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Influence of Anatomic Site on Tumor Outcome Quiz

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Influence of Anatomic Site on Tumor Outcome Quiz

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Questions and Answers

What is a common feature of astrocytoma, IDH-mutant, grade 3?

Microvascular proliferation

Necrosis

Prominent cytologic atypia

Fibrillary background with mitotic figures (correct)

What distinguishes astrocytoma, IDH-mutant, grade 4 from grade 3?

Absence of mitotic figures

Presence of homozygous deletion of CDKN2A &/or CDKN2B (correct)

More nuclear pleomorphism

Lack of astrocytic cell processes in the background

Which feature is NOT present in astrocytoma, IDH-mutant, grade 3?

Mitotic activity

Microvascular proliferation (correct)

Fibrillary background

Enlarged irregular nuclei

What type of stain is used to identify tumor cells in astrocytoma?

IDH1 immune stain Signup and view all the answers

In astrocytoma, what protein is used to identify the glial cells?

GFAP Signup and view all the answers

In astrocytoma, IDH-mutant, grade 4, which feature distinguishes it from grade 3?

Homozygous deletion of CDKN2A &/or CDKN2B Signup and view all the answers

Which characteristic is NOT typically found in astrocytoma, IDH-mutant, grade 3?

Microvascular proliferation Signup and view all the answers

What cellular feature is commonly observed in astrocytoma, IDH-mutant, grade 4?

Prominent mitotic activity Signup and view all the answers

Which stain is positive in tumor cells of astrocytoma?

IDH1 Signup and view all the answers

What is a distinguishing feature of astrocytoma, IDH-mutant, grade 4 compared to lower grades?

Presence of necrosis Signup and view all the answers

Which factor plays a significant role in grading astrocytomas?

Presence of mitotic figures Signup and view all the answers

What feature is NOT typically observed in astrocytoma, IDH-mutant, grade 3?

Microvascular proliferation Signup and view all the answers

Which characteristic is common to both astrocytoma, IDH-mutant, grades 3 and 4?

Mitotic activity Signup and view all the answers