminal deoxyribonucletidyl transferase
What occurs in the large Pre-B cells during the maturation of B lymphocytes?
Final rearrangement of the VDJ gene for the heavy chain
What is the function of the pre-BCR complex in the maturation of B cells?
Promote survival and proliferation of B lineage cells
Which process accounts for unlimited diversity in antigen recognition by Ig and TCR?
Junctional Diversity
At what stage does a Pro-B cell develop into a Pre-B cell?
When it forms an Ig μ heavy chain
Explore the structure of inherited antigen receptor genes found in hematopoietic stem cells, including Ig (heavy and light chain) and TCR (α and β chain). Learn about the V, D, J, and C gene segments present in these receptors and how they come together to form functional antigen receptors as lymphocytes mature.
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