Podcast Beta
Questions and Answers
What is the primary mechanism of action of Oseltamivir?
What is a common side effect of taking Oseltamivir?
Which of the following is a contraindication for Oseltamivir?
When should Oseltamivir be started for it to be effective?
Signup and view all the answers
What is a serious adverse effect associated with Oseltamivir?
Signup and view all the answers
Study Notes
Influenza Virus Release Inhibitors
- Mechanism of Action: Inhibit influenza neuraminidase, preventing newly made virus particles from detaching from host cells.
-
Oseltamivir (Tamiflu®):
- Given orally (PO) as an inactive prodrug (oseltamivir phosphate).
- Activated in the liver by ester hydrolysis.
- Renal Adjustment: Dose adjustments are required for patients with kidney dysfunction.
- CDC Recommendation: Recommended by the CDC for treatment and prophylaxis.
- Black Box Warning (BBW): None.
- Contraindications: None.
- Clinical use: Effective against influenza A and B, for both treatment and prevention.
- Timing: Start taking within 48 hours of symptom onset.
- Administration: Take with food
- Common Side Effects: Nausea, vomiting, abdominal pain.
- Serious Side Effects: Rash (Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis), Neuropsychiatric events.
- Drug Interactions: Live influenza vaccine.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz covers the mechanism of action and clinical use of influenza virus release inhibitors, focusing on oseltamivir (Tamiflu®). It includes information on dosing, side effects, and recommendations from the CDC. Test your knowledge about this important antiviral treatment for influenza A and B.
