Podcast
Questions and Answers
Which cytokine has been identified as a key mediator in the inflammatory processes of acute gout flares and bone destruction?
Which cytokine has been identified as a key mediator in the inflammatory processes of acute gout flares and bone destruction?
- Interleukin-1 (correct)
- Tumor necrosis factor-alpha
- Interleukin-6
- Interferon-gamma
What type of drug has been tested as a potential treatment for acute gout?
What type of drug has been tested as a potential treatment for acute gout?
- Anakinra, a recombinant form of the human interleukin-1 receptor antagonist (correct)
- Corticosteroids
- Colchicine
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
What is a potential future agent for the treatment of gout?
What is a potential future agent for the treatment of gout?
- Lesinurad, a uricosuric drug (correct)
- Allopurinol
- Methotrexate
- Corticosteroids
What are some of the limitations of current medications for gout?
What are some of the limitations of current medications for gout?
What is a novel therapeutic target that has been identified in the understanding of gout and hyperuricemia?
What is a novel therapeutic target that has been identified in the understanding of gout and hyperuricemia?
What is the primary focus of future directions in gout pharmacotherapy according to the text?
What is the primary focus of future directions in gout pharmacotherapy according to the text?
What is the key step in processing IL-1ß from its pro-form to active cytokine?
What is the key step in processing IL-1ß from its pro-form to active cytokine?
Which of the following is an IL-1 blocker with a longer half-life that is under investigation in gout?
Which of the following is an IL-1 blocker with a longer half-life that is under investigation in gout?
What is the key determinant of increased serum urate levels?
What is the key determinant of increased serum urate levels?
Which enzyme is a potential therapeutic target for gout due to its role in guanine nucleotide biosynthesis?
Which enzyme is a potential therapeutic target for gout due to its role in guanine nucleotide biosynthesis?
Which approach can select the best treatment in specific patient phenotypes in a shorter time span than testing every phenotype in a separate trial?
Which approach can select the best treatment in specific patient phenotypes in a shorter time span than testing every phenotype in a separate trial?
What is a major limitation of the traditional approach of using the same dose of a drug for all patients?
What is a major limitation of the traditional approach of using the same dose of a drug for all patients?
