Inflammatory Myopathies Quiz

What is the most likely diagnosis for Luke based on the presented case?

Inclusion body myositis (correct)

Dermatomyositis

Lambert-Eaton myasthenic syndrome

Polymyositis

Which of the following diagnostic tests would be most beneficial for confirming the suspected diagnosis?

Muscle biopsy (correct)

Autoantibody testing

Serum creatine kinase (CK) levels

Electromyography (EMG)

What histological findings would be expected in muscle biopsy of a patient with suspected inclusion body myositis?

Endomysial inflammation with CD8+ T cells

Rimmed vacuoles and cytoplasmic inclusions (correct)

Prominent perimysial inflammation

Presence of perifascicular atrophy

Which of the following is a characteristic feature of dermatomyositis that is not present in Luke's case?

Perifascicular atrophy Signup and view all the answers

What autoimmune marker may be elevated in patients with inflammatory myopathies such as dermatomyositis and polymyositis?

Anti-Jo-1 antibodies Signup and view all the answers

Which of the following is not typically associated with Lambert-Eaton myasthenic syndrome, making it less likely in Luke's case?

Proximal muscle weakness Signup and view all the answers

Which autoimmune systemic connective tissue disease primarily affects the skeletal muscles and is characterized by a prominent mononuclear inflammatory cell infiltrate in the endomysium?

Sporadic inclusion body myositis (IBM) Signup and view all the answers

What is the serum total creatine kinase level in the patient described?

645 IU/L Signup and view all the answers

Which muscle group exhibited asymmetric atrophy and had a muscle strength of 1/5 on hip flexion and knee extension of the right side?

Quadriceps Signup and view all the answers

What was the result of serology testing for cytoplasmic 5’-nucleotidase 1A (cN1A) autoantibody?

Positive Signup and view all the answers

Which of the following is NOT mentioned as a common environmental agent implicated in idiopathic inflammatory myopathies?

Fungi Signup and view all the answers

What does IIM stand for in the text?

Idiopathic Inflammatory Myopathies Signup and view all the answers

What is the normal range for serum total creatine kinase level?

$55-170 IU/L$ Signup and view all the answers

Which of the following are the components of basic metabolic panel mentioned in the text?

$Na^+, Cl^-, CO_2, BUN, Creatinine$ Signup and view all the answers

What does ESR stand for in the text?

$Erythrocyte Sedimentation Rate$ Signup and view all the answers

What was the main pathological finding in the muscle biopsy of right vastus lateralis?

$All of the above$ Signup and view all the answers