Inherited Antigen Receptor Genes Overview

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Which gene segments are found in all antigen receptors?

J, D, and C gene segments
Only V and C gene segments
V, D, and C gene segments
V, J, and C gene segments (correct)

Which gene segment is found in the Ig heavy chain and TCR β chain, but not in the Ig light chain or TCR α chain?

C gene segment
D gene segment (correct)
J gene segment
V gene segment

What is the role of the VDJ recombinase enzyme during lymphocyte maturation?

It randomly selects one D gene and one J segment to form the DJ complex.
It rearranges a V segment to the fused DJ complex.
It brings two Ig or TCR gene segments close together and cleaves the DNA at specific sites.
All of the above (correct)

What is the significance of the CDR3 sequence in antigen receptors?

It is important for detecting the proliferative expansion of B or T cells. (D) Signup and view all the answers

Which of the following is the correct order of events during the production of an antigen receptor?

Random selection of 1 D gene and 1 J segment, rearrangement of a V segment to the fused DJ complex, VDJ recombinase, and ligase. (A) Signup and view all the answers

What is the first step in the production of an Ig heavy chain during lymphocyte maturation?

Translation to produce the μ heavy chain. (C) Signup and view all the answers

What is the main function of B-lymphocytes?

Identify antigens from macromolecules (B) Signup and view all the answers

Which region of the antigen receptor is responsible for antigen recognition?

Variable region (D) Signup and view all the answers

What is the composition of an antibody molecule?

Two identical heavy chains and two identical light chains (A) Signup and view all the answers

Which type of antigens do T-lymphocytes primarily recognize?

Peptides and smaller molecules (D) Signup and view all the answers

What is the role of the complementarity-determining regions (CDRs) in antigen receptors?

Maximize the variability of the antigen-binding part (C) Signup and view all the answers

What are the forms of antibodies/immunoglobulins produced by B-lymphocytes?

Both membrane-bound and secreted (A) Signup and view all the answers

What is responsible for the diversity in antigen recognition by Ig and TCR?

Combinatorial Diversity (D) Signup and view all the answers

Which enzyme is involved in the addition or removal of nucleotides during antigen receptor diversity?

Terminal deoxyribonucletidyl transferase (B) Signup and view all the answers

What occurs in the large Pre-B cells during the maturation of B lymphocytes?

Final rearrangement of the VDJ gene for the heavy chain (C) Signup and view all the answers

What is the function of the pre-BCR complex in the maturation of B cells?

Promote survival and proliferation of B lineage cells (D) Signup and view all the answers

Which process accounts for unlimited diversity in antigen recognition by Ig and TCR?

Junctional Diversity (A) Signup and view all the answers

At what stage does a Pro-B cell develop into a Pre-B cell?

When it forms an Ig μ heavy chain (A) Signup and view all the answers