Gout and Hyperuricemia Management
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Questions and Answers

What is the primary cause of gout?

  • Low uric acid concentration in the blood
  • Excessive fluid retention in the joints
  • Increased calcium deposition in tissues
  • High uric acid concentration in the blood (correct)
  • Which phase of gout is characterized by periods with no symptoms?

  • Acute gout attacks
  • Asymptomatic hyperuricemia (correct)
  • Chronic tophaceous gout
  • Chronic gouty arthritis
  • What is recommended for long-term control of gout?

  • Antibiotics
  • Antiviral medication
  • Steroids
  • Urate-lowering therapy (correct)
  • What drug is considered first-line therapy for urate-lowering in gout?

    <p>Allopurinol</p> Signup and view all the answers

    What should be co-prescribed with NSAIDs for acute gout attacks to prevent gastrointestinal issues?

    <p>Gastro-protective drug</p> Signup and view all the answers

    Which medication has limited use due to toxicity but can be co-administered with anticoagulants during acute gout attacks?

    <p>Colchicine</p> Signup and view all the answers

    What is the recommended dosage range for plant alkaloids (colchicine) when used for acute gout treatment in adults?

    <p>500 micrograms to 1 mg twice daily</p> Signup and view all the answers

    What is the recommended dosage range for allopurinol maintenance in adults?

    <p>500-600 mg daily in divided doses</p> Signup and view all the answers

    Which condition is NOT a contraindication for the use of plant alkaloids (colchicine)?

    <p>Renal impairment</p> Signup and view all the answers

    What is the recommended starting dose of febuxostat for adults with chronic hyperuricaemia in gout?

    <p>80 mg once daily</p> Signup and view all the answers

    Which of the following is NOT listed as a potential side effect or reaction related to allopurinol treatment?

    <p>Myocardial infarction</p> Signup and view all the answers

    What is the recommended dose adjustment for patients with an eGFR less than 10 mL/minute/1.73 m2 when using plant alkaloids (colchicine)?

    <p>Reduce the dosage</p> Signup and view all the answers

    For what purpose is short-term prophylaxis recommended during initial therapy with allopurinol and uricosuric drugs?

    <p>To treat acute gout attacks</p> Signup and view all the answers

    Which of the following is a use of febuxostat according to the text?

    <p>Prevention of acute gout attacks</p> Signup and view all the answers

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