Gout and Hyperuricemia Management

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What is the primary cause of gout?

Low uric acid concentration in the blood

Excessive fluid retention in the joints

Increased calcium deposition in tissues

High uric acid concentration in the blood (correct)

Which phase of gout is characterized by periods with no symptoms?

Acute gout attacks

Asymptomatic hyperuricemia (correct)

Chronic tophaceous gout

Chronic gouty arthritis

What is recommended for long-term control of gout?

Antibiotics

Antiviral medication

Steroids

Urate-lowering therapy (correct)

What drug is considered first-line therapy for urate-lowering in gout?

Allopurinol Signup and view all the answers

What should be co-prescribed with NSAIDs for acute gout attacks to prevent gastrointestinal issues?

Gastro-protective drug Signup and view all the answers

Which medication has limited use due to toxicity but can be co-administered with anticoagulants during acute gout attacks?

Colchicine Signup and view all the answers

What is the recommended dosage range for plant alkaloids (colchicine) when used for acute gout treatment in adults?

500 micrograms to 1 mg twice daily Signup and view all the answers

What is the recommended dosage range for allopurinol maintenance in adults?

500-600 mg daily in divided doses Signup and view all the answers

Which condition is NOT a contraindication for the use of plant alkaloids (colchicine)?

Renal impairment Signup and view all the answers

What is the recommended starting dose of febuxostat for adults with chronic hyperuricaemia in gout?

80 mg once daily Signup and view all the answers

Which of the following is NOT listed as a potential side effect or reaction related to allopurinol treatment?

Myocardial infarction Signup and view all the answers

What is the recommended dose adjustment for patients with an eGFR less than 10 mL/minute/1.73 m2 when using plant alkaloids (colchicine)?

Reduce the dosage Signup and view all the answers

For what purpose is short-term prophylaxis recommended during initial therapy with allopurinol and uricosuric drugs?

To treat acute gout attacks Signup and view all the answers

Which of the following is a use of febuxostat according to the text?

Prevention of acute gout attacks Signup and view all the answers

Gout and Hyperuricemia Management

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