Influenza Virus Release Inhibitors

Play Quiz

Study Flashcards

Spaced Repetition

Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Download our mobile app to listen on the go

Get App

<p>Within 48 hours of symptom onset (D)</p> Signup and view all the answers

<p>Rash (SJS/TENS) (A)</p> Signup and view all the answers

Flashcards are hidden until you start studying

Mechanism of Action: Inhibit influenza neuraminidase, preventing newly made virus particles from detaching from host cells.
Oseltamivir (Tamiflu®):
- Given orally (PO) as an inactive prodrug (oseltamivir phosphate).
- Activated in the liver by ester hydrolysis.
- Renal Adjustment: Dose adjustments are required for patients with kidney dysfunction.
- CDC Recommendation: Recommended by the CDC for treatment and prophylaxis.
- Black Box Warning (BBW): None.
- Contraindications: None.
- Clinical use: Effective against influenza A and B, for both treatment and prevention.
- Timing: Start taking within 48 hours of symptom onset.
- Administration: Take with food
- Common Side Effects: Nausea, vomiting, abdominal pain.
- Serious Side Effects: Rash (Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis), Neuropsychiatric events.
- Drug Interactions: Live influenza vaccine.