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Questions and Answers
What is the primary mechanism of action of Oseltamivir?
What is the primary mechanism of action of Oseltamivir?
What is a common side effect of taking Oseltamivir?
What is a common side effect of taking Oseltamivir?
Which of the following is a contraindication for Oseltamivir?
Which of the following is a contraindication for Oseltamivir?
When should Oseltamivir be started for it to be effective?
When should Oseltamivir be started for it to be effective?
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What is a serious adverse effect associated with Oseltamivir?
What is a serious adverse effect associated with Oseltamivir?
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Study Notes
Influenza Virus Release Inhibitors
- Mechanism of Action: Inhibit influenza neuraminidase, preventing newly made virus particles from detaching from host cells.
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Oseltamivir (Tamiflu®):
- Given orally (PO) as an inactive prodrug (oseltamivir phosphate).
- Activated in the liver by ester hydrolysis.
- Renal Adjustment: Dose adjustments are required for patients with kidney dysfunction.
- CDC Recommendation: Recommended by the CDC for treatment and prophylaxis.
- Black Box Warning (BBW): None.
- Contraindications: None.
- Clinical use: Effective against influenza A and B, for both treatment and prevention.
- Timing: Start taking within 48 hours of symptom onset.
- Administration: Take with food
- Common Side Effects: Nausea, vomiting, abdominal pain.
- Serious Side Effects: Rash (Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis), Neuropsychiatric events.
- Drug Interactions: Live influenza vaccine.
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Description
This quiz covers the mechanism of action and clinical use of influenza virus release inhibitors, focusing on oseltamivir (Tamiflu®). It includes information on dosing, side effects, and recommendations from the CDC. Test your knowledge about this important antiviral treatment for influenza A and B.
