Inflammation and Fever: Body's Defense Mechanisms
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Questions and Answers

Which physiological process exemplifies a localized inflammatory response aimed at tissue repair rather than a systemic immune activation?

  • Vasodilation causing redness and heat around a skin laceration. (correct)
  • Development of a high fever in response to a systemic bacterial infection.
  • Increased antibody production by plasma cells in response to a viral infection.
  • The release of acute phase proteins by the liver during a widespread infection.

How does a moderate fever contribute to the body's defense mechanisms, beyond merely inhibiting microbial growth?

  • By directly neutralizing bacterial toxins through thermal denaturation.
  • By selectively inhibiting the replication of all viruses, regardless of their temperature sensitivity.
  • By enhancing the mobility and activity of leukocytes, thereby accelerating the immune response. (correct)
  • By inducing a state of hibernation in immune cells, conserving energy for future battles.

In the context of inflammation, which cellular event primarily contributes to the sensation of pain?

  • The stimulation of nociceptors by inflammatory mediators such as bradykinin and prostaglandins. (correct)
  • The phagocytosis of pathogens by macrophages, reducing the microbial load.
  • The release of histamine causing vasodilation and increased blood flow.
  • The increased proliferation of fibroblasts leading to scar tissue formation.

Considering the dual nature of fever as both a defense mechanism and a potential threat, which scenario necessitates immediate medical intervention?

<p>A rapidly escalating high fever ($40^{\circ}C$ or higher) accompanied by seizures or altered mental status. (A)</p> Signup and view all the answers

How would the administration of non-steroidal anti-inflammatory drugs (NSAIDs) affect the body's inflammatory and febrile responses to an infection?

<p>NSAIDs would suppress inflammation and reduce fever by inhibiting prostaglandin synthesis. (A)</p> Signup and view all the answers

Flashcards

Inflammation

A nonspecific response to tissue trauma with heat, swelling, redness, and pain.

Signs of Inflammation

Key indicators include heat, swelling, redness, and pain.

Role of Fever

Acts as a nonspecific defense mechanism against trauma and infections.

Pyrogens

Substances that trigger fever by affecting the hypothalamus in the brain.

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Benefits of Fever

Retards growth of temperature-sensitive microorganisms and stimulates immune response.

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Study Notes

Inflammation

  • Inflammation is a non-specific response to tissue trauma.
  • Signs of inflammation include heat, swelling, redness, and pain.
  • Inflammation mobilizes immune system components, initiates repair mechanisms, and attracts phagocytes to destroy microorganisms.

Fever

  • Fever is a nonspecific defense mechanism triggered by various traumas.
  • Pyrogens, circulating substances, initiate fever by affecting the hypothalamus.
  • The hypothalamus raises body temperature.
  • While excessive fever is dangerous, fever benefits by slowing microbial growth.
  • Fever boosts body cell metabolism and stimulates the immune response.

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Description

Overview of inflammation as a non-specific response to tissue trauma, with signs like heat and swelling. Discussion of fever as a defense mechanism triggered by pyrogens, highlighting its benefits in slowing microbial growth and boosting the immune response.

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