Inflammatory Myopathies Quiz
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Questions and Answers

What is the most likely diagnosis for Luke based on the presented case?

  • Inclusion body myositis (correct)
  • Dermatomyositis
  • Lambert-Eaton myasthenic syndrome
  • Polymyositis
  • Which of the following diagnostic tests would be most beneficial for confirming the suspected diagnosis?

  • Muscle biopsy (correct)
  • Autoantibody testing
  • Serum creatine kinase (CK) levels
  • Electromyography (EMG)
  • What histological findings would be expected in muscle biopsy of a patient with suspected inclusion body myositis?

  • Endomysial inflammation with CD8+ T cells
  • Rimmed vacuoles and cytoplasmic inclusions (correct)
  • Prominent perimysial inflammation
  • Presence of perifascicular atrophy
  • Which of the following is a characteristic feature of dermatomyositis that is not present in Luke's case?

    <p>Perifascicular atrophy</p> Signup and view all the answers

    What autoimmune marker may be elevated in patients with inflammatory myopathies such as dermatomyositis and polymyositis?

    <p>Anti-Jo-1 antibodies</p> Signup and view all the answers

    Which of the following is not typically associated with Lambert-Eaton myasthenic syndrome, making it less likely in Luke's case?

    <p>Proximal muscle weakness</p> Signup and view all the answers

    Which autoimmune systemic connective tissue disease primarily affects the skeletal muscles and is characterized by a prominent mononuclear inflammatory cell infiltrate in the endomysium?

    <p>Sporadic inclusion body myositis (IBM)</p> Signup and view all the answers

    What is the serum total creatine kinase level in the patient described?

    <p>645 IU/L</p> Signup and view all the answers

    Which muscle group exhibited asymmetric atrophy and had a muscle strength of 1/5 on hip flexion and knee extension of the right side?

    <p>Quadriceps</p> Signup and view all the answers

    What was the result of serology testing for cytoplasmic 5’-nucleotidase 1A (cN1A) autoantibody?

    <p>Positive</p> Signup and view all the answers

    Which of the following is NOT mentioned as a common environmental agent implicated in idiopathic inflammatory myopathies?

    <p>Fungi</p> Signup and view all the answers

    What does IIM stand for in the text?

    <p>Idiopathic Inflammatory Myopathies</p> Signup and view all the answers

    What is the normal range for serum total creatine kinase level?

    <p>$55-170 IU/L$</p> Signup and view all the answers

    Which of the following are the components of basic metabolic panel mentioned in the text?

    <p>$Na^+, Cl^-, CO_2, BUN, Creatinine$</p> Signup and view all the answers

    What does ESR stand for in the text?

    <p>$Erythrocyte Sedimentation Rate$</p> Signup and view all the answers

    What was the main pathological finding in the muscle biopsy of right vastus lateralis?

    <p>$All of the above$</p> Signup and view all the answers

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