Infectious Diseases Quiz
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Questions and Answers

What is the definition of etiology in the context of infectious diseases?

  • The study of disease processes
  • The symptoms experienced by a patient
  • The cause of a disease (correct)
  • The presence of bacteria in the bloodstream
  • Which phase of disease occurs immediately after the incubation period?

  • Illness phase (correct)
  • Chronic phase
  • Convalescence
  • Latency period
  • What is a significant risk factor for reactivation of a disease?

  • High levels of hydration
  • Increased immune system strength
  • Immediate medical intervention
  • Weak immune response (correct)
  • In the context of sepsis, what does bacteremia refer to?

    <p>The presence of bacteria in the blood (D)</p> Signup and view all the answers

    According to Hugo Schottmüller, what is a necessary condition for diagnosing sepsis?

    <p>Bacteremia (D)</p> Signup and view all the answers

    What term describes the period of recuperation and recovery following the illness phase?

    <p>Convalescence (C)</p> Signup and view all the answers

    What key factor is crucial in determining patient outcomes from sepsis?

    <p>The host response to the infection (D)</p> Signup and view all the answers

    What distinguishes infection from disease?

    <p>Infection refers to microbial invasions that may not cause symptoms (C)</p> Signup and view all the answers

    Which of the following diseases is NOT commonly contracted via the skin?

    <p>Cholera (B)</p> Signup and view all the answers

    What is a common disease contracted through the conjunctiva?

    <p>Herpes ocularis (B), Chlamydiasis (C)</p> Signup and view all the answers

    Which factor does NOT contribute to the establishment of disease?

    <p>Severity of symptoms at first infection (B)</p> Signup and view all the answers

    What common disease can be contracted parenterally?

    <p>Hepatitis (A)</p> Signup and view all the answers

    Which pathogen is uniquely affected by its portal of entry, as described in the content?

    <p>Salmonella typhi (C), Streptococcus pneumoniae (D)</p> Signup and view all the answers

    Which of the following is NOT a sexually transmitted disease listed?

    <p>Shigellosis (B)</p> Signup and view all the answers

    How do microorganisms typically enter the body through parenteral routes?

    <p>Through the bloodstream (A)</p> Signup and view all the answers

    Which of the following correctly identifies the primary portal of entry for HIV?

    <p>Mucous membranes of the genitourinary tract (A)</p> Signup and view all the answers

    What characterizes commensalism in host-pathogen relationships?

    <p>Neither organism benefits or is harmed. (C)</p> Signup and view all the answers

    Which of the following is an example of mutualism?

    <p>E.coli in the gut (A)</p> Signup and view all the answers

    What defines a pathogen's pathogenicity?

    <p>The susceptibility of the host and virulence of the pathogen. (C)</p> Signup and view all the answers

    Opportunistic pathogens typically do not cause disease except under which circumstances?

    <p>Compromised immune system or abnormal environment. (B)</p> Signup and view all the answers

    Which portal of entry is most frequently used by pathogens?

    <p>Mucous membranes of the respiratory tract (A)</p> Signup and view all the answers

    How do microbes typically enter the gastrointestinal tract?

    <p>Through contaminated food and water. (C)</p> Signup and view all the answers

    What is required for a microbe to cause disease after entering a host?

    <p>Evading host defenses and damaging host tissues. (B)</p> Signup and view all the answers

    Which pathogen is often associated with secondary infections after the flu due to a compromised environment?

    <p>Pneumocystis carinii (A)</p> Signup and view all the answers

    What does LD50 refer to in microbiology?

    <p>The number of microbes in a dose that kill 50% of the organisms infected (C)</p> Signup and view all the answers

    Which statement accurately describes ID50?

    <p>It denotes the number of microbes required to cause disease in 50% of infected organisms. (D)</p> Signup and view all the answers

    What is the role of pili in the pathogenic process?

    <p>To bind to host glycoproteins and aid in adherence (C)</p> Signup and view all the answers

    In the context of pathogenicity, what does the term 'virulence factor' refer to?

    <p>Substances produced by pathogens that help establish and maintain disease (D)</p> Signup and view all the answers

    During bacterial invasion, which requirement must be met to succeed?

    <p>The pathogen must obtain essential nutrients and protect itself from host defenses (B)</p> Signup and view all the answers

    What type of damage is primarily caused by byproducts of bacterial growth?

    <p>Tissue destruction and the release of degradative enzymes (A)</p> Signup and view all the answers

    Which of the following is NOT a type of virulence factor?

    <p>Nutrient absorption mechanisms (B)</p> Signup and view all the answers

    Fibronectin Binding Proteins function primarily as what type of virulence factor?

    <p>Adhesion factors that bind to specific tissue receptors (D)</p> Signup and view all the answers

    Which mechanism allows bacteria to be 'not seen' by immune system cells?

    <p>Encapsulation (A)</p> Signup and view all the answers

    What is a significant change in an antigen called that can stimulate antibody production?

    <p>Antigenic shift (D)</p> Signup and view all the answers

    Which bacterial characteristic is primarily composed of polysaccharides and helps prevent phagocytosis?

    <p>Capsule (B)</p> Signup and view all the answers

    Leukocidins are involved in which of the following immune evasion strategies?

    <p>Destruction of phagocyte (C)</p> Signup and view all the answers

    What is the outcome of antigenic mimicry in pathogens?

    <p>Evasion of antibody recognition (D)</p> Signup and view all the answers

    The process by which phagolysosome fusion is inhibited primarily aids in which type of microbial strategy?

    <p>Intracellular replication (D)</p> Signup and view all the answers

    What do hemolysins primarily target in the host body?

    <p>Red blood cells (A)</p> Signup and view all the answers

    Which strategy is NOT a defense mechanism employed by microbes to evade the immune response?

    <p>Phagocyte recruitment (D)</p> Signup and view all the answers

    What is the primary function of coagulase in pathogenic bacteria?

    <p>Protects bacteria from phagocytosis (B)</p> Signup and view all the answers

    Which enzyme is responsible for the shedding of blood clots and facilitating bacteremia?

    <p>Streptokinase (D)</p> Signup and view all the answers

    What type of bacteria typically produces hyaluronidase?

    <p>Both Streptococci and Staphylococci (C)</p> Signup and view all the answers

    Which of the following conditions is most associated with collagenase activity during infection?

    <p>Gas Gangrene (D)</p> Signup and view all the answers

    What effect does the necrotizing factor have on tissue cells?

    <p>Causes necrosis (C)</p> Signup and view all the answers

    Alpha hemolytic streptococci are characterized by their ability to:

    <p>Cause incomplete lysis of red blood cells (A)</p> Signup and view all the answers

    What is a common characteristic of beta hemolytic streptococci?

    <p>They cause complete lysis of red blood cells (C)</p> Signup and view all the answers

    Which statement about hyaluronic acid is incorrect?

    <p>It stimulates blood clot formation. (C)</p> Signup and view all the answers

    Flashcards

    What is Pathology?

    The study of diseases. It focuses on the causes, mechanisms, and effects of diseases.

    What is Etiology?

    The cause of a disease. It identifies the agent or factor responsible for triggering the disease.

    What is Pathogenesis?

    The sequence of events that occur during the development of a disease, from initial interaction with the causing agent to the final outcome.

    What is Infection?

    The colonization of a host organism by a microbial parasite. It doesn't necessarily mean the host is experiencing symptoms.

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    What's Disease?

    A state of ill health with recognizable symptoms and signs. It indicates that the host's normal functioning is disrupted.

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    What is Virulence?

    The degree of pathogenicity of a microbe, indicating its ability to cause disease. It measures how good a microbe is at making you sick.

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    What is Bacteremia?

    The presence of bacteria in the bloodstream.

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    What is Sepsis?

    A generalized inflammatory response to infection. It involves multiple organs and can be life-threatening.

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    Commensalism

    A type of symbiotic relationship where one organism benefits, while the other is neither harmed nor helped. An example is Corynebacterium living in the eye.

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    Mutualism

    A symbiotic relationship where both organisms benefit. For example, E. coli in the gut helps with digestion and provides us with vitamin K.

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    Parasitism

    A symbiotic relationship where one organism benefits at the expense of the other. This is the case for all pathogens where the pathogen benefits, while the host is harmed.

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    Normal Microbiome

    Microorganisms that normally live on the body of a healthy individual. These microorganisms are often beneficial and contribute to our overall health.

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    Opportunistic Pathogens

    Microorganisms that are usually harmless, but can cause disease under specific circumstances like a compromised immune system or being in the wrong location.

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    Portals of Entry

    Paths by which pathogens enter the body. Examples include mucous membranes, skin, parenteral route, and placenta.

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    Respiratory Tract as a Portal of Entry

    The respiratory tract is one of the most common portals of entry for pathogens. Microbes can be inhaled in droplets or dust particles, leading to various respiratory infections.

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    Gastrointestinal Tract as a Portal of Entry

    The gastrointestinal tract is another common portal of entry for pathogens, often through contaminated food or water.

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    Salmonellosis

    A condition caused by the bacterium Salmonella, typically through contaminated food or water. It can cause diarrhea, fever, and abdominal cramps.

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    Shigellosis

    An infection caused by the bacterium Shigella, often spread through contaminated food or water. It leads to watery diarrhea, fever, and abdominal cramps.

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    Botulism

    A serious illness caused by the bacterium Clostridium botulinum. It produces a toxin that blocks nerve signals, causing muscle paralysis. It can be contracted through contaminated food, especially improperly canned goods.

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    Cholera

    An infection caused by the bacterium Vibrio cholerae, spread through contaminated water and food. It can cause severe watery diarrhea, dehydration, and even death.

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    Sexually Transmitted Diseases (STDs)

    A group of sexually transmitted infections (STIs) that affect the genitourinary tract, including the urethra, cervix, and rectum.

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    Conjunctivitis (Pink Eye)

    A bacterial infection that affects the conjunctiva, the membrane that covers the eyeball and lines the eyelid. It can cause redness, swelling, and discharge.

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    Staphylococcal Infection

    A bacterial infection that affects the skin, often causing boils, pimples, and other skin lesions.

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    Mycosis

    A fungal infection that affects the skin, causing various symptoms depending on the type of fungus involved. Examples include athlete's foot and ringworm.

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    LD50

    The number of microbes in a dose that kills 50% of the organisms infected in a sample.

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    ID50

    The number of microbes in a dose that causes disease in 50% of the organisms infected.

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    Pili or Fimbriae

    Pathogens have structures that attach to host cells. Pili, also known as fimbriae, are protein structures that bind to host glycoproteins.

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    Invasion/Colonization

    The ability of a pathogen to penetrate and multiply within a host's tissues. This involves accessing food and nutrients, protecting itself from host defenses, and multiplying.

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    Production of Toxins

    Bacteria produce toxic substances that cause damage to host tissues. These toxins can be directly harmful or trigger destructive biological activities.

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    Virulence Factor

    A pathogen-produced substance that promotes the establishment and maintenance of disease. These factors help pathogens succeed in causing illness.

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    Adhesins

    Molecules that attach to specific receptors on tissue surfaces, aiding in pathogen attachment.

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    Fibronectin Binding Proteins

    These are a type of adhesin protein that binds to both fibronectin and fibrinogen, impacting cell binding and immune response.

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    Encapsulation

    Microbes can evade the immune system by creating a protective layer that prevents phagocytosis. Think of it like a disguise that makes them invisible to immune cells.

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    Antigenic Mimicry

    Microbes can mimic the antigens present on host cells, tricking the immune system into not recognizing them as foreign.

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    Antigenic Shift

    A sudden and significant change in the antigens of a microbe, making it unrecognizable to the immune system, often seen with influenza viruses.

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    Inhibition of Phagolysosome Fusion

    Some microbes stop the fusion of phagocytic vesicles with lysosomes, preventing the breakdown of pathogens inside the cell.

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    Production of Antiimmunoglobulin Proteases

    A microbe's ability to produce enzymes that break down antibodies, weakening the immune response.

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    Destruction of Phagocyte

    Microbes can kill phagocytes, directly targeting the immune cells that engulf and destroy them.

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    Inhibition of Chemotaxis

    Some microbes prevent the movement of immune cells to the site of infection, hindering the immune response.

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    Resistance to Lysosomal Enzymes

    Microbes can resist the breakdown by lysosomal enzymes within phagocytes, ensuring their survival and propagation.

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    Coagulase

    The ability of some bacteria to cause blood to coagulate, forming blood clots that protect them from white blood cells and other immune defenses.

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    Kinases

    Enzymes that dissolve blood clots, helping bacteria spread throughout the body.

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    Hyaluronidase

    An enzyme that breaks down hyaluronic acid, a component of connective tissue, allowing bacteria to spread deeper into the body.

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    Collagenase

    An enzyme that breaks down collagen, a key protein found in connective tissues, enabling bacteria to invade deeper tissues.

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    Necrotizing Factor

    A factor produced by certain bacteria that causes tissue death (necrosis), often associated with a severe inflammatory response.

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    Beta Hemolysis

    A bacterial enzyme that breaks down red blood cells (RBCs) completely, resulting in a clear zone around the bacteria on a blood agar plate.

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    Alpha Hemolysis

    A bacterial enzyme that causes partial breakdown of red blood cells (RBCs) resulting in a greenish discoloration around the bacteria on a blood agar plate.

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    Bacteremia

    The presence of bacteria in the bloodstream.

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    Study Notes

    Host-Pathogen Relationships

    • Host-pathogen relationships involve the interaction between a host and a pathogen.
    • Commensalism: one benefits, the other is unaffected. An example is Corynebacterium in the eyes.
    • Mutualism: both benefit. An example is E. coli in the gut.
    • Parasitism: one benefits, the other is harmed. An example is any pathogen.
    • Pathogenicity depends on host susceptibility and pathogen virulence.

    Chapter Overview

    • Infectious diseases require basic concepts.
    • Host-pathogen relationships determine portals of entry and virulence factors.
    • Virulence factors facilitate disease establishment and maintenance.

    Definitions

    • Pathology: study of disease.
    • Etiology: the cause of a disease.
    • Pathogenesis: the development of a disease.
    • Infection: colonization of a microbe.
    • Disease: illness.
    • Virulence: degree of pathogenicity.
    • Bacteremia: presence of bacteria in the blood.
    • Sepsis/Septicemia: body's inflammatory response to an infection.

    Infection and Disease

    • Infection: invasion by parasitic microbes. Infection doesn't always cause disease.
    • HIV infection can lead to AIDS.
    • Disease is a change in health, damage to the host.

    Phases of Disease

    • Incubation: the time between pathogen introduction and symptom onset (variable).
    • Illness: experience of disease signs and symptoms.
    • Convalescence: recovery period, potentially with pathogen spread.

    Types of Disease

    • Acute: organism disappears after illness, generally with immunity.
    • Chronic: illness persists or recurs.
    • Latent: illness may recur, if immunity weakens, after a period of no symptoms.

    Sepsis

    • Sepsis is a severe systemic inflammatory response to microbial invasion.
    • The host response is as important as the pathogen's virulence.
    • Bacteremia is critical for diagnosis, however the host's response is the key driver of outcome.

    Microbiome

    • Microbiome: the community of microorganisms routinely found on a healthy individual.
    • Humans have more microbes than stars.
    • Most of the microbiome is located in the GI tract.
    • The microbiome has significant influence on health and disease.

    Opportunistic Pathogens

    • Opportunistic pathogens usually do not cause disease.
    • However, in certain circumstances, normal flora can cause disease. (In the wrong environment, such as a compromised immune system).
    • E. coli in the urinary tract is an example.
    • Weakened immunity, such as in AIDS, or conditions like pneumonia can cause opportunistic infections.

    Pathogenic Microorganisms

    • For disease to occur, a microbe must gain access and evade defenses.
    • Possible entry points are mucous membranes, skin, and parenteral(punctures etc).
    • The pathogen must then damage tissues.

    Portals of Entry

    • Respiratory tract: Microbes enter via inhaled moisture or dust particles, causing common cold, flu, tuberculosis, and whooping cough.
    • Gastrointestinal tract: Microbes enter via contaminated food or water, causing salmonellosis, shigellosis, botulism, and cholera.
    • Genitourinary tract: Sexually transmitted diseases (STDs) like gonorrhea, syphilis, chlamydia, and HIV.
    • Conjunctiva: Common diseases include chlamydia and herpes ocularis.
    • Skin: Some microbes enter through skin openings or damage, causing staphylococcal infections and mycosis.
    • Parenteral: microbes enter through punctures, injections, bites, scratches, or surgery, causing diseases like hepatitis and HIV.

    Factors That Determine Disease Establishment

    • Pathogen entry does not always result in disease.
    • Preferred portal of entry is important.
    • Virulence factors (like toxins, or capsule) are essential considerations.

    Steps for Pathogen Infection

    • Step 1: Adherence: pathogens use pili or other structures to attach to host cells.
    • Step 2: Invasion/Colonization: Pathogens multiply, gain nutrients, and evade host defenses (especially the immune system).
    • Step 3: Cause Damage: Pathogens destroy tissues through toxins (such as exotoxins and endotoxins) and enzymes.

    Virulence Factors

    • Virulence factors are substances that promote and maintain disease.
    • Types include adhesion factors, evasion of immune responses, degradative enzymes, and toxins.

    Adhesion Factors

    • Pili (fimbriae) are short, rigid, numerous protrusions.
    • Adhesins bind to host receptors on tissues.

    Evading Immune Response

    • Encapsulation: prevents phagocytosis (by macrophages etc).
    • Antigenic mimicry: pathogens resemble host cells.
    • Antigenic shift: change in pathogen proteins (antigens) that causes antibody ineffectiveness.
    • Inhibition of phagolysosome fusion: inhibits the pathogen from being destroyed.
    • Immunoglobulin protease production
    • Destruction of phagocyte
    • Inhibition of chemotaxis
    • Resistance to lysosomal enzymes
    • Intracellular replication

    Degradative Enzymes

    • Leukocidins: kill white blood cells, preventing phagocytosis, (and preventing the host's defense mechanisms from functioning appropriately).
    • Hemolysins: cause lysis (breakdown) of red blood cells.
    • Coagulase: causes blood clotting, protecting bacteria from phagocytes.
    • Kinases: dissolve blood clots, enabling pathogen spread.
    • Hyaluronidase: breaks down hyaluronic acid, enabling pathogen spread through tissues.
    • Collagenase: breaks down collagen, enabling pathogen spread through tissues.
    • Necrotizing factors: cause tissue death.

    Toxins

    • Toxins are poisonous substances.
    • Exotoxins are secreted, heat labile, and may or may not be able to produce an antitoxin.
    • Endotoxins (part of cell wall) are similar among species, cause similar symptoms, and are difficult to neutralize.
    • Toxemia: toxins in the blood stream causing disease.

    Classification of Exotoxins

    • Leukotoxins: target white blood cells.
    • Cytotoxins: damage host cells (eg., kill).
    • Neurotoxins: target nervous system.
    • Enterotoxins: target the digestive system.
    • Hepatotoxins: target the liver.
    • Cardiotoxins: target the heart.

    Leukotoxins: Superantigens

    • Invoke very strong immune responses.
    • Affect T cells, causing severe symptoms

    Cytotoxins: Membrane Disrupting Toxins

    • Disrupt host plasma membranes (via impacting phospholipids or protein structures).
    • Examples include toxins that target RBCs or phagocytes.

    Neurotoxins: A-B Toxins

    • Toxins of Clostridium botulinum and Clostridium tetani affect neuromuscular transmission; including blocking/stimulating nerve activity.

    ###Endotoxins

    • Component of the outer membrane of Gram-negative bacteria.
    • Cause similar symptoms in various species.
    • Not easily deactivated.
    • Induce excessive/destructive host immune responses.
    • Induce TNF release from macrophages.

    Endotoxin Symptoms

    • Pyrogenic (fever) response: Interleukin-1 prompts prostaglandin release from the hypothalamus.
    • Leukopenia followed by leukocytosis – white blood cell abnormalities
    • Activation of complement: complement proteins are involved in host immune defenses.
    • Thrombocytopenia: abnormal decrease in platelets.
    • Disseminated Intravascular Coagulation (DIC): widespread clotting.
    • Shock and death.

    Host Susceptibility/Resistance

    • Factors influencing the host's susceptibility/resistance to infection include age, pre-existing conditions, diet, hygiene, and behavior.
    • Stress factors such as weather, can also affect the susceptibility to pathogens.

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    Test your knowledge on key concepts of infectious diseases including etiology, phases of disease, and patient outcomes. This quiz covers essential terms and risks related to infection and sepsis. Perfect for students and professionals in the health sciences field.

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