Podcast
Questions and Answers
How are the light and heavy chains of an antibody molecule connected?
How are the light and heavy chains of an antibody molecule connected?
Each light chain is attached to one heavy chain, and the two heavy chains are attached to each other, all by disulfide bonds.
What are the components of an antibody molecule?
What are the components of an antibody molecule?
An antibody molecule is composed of four polypeptide chains - two identical heavy (H) chains and two identical light (L) chains.
What is the structure of an Ig domain?
What is the structure of an Ig domain?
An Ig domain consists of two layers of a β-pleated sheet held together by a disulfide bridge.
How many C domains does a heavy chain of an antibody molecule have?
How many C domains does a heavy chain of an antibody molecule have?
Signup and view all the answers
What are the features of antigen receptors of B and T lymphocytes important for their functions in adaptive immunity?
What are the features of antigen receptors of B and T lymphocytes important for their functions in adaptive immunity?
Signup and view all the answers
What are the fundamental differences in the types of antigenic structures recognized by B cells and T cells?
What are the fundamental differences in the types of antigenic structures recognized by B cells and T cells?
Signup and view all the answers
What are the three CDRs responsible for antigen recognition in Ig molecules?
What are the three CDRs responsible for antigen recognition in Ig molecules?
Signup and view all the answers
Where is the greatest variability found among the three hypervariable regions in Ig molecules?
Where is the greatest variability found among the three hypervariable regions in Ig molecules?
Signup and view all the answers
What is the fragment of an antibody that contains the portion required for antigen recognition?
What is the fragment of an antibody that contains the portion required for antigen recognition?
Signup and view all the answers
What is the portion of the antibody that tends to crystallize in solution?
What is the portion of the antibody that tends to crystallize in solution?
Signup and view all the answers
What region of the antibody molecule allows the two antigen-binding Fab regions to move independently?
What region of the antibody molecule allows the two antigen-binding Fab regions to move independently?
Signup and view all the answers
How many identical Fab regions that bind antigen are there in each Ig molecule?
How many identical Fab regions that bind antigen are there in each Ig molecule?
Signup and view all the answers
Where is the C-terminal end of the heavy chain anchored in some Ig molecules?
Where is the C-terminal end of the heavy chain anchored in some Ig molecules?
Signup and view all the answers
How many types of heavy chains are there in Ig molecules?
How many types of heavy chains are there in Ig molecules?
Signup and view all the answers
What are the antigen receptors of naive B lymphocytes?
What are the antigen receptors of naive B lymphocytes?
Signup and view all the answers
What happens to the antigen-specific B lymphocyte clone after stimulation by antigen and helper T lymphocytes?
What happens to the antigen-specific B lymphocyte clone after stimulation by antigen and helper T lymphocytes?
Signup and view all the answers
