Inflammation Pathology Quiz

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Questions and Answers

What is the main reason for redness in inflammation?

  • Vasodilatation (correct)
  • Histamine release
  • Swollen endothelium
  • Vasoconstriction

What causes pain in inflammation?

  • Vasoconstriction
  • Leukocyte migration
  • Hemoconcentration
  • Compression of nerves by exudate (correct)

Which process involves leukocytes passing through gaps between intact endothelium?

  • Activation
  • Chemo-attraction
  • Transmigration (correct)
  • Adhesion

What is the main reason for swelling of endothelial cells during inflammation?

<p>Diapedesis through intact vessels (D)</p> Signup and view all the answers

Which molecules cause the immobilization of leukocytes during adhesion in inflammation?

<p>Integrin and Endothelial cells (C)</p> Signup and view all the answers

What initiates the rolling phase of leukocytes during the inflammatory response?

<p>Recognition of pathogens by leukocytes (B)</p> Signup and view all the answers

What is the purpose of inflammation?

<p>To eliminate the cause of injury (A)</p> Signup and view all the answers

Which component is NOT involved in inflammation?

<p>Nervous system (A)</p> Signup and view all the answers

What is the main function of leukocytes in inflammation?

<p>To eliminate pathogens and damaged cells (B)</p> Signup and view all the answers

Which term describes the reaction of living tissue against injury?

<p>Inflammation (A)</p> Signup and view all the answers

What is the primary reason for leukocytes extravasation during inflammation?

<p>To migrate from blood vessels to the site of injury (D)</p> Signup and view all the answers

What is the function of neutrophils in the inflammation area?

<p>Perform phagocytosis and kill microbes (D)</p> Signup and view all the answers

Which process involves forming a network of fibrin threads to localize infection?

<p>Fibrinogen clot formation (D)</p> Signup and view all the answers

What is the role of antibodies in the immune system?

<p>Block antigen receptors (C)</p> Signup and view all the answers

Which protein complex forms a hole in the cell membrane during cell lysis?

<p>Membrane attack complex (D)</p> Signup and view all the answers

What stimulates histamine release and acts as a strong leukocyte chemoattractant?

<p>Anaphylatoxins (C)</p> Signup and view all the answers

What promotes phagocytosis by neutrophils and macrophages by binding to specific receptors?

<p>Complement proteins (A)</p> Signup and view all the answers

What are the harmful effects of inflammation?

<p>Swelling of inflamed tissues with obstruction and loss of function (C)</p> Signup and view all the answers

What is the main characteristic of hypersensitivity in inflammation?

<p>Exaggerated response of inflammatory cells (C)</p> Signup and view all the answers

What do selectins and integrins refer to in the context of inflammation?

<p>Adhesion molecules on endothelial cells and leukocytes (B)</p> Signup and view all the answers

What does opsonization refer to in the process of inflammation?

<p>Enhancement of phagocytosis by coating pathogens (D)</p> Signup and view all the answers

Which of the following best describes the role of complement in inflammation?

<p>Enhancing phagocytosis and immune response (A)</p> Signup and view all the answers

What is the main function of neutrophils and macrophages in the context of phagocytosis?

<p>Remove waste materials from the area of inflammation (D)</p> Signup and view all the answers

Which of the following factors help enhance phagocytosis alongside opsonins and complement?

<p>Fibrin (B)</p> Signup and view all the answers

What is the term for the process where a phagocyte engulfs a microbe after chemotaxis and adherence?

<p>Phagocytosis (D)</p> Signup and view all the answers

In chronic inflammation, which type of cells are typically present in higher numbers compared to acute inflammation?

<p>Plasma cells (A)</p> Signup and view all the answers

What is a common manifestation of acute inflammation microscopically when examining blood vessels?

<p>BNL polymorphs (C)</p> Signup and view all the answers

Which component of the immune system is involved in producing collagen during tissue repair in cases of chronic inflammation?

<p>Tissue histiocytes (B)</p> Signup and view all the answers

Flashcards

Why does inflammation cause redness?

Dilation widens blood vessels, increasing blood flow to the area.

What causes pain during inflammation?

Exudate accumulation compresses nerve endings, causing discomfort.

What is transmigration?

Leukocytes squeeze through endothelial cell junctions in a process known as transmigration.

Why do endothelial cells swell during inflammation?

Swelling results from leukocytes passing through the intact blood vessel walls.

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Which molecules immobilize leukocytes?

Integrins on leukocytes and endothelial cell ligands mediate firm adhesion.

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What starts leukocyte rolling?

Leukocyte receptors recognize pathogens, initiating contact and rolling.

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What is the purpose of inflammation?

Eliminating the source of tissue damage to promote healing.

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Which system is NOT involved in inflammation?

Nervous system isn't a direct component although it can be affected by inflammatory mediators.

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What is the main function of leukocytes?

Leukocytes clear pathogens and cellular debris through phagocytosis.

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Inflammation definition

Inflammation is the body's response to protect itself against injury.

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Why leukocyte extravasation?

Leukocytes move out of blood vessels toward the site of damage.

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Neutrophil function

Neutrophils engulf and digest microbes, cleaning the area.

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What does fibrinogen clot formation achieve?

Fibrin clot formation isolates infection.

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Antibody role

Antibodies attach to antigens, blocking their receptors.

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Membrane attack complex function

Membrane attack complex creates pores in cell membranes, causing cell lysis.

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Anaphylatoxin role

Anaphylatoxins stimulate histamine release and attract leukocytes.

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Complement protein's role

Complement proteins bind and facilitate phagocytosis.

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Harmful effects of inflammation?

Harmful effects include swelling and loss of function.

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Hypersensitivity in inflammation?

Hypersensitivity is an overreaction by inflammatory cells.

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Selectins and Integrins

Adhesion molecules help in leukocyte and endothelial cell interactions.

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What is opsonization?

Coating pathogens to enhance phagocytosis efficiency.

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Role of complement

Enhancing phagocytosis and immune response.

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Neutrophils & macrophages

Neutrophils and macrophages clear waste materials through phagocytosis.

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Factors enhancing phagocytosis

Fibrin aids phagocytosis alongside opsonins and complement.

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What is phagocytosis?

Phagocytosis involves engulfing a microbe after chemotaxis and adherence.

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Chronic inflammation cell type

Chronic inflammation presents more plasma cells.

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Acute inflammation blood vessels

BNL Polymorphs are typically present microscopically during acute inflammation

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Collagen production

Tissue histiocytes are involved in producing collagen for repair.

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