Inflammation and Its Mechanisms
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Questions and Answers

What is the primary reaction associated with inflammation?

  • Mutation
  • Apoptosis
  • Damage (correct)
  • Irritation
  • Which action is not associated with histamine acting on H2 receptors?

  • Dilatation of arterioles
  • Bronchodilation
  • Exocytosis
  • Bronchospasm (correct)
  • Phagocytes are able to target antigens in inflamed areas due to which surface presence?

  • Peptides
  • Hormones
  • Ions
  • Receptionists (correct)
  • Which of the following does not qualify as an antiinflammatory mediator?

    <p>Platelet-activating factor (B)</p> Signup and view all the answers

    Which enzyme is responsible for neutralizing free radicals in inflammation?

    <p>Superoxiddismutase (D)</p> Signup and view all the answers

    What type of exudate is characterized by a large number of neutrophils observed under microscopy?

    <p>Purulent (D)</p> Signup and view all the answers

    Which of the following is most closely associated with apoptosis?

    <p>Programmed cell death (D)</p> Signup and view all the answers

    Which mediator is primarily involved in the inhibition of chemotaxis?

    <p>Interleukin-10 (D)</p> Signup and view all the answers

    What type of cells are responsible for the formation of prostacyclin in an area of inflammation?

    <p>Endotheliocytes (B)</p> Signup and view all the answers

    Which of the following does not contribute to protective phenomena during inflammation?

    <p>Emigration of leucocytes (D)</p> Signup and view all the answers

    The respiratory coefficient during an area of inflammation decreases due to which of the following?

    <p>Activation of anaerobic glycolysis (B)</p> Signup and view all the answers

    What plays a critical role in the fixation of leucocytes to the vascular wall during inflammation?

    <p>Fibrin (C)</p> Signup and view all the answers

    Which substance is primarily responsible for acidosis in an area of inflammation due to accumulation?

    <p>Lactic acid (A)</p> Signup and view all the answers

    In which cells does the formation of prostacyclin primarily occur?

    <p>Endothelial cells (A)</p> Signup and view all the answers

    Which of the following is a key factor in promoting edema during the inflammation process?

    <p>Capillary permeability (C)</p> Signup and view all the answers

    During inflammation, which of the following would most likely stimulate fever?

    <p>Interleukin-1 activity (B)</p> Signup and view all the answers

    Which substance has cytolytic properties that are peculiar in inflammation?

    <p>Bradykinin (A)</p> Signup and view all the answers

    What type of cells are predominantly found in purulent exudate?

    <p>Neutrophils (C)</p> Signup and view all the answers

    Which cells are attributed to phagocytic activity in inflammation?

    <p>Monocytes (C)</p> Signup and view all the answers

    During inflammation, what do monocytes predominantly seize?

    <p>Fibrin (B)</p> Signup and view all the answers

    What is primarily involved in neoangiogenesis at the termination of inflammation?

    <p>Endotheliocytes (C)</p> Signup and view all the answers

    In the context of inflammation, what role do neutrophils play?

    <p>They are the main cells seen in purulent exudate. (C)</p> Signup and view all the answers

    Which of the following cells is least likely to be involved in the phagocytic response during inflammation?

    <p>Eosinophils (D)</p> Signup and view all the answers

    Which factor is significant in the migration of cells during neoangiogenesis?

    <p>Endothelial cell activation (B)</p> Signup and view all the answers

    Which substance does not contribute to scar formation in inflammation?

    <p>Collagen (B)</p> Signup and view all the answers

    What is the basic anti-inflammatory effect of alpha-macroglobulin?

    <p>Decrease of vascular permeability (D)</p> Signup and view all the answers

    What stimulates the synthesis of acute phase proteins in inflammatory processes?

    <p>Interleukin (B)</p> Signup and view all the answers

    Which of the following is a peptide-origin plasmatic mediator of inflammation?

    <p>Bradykinin (A)</p> Signup and view all the answers

    Which substance is effective in stopping destructive effects in inflammation by suppressing free radicals?

    <p>Glutathione (B)</p> Signup and view all the answers

    How is inflammation characterized as a pathological process?

    <p>Typical (D)</p> Signup and view all the answers

    Which of the following describes an event in the inflammatory response?

    <p>Swelling due to fluid accumulation (B)</p> Signup and view all the answers

    Which mediator is involved in the vascular response during inflammation?

    <p>Histamine (A)</p> Signup and view all the answers

    What is the most early and transitory reaction of vessels in the microvascular blood stream during inflammation?

    <p>Arteriole dilatation (D)</p> Signup and view all the answers

    Which of the following does not pertain to lysosomal factors involved in inflammation?

    <p>Unenzymic cationic proteins (C)</p> Signup and view all the answers

    Which cellular factor is responsible for the development of arterial hyperemia in the area of inflammation?

    <p>Bradykinin (C)</p> Signup and view all the answers

    Which protein is likely to escape due to increased vascular permeability during inflammation?

    <p>Fibrinogen (B)</p> Signup and view all the answers

    What is the main cause of the formation of humoral mediators in inflammation?

    <p>Exudation (B)</p> Signup and view all the answers

    Which factor is most likely to trigger increased vascular permeability during an inflammatory response?

    <p>Histamine (B)</p> Signup and view all the answers

    Which of the following proteins is typically elevated in inflammation due to its role in the immune response?

    <p>Immunoglobulin M (A)</p> Signup and view all the answers

    Which cellular mediator commonly leads to pain during inflammation?

    <p>Bradykinin (A)</p> Signup and view all the answers

    What cells play the main role in the process of proliferation in wound healing with rapid recovery and no scar formation?

    <p>Fibroblasts (B)</p> Signup and view all the answers

    Based on an exudate with a protein level of 34 g/l, a cell count of 3600/mcl with prevailing neutrophils, and a pH of 6.8, what type of exudate is present?

    <p>Purulent (A)</p> Signup and view all the answers

    Which sign of inflammation, part of the pentalogy of Celsus-Galena, is indicated in the patient with eczema?

    <p>Redness (B)</p> Signup and view all the answers

    In a case where a patient presents with purulent exudate that has an unpleasant smell, what condition is most likely indicated?

    <p>Peritonitis (B)</p> Signup and view all the answers

    Which condition is most likely indicated in a patient with purulent exudate during pleural cavity puncture?

    <p>Tuberculosis (C)</p> Signup and view all the answers

    What type of inflammation is characterized by the presence of a large number of purulent bodies due to destruction?

    <p>Purulent inflammation (D)</p> Signup and view all the answers

    In terms of cellular response, which type of cell is primarily involved in the acute inflammatory response with a high count in exudate?

    <p>Neutrophils (D)</p> Signup and view all the answers

    What is indicated by a pleural effusion that is purulent and has a low pH, typically around 6.8?

    <p>Acute bacterial infection (C)</p> Signup and view all the answers

    Flashcards

    Inflammation

    A reaction of the body to injury, irritation, or infection, characterized by redness, swelling, heat, and pain.

    Neutrophils

    A type of white blood cell that plays a key role in the immune system. They are the first responders to inflammation, engulfing and destroying harmful pathogens.

    Histamine

    A type of inflammatory mediator released by mast cells and basophils. It causes dilation of blood vessels, increased vascular permeability, and smooth muscle contraction.

    Cytokines

    A type of inflammatory mediator that is released by various cells, including macrophages and lymphocytes. They play a crucial role in inflammation by regulating immune responses and promoting tissue repair.

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    Superoxide dismutase (SOD)

    A type of enzyme that removes free radicals from the body. It is important in protecting cells from damage during inflammation.

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    Purulent exudate

    An inflammatory exudate that is characterized by a high concentration of neutrophils.

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    Anti-inflammatory mediators

    Anti-inflammatory mediators are substances that help to reduce inflammation. They work by inhibiting the release of pro-inflammatory mediators or by blocking their actions.

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    Interleukin-10 (IL-10)

    A type of anti-inflammatory mediator that is produced by the body. It helps to regulate immune responses and suppress inflammation.

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    Eosinophils

    A type of white blood cell involved in allergic reactions and parasitic infections.

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    Prostacyclin

    A potent vasodilator and inhibitor of platelet aggregation produced by endothelial cells.

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    Endotheliocytes

    Specialized cells lining blood vessels that release prostacyclin.

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    Emigration of Leukocytes

    The movement of white blood cells from blood vessels to the site of inflammation.

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    Leucocytosis

    An increase in the number of white blood cells in the blood, often seen during inflammation as a response to infection.

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    Reparation

    The process of tissue repair following injury or inflammation.

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    Respiratory Coefficient

    The ratio of carbon dioxide produced to oxygen consumed during cellular respiration.

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    Anaerobic Glycolysis

    The process of producing lactic acid as a byproduct of energy production in the absence of oxygen.

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    What protein does not contribute to scar formation in inflammation?

    A protein that doesn't contribute to scar formation during inflammation.

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    What is the effect of α2-macroglobulin on vascular permeability?

    A large protein that reduces inflammation by decreasing vascular permeability (leakiness).

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    What stimulates the synthesis of "acute phase" proteins?

    A molecule that acts as a stimulator for the synthesis of "acute phase" proteins during inflammation.

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    What is a peptide mediator of inflammation in the blood?

    A peptide that is a plasmatic mediator, meaning it plays a role in inflammation within the blood.

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    What molecule helps control inflammation by neutralizing damaging free radicals?

    An anti-inflammatory molecule that neutralizes free radicals in the extracellular space. It helps to stop damage caused by these reactive molecules.

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    What is the term for inflammation with a predictable progression?

    This refers to inflammation that follows a predictable pattern of development and is considered normal.

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    What is a substance released by Mast Cells that causes vasodilation, increased vascular permeability, and smooth muscle contraction?

    A substance released by mast cells and basophils, that causes vasodilation, increased vascular permeability, and smooth muscle contraction.

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    What are the small proteins called that regulate immune responses and tissue repair during inflammation?

    These molecules are released by various cells during inflammation and regulate immune responses and tissue repair.

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    Proliferation

    The process of creating new cells to repair damaged tissue.

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    Pleural exudate

    A collection of fluid in the pleural cavity, the space between the lungs and the chest wall. It can occur due to inflammation or infection.

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    Fibrinous exudate

    An inflammation characterized by fibrin deposition in the exudate, causing a sticky, yellow appearance.

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    Putrefactive exudate

    A type of inflammation that is characterized by an accumulation of pus and a foul odor.

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    Hemorrhagic exudate

    A type of inflammation that is characterized by the presence of blood in the exudate.

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    Serous exudate

    A type of inflammation that is characterized by a clear, watery fluid.

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    Arteriole dilation

    The earliest and most fleeting response of blood vessels within the microcirculation during inflammation, characterized by the dilation of arterioles.

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    Stasis

    A crucial step in inflammation, characterized by the slowing of blood flow within the microcirculation due to increased vascular permeability and leukocyte adhesion.

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    Thrombosis

    The formation of a blood clot within a blood vessel, a potential complication of inflammation, often associated with stasis and increased vascular permeability.

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    Embolism

    The blockage of a blood vessel by a foreign object, a potential complication of inflammation, which can occur during inflammation.

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    Insignificant Increase in Vascular Permeability

    An insignificant increase in vascular permeability in the area of inflammation, allowing fluid to escape from the blood vessels into the tissues, leading to edema.

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    Alteration

    The primary cause of the formation of humoral mediators of inflammation, such as prostaglandins and leukotrienes, which contribute to the inflammatory response.

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    Diapedesis

    The process of leukocytes, or white blood cells, moving out of blood vessels and into tissues, a crucial step in the inflammatory process.

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    What is a cytolytic substance released during inflammation?

    A chemical substance that has cytolytic properties, meaning it can destroy cells. It is often released during inflammation and plays a role in the inflammatory response.

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    Which cell type is the primary defender in purulent exudate?

    A type of white blood cell that is the first responder to inflammation. They engulf and destroy harmful pathogens, playing a crucial role in fighting infection.

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    What type of exudate is associated with high neutrophil presence?

    An inflammatory exudate that is characterized by a high concentration of neutrophils. It is often thick and yellowish-green in appearance and is commonly found in abscesses.

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    Which cell type engages in the process of 'seizing' pathogens during inflammation?

    A type of white blood cell that is involved in the immune response. They are known for their ability to 'seize' and engulf pathogens. These cells play a role in both innate and adaptive immunity.

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    What is the term for the new blood vessel growth caused by inflammation?

    The process of new blood vessel formation. This process is often triggered by inflammation and plays a role in tissue repair and regeneration.

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    Which cell type is responsible for building new connective tissue during inflammation?

    A type of cell that contributes to the formation of connective tissue. These cells play a crucial role in the healing process after inflammation by producing collagen and other extracellular matrix components.

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    What is the name of a substance that activates the inflammatory cascade?

    A chemical substance that triggers an inflammatory response. This substance causes dilation of blood vessels, increased vascular permeability, and other inflammatory processes.

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    What cell type is traditionally associated with parasitic infections?

    A white blood cell that is involved in certain types of allergies and parasitic infections. They release substances to fight off parasites and some allergic reactions.

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    Study Notes

    Inflammation - Questions and Answers

    • Question 1: Endotheliocytes migrate to areas of inflammation, where they take part in:

      • Formation of vessels
    • Question 2: Resident cells in areas of inflammation include:

      • Monocytes
    • Question 3: Mediator of inflammation that must be inhibited for decreased exudation:

      • Histamine
    • Question 4: Inflammation characteristic of dysentery:

      • Fibrinous
    • Question 5: Inactivator of inflammatory mediators:

      • Decarboxylase
    • Question 6: Physical-chemical change in acute inflammation:

      • Hyperoncia (likely a typo for hyperemia)
    • Question 7: Initial pathogenic factor in inflammatory edema from a bee sting:

      • Increased microvascular permeability
    • Question 8: Glucocorticoids inhibit this enzyme for anti-inflammatory action:

      • Phospholipase A2
    • Question 9: Cells of reproductive origin characterized by inflammation:

      • Uncertain, no definitive answer
    • Question 10: Enzyme responsible for leukotriene formation from arachidonic acid:

      • Lipooxygenase
    • Question 11: Cells that react first to antigen entry:

      • Macrophages
    • Question 12: Surface components on phagocytes for antigen capture:

      • Mediators
    • Question 13: Anti-inflammatory mediators not concerned:

      • Platelet-activating factor (likely)
    • Question 14: Enzyme that neutralizes free radicals to diminish inflammation:

      • Superoxiddismutase
    • Question 15: Exudate type associated with neutrophils observed in microscopy:

      • Purulent
    • Question 16: Predominant cell type in tuberculous exudate:

      • Neutrophils
    • Question 17: Type of exudate from a neutrophil microscopy perspective:

      • Serous
    • Question 18: Substance neutralizing free radicals:

      • Superoxiddismutase
    • Question 19: Anti-inflammatory mediator not concerned:

      • Uncertain, no clear answer provided (likely Histaminase )
    • Question 20: Primary cell type migrating to areas of inflammation:

      • Neutrophils
    • Question 21: Substance that signals endotheliocytes to inflamed areas:

      • Oxygen
    • Question 22: Substance important in area inflammation for prostacyclin formation:

      • Endothelial cells
    • Question 23: Substance not concerned in scar formation in inflammation:

      • Uncertain (likely one of the substances other than Fibrin )
    • Question 24: Main cellular type that forms prostacyclin:

      • Endotheliocytes
    • Question 25: Protective phenomenon not in inflammation:

      • Reparation (likely)
    • Question 26: Cause for decreased respiratory coefficient during inflammatory response:

      • Inhibition of aerobic glycolysis
    • Question 27: Substance for fixation of leucocytes in inflammation area:

      • Fibrin
    • Question 28: Acidosis in inflamed area is caused by accumulation of:

      • Lactic acid
    • Question 29: Cytolytic property of inflammation:

      • Uncertain (likely one of the substances other than Bradykinin )
    • Question 30: Substance observed in oral cavity abscess exudate:

      • Neutrophils
    • Question 31: Cells of inflammation seize:

      • Cells
    • Question 32: Process involving migration of endothelial cells in inflammation:

      • Uncertain (likely neoangiogenesis)
    • Question 33: Cell involved in neoangiogenesis termination:

      • Uncertain (likely endotheliocytes)
    • Question 34: Protein not involved in scar formation:

      • Uncertain (likely one of the substances other than Fibrin )
    • Question 35: Characteristic in acute inflammation of the pancreas:

      • Diffuse
    • Question 36: Inflammatory mediator of humoral origin:

      • Uncertain (likely one of the substances other than Serotonin )
    • Question 37: Substance that increases vascular permeability during inflammation:

      • Bradykinin
    • Question 38: Substance that stimulates fibroblast growth in monocytes during inflammation:

      • Interleukin - 1
    • Question 39: Cytokine not concerned in inflammatory action:

      • uncertain (likely platelet-activating factor)
    • Question 40: Initial reaction of tissues to inflammation:

      • Arteriole dilatation
    • Question 41: Lysosomal factors not implicated in inflammation:

      • Free radicals
    • Question 42: Cellular factor for arterial hyperemia:

      • Kallikrein
    • Question 43: Minimal vascular permeability substance:

      • uncertain
    • Question 44: Substance increasing vascular permeability regarding humoral response:

      • uncertain (likely histamine)
    • Question 45: Humoral mediators of inflammation:

      • Uncertain (likely one of the substances other than Interleukin-1 )
    • Question 46: Process for leucocytes escaping area of inflammation:

      • Marginalis
    • Question 47: Main cause of humoral mediators of inflammation:

      • Aggregation
    • Question 48: Stimulator for the growth of fibroblasts in monocytes:

      • Interleukin-1
    • Question 49: Peptide inflammatory mediators from blood plasma:

      • Uncertain (likely one of the substances other than Insulin )
    • Question 50: Physical-chemical change not concerned in inflammation:

      • uncertain
    • Question 51: Humoral mediators of inflammation:

      • uncertain
    • Question 52: Inflammation of the liver not expressed:

      • uncertain
    • Question 53: Process relating to proinflammatory action in inflammation:

      • uncertain
    • Question 54: Phenomena that is not a part of inflammation protection:

      • uncertain
    • Question 55: Formation of inflammatory barrier in inflammation region:

      • Uncertain
    • Question 56: Infection type that happens due to absence of neutrophils and phagocytosis:

      • uncertain
    • Question 57: Type of exudate in a patient regarding protein and cell content:

      • uncertain

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