Podcast
Questions and Answers
What cellular process is a hallmark of chronic inflammation, indicative of the body's attempt to repair damaged tissue?
What cellular process is a hallmark of chronic inflammation, indicative of the body's attempt to repair damaged tissue?
- Stromal proliferation (correct)
- Neutrophil extravasation culminating in pus formation
- Eosinophil degranulation, leading to amplified allergic response
- Massive coagulation necrosis, preventing tissue repair
A patient's biopsy reveals tissue damage occurring at the same time as tissue repair. Which type of inflammation is the MOST likely diagnosis?
A patient's biopsy reveals tissue damage occurring at the same time as tissue repair. Which type of inflammation is the MOST likely diagnosis?
- Serous Inflammation
- Acute inflammation
- Fibrosis
- Chronic inflammation (correct)
Which of the following infectious agents is MOST likely to cause chronic inflammation due to its difficulty to eradicate?
Which of the following infectious agents is MOST likely to cause chronic inflammation due to its difficulty to eradicate?
- Streptococcus pyogenes
- Mycobacteria (correct)
- Staphylococcus aureus
- Escherichia coli
A patient presents with silicosis after prolonged exposure to particulate silica. What type of chronic inflammation is MOST likely occurring in the patient's lungs?
A patient presents with silicosis after prolonged exposure to particulate silica. What type of chronic inflammation is MOST likely occurring in the patient's lungs?
What cellular process is induced by a persistent offending agent in chronic inflammation, leading to tissue damage?
What cellular process is induced by a persistent offending agent in chronic inflammation, leading to tissue damage?
In the context of chronic inflammation, the attempt at healing damaged tissue involves connective tissue replacement. Which of the following processes is MOST directly associated with this?
In the context of chronic inflammation, the attempt at healing damaged tissue involves connective tissue replacement. Which of the following processes is MOST directly associated with this?
What is the role of cytokines, such as IFN-γ, in the activation of macrophages during chronic inflammation?
What is the role of cytokines, such as IFN-γ, in the activation of macrophages during chronic inflammation?
What is the MAIN role of growth factors (PDGF, FGF, TGF-β) released by macrophages in chronic inflammation?
What is the MAIN role of growth factors (PDGF, FGF, TGF-β) released by macrophages in chronic inflammation?
Which process is MOST closely associated with the "remodeling" of collagen during fibrosis in chronic inflammation?
Which process is MOST closely associated with the "remodeling" of collagen during fibrosis in chronic inflammation?
A biopsy from a chronically inflamed tissue site shows a collection of macrophages. What is the NEXT step to determine if this is a non-specific chronic inflammation or a granulomatous inflammation?
A biopsy from a chronically inflamed tissue site shows a collection of macrophages. What is the NEXT step to determine if this is a non-specific chronic inflammation or a granulomatous inflammation?
What type of inflammatory response is characterized by granuloma formation in the affected tissue?
What type of inflammatory response is characterized by granuloma formation in the affected tissue?
What is the primary cellular component of a granuloma, which distinguishes it from other forms of chronic inflammation?
What is the primary cellular component of a granuloma, which distinguishes it from other forms of chronic inflammation?
Which infectious disease is MOST strongly associated with granuloma formation due to infection by Mycobacterium tuberculosis?
Which infectious disease is MOST strongly associated with granuloma formation due to infection by Mycobacterium tuberculosis?
A patient is diagnosed with leprosy. What is the causative agent MOST likely responsible for the granulomatous inflammation?
A patient is diagnosed with leprosy. What is the causative agent MOST likely responsible for the granulomatous inflammation?
Which staining technique is MOST appropriate for identifying Mycobacterium in a granulomatous lesion?
Which staining technique is MOST appropriate for identifying Mycobacterium in a granulomatous lesion?
A granuloma contains a central area of necrosis, what is this MOST likely?
A granuloma contains a central area of necrosis, what is this MOST likely?
What is the etiology of sarcoidosis, a disease known to cause granulomatous inflammation?
What is the etiology of sarcoidosis, a disease known to cause granulomatous inflammation?
In Crohn's disease, what type of inflammatory process is typically observed in the bowel?
In Crohn's disease, what type of inflammatory process is typically observed in the bowel?
What triggers the formation of a foreign body granuloma?
What triggers the formation of a foreign body granuloma?
Which of the following is a characteristic of non-specific chronic inflammation?
Which of the following is a characteristic of non-specific chronic inflammation?
What type of cells are commonly found in both non-specific and granulomatous inflammation?
What type of cells are commonly found in both non-specific and granulomatous inflammation?
Which of the following is a typical feature of non-specific chronic inflammation?
Which of the following is a typical feature of non-specific chronic inflammation?
What is a major difference between acute and chronic inflammation in terms of cellular infiltrate?
What is a major difference between acute and chronic inflammation in terms of cellular infiltrate?
In the context of chronic inflammation following tissue injury, uncontrolled fibrosis can lead to which of the following outcomes?
In the context of chronic inflammation following tissue injury, uncontrolled fibrosis can lead to which of the following outcomes?
Considering a patient with prolonged exposure to asbestos, which pathological process is MOST likely to occur in the lungs as a result?
Considering a patient with prolonged exposure to asbestos, which pathological process is MOST likely to occur in the lungs as a result?
What role do chemokines play in the progression of chronic inflammation?
What role do chemokines play in the progression of chronic inflammation?
Which of the following distinguishes chronic inflammation from acute inflammation regarding the cells involved in the process?
Which of the following distinguishes chronic inflammation from acute inflammation regarding the cells involved in the process?
Which of the following processes is MOST directly associated with the development of granulomas?
Which of the following processes is MOST directly associated with the development of granulomas?
A patient is diagnosed with silicosis following long-term occupational exposure. What cellular changes MOST likely contribute to the pathophysiology of this condition?
A patient is diagnosed with silicosis following long-term occupational exposure. What cellular changes MOST likely contribute to the pathophysiology of this condition?
Flashcards
Chronic Inflammation Onset
Chronic Inflammation Onset
May occur from the start or follow unresolved acute inflammation.
Chronic Inflammation Characteristics
Chronic Inflammation Characteristics
Tissue injury or persistence of the injurious agent occurring along with tissue repair.
Hallmarks of Chronic Inflammation
Hallmarks of Chronic Inflammation
Infiltration by macrophages and stromal proliferation.
Causes of Chronic Inflammation
Causes of Chronic Inflammation
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Morphologic Features of Chronic Inflammation
Morphologic Features of Chronic Inflammation
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Mononuclear Cells in Chronic Inflammation
Mononuclear Cells in Chronic Inflammation
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Causes of Tissue Destruction in Chronic Inflammation
Causes of Tissue Destruction in Chronic Inflammation
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Healing Mechanisms in Chronic Inflammation
Healing Mechanisms in Chronic Inflammation
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Classifications of chronic inflammation
Classifications of chronic inflammation
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Chronic Granulomatous Inflammation
Chronic Granulomatous Inflammation
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Examples of Granulomatous Inflammation
Examples of Granulomatous Inflammation
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Granuloma Definition
Granuloma Definition
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Non-Specific Chronic Inflammation
Non-Specific Chronic Inflammation
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Study Notes
- Chronic inflammation can start "ab initio" (from the beginning) or result from unresolved acute inflammation.
- Tissue injury, or the persistence of an injurious agent, happens simultaneously with tissue repair in chronic inflammation.
- Hallmarks of chronic inflammation include infiltration by macrophages and stromal proliferation.
Causes of Chronic Inflammation
- Persistent infections by microorganisms that are difficult to eradicate are a cause of chronic inflammation.
- Examples of microorganisms that cause persistent infections include mycobacteria, viruses, fungi, and parasites.
- Chronic inflammation can be caused by immune-mediated inflammatory diseases.
- Another cause of chronic inflammation is prolonged exposure to potentially toxic agents, which can be exogenous or endogenous.
- An example of an exogenous agent is particulate silica, which leads to silicosis.
Morphologic Features
- Infiltration with mononuclear cells is a key morphologic feature, including macrophages, lymphocytes, and plasma cells.
- Tissue destruction, induced by a persistent offending agent and inflammatory cells also occurs.
- In chronic inflammation the body attempts to heal by connective tissue replacement of damaged tissue.
- This is accomplished by angiogenesis and fibrosis.
Chronic Granulomatous Inflammation
- Granuloma formation in affected tissue characterizes this
- A granuloma is a microscopic aggregation of macrophages transformed into epithelium-like cells.
Conditions
- Tuberculosis, where the causative agent is Mycobacterium tuberculosis
- Leprosy, where the causative agent is Mycobacterium leprae
- Syphilis, where the causative agent is Treponema pallidum
- Cat-scratch disease, caused by a Gram-negative bacillus
- Sarcoidosis, which has an unknown etiology
- Crohn disease, which is an inflammatory bowel disease
Non-Specific Chronic Inflammation
- Inflammatory cells are similar to those in granulomatous inflammation
- No specific ordering of cells occurs.
- Usually does not show a specific etiology.
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